• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.496-496
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• 2005

• Proceedings of the KIEE Conference
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• 2004.07d
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• pp.2212-2214
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• 2004

Robust stable analysis with the system bounded parameteric variation is very important among the various control theory. This study is to investigate the robust stable conditions using the quadratic form Lyapunov function in which the coefficient matrix is affined linear system. The quadratic stability using the quadratic form Lyapunov function is not investigated yet. The Lyapunov unction is robust stable not to be dependent by the variable parameters, which means that the Lyapunov function is conservative. We suggest the robust stable conditions in the Lyapunov function in which the variable parameters are dependent in order to reduce the conservativeness of quadratic stability.

• Molecules and Cells
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• v.21 no.1
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• pp.29-33
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• 2006

We have established three immortal bovine muscular epithelial (BME) cell lines, one spontaneously immortalized (BMES), the second SV40LT-mediated (BMEV) and the third hTERT-mediated (BMET). The morphology of the three immortal cell lines was similar to that of early passage primary BME cells. Each of the immortal cell lines made cytokeratin, a typical epithelial marker. BMET grew faster than the other immortal lines and the BME cells, in 10% FBS-DMEM medium, whereas neither the primary cells nor the three immortal cell lines grew in 0.5% FBS-DMEM. The primary BME cells and the immortal cell lines, with the exception of BMES, made increasing amounts of p53 protein when treated with doxorubicin, a DNA damaging agent. On the other hand, almost half of the cells in populations of the three immortal cell lines may lack $p16^{INK4a}$ regulatory function, compared to primary BME cells that were growth arrested by enforced expression of $p16^{INK4a}$. In soft-agar assays, the primary cells and immortal cell lines proved to be less transformed in phenotype than HeLa cells. The three immortal epithelial-type cell lines reported here are the first cell lines established from muscle tissue of bovine or other species.

• Journal of the Korean Chemical Society
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• v.59 no.5
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• pp.466-470
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• 2015

• Journal of Cardiovascular Imaging
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• v.31 no.1
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• pp.41-48
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• 2023

BACKGROUND: The function of left atrium (LA) is difficult to assess because of its ventricle-dependent, dynamic movement. The aim of this study was to assess LA function using velocity vector imaging (VVI) and compare LA function in patients with hypertrophic cardiomyopathy (HCMP) and left ventricular hypertrophy (LVH) with normal controls. METHODS: Fourteen patients with HCMP (72% male, mean age of 52.6 ± 9.8), 15 hypertensive patients with LVH (88% male, mean age of 54.0 ± 15.3), and 10 age-matched controls (83% male, mean age of 50.0 ± 4.6) were prospectively studied. Echocardiographic images of the LA were analyzed with VVI, and strain rate (SR) was compared among the 3 groups. RESULTS: The e' velocity (7.7 ± 1.1; 5.1 ± 0.8; 4.5 ± 1.3 cm/sec, p = 0.013), E/e' (6.8 ± 1.6; 12.4 ± 3.3; 14.7 ± 4.2, p = 0.035), and late diastolic SR at mid LA (-1.65 ± 0.51; -0.97 ± 0.55; -0.82 ± 0.32, p = 0.002) were significantly different among the groups (normal; LVH; HCMP, respectively). The e' velocity, E/e', and late diastolic SR at mid LA were significantly different between normal and LVH (p = 0.001; 0.022; 0.018), whereas LA size was similar between normal and LVH (p = 0.592). The mean late diastolic peak SR of mid LA was significantly correlated with indices of diastolic function (E/e', e', and LA size). CONCLUSIONS: The SR is a useful tool for detailed evaluation of LA function, especially early dysfunction of LA in groups with normal LA size.

• KSBB Journal
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• v.22 no.5
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• pp.341-344
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• 2007

Obesity is a major obstacle for human health, which induces various diseases such as cardiac injury and type 2 diabetes. Ginsenosides, active components of ginseng extract, exert various physiological effects. However, There are still no evidence for their anti obesity effects. In this study, we investigated the effects of ginsenoside Rd on adipocyte differentiation in 3T3-L1 cells. Our data show that ginsenoside Rd (80 uM) was effective in adipocyte differentiation inhibition. These inhibitory effects of ginsenosides on adipocyte differentiation were accompanied by PPAR gamma inhibition in rosiglitazone-treated cells. We also tested whether AMP-activated protein kinase (AMPK) activation was involved in the effects of these ginsenosides. AMPK is a master target for obesity, ginsenoside Rd significantly activated AMPK. Taken together, these results suggest that the anti obesity effects of ginsenoside Rd involve the AMPK signaling pathway and PPAR-gamma inhibition.

• Communications for Statistical Applications and Methods
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• v.8 no.1
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• pp.229-235
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• 2001

Let {X$\_$n/, n$\geq$1] be a stationary sequence of negatively associated random variables with distribution function F(x)=P(X$_1$$\leq$x). The empirical distribution function F$\_$n/(x) based on X$_1$, X$_2$,....., X$\_$n/ is proposed as an estimator for F$\_$n/(x). Strong consistency and asymptotic normality of F$\_$n/(x) are studied. We also apply these ideas to estimation of the survival function.

• Journal of the Korea Convergence Society
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• v.9 no.4
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• pp.285-301
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• 2018

The purpose of this study was to investigate the relationship between health-related physical fitness factors and cognitive function and isolation on 308 elderly over 65 years old in Seoul and Gyeonggi do. The measuring instrument were as follows demographic characteristics(age, education level, drink, spouse, participation on in exercise) and health-related physical fitness(grip strength, leg strength, flexibility, balance), cognitive function (MMSE-K, digit span test) and emotional/social aspects of loneliness and isolation was measured. As a results, first, depending on the degree of demographic characteristics of elderly had significant difference. Second, health-related physical fitness and cognitive function are positive correlated, negative correlation between cognitive function and isolation. Third, health-related physical fitness of the elderly had a significant effect on cognitive function. Fourth, health-related fitness of the elderly had a significant effect on isolation. Fifth, the cognitive function of the elderly had a significant effect on isolation. In conclusion, this study will provide basic data for future aged man welfare studies and contribute to extended studies.

• Clinical and Experimental Pediatrics
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• v.58 no.6
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• pp.218-223
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• 2015

Purpose: Idiopathic scoliosis is a structural lateral curvature of the spine of unknown etiology. The relationship between degree of spine curvature and cardiopulmonary function has not yet been investigated. The purpose of this study was to determine the association between scoliosis and cardiopulmonary characteristics. Methods: Ninety children who underwent preoperative pulmonary or cardiac evaluation at a single spine institution over 41 months were included. They were divided into the thoracic-dominant scoliosis (group A, n=78) and lumbar-dominant scoliosis (group B, n=12) groups. Scoliosis severity was evaluated using the Cobb method. In each group, relationships between Cobb angles and cardiopulmonary markers such as forced vital capacity (FVC), forced expiratory volume in one second ($FEV_1$), $FEV_1$/FVC, left ventricular ejection fraction, pulmonary artery flow velocity, and tissue Doppler velocities (E/E', E'/A') were analyzed by correlation analysis linear regression. Results: In group A, 72 patients (92.3%) underwent pulmonary function tests (PFTs), and 41 (52.6%) underwent echocardiography. In group B, 9 patients (75.0%) underwent PFT and 8 (66.7%) underwent echocardiography. Cobb angles showed a significant negative correlation with FVC and $FEV_1$ in group A (both P<0.05), but no such correlation in group B, and a significant negative correlation with mitral E/A ratio (P<0.05) and tissue Doppler E'/A' (P<0.05) in group A, with a positive correlation with mitral E/A ratio (P<0.05) in group B. Conclusion: Pulmonary and cardiac function was significantly correlated with the degree of scoliosis in patients with thoracic-dominant scoliosis. Myocardial diastolic function might be impaired in patients with the most severe scoliosis.

• Journal of the Korea Convergence Society
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• v.9 no.5
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• pp.219-229
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• 2018

The purpose of this study was to investigate the relationship among Exercising Activity, muscle mass, Muscular strength and cognitive function of 274 elderly people aged 65 years and older living in Seoul and Gyeonggi-do As for the data collection methods, were measured the Exercising Activity, muscle mass and muscular strength and the Korean version of Mini Mental State Examination(MMSE-K) and digit span test were measured. The results are as follows First, there was a statistically significant correlation between Exercising activity, muscle mass, muscular strength, and cognitive function of the elderly. Second, Exercising activity of the elderly showed a positive (+) influence on muscle mass, muscular strength, and cognitive function. Third, the muscle mass of the elderly showed a statistically significant (+) influence on muscular strength and cognitive function. Fourth, the strength of the elderly showed a positive (+) influence on cognitive function.