• IMMUNE NETWORK
• /
• v.9 no.3
• /
• pp.75-83
• /
• 2009

Recent years have seen an explosion of new knowledge defining the molecular events that are critical for development and activation of immune cells. Much of this new information has come from a careful molecular dissection of key signal transduction pathways that are initiated when immune cell receptors are engaged. In addition to the receptors themselves and critical effector molecules, these signaling pathways depend on adapters, proteins that have no intrinsic effector function but serve instead as scaffolds to nucleate multimolecular complexes. This review summarizes some of what has been learned about one such adapter protein, SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76), and how it regulates and integrates signals after engagement of immunoreceptors and integrins on various immune cell lineages.

• Journal of information and communication convergence engineering
• /
• v.2 no.1
• /
• pp.40-45
• /
• 2004

This paper describes a modeling of service composition manager based on TINA (Telecommunication Information Networking Architecture). The Service composition function is mainly motivated by the desire to easily generate new service using existing services from retailers or $3^{rd}$-party service providers. The TINA-C specification for the service composition does not include the detailed composition procedure and its object models. In this paper, we propose a model of components for the service composition, which adapts a static composition feature in a single provider domain. To validate the proposed modeling, we implemented prototype service composition function, which combines two multimedia services; a VOD service and a VCS service. As a result, we obtain the specification of the detailed composition architecture between a retailer domain and a $3^{rd}$-party service provider domain.

• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2003.03a
• /
• pp.232-237
• /
• 2003

A new displacement-based transmitting boundary is developed for the transient analysis of dynamics interactions between flexible dam body and reservoir impounding compressible water The mechanical model is derived analytically in time domain from the kernel function, Bessel function, appearing in the convolution integral and corresponding mechanical model is developed that consists of mass, damping and stiffness matrices. The resulting system of, equations uses displacement degrees of freedom. Hence it can be coupled directly with the displacement-based solid finite element model of dam body, linear of nonlinear. The method was applied to the rigid and flexible dam models. The results showed very good agreement : with the semi-analytic frequency domain solutions.

• Journal of the Korean Magnetics Society
• /
• v.5 no.5
• /
• pp.372-375
• /
• 1995

The magnetization pattern of the central cross section deduced from the ac susceptibility measurement is described with an analytical function. The function is based on a charge-free configuration. The thickness of the $^{\circ}$ wall lying in a (100) plane and the wall energy are calculated analytically. Total energy of the domain structure has been minimized with Ritz's method. As the result of the minimization, the energy density of the $^{\circ}$ wall lying in a (100) plane is $0.58\;erg/cm^{2}$ and the one for a (110) plane is $1.18\;erg/cm^{2}$. Thicknesses of these walls are calculated numerically. Also, the calculation indicates there is a small central domain at the cross section without applied current. With the ac susceptibility measurement the existence of the domain without current can be identified.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.22 no.1
• /
• pp.35-44
• /
• 2009

This paper describes an application of domain decomposition method for parallel finite element analysis which is required to large scale 3D structural analysis. A parallel finite element method system which adopts a domain decomposition method is developed. Node is generated if its distance from existing node points is similar to the node spacing function at the point. The node spacing function is well controlled by the fuzzy knowledge processing. The Delaunay triangulation method is introduced as a basic tool for element generation. Domain decomposition method using automatic mesh generation system holds great benefits for 3D analyses. Aa parallel numerical algorithm for the finite element analyses, domain decomposition method was combined with an iterative solver, i.e. the conjugate gradient(CG) method where a whole analysis domain is fictitiously divided into a number of subdomains without overlapping. Practical performance of the present system are demonstrated through several examples.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.2
• /
• pp.1073-1075
• /
• 2013

Background: In normal cells, activated epidermal growth factor receptor (EGFR) molecules are subjected to ubiquitination-mediated proteasome degradation pathway by c-Cbl, an ubiquitin ligase that checks uncontrolled proliferation. Hence expression of wild type c-Cbl molecule is essential to keep this degradation machinery in a functional state. Loss of expression or function of c-Cbl may consequently lead to sustained activation of EGFR and promote carcinogenesis, loss of function mutations in the c-Cbl gene already being reported in lung and hematopoietic cancers. However, the genetic status of c-Cbl in oral squamous cell carcinoma (OSCC) is not known. Hence in the present study we investigated the genomic DNA isolated from OSCC tissue biopsy samples for mutations in the RING finger domain coding region of c-Cbl gene, which has also been reported to be most frequently mutated in other cancers. Materials and Methods: Total genomic DNA isolated from thirty two post surgical OSCC tissue samples were amplified using primers flanking the exon 8 of c-Cbl gene that codes for the RING finger domain. The PCR amplicons were then resolved in a 1.2% agarose gel, purified and subjected to direct sequencing to screen for mutations. Results: The sequencing data of the thirty two OSCC samples did not identify mutations in the RING finger domain coding region of c-Cbl gene. Conclusions: To the best of our knowledge, this is the first time that the genetic status of c-Cbl gene in OSCC samples has been investigated. The present data indicates that genetic alteration of RING finger domain coding region of c-Cbl gene is relatively infrequent in OSCC samples.

• Honam Mathematical Journal
• /
• v.36 no.3
• /
• pp.659-668
• /
• 2014

In this paper, we express the Green function in terms of the classical kernel functions in potential theory. In particular, we obtain a formula relating the Green function and the Szegő kernel function which consists of only the Szegő kernel function in a $C^{\infty}$ smoothly bounded finitely connected domain in the complex plane.

• Genomics & Informatics
• /
• v.12 no.3
• /
• pp.105-113
• /
• 2014

A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain. This Peg3 domain shares several features with the other imprinted domains, including an evolutionarily conserved domain structure, along with transcriptional co-regulation through shared cis regulatory elements, as well as functional roles in controlling fetal growth rates and maternal-caring behaviors. The Peg3 domain also displays some unique features, including YY1-mediated regulation of transcription and imprinting; conversion and adaptation of several protein-coding members as ncRNA genes during evolution; and its close connection to human cancers through the potential tumor suppressor functions of Peg3 and Usp29. In this review, we summarize and discuss these features of the Peg3 domain.

• Bulletin of the Korean Mathematical Society
• /
• v.39 no.4
• /
• pp.687-704
• /
• 2002

We show that the class of inner chordarc domains is properly contained in the class of exterior quasiconvex domains. We also show that the class of exterior quasiconvex domains is properly contained in the class of John disks. We give the conditions which make the converses of the above results be true. Next , we show that an exterior quasiconvex domain satisfies certain growth conditions for the exterior Riemann mapping. From the results we show that the domain satisfies the Bernstein inequality and the integrated version of it. Finally, we assume that f is a function which is continuous in the closure of a domain D and analytic in D. We show connections between the smoothness of f and the rate at which it can be approximated by polynomials on an exterior quasiconvex domain and a $Lip_\alpha$-extension domain.

• Bulletin of the Korean Mathematical Society
• /
• v.46 no.6
• /
• pp.1237-1248
• /
• 2009

The domain of attraction of a nonlinear differential equations is the region of initial points of solution tending to the equilibrium points of the systems as the time going. Determining the domain of attraction is one of the most important problems to investigate nonlinear dynamical systems. In this article, we first present two algorithms to determine the domain of attraction by using the moment matrices. In addition, as an application we consider a class of SIRS infection model and discuss asymptotical stability by Lyapunov method, and also estimate the domain of attraction by using the algorithms.