• Ocean Systems Engineering
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• v.7 no.4
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• pp.435-460
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• 2017

The main objective of this study is to investigate the turning and zig-zag maneuvering performance of the well-known naval surface combatant DTMB (David Taylor Model Basin) 5415 hull with URANS (Unsteady Reynolds-averaged Navier-Stokes) method. Numerical simulations of static drift tests have been performed by a commercial RANS solver based on a finite volume method (FVM) in an unsteady manner. The fluid flow is considered as 3-D, incompressible and fully turbulent. Hydrodynamic analyses have been carried out for a fixed Froude number 0.28. During the analyses, the free surface effects have been taken into account using VOF (Volume of Fluid) method and the hull is considered as fixed. First, the code has been validated with the available experimental data in literature. After validation, static drift, static rudder and drift and rudder tests have been simulated. The forces and moments acting on the hull have been computed with URANS approach. Numerical results have been applied to determine the hydrodynamic maneuvering coefficients, such as, velocity terms and rudder terms. The acceleration, angular velocity and cross-coupled terms have been taken from the available experimental data. A computer program has been developed to apply a fast maneuvering simulation technique. Abkowitz's non-linear mathematical model has been used to calculate the forces and moment acting on the hull during the maneuvering motion. Euler method on the other hand has been applied to solve the simultaneous differential equations. Turning and zig-zag maneuvering simulations have been carried out and the maneuvering characteristics have been determined and the numerical simulation results have been compared with the available data in literature. In addition, viscous effects have been investigated using Eulerian approach for several static drift cases.

• Archives of Pharmacal Research
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• v.24 no.3
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• pp.207-210
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• 2001

A fully automated high performance liquid chromatography with column-switching was developed for the simultaneous determination of KR60436, a new reversible proton pump inhibitor, and its active metabolite O-Demethyl-KR60436 from rat plasma samples. Plasma sample (50$\mu$l) was directly introduced onto a Capcell Pak MF Ph-1 column ($10{\times}4$ mm I.D.) where primary separation was occurred to remove proteins and concentrate target Substances Using acetonitrile-Potassium Phosphate (PH 7, 0.1 M) (2 : 8, v/v). The drug molecules eluted from MF Ph-1 column were focused in an intermediate column ($10{\times}2$ I.D.) by the valve switching step. The substances enriched in intermediate column were eluted and separated on a Vydac 218MR53 column ($250{\times}3.2$ I.D.) using acetonitrilepotassium phosphate (pH 7, 0.02 M) (47:53, v/v) at a flow rate of 0.5 ml/min when the valve status was switched back to A position. The method showed excellent sensitivity (detection limit of 2 ng/ml) with small volume of samples ($50{\mu}$l), good precision and accuracy, and speed (total analysis time 24 min) without any loss in chromatographic efficiency. The response was linear ($r^2{\geq}0.797$) over the concentration range of 5-500 ng/ml.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.32 no.5
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• pp.72-79
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• 2000

On the other hand, the fiber orientation at the surface and middle layer of the sheet controls the bending stiffness of paperboard. Therefore, a reliable measurement of paper surface fiber orientation gives us a magnificent tool to investigate and predict paper curling and cockling tendency, and provides the necessary information to fine-tune the manufacturing process for optimum quality. Many papers, especially heavily calendered and coated grades, do resist liquid and gas penetration very much, being beyond the measurement range of the traditional instruments or resulting inconveniently long measuring time per sample. The increased surface hardness and use of filler minerals and mechanical pulp make a reliable, non-leaking sample contact to the measurement head a challenge of its own. Paper surface coating causes, as expected, a layer which has completely different permeability characteristics compared to the other layers of the sheet. The latest developments in sensor technologies have made it possible to reliably measure gas flow n well controlled conditions, allowing us to investigate the gas penetration of open structures, such as cigarette paper, tissue or sack paper, and in the low permeability range analyze even fully greaseproof papers, silicon papers, heavily coated papers and boards or even detect defects in barrier coatings! Even nitrogen or helium may be used as the gas, giving us completely new possibilities to rank the products or to find correlation to critical process or converting parameters. All the modern paper machines include many on-line measuring instruments which are used to give the necessary information for automatic process control systems. Hence, the reliability of this information obtained from different sensors is vital for good optimizing and process stability. If any of these on-line sensors do not operate perfectly as planned (having even small measurement error or malfunction), the process control will set the machine to operate away from the optimum, resulting loss of profit or eventual problems in quality or runnability. To assure optimum operation of the paper machines, a novel quality assurance policy for the on-line measurements has been developed, including control procedures utilizing traceable, accredited standards for the best reliability and performance.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.277.1-277.1
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• 2013

Molecular diagnostics consists of three processes, which are a sample pretreatment, a nucleic acid amplification, and an amplicon detection. Among three components, sample pretreatment is an important process in that it can increase the limit of detection by purifying nucleic acid in biological sample from contaminants that may interfere with the downstream genetic analysis such as nucleic acid amplification and detection. To achieve point-of-care virus detection system, the sample pretreatment process needs to be simple, rapid, and automatic. However, the commercial RNA extraction kits such as Rneasy (Qiagen) or MagnaPure (Roche) kit are highly labor-intensive and time-consuming due to numerous manual steps, and so it is not adequate for the on-site sample preparation. Herein, we have developed a rotary microfluidic system to extract and purify the RNA without necessity of external mechanical syringe pumps to allow flow control using microfluidic technology. We designed three reservoirs for sample, washing buffer, and elution buffer which were connected with different dimensional microfluidic channels. By controlling RPM, we could dispense a RNA sample solution, a washing buffer, and an elution buffer successively, so that the RNA was captured in the sol-gel solid phase, purified, and eluted in the downstream. Such a novel rotary sample preparation system eliminates some complicated hardwares and human intervention providing the opportunity to construct a fully integrated genetic analysis microsystem.

• Plant Journal
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• v.13 no.4
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• pp.48-50
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• 2017

A program for analyzing the transient behaviors of industrial gas turbines was developed. Each component (compressor, combustor, turbine and ducts)of gas turbine is modeled as a fully module to enhance the expandability of the program. We used object-oriented programing for this purpose. The mass and energy balance equations are solved numerically by Multivariable Newton Raphson method. The characteristic maps for the compressor and turbine were used for predicting the performance of a gas turbine engine. Combustion in the combustor is assumed to be complete combustion. PID control is used to maintain constant rotational speed and turbine exhaust temperature by the control of the fuel flow rate and the changing of the compressor inlet guide vane angle at the same time. It was confirmed that stable control of the gas turbine was possible, even for a rapid load change.

• Journal of Ginseng Research
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• v.43 no.4
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• pp.692-698
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• 2019

Background: Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria. CK has been studied for its cardioprotective, antiinflammatory, and liver-protective effects; however, the role of CK in breast cancer is not fully understood. Methods: To investigate the anticancer effects of CK in SKBR3 and MDA-MB-231 cells, cell viability assays and flow cytometry analysis were used. In addition, the direct targets of CK anticancer activity were identified using immunoblotting analysis and overexpression experiments. Invasion, migration, and clonogenic assays were carried out to determine the effects of CK on cancer metastasis. Results: CK-induced cell apoptosis in SKBR3 cells as determined through 3-(4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assays, propidium iodide (PI) and annexin V staining, and morphological changes. CK increased the cleaved forms of caspase-7, caspase-8, and caspase-9, whereas the expression of Bcl-2 was reduced by CK. In assays probing the cell survival pathway, CK activated only AKT1 and not AKT2. Moreover, CK inhibited breast cancer cell invasion, migration, and colony formation. Through regulation of AKT1 activity, CK exerts anticancer effects by inducing apoptosis. Conclusion: Our results suggest that CK could be used as a therapeutic compound for breast cancer.

• International Journal of Computer Science & Network Security
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• v.21 no.4
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• pp.255-263
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• 2021

Smart grid is a fully-automated, bi-directional, power transmission network based on the physical grid system, which combines sensor measurement, computer, information communication, and automatic control technology. Blockchain technology, with its security features, can be integrated with Smart Grids to provide secure and efficient power management and transmission. This paper dicusses the deployment of Blockchain technology in Smart Grid. It presents application areas and protocols in which blockchain can be applied to in securing smart grid. One application of each area is explored in detail, such as efficient peer-to-peer transaction, lower platform costs, faster processes, greater flexibility in power generation to transmission, distribution and power consumption in different energy storage systems, current barriers obstructing the implementation of blockchain applications with some level of maturity in financial services but concepts only in energy and other sectors. Wide range of energy applications suggesting a suitable blockchain architecture in smart grid operations, a sample block structure and the potential blockchain technicalities employed in it. Also, added with efficient data aggregation schemes based on the blockchain technology to overcome the challenges related to privacy and security in the smart grid. Later on, consensus algorithms and protocols are discussed. Monitoring of the usage and statistics of energy distribution systems that can also be used to remotely control energy flow to a particular area. Further, the discussion on the blockchain-based frameworks that helps in the diagnosis and maintenance of smart grid equipment. We have also discussed several commercial implementations of blockchain in the smart grid. Finally, various challenges have been discussed for integrating these technologies. Overall, it can be said at the present point in time that blockchain technology certainly shows a lot of potentials from a customer perspective too and should be further developed by market participants. The approaches seen thus far may have a disruptive effect in the future and might require additional regulatory intervention in an already tightly regulated energy market. If blockchains are to deliver benefits for consumers (whether as consumers or prosumers of energy), a strong focus on consumer issues will be needed.

• International Journal of Naval Architecture and Ocean Engineering
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• v.13 no.1
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• pp.236-245
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• 2021

In this study, direct numerical and large eddy simulations of transitional flows around studs were conducted to investigate the effectiveness of turbulence stimulators at very low speeds for the minimum propulsion power condition of four knots. For simplicity, the studs were assumed to be installed on a flat plate, while the wake was observed up to 0.23 m downstream behind the second stud. For applicability to a model ship, we also studied the flow characteristics behind the first and second studs installed on a curved plate, which was designed to describe the geometry of a bulbous bow. A laminar-to-turbulent transition was observed in the wake at Re_D ≥ 921 (U_∞≥0.290 m/s), and the wall shear stress at Re_D = 1162 (U_∞ = 0.366 m/s) in the second wake was similar to that of the fully developed turbulent boundary layer after a laminar-to-turbulent transition in the first wake. At Re_D = 581 (U_∞ = 0.183 m/s), no turbulence was stimulated in the wake behind the first and second studs on the flat plate, while a cluster of vortical structures was observed in the first wake over the curved plate. However, a cluster of vortical structures was revealed to be generated by the reattachment process of the separated shear layer, which was disturbed by the first stud rather than directly initiated by the first stud. It was quite different from a typical process of transition, which was observed at relatively high Re_D that the spanwise scope of the turbulent vortical structures expanded gradually as it went downstream.

• Nuclear Engineering and Technology
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• v.56 no.2
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• pp.463-471
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• 2024

Average and local convective heat transfer coefficients of nitrogen are measured experimentally in an electrically heated circular tube for a range of Reynolds number from 1.08 × 10⁴ to 3.60 × 10⁴, and wall-to-bulk temperature ratio from 1.01 to 1.77. The exit Mach number is up to 0.17, and the heat flux is up to 46 kW·m^-2. The molybdenum test section has a 62 diameters heated section with an inside diameter of 5 mm and a 30 diameters entrance section to ensure the fully-developed flow. Uncertainty of Nusselt number is less than 1.6 % in this study. The results indicate that the average heat transfer correlations evaluated by both the bulk and the modified film Reynolds numbers agree well with the experimental data. The local heat transfer results based on bulk properties are compared with previous empirical correlations. New prediction correlations are recommended which are significantly affected by the property variation and heated length. The comparison between the proposed correlations and experimental points shows that 88 % of experimental data fall into an error of 10 %, and almost all data are within an error of 20 %.

• Journal of Advanced Marine Engineering and Technology
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• v.34 no.5
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• pp.638-644
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• 2010

Numerical predictions of a fully developed turbulent flow through a square duct ($30mm{\times}30mm$) with twisted tape inserts and with twisted tape plus interrupted ribs are respectively conducted to investigate regionally averaged heat transfer and flow patterns. A rib height-to-channel hydraulic diameter(e/$D_h$) of 0.067 and a lengthto-hydraulic diameter(L/$D_h$) of 30 are considered at Reynolds number ranging 8,900 to 29,000. The interrupted ribs are axially arranged on the bottom wall. The twisted tape is 0.1 mm thick carbon steel sheet with diameter of 28 mm, length of 900 mm, and 2.5 turns. Each wall of the square channel is composed of isolated aluminum sections. Two heating conditions are investigated for test channels with twisted tape inserts and rib turbulators: (1) electric heat uniformly applied to four side walls of the square duct, and (2) electric heat uniformly applied to two opposite walls of the square channel. The results show that uneven surface heating enhances the heat transfer coefficient over uniform heating conditions, and significant improvements can be achieved with twisted tape inserts plus interrupted ribs.