• The Journal of Internal Korean Medicine
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• v.37 no.4
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• pp.645-652
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• 2016

Objectives: To compare the effects of Eastern-Western integrative medical care (EWIM) and Western single rehabilitation therapy (WSRT) on the functional recovery of stroke patients.Methods: Seventy-six stroke patients were recruited retrospectively. The participants were divided into two groups: EWIM and WSRT. Data on age, sex, stroke-related risk factors, stroke type, neurological deficits according to the National Institutes of Health Stroke Scale (NIHSS), elapsed time to the initiation of rehabilitation, duration from the onset to follow up, initial functional status, and function after therapy for 3 mon were obtained from a review of the patients’ medical records. Between-group differences in functional outcomes were analyzed before and after treatment using the functional ambulation category (FAC), Fugl-Meyer assessment (FMA), modified Barthel Index-Korean version (K-MBI), and Euro-Quality of Life-5 Dimension (EQ-5D).Results: At 3-mon poststroke, all the functional outcome measures had improved in both groups (P<0.05). However, the improvements were greater in the EWIM group, and the improvement was statistically significant in the K-MBI (P=0.048) and EQ-5D (P=0.042).Conclusions: With respect to activities of daily living and health-related quality of life, EWIM is a more effective stroke therapy than WSRT.

• International Journal of Clinical Preventive Dentistry
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• v.14 no.4
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• pp.256-263
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• 2018

Objective: This study aimed to investigate the factors associated with masticatory performance, as measured with a chewing gum containing spherical resinous microparticles, and to evaluate the method by examining the relationship with self-reported masticatory status. Methods: The participants in this study comprised 903 industrial workers (mean age, $42.2{\pm}11.6years$). A questionnaire was administered to assess self-reported masticatory status. The masticatory performance score was calculated by counting the number of particles in the chewing gum. Clinical oral examinations were administered. Multiple linear regression analysis was conducted on the masticatory performance scores to examine the related factors. Analysis of covariance was conducted to investigate the association between the masticatory performance score and the self-reported masticatory status. Results: Significant predictors of the masticatory performance score were sex (p<0.001), age (p<0.001), decayed teeth (p=0.009), total-functional tooth units (p<0.001), periodontitis (p=0.003), and malocclusion (p=0.011). The relationship between the masticatory performance score and the self-reported masticatory status was attenuated after controlling for confounding factors. Conclusion: The masticatory performance increased with age and decreased as the oral health status worsened. Using this chewing gum method partly, but not comprehensively, reflects masticatory performance. Therefore, various masticatory performance-related indexes should be employed to measure masticatory performance accurately.

• Journal of Acupuncture Research
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• v.24 no.1
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• pp.1-12
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• 2007

Objectives : Functional dyspepsia is a prevalent disease. It impedes subjective quality of life. The purpose of this research is to examine the effect of acupuncture treatment for functional dyspepsia. Methods : In this randomized, single blind, placebo-controlled study, we compared active acupuncture with sham acupuncture for the treatment of functional dyspepsia. Volunteers who satisfied the requirements were enrolled in study. Severity of dyspepsia was measured by Nepean Dyspepsia Index(NDI) and Functional Dyspepsia Quality fo Life(FD-QOL) before and after treatments. Results : 68 subjects finished study. There were not difference between two groups on age, sex, weight, height, severity of dyspepsia, subtype, Byeonjeung, surmise of treatment. After treatment total key symptoms score, improve rate of key symptoms were decreased than before treatment in active acupuncture group, but there were no statistical significance compared with sham acupuncture group. After treatment "pressure in upper abdomen" and " cramps in upper abdomen" were more decreased in active acupuncture group compared with sham acupuncture group(p=0.001, p=0.014). After treatment total symptom score and QOL of NDI were decreased than before treatment in active acupuncture group, but there were no statistical significance compared with sham acupuncture group. After treatment eating status of FD-QOL in active acupuncture group was significantly increased than sham acupuncture group(p=0.008). After treatment liveliness status of FD-QOL and total score of FDQOL in active acupuncture group was increased than sham acupuncture group though statistically insignificant(p=0.095, p=0.077). Conclusion : Acupuncture treatment is effective to improve the symptoms and quality of life in patients with functional dyspepsia.

• BMB Reports
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• v.45 no.11
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• pp.671-676
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• 2012

Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our results demonstrate that CR induced an increase in protein carbonylation in the heart without changing the content of sulfhydryl groups or the activities of superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney. Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney.

• Language and Information
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• v.14 no.2
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• pp.71-84
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• 2010

The aim of this paper is to propose that a category P is encapsulated within a functional layer above the lexical layer, just like vP containing a lexical VP. As is well known, the category P has long been in the obscure domain of syntactic studies: Marantz (2001) and den Dikken (2003), for example, argue that P is a lexical category, but Emonds (1985), Grimshaw (1991), and Baker (2003), maintain that the category P is functional and is a closed category without its own intrinsic meaning. On the other hand, Zwart (2005) argues that it does have some meaning. Following the works of Svenonius (2003, 2006, 2007), and the spirit of Rizzi's (1997) split CP hypothesis, we elaborate and develop Svenonius' idea of split-pP analysis with detailed schematic representations of the novel examples in English, Korean, and Chinese in this paper. Unlike Svenonius, however, this paper incorporates KP into pP-Shell, which is a substantial simplification. Furthermore, Chinese Localizers that have long been considered as Postpositions are now under the category of Prepositions. This proposal renders an X-bar theoretic consistency over the categorical status of Chinese phrasal structures. In short, the present analysis accounts for inconsistency found in English complex preposition phrase (Quirk, et al, 1972, 1985), Chinese circumposition phrase (Ernst 1988, Liu, 2002) and Korean postposition phrase in a unified and consistent manner. Furthermore, by proposing a finer-grained phrasal architecture for the category P, the controversial status of the category subsides within this analysis.

• Korean Journal of Oriental Medicine
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• v.15 no.3
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• pp.35-43
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• 2009

Introduction : Interests in personalized medicine or tailored medicine is growing in recent years, but traditional medicine with properties of tailored medicine have already been developing from many parts of the world. In this review paper, we tried to investigate the current research status and characteristics of traditional constitutional medicine by a comparative study. Methods and Material : We compared Sasang medicine from Korea, Ikkando medicine from Japan, Chinese constitutional medicine, Ayurveda from India. We investigated the current research status by searching academic DBs such as Medline, Riss4u, Kiss, CNKI, CINII. Then we examined characteristics of each medicine from various aspects of physiology-pathology-diagnosis-treatment-prevention. Results : We found out that each constitutional medicine is being studied the most in their native land. In addition, after analysing characteristics of these constitutional medicine, we learned that Sasang medicine and Ayurveda were putting emphasis on psychological factors in physiology-pathology-diagnosis-treatment-prevention, while Chinese constitutional medicine and Ikkando medicine were focusing on pathological factors. Discussion : We studied theories of constitutional medicine in various traditional medicine, and verified that Sasang medicine shares similarities and differences with these medicine. We suggest that deeper understandings of other constitutional medicine and attempts at clinical application can lead to advance of Sasang medicine.

• Korean Journal of Human Ecology
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• v.17 no.4
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• pp.797-805
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• 2008

The present study was investigated on type 2 diabetics' actual status of anti-diabetic functional food intake by patients who came to oriental medicine clinics in Daejeon. The male was 37.3% and female was 62.7% of the subjects. The onset of the disease was most common in the age of 50's. Also 40% of the subjects have been suffering for more than 5 years. 35.7% of men, 53.2% for women had family history. Also 61.5% of the patients chose to carry out both diabetic therapy and exercise at the same time. 69.3% of the subjects have had experiences in anti-diabetic functional foods. Anti-diabetic functional foods used to surveyed people were bean, ginseng, and ginseng steamed red of which efficacies were already well known. Besides these foods, other foods such as loach, crucian carp were also used as anti-diabetic foods, but their benefits as anti-diabetic functional foods are not yet fully investigated. Subjects first knew about the therapy because friends or relatives recommended to them and most of them have used for 6 months to 1 year. However, 78.9% of subjects answered 'not so effective' in a question about satisfaction of anti-diabetic functional food. Although many of the patients have tried taking functional foods, they only use them for short period of time and they don't show prominent effect. Therefore these results suggest that in order to use scientifically studied functional foods, education about anti-diabetic functional foods should taken.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.4
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• pp.1-9
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• 2021

Purpose : The purpose of this study was to investigate functional disability for the elderly in rural Korea and to identify influencing factors of functional disability. Methods : The data were collected for 76 community-dwelling elderly in rural area and above 65 years. We assessed cognitive function, functional disability, depression using LACLS, WHODAS 2.0, SGDS-K. Data were analyzed using descriptive statistics for general characteristics of subjects, Spearman's correlation among LACLS, SGDS-K, WHODAS 2.0, age, educational levels. And multiple regression was used to find influencing factors of functional disability. Results : As a result of this study, we identified that WHODAS 2.0 total score was 50.59, summary score was 9.94 and functional disability of the elderly in rural area is in the 70^th percentile. The highest level of disability occurred in areas related to 'life activities (household)', 'participation in society' and the lowest level of disability occured in areas of 'self-care', 'getting along with people'. Functional disability was significantly correlated with age (r=.398), cognitive function (r=-.547), depression (r=-.563) but not educational levels (r=-.215). Finally, we confirmed that depression (𝛽=.371), cognitive function (𝛽=-.263), widowed status (𝛽=.303), age (𝛽=.272), non-participation of community program (𝛽=.165) was significantly influencing factors of functional disability and the explanatory power of these factors was 52.80 %. Conclusion : This study revealed important factors of functional disability. Therefore, we need to consider these factors when we developed program related to health for the elderly (aged > 65 years) in rural Korea. Further, we need to standardize WHODAS 2.0 in order to enhance its applicability in clinical practices.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3763-3766
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• 2014

Human mammary epithelial cells have different proliferative statuses and demonstrate a close relationship with age and cell proliferation. Research on this topic could help understand the occurrence, progression and prognosis of breast cancer. In this article, using significance analysis of a microarray algorithm, we analyzed gene expression profiles of human mammary epithelial cells of different proliferative statuses and different age groups. The results showed there were significant differences in gene expression in the same proliferation status between elderly and young groups. Three common differentially expressed genes were found to dynamically change with the proliferation status and to be closely related to tumorigenesis. We also found elderly group had less status-related differential genes from actively proliferating status to intermediate status and more statusrelated differential genes from intermediate status than the young group. Finally, functional enrichment analyses allowed evaluation of the detailed roles of these differentially-expressed genes in tumor progression.

• The Journal of Korean Physical Therapy
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• v.17 no.1
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• pp.43-68
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• 2005

The purpose of this study was to report the physical status of adult with cerebral palsy who live in local community areas including Seoul, Busan, Daegu in Republic of Korea at 2004. 202-individuals with cerebral palsy(140 male, 62 female; mean age 31.9 years; range 19 to 64 years) were surveyed. Measures included a 29-item self-reported health status measure focusing on musculoskeletal status and functional performances. Adult cerebral palsy required continuous management for musculoskeletal and ambulatory function through therapeutic approach. This survey is restricted to population who had cared in welfare center for cerebral palsy in local community, so it needs to investigate home-residual adults with cerebral palsy and the population in rural community. The results were as follows: 1. Participants reported that they had a limitation of a daily of life activity due to musculoskeletal pain($43\%$), there was significant differences between a limitation of a daily of life activity and the decreased ambulatory function(p<.05). 2. Thirty six point six percentile of participants had the decreased ADL function, it was significant related with the impaired body location(p<.05) 3. Thirty nine point one percentile of participants who can independently gait had the decreased ambulatory function, it was significant differences with the usage of ambulatory assistive devices(p<.05). 4. There was significant differences ambulatory function both the body region with impairment and a grade of disability(p<.05). 5. Sixteen point three percentile of participants could not ambulate any more, there was significant differences between a age and a point of time for non-ambulation(p<.05). 6. There was significant differences between ambulatory function and physical activity(p<.05).