• Geomechanics and Engineering
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• 제16권5호
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• pp.539-545
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• 2018

Longitudinal Displacement Profile (LDP) is an appropriate tool for determination of the displacement magnitude of the tunnel walls as a function of the distance to the tunnel face. Some useful formulations for calculation of LDP have been developed based on the monitoring data on site or by 3D numerical simulations. However, the presented equations are only based on the tunnel dimensions and for different quality of rock masses proposed a unique LDP. In the present study, it is tried to present a new formulation, for calculation of LDP, on the basis of Rock mass quality. For this purpose, a comprehensive numerical simulation program was developed to investigate the effect of rock mass quality on the LDP. Results of the numerical modelling were analyzed and the least square technique was used for fitting an appropriate curve on the derived data from the numerical simulations. The proposed formulation in the present study, is a logistic function and the constants of the logistic function were predicted by rock mass quality index (GSI). Results of this study revealed that, the LDP curves of the tunnel surrounded by rock masses with high quality (GSI>60) match together; because the rock mass deformation varies over an elastic range.

• Molecules and Cells
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• 제42권3호
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• pp.210-217
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• 2019

The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which senescence amelioration in normal aging cells is mediated by the recovered mitochondrial function upon Ataxia telangiectasia mutated (ATM) inhibition. However, it remains elusive whether this mechanism is also applicable to senescence amelioration in accelerated aging cells. In this study, we examined the role of ATM inhibition on mitochondrial function in Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) cells. We found that ATM inhibition induced mitochondrial functional recovery accompanied by metabolic reprogramming, which has been known to be a prerequisite for senescence alleviation in normal aging cells. Indeed, the induced mitochondrial metabolic reprogramming was coupled with senescence amelioration in accelerated aging cells. Furthermore, the therapeutic effect via ATM inhibition was observed in HGPS as evidenced by reduced progerin accumulation with concomitant decrease of abnormal nuclear morphology. Taken together, our data indicate that the mitochondrial functional recovery by ATM inhibition might represent a promising strategy to ameliorate the accelerated aging phenotypes and to treat age-related disease.

• Journal of Information Processing Systems
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• 제17권3호
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• pp.645-657
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• 2021

Along with the rapid development of the economy, the urban scale has extended rapidly, leading to the formation of different types of urban function districts (UFDs), such as central business, residential and industrial districts. Recognizing the spatial distributions of these districts is of great significance to manage the evolving role of urban planning and further help in developing reliable urban planning programs. In this paper, we propose an automatic UFD division method based on big data analysis of point of interest (POI) data. Considering that the distribution of POI data is unbalanced in a geographic space, a dichotomy-based data retrieval method was used to improve the efficiency of the data crawling process. Further, a POI spatial feature analysis method based on the mean shift algorithm is proposed, where data points with similar attributive characteristics are clustered to form the function districts. The proposed method was thoroughly tested in an actual urban case scenario and the results show its superior performance. Further, the suitability of fit to practical situations reaches 88.4%, demonstrating a reasonable UFD division result.

• BMB Reports
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• 제43권5호
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• pp.305-310
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• 2010

Syndecans, cell surface heparansulfate proteoglycans, have been proposed to act as cell surface receptors and/or coreceptors to play critical roles in multiple cellular functions. However, recent reports suggest that the function of syndecans can be further extended through shedding, a cleavage of extracellular domain. Shedding constitutes an additional level for controlling the function of syndecans, providing a means to attenuate and/or regulate amplitude and duration of syndecan signals by modulating the activity of syndecans as cell surface receptors. Whether these remaining cleavage products are still capable of functioning as cell surface receptors to efficiently transduce signals inside of cells is not clear. However, shedding transforms cell surface receptor syndecans into soluble forms, which, like growth factors, may act as novel ligands to induce cellular responses by association with other cell surface receptors. It is becoming interestingly evident that shed syndecans also contribute significantly to syndecan functions in cancer biology. This review presents current knowledge about syndecan shedding and its functional significance, particularly in the context of cancer.

• 대한한의학회지
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• 제37권3호
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• pp.74-86
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• 2016

Objectives: This article aims to review clinical studies related to traditional Korean medicine (TKM) for cancer-related cognitive impairment (CRCI) up to date. Methods: EMBASE, Pubmed and eight Korean databases were searched for clinical studies about TKM for CRCI up to July 2016. We selected articles about subjects with cancer, using TKM interventions including acupuncture, moxibustion or herbal medicine, containing assessment about cognitive function. Results: Two randomized controlled trials (RCTs) and one randomized controlled feasibility study were included. Selected studies were containing assessments about cognitive function but not as primary outcomes. The three studies included one acupuncture study and two herbal-medicine studies. Only one herbal-medicine study showed improvement in cognitive function. Conclusions: Few clinical studies mainly focusing CRCI treated with TKM have been performed and have shown contradictory results until now. Future studies should be performed considering findings from pre-clinical and clinical studies altogether, and they should be controlled to minimize risk of bias thorough out overall courses of designing, conducting and reporting them.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 B
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• pp.657-659
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• 1998

In order to optimize fuzzy modeling of nonlinear system, we proposed a optimal fuzzy model according to the characteristic of I/O relationship, HCM method, the genetic algorithm, and the objective function with weighting factor. A conventional fuzzy model has difficulty in definition of membership function. In order to solve its problem, the premise structure of the proposed fuzzy model is selected by both the partition of input space and the analysis of input-output relationship using the clustering algorithm. The premise parameters of the fuzzy model are optimized respectively by the genetic algorithm and the consequence parameters of the fuzzy model are identified by the standard least square method. Also, the objective function with weighting factor is proposed to achieve a balance between the performance results for the training and testing data.

• Plant Breeding and Biotechnology
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• 제6권4호
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• pp.313-320
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• 2018

Rice is the staple food of more than 50% of the world population. Cultivated rice has the AA genome (diploid, 2n = 24) and small genome size of only 430 megabase (haploid genome). As the sequencing of rice genome was completed by the International Rice Genome Sequencing Project (IRGSP), many researchers in the world have been working to explore the gene function on rice genome. Insertional mutagenesis has been a powerful strategy for assessing gene function. In maize, well characterized transposable elements have traditionally been used to clone genes for which only phenotypic information is available. In rice endogenous mobile elements such as MITE and Tos have been used to generate gene-tagged populations. To date T-DNA and maize transposable element systems have been utilized as main insertional mutagens in rice. The Ac/Ds system offers the advantage of generating new mutants by secondary transposition from a single tagged gene. To enhance the efficiency of gene detection, advanced gene-tagging systems (i.e. activation, gene or enhancer trap) have been employed for functional genomic studies in rice. Internationally, there have been many projects to develop large scales of insertional mutagenized populations and databases of insertion sites has been established. Ultimate goals of these projects are to supply genetic materials and informations essential for functional analysis of rice genes and for breeding using agronomically important genes. In this report, we summarize the current status of Ac/Ds-mediated gene tagging systems that has been conducted by collaborative works in Korea.

• Applied Microscopy
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• 제45권1호
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• pp.1-8
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• 2015

We have developed a new HD-2700 (Hitachi High-Technologies Corp., Japan) scanning transmission electron microscope (STEM) that includes an automatic aberration correction function, and a large-solid-angle energy-dispersive X-ray spectroscopy detector that enables high-resolution and sensitive analysis. For observation with atomic resolution, using spherical-aberration-corrected STEM, in order that satisfactory performance of the device can be achieved readily, and within a short time, irrespective of the operator's skill level, a spherical-aberration-correction device with an automatic aberration-correction function was developed. This automatic aberration-correction function carries out the entire correction-related process (aberration measurement, selection and correction) automatically, with automatic selection of the aberrations that require correction, and automatic measurement of the appropriate corrections.

• 천문학회지
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• 제35권1호
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• pp.29-34
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• 2002

We have conducted UBVI CCD photometry of an intermediate-age open cluster NGC 559 to investigate the effect of dynamical evolution on the stellar distributions in NGC 559. Our photometry allows better estimates of distance and age of the cluster owing to much deeper photometry (V $\le$ 21) than previous ones. It is found that the luminosity function and mass function as well as the spatial stellar distributions are affected by the dynamical evolution. Mass segregation leads to the central concentration of the high mass stars, which results in the flattened mass function inside the half mass radius.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.286-286
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• 2000

We consider a negative unity feedback control system in which Che PIO, PI, PD or P controller and a transfer function having only poles are in cascade, We define the notion of the structural polynomial which means that there exists a subdomain of the coefficient space in which the polynomial is Hurwitz (left half plane stable) polynomial. We obtain the necessary and sufficient condition of the structure of the transfer function of which the characteristic polynomial is a structural polynomial, In addition, this paper present another necessary and sufficient condition for the existence of a constant gain controller with which the characteristic polynomial is structurally stable, For the structurally stabilizable P controller, it is allowed that the transfer function may not to all pole plants.