• 대한골관절종양학회지
• /
• 제18권2호
• /
• pp.51-58
• /
• 2012

목적: 슬관절 주위에 발생한 골종양 환자에서 종양 대치물을 이용한 재건술의 결과와 보행 분석의 유용성을 알아보고자 하였다. 대상 및 방법: 2001년부터 2010년까지 슬관절 주위에 발생한 골종양에 대하여 광범위 절제술 후 종양 대치물을 이용한 재건술을 시행 받은 30명 중 7명을 대상으로 하였으며 기능적 결과 및 보행 분석 검사를 평가하였다. 결과: SF-36 점수는 신체적, 정신적 역할제한 항목에서 각각 100% (100점)으로 높은 점수를 보였으며 일반 건강상태, 신체적 기능 정도, 활력, 사회적 기능에서 낮은 점수를 나타냈다. 또한 MSTS 평가의 종합 평균 점수는 88.1% (23.8점[17-27])였다. 보행 분석 검사상 평균 보행속도 97.2 m/s, 평균 분속수 105.6 step/min, 평균 활보장 111.3 m, 평균 보장 61.5 cm, 유각기 39.8%cycle, 입각기 60.1%cycle, 평균 단하지 지지기 37.1%cycle, 평균 양하지 지지기 13.0%cycle, 평균 발 들림시기 60.7%cycle였다. 결론: 슬관절 주위 종양에 대한 광범위 절제술 후 종양 대치물을 이용한 재건술은 좋은 기능적결과를 기대할 수 있으며, 보행 분석 검사는 술후 환자의 상태를 정량적으로 평가함으로써 보행 모습 및 기능을 객관화 할 수 있는 한 방법으로 사료되며 기능적 평가 방법과 함께 치료 및 술 후 재활 계획을 세우는데 도움이 되리라 생각된다.

• 한국약용작물학회:학술대회논문집
• /
• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
• /
• pp.527-528
• /
• 2010

• 한국철도학회:학술대회논문집
• /
• 한국철도학회 2008년도 춘계학술대회 논문집
• /
• pp.1802-1808
• /
• 2008

Recent interest in the construction sector, rising about the environment and eco-friendly recycled material resources, and increase the development of method But despite these efforts, and the diverse functional and structural changes in the structure can not be an appropriate response to the functional waterproof structural changes in the structures and appropriate response Diversification does not waterproof and functional issues such as durability, and which are occurring due to the structure to secure stability and durability, never sees the conservative economic losses due to import constructability reinforcement situation. Therefore, this study applies to structure the existing waterproof method (hereinafter referred to as structures water-resistant methode), and to review recent issues of environmental pollution and resource waste, and taking on environmental issues, such as Revelation and functional Inorganic mixed in a way to leverage the manufacturing water-resistant material "Re Inorganic, functional and environmentally friendly high-viscosity mix asphalt waterproof rubber reinforcements, and taking conservative" for the characterization and performance assessment to the issues raised by the structure and whether the judge would respond.

• Molecules and Cells
• /
• 제28권6호
• /
• pp.553-558
• /
• 2009

In the periphery, a galectin-1 receptor, CD7, plays crucial roles in galectin-1-mediated apoptosis of activated T-cells as well as progression of T-lymphoma. Previously, we demonstrated that $NF-{\kappa}B$ downregulated CD7 gene expression through the p38 MAPK pathway in developing immature thymocytes. However, its regulatory pathway is not well understood in functional mature T-cells. Here, we show that CD7 expression was downregulated by Twist2 in Jurkat cells, a human acute T-cell lymphoma cell line, and in EL4 cells, a mature murine T-cell lymphoma cell line. Furthermore, ectopic expression of Twist2 in Jurkat cells reduced galectin-1-induced apoptosis. While full-length Twist2 decreased CD7 promoter activity, a C-terminal deletion form of Twist2 reversed its inhibition, suggesting an important role of the C-terminus in CD7 regulation. In addition, CD7 expression was enhanced by histone deacetylase inhibitors such as trichostatin A and sodium butyrate, which indicates that Twist2 might be one of candidate factors involved in histone deacetylation. Based on these results, we conclude that upregulation of Twist2 increases the resistance to galectin-1-mediated-apoptosis, which may have significant implications for the progression of some T-cells into tumors such as Sezary cells.

• 대한물리의학회지
• /
• 제17권1호
• /
• pp.11-20
• /
• 2022

PURPOSE: A gait assessment is an important component of the rehabilitation process, and observational gait assessment (OGA) is used routinely in clinical settings. This study examined the association of OGA tools with the independent walking ability in stroke patients to determine a cutoff value of the OGA tool according to independence levels of stroke patient gait. METHODS: Two hundred ten hemiparetic stroke patients participated in the study. The independence of gait was identified using the Functional Ambulation Category (FAC) classifications. The walking ability was assessed using OGA tools (Rivermead Visual Gait Assessment [RVGA], Wisconsin Gait Scale [WGS], Tinetti Gait Scale [TGS], and Functional Gait Analysis [FGA]). RESULTS: Stepwise multiple regression analysis showed that among the OGA tools, the FGA correlated with the FAC. The FGA explained approximately 77% of the variance in FAC. In distinguishing the independence levels, the cutoff values were as follows: between FAC 1 and FAC 0 was .5 points; between FAC 2 and lower levels, 5.5; between FAC 3 and lower levels, 11.5; between FAC 4 and lower levels, 14.5; and between FAC 5 and lower levels, 18.5. Items 1, 2, 3, and 10 were identified as explaining most of the variance in the FGA in the stepwise multiple regression. CONCLUSION: The present study found that the FGA is an assessment tool related to the level of gait independence after stroke. Furthermore, the FGA total score can serve as an index of the increase in independence level after stroke.

• Journal of Acupuncture Research
• /
• 제26권6호
• /
• pp.215-224
• /
• 2009

Objectives : Low back pain is the most prevalent condition for receiving Korean traditional medical treatment. The aim of this review is to provide fundamental data for development of low back pain classification and assessment criteria which can be used in clinical trials and clinical practice. Methods : Domestic and international clinical studies on oriental medicine treatment for low back pain were searched through on-line databases. The searched articles were reviewed and the evaluation tools used in the studies were investigated. Results : A total of 38 possibly relevant articles in Pubmed were identified, of which 34 articles included assessment criteria for low back pain. And 38 articles were reviewed in the Journal of Korean Oriental Medicine and the Journal of Korean Acupuncture & Moxibustion Society. 29 articles used pain scales, 24 used functional scales, and 20 among 34 articles in PubMed used both pain and functional scales. The majority of articles which published in Korea used worthless assessment scales of simple grades. There was no articles which used assessment scales related to the concepts of Korean traditional medicine. Conclusions : Our review of articles suggests that we would use both pain and functional scales. Future assessment scales should include the concepts of Korean traditional medicine.

• Nutrition Research and Practice
• /
• 제12권4호
• /
• pp.275-282
• /
• 2018

BACKGROUND/OBJECTIVE: There is intense interest in soy isoflavone as a hormone replacement therapy for the prevention of postmenopausal osteoporosis. A new kind of isoflavone-enriched whole soy milk powder (I-WSM) containing more isoflavones than conventional whole soy milk powder was recently developed. The aim of this study was to investigate the effects of I-WSM on bone metabolism in ovariectomized mice. MATERIALS/METHODS: Sixty female ICR mice individually underwent ovariectomy (OVX) or a sham operation, and were randomized into six groups of 10 animals each as follows: Sham, OVX, OVX with 2% I-WSM diet, OVX with 10% I-WSM diet, OVX with 20% I-WSM diet, and OVX with 20% WSM diet. After an 8-week treatment period, bone mineral density (BMD), calcium, alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP) 5b, osteocalcin (OC), procollagen 1 N-terminal propeptide (P1NP), and osteoprotegenin (OPG) were analyzed. RESULTS: BMD was significantly lower in the OVX group compared to the Sham group but was significantly higher in OVX + 10% I-WSM and OVX + 20% I-WSM groups compared to the OVX group (P < 0.05). Serum calcium concentration significantly increased in the OVX + 10% and 20% I-WSM groups. Serum ALP levels were significantly lower in the OVX + 10% and 20% I-WSM groups compared to the other experimental groups (P < 0.05). OC was significantly reduced in the OVX group compared to the Sham group (P < 0.05), but a dose-dependent increase was observed in the OVX groups supplemented with I-WSM. P1NP and OPG levels were significantly reduced, while TRAP 5b level was significantly elevated in the OVX group compared with the Sham group, which was not affected by I-WSM (P < 0.05). CONCLUSIONS: This study suggests that I-WSM supplementation in OVX mice has the effect of preventing BMD reduction and promoting bone formation. Therefore, I-WSM can be used as an effective alternative to postmenopausal osteoporosis prevention.

• 디지털융복합연구
• /
• 제12권4호
• /
• pp.379-397
• /
• 2014

본 연구의 목적은 장애인의 소득보장정책을 포함한 장애인 고용정책으로 전환하기 위한 필수요건인 근로능력평가 척도를 개발하기 위한 것이다. 현행 체계는 장애연금이 의학적 기준에 의해 신체상의 장애상태를 평가하고 있어 근로능력에 대한 강한 예측력을 보여주지 못하고 있는 문제가 있다. 이에 선행연구, 국 내외의 근로능력평가 척도, 국제기능장애건강분류(ICF) 모델의 결과를 토대로 전국 880명의 장애연금 장애인을 대상으로 자료를 수집하여 인분석 한 결과 최종적으로 7요인 58문항의 척도를 개발하였다. 확인적 요인분석을 실시하여 적합도 지수를 구한 결과 촉도의 개념 구성 타당도가 검증되었다. 개발된 척도의 신뢰도 검증에서 척도 전체의 Cronbach's ${\alpha}$계수가 .94이고 7개요인 각각의 신뢰도는 .74~.90이다. 향후 근로능력평가 척도의 타당도를 높이기 위해서 본 연구에서 제시된 평가척도를 표준화하는 방안, 각 평가에 대한 세부 지침, 다수에 의한 평가 체계 운영 방안의 추후 연구 과제를 제시하였다.

• Journal of Dairy Science and Biotechnology
• /
• 제32권1호
• /
• pp.55-62
• /
• 2014

본 연구는 국내 기능성 축산식품 관리제도 도입과 관련하여, 이를 반영하기 위한 기능성 물질(성분)의 과학적 분석기술 및 기능성 축산물별 검사방법 등 세부관리기준과 인증 방안을 마련하여 시행규칙을 제안하고자 한다. 기능성 축산식품을 관리하기 위한 새로운 법률 개정에 발맞추어 기능성 물질(성분)의 효용성(efficacy)과 안전성(safety)을 확인(검증)할 수 있는 분석 평가기술의 재정립을 통하여, 기능성 식품의 분석 평가 현황을 파악하고, 축산식품을 위한 기능성 물질의 범위를 정하여 이에 부합하는 표준검사법을 확립하고, 표준화를 제안한다. 본 연구를 통해 그 동안 우리나라에서 건강지향식품들의 지속적 노력에도 불구하고, 질적인 발전을 이루지 못한 과거의 문제점을 해결하여, 합리적인 관리체계 안에서 안전하고 우수한 품질을 갖는 기능성 축산식품을 제조 판매하는데 이바지 하며, 소비자의 건강증진은 물론 잘못된 건강기능식품의 섭취로 인한 피해를 방지하고자 한다.

• 한국환경복원기술학회지
• /
• 제24권1호
• /
• pp.15-24
• /
• 2021

This study was carried out to propose the functional assessment and a wise use strategy on the ecologically valuable 'village wetlands' distributed in living area in Geumsan gun, Chungnam province, Korea. The targets of the functional evaluation were 24 wetlands, selected from 123 village wetlands, where villages and agricultural lands or core ecosystems are located within living area near the wetland and wetlands with historical and cultural significance. The functional evaluation was carried out by RAM (Rapid Assessment Model) and the conservation strategies were suggested. As a result of the functional evaluation, 9 wetlands were rated 'high' (2 'absolute conservation' and 7 'conservation' strategies), 14 wetlands were rated 'medium' ('enhancement' strategies), and one wetland was rated 'low' ('restore or enhancement' strategy). In consideration of the results of the functional evaluation, interviews with village residents, and historic meaning, 6 important village wetlands were selected that require additional management strategies, such as conservation, enhancement, and restoration. 2 wetlands were from "absolute conservation" strategy and 4 wetlands derived from "conservation" and "enhancement" strategy wetlands in consideration of the ecological connectivity of wetlands, the use of surrounding land, and the function as a biological habitat. The wise use and conservation strategy was specifically proposed respectively.