• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.168-174
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• 2014

Objectives Sensory gating dysfunctions in patients with schizophrenia and bipolar disorder have been investigated through two similar methods ; P50 suppression and prepulse inhibition paradigms. However, recent studies have demonstrated that the two measures are not correlated but rather constitute as distinct neural processes. Recent studies adopting spectral frequency analysis suggest that P50 suppression reflects the interaction between gamma and other frequency bands. The aim of the present study is to investigate which frequency component shows more significant interaction with gamma band. Methods A total of 108 mood disorder patients and 36 normal subjects were included in the study. The P50 responses to conditioning and test stimuli with an intra-pair interval of 500 msec were measured in the study population. According to P50 ratio (amplitude to the test stimulus/amplitude to the conditioning stimulus), the subjects with P50 ratio less than 0.2 were defined as suppressed group (SG) ; non-suppressed group (NSG) consisted of P50 ratio more than 0.8. Thirty-five and 25 subjects were included in SG and NSG, respectively. Point-to-point correlation coefficients (PPCCs) of both groups were calculated between two time-windows : the first window (S1) was defined as the time-window of one hundred millisecond after the conditioning auditory stimulus and the second window (S2) was defined as the time-window of 100 msec after the test auditory stimulus. Spectral frequency analysis was performed to investigate which frequency band results in the difference of PPCC between SG and NSG. Results Significant reduction of PPCC between S1 and S2 was observed in the SG (Pearson's r = 0.24), compared to PPCC of the NSG (r = 0.58, p < 0.05). In spectral frequency analysis, gamma band showed "phase-reset" and similar responses after the two auditory stimuli in suppressed and non-suppressed group. However in the case of alpha band, comparison showed significantly low PPCC in SG (r = -0.14) compared to NSG (r = 0.36, p < 0.05). This may be reflecting "phase-out" of alpha band against gamma band at approximately 50 msecs after the test stimulus in the SG. Conclusions Our study suggests that normal P50 suppression is caused by phase-out of alpha band against gamma band after the second auditory stimulus. Thus it is demonstrated that normal sensory gating process is constituted with attenuated alpha power, superimposed on consistent gamma response. Implications of preserved gamma and decreased alpha band in sensory gating function are discussed.

• The Journal of the Acoustical Society of Korea
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• v.24 no.7
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• pp.402-409
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• 2005

In this paper. we propose a coding method using a matching pursuit algorithm in a strongly periodic highband signal. Also. we propose an efficient quantizer for the estimated parameters : spectral magnitude and phase. Based on the error concealment principle and sinusoidal model. the MP algorithm requires the high-precision pitch period estimation. To estimate more accurate pitch period. the refined pitch obtained from lowband speech is used. which increases the efficiency of bit allocation. The spectral magnitude parameters are quantized by the method which is combined with MDCT (Modified Discrete Cosine Transform) and multi-stage structure. The spectral phase quantizer uses the $2{\pi}$ modular characteristic of phases and the weighted function by spectral magnitudes. To evaluate the efficiency of the proposed method. we applied it to analysis-by-synthesis system. Furthermore we suggest the possibillity of scalable wideband speech codecs based on band-split structure.

• Journal of Biomedical Engineering Research
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• v.36 no.5
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• pp.191-197
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• 2015

Laser acupuncture is defined as the stimulation of traditional acupuncture points with low-intensity, nonthermal laser irradiation. Possible advantages in using laser acupuncture are the noninvasive, painless and low risks of infection treatment. The purpose of this study is to assess the effect of laser acupuncture on the quality and waveform of arterial pulses. Ten acupuncture points were stimulated repeatedly three times in 30 individuals by laser with emission in the near infrared spectral region (808 nm) using an out power and power density of 45 mW and $143W/cm^2$. The analysis of pulse quality and waveform was performed based on the measurement of arterial pressure of the left and right wrist, using a 3-dimensional blood pressure pulse analyzer. Excess-like pulse quality of subjects before laser acupuncture changed significantly to balanced pulse quality after 10, 20, and 30 minutes of laser acupuncture; coefficient of deficient or excess, $C_{DE}$, decreased significantly from 0.68 before acupuncture to 0.61, 0.55, and 0.55 after 10, 20, 30 minutes of laser acupuncture ($$p{\leq_-}0.006$$), respectively. Other pulse qualities, floating or sinking, slow or rapid, choppy or slippery did not change significantly by laser acupuncture (p > 0.05). Pulse waveform analysis showed that amplitude of main peak (systolic function or aortic compliance, $h_1$) of left and right artery pulse waves decreased significantly after 10, 20, and 30 minutes of laser acupuncture (p < 0.05). Other parameters, duration of one cardiac cycle (T), duration of rapid systolic ejection ($T_1$), duration of the systolic phase ($T_4$), and duration of the diastolic phase ($T_5$) of left and right artery pulses did not change significantly after laser acupuncture (p > 0.05).

• Journal of the Korea Institute of Military Science and Technology
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• v.2 no.1
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• pp.38-60
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• 1999

The main objective of this study is systemization of the technique of ROC quantification and optimization of baseline design by applying CE principle to the acquisition process of a weapon system. QFD and TOA techniques can be employed to a good working example of the conceptual design of a future main battle tank. In this paper, Product Planning Phase, the first phase of four QFD phases, is deployed in terms of eight steps including customer requirements and final product control characteristics. TOA is carried out considering only combat weight. In order to perform combat weight analysis and performance TOA, Preliminary Configuration Synthesis Methodology is used. Preliminary Configuration Synthesis Methodology employs the method of least squares and described linear equations of weight interrelation equation for each component of tank. As a result of QFD based upon the ROC, it was cleared that armor piercing power, main armament, type of ammunition, cruising range, combat weight, armor protection, power loading, threat detection and cost are primary factors influencing design and that combat weight is the most dominant one. The results of TOA based on the combat weight constraint show that 5100 lb reduction was required to satisfy the ROC. The baseline design of a future main battle tank is illustrated with assumption that all phases of QFD are employed to development and production process of subsystems, components, and parts of main battle tank. TOA is applied in iterative process between initial baseline design and ROC. The detailed design of each component is illustrated for a future main battle tank.

• Journal of Periodontal and Implant Science
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• v.31 no.1
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• pp.135-148
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• 2001

Gingival fibroblasts are major cellular component of gingiva. However, the molecular mechanisms of senescence of human gingival fibroblasts are unknown. Human fibroblasts undergo replicative senescence in vitro after a limited number of population doublings. A reduced rate of proliferation is a prominent phenomenon observed in senescent fibroblasts. This phenomenon is controled by cell cycle regulatory proteins. The purpose of present study was to investigate the effect of replicative senescence on cell cycle progression and to find out its molecular mechanisms in human gingival fibroblasts. Replicative senescence of gingival fibroblasts were induced by subsequent cultures that were repeated up to 18 passage. In the present study, I examined change of cell proliferation, cell activity, cell viability and cell cycle progression during the replicative process. Also, I examined expression of cell cycle regulatory proteins which was estimated by western blot analysis. Cell proliferation, cell activity and cell viability of gingival fibroblasts were notably decreased with increase of population doubling level(PDL). S phase was decreased and G1 phase was increased with increase of PDL. Western blot analysis showed that levels of P16, p21 and p53 of senescent gingival fibroblasts(PDL41, PDL58) were higher than young fibroblasts(PDL27) and cdk4 were lower than young fibroblasts(PDL27). In conclusion, these results suggest that proliferative function of human gingival fibroblasts may be decreased by replicative senescence and its molecular mechanisms may be activatied with p16, p21, p53 and pRB, and repressed wtih cdk4.

• Korean Journal of Optics and Photonics
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• v.5 no.2
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• pp.278-285
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• 1994

We investigated the spectral characteristics for temperature and driving current change in visible laser diode. As a result of spectrum analysis, the ratio of frequency change for temperature and driving current change were about $33 GHz/^{\circ}C$, 6.6 GHz/mA in the region which was not mode hopping range. Compared to the sharp mode hopping in the near IR single mode AlGaAs lasers, the visible laser diode showed relatively broad multimode operation in the mode hopping region. We performed the experiment of injection-locking characteristics analysis for visible laser diode. Locking half bandwidth(LHBW) was measured 0~5.0 GHz for $0~25\muW$ input power and it was dependent on the input power. Also, LHBW for polarization angle was dependent on the difference of polarization angle between master laser and slave laser. The phase change of injection-locked output beam of the slave laser diode as a function of the drive current was measured in the interferometer which was composed of master laser and slave laser. The ratio of phase change with the slope of 5.0~1.3 rad/mA was obtained within injection-locking range for the change of $2~25\muW$ input power. power.

• Journal of the Korea Computer Industry Society
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• v.2 no.6
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• pp.859-866
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• 2001

Successful project planning relies on a good estimation of the effort required to complete a project, together with the schedule options that may be available. Despite the extensive research done developing new and better models, existing software effort estimation models are present only the total effort and effort (or manpower： people per unit time) function for the software life-cycle. Also, Putnam presents constant effort rate in each subcycles. However, the size of total efforts are variable according to the software projects under the influence of its size, complexity and operational environment. As a result, the allocated effort in subcycle also differ from project to project. This paper suggests the linear and polynomial effort estimation models in specifying, building and testing phase followed by the project total effort. These models are derived from 128 different projects. This result can be considered as a practical guideline in management of project schedule and effort allocation.

• Applied Chemistry for Engineering
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• v.18 no.1
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• pp.71-76
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• 2007

We have demonstrated the resonant resistance pattern changes of the polymer film in the quartz crystal analysis by the function of the molecular polarity phase transition phenomena. PVA and PMMA/PVAc blend films were used as hydrophilic and/or hydrophbic film, respectively. In the comparison between the hydrophilic shows the pattern changes near by the phase transition temperature. For more detailed explanation, the static capacity in the oscillation parameter was measured and the morphology of Au quartz crystal electrode was studied by AFM. It is suggested that the different resonant resistance pattern change is reliable in the condition of different polarity, and the conclusion is important to analysis of the real mechanism a normal quartz crystal experiments.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.88-95
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• 2001

To convert the construction industry from 'the high cost, the low efficiency' to 'the low cost, the high efficiency and value-added industry' and to enhance the performance and quality of products while reducing the cost, the related law and guideline were established and promulgated, which regulate that value engineering workshop during the preliminary design and the detail design stage should be a mandatory process. But VE practitioners are still confusing in choosing the proper value engineering process, because processes those are described in the various references use the different terms, steps and activities, even though they have their own specific characteristics. To resolve these confusions, the existing steps and activities of three kinds of the literature, four kinds of the organization's policy and other four kinds of study examples relating to the design VE were examined. And then, the differences and expecting problems were extracted through the comparison and analysis of those materials. After that, VE specialists' opinion through the questionnaire survey were grasped. Based on those studies the improved design VE Job Plan and activity statements were suggested.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.5
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• pp.1038-1044
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• 2011

In this paper, the multichannel intermediate frequency transceiver for broadband multimedia system is designed and the experimental results are analyzed. Basic elements of the transceiver such as frequency synthesizer, amplifier, mixer, automatic gain control amplifier are introduced. The analysis technique described here applies not only to amplifier but also to any other nonlinear components such as mixers and frequency doubler. Through the investigation of the power spectrum density of the transmitted signal, the phase noise of the local oscillator is evaluated below 70 dBc/kHz. The frequency characteristics of the modulated signal is flat within the system bandwidth. Also the effects of adjacent channel interference and supurious emission are analyzed. And the function of automatic gain control amplifier is well operated.