• Journal of Korean Neurosurgical Society
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• 제45권4호
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• pp.219-223
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• 2009

Objective : Functional magnetic resonance imaging (fMRI) is frequently used to localize language areas in a non-invasive manner. Various paradigms for presurgical localization of language areas have been developed, but a systematic quantitative evaluation of the efficiency of those paradigms has not been performed. In the present study, the authors analyzed different language paradigms to see which paradigm is most efficient in localizing frontal language areas. Methods : Five men and five women with no neurological deficits participated (mean age, 24 years) in this study. All volunteers were right-handed. Each subject performed 4 tasks, including fixation (Fix), sentence reading (SRI. pseudoword reading (PR), and word generation (WG). Fixation and pseudoword reading were used as contrasts. The functional area was defined as the area(s) with a t-value of more than 3.92 in fMRI with different tasks. To apply an anatomical constraint, we used a brain atlas mapping system, which is available in AFNI, to define the anatomical frontal language area. The numbers of voxels in overlapped area between anatomical and functional area were individually counted in the frontal expressive language area. Results : Of the various combinations, the word generation task was most effective in delineating the frontal expressive language area when fixation was used as a contrast (p<0.05). The sensitivity of this test for localizing Broca's area was 81 % and specificity was 70%. Conclusion : Word generation versus fixation could effectively and reliably delineate the frontal language area. A customized effective paradigm should be analyzed in order to evaluate various language functions.

• Annals of Clinical Neurophysiology
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• 제24권1호
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• pp.21-25
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• 2022

The newly identified frontal aslant tract (FAT) that connects the posterior Broca's area to the supplementary motor area is known to be involved in speech and language functions. We successfully intraoperatively monitored FAT using cortico-cortical evoked potentials generated by single-pulse electrical cortical stimulation in a patient with oligodendroglioma.

• 대한두개안면성형외과학회지
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• 제10권1호
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• pp.37-39
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• 2009

Purpose: Langerhans cell histiocytosis is a heterogenous group of Langerhans cell proliferative disorders and includes eosinophilic granuloma, Letterer-Siwe diseases, and Hand-Schuller Christian disease. We report a case of eosinophilic granuloma on frontal area. Methods: A 17-year-old male presented with swelling and tenderness on Lt. frontal and periorbital area. CT and MRI showed a $33{\times}25mm$ sized mass that involved Lt. frontal calvarium, frontotemporal meninges, and orbital roof. Results: Total excision of the mass and adjacent soft tissue, calvarium, and orbital roof was performed. Orbital roof defect was reconstructed with absorbable plate and calvarial defect was done with outer cortex of temporal bone flap. The histology revealed proliferation of histiocytes and eosinophils. Immunologically, these histiocytic cells expressed S-100 protein and CD1a. The patient is currently taking conservative treatment. Conclusion: The severity of these disease and their prognosis and treatments are various. For unifocal cranial Langerhans cell histiocytosis, complete excision is the treatment of choice. We report this case with review of literature.

• The Journal of Korean Physical Therapy
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• 제15권3호
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• pp.295-345
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• 2003

This study investigated activation of cerebral cortex in patients with hemiplegia that was caused by neural damage. Key-point control movement therapy of Bobath was performed for 9 weeks in 3 subjects with hemiplegia and fMRI was used to compare and analyze activated degree of cerebral cortex in these subjects. fMRI was conducted using the blood oxygen level-dependent(BOLD) technique at 3.0T MR scanner with a standard head coil. The motor activation task consisted of finger flexion-extension exercise in six cycles(one half-cycles = 8 scans = $3\;sec{\times}\;8\;=\;24\;sec$). Subjects performed this task according to visual stimulus that sign of right hand or left hand twinkled(500ms on, 500ms off). After mapping activation of cerebral motor cortex on hand motor function, below results were obtained. 1. Activation decreased in primary motor area, whereas it increased in supplementary motor area and visual association area(p<.001). 2. Activation was observed in bilateral medial frontal gyrus, middle frontal gyrus of left cerebrum, inferior frontal gyrus, inter-hemispheric, fusiform gyrus of right cerebrum, superior parietal lobule of parietal lobe and precuneus in subjedt 1, parahippocampal gyrus of limbic lobe and cingulate gyrus in subject 2, and inferior frontal gyrus of right frontal lobe, middle frontal gyrus, and inferior parietal lobule of left cerebrum in subject 3 (p<.001). 3. Activation cluster extended in declive of right cellebellum posterior lobe in subject 1, culmen of anterior lobe and declive of posterior lobe in subject 2, and dentate gyrus of anterior lobe, culmen and tuber of posterior lobe in subject 3 (p<.001). In conclusion, these data showed that Key-point control movement therapy of Bobath after stroke affect cerebral cortex activation by increasing efficiency of cortical networks. Therefore mapping of brain neural network activation is useful for plasticity and reorganization of cerebral cortex and cortico-spinal tract of motor recovery mechanisms after stroke.

• 대한의용생체공학회:의공학회지
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• 제27권6호
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• pp.318-322
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• 2006

The purpose of this study is to examine differences between 20s and 40s in visuospatial performance and brain activation areas using functional Magnetic Resonance Imaging (fMRI). Eight male college students in their twenties ($21.5{\pm}2.3$ years old) and six male adults in their forties ($45.7{\pm}2.6$ years old) who were graduated from college participated in the study. A visuospatial task was presented while brain images were acquired by a 3T fMRI system. Compared to the 20s the 40s showed lower visuospatial performance. There were more activations observed at the parietal and superior frontal areas at 20s compared to 40s. There were more activations observed at the middle frontal and occipital areas at 40s compared to 20s. The results of this study show that the lowering of visuospatial performance with aging was correlated to the decrease of activation area at the parietal lobe and the change of activation area at the frontal lobe.

• 대한예방한의학회지
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• 제4권2호
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• pp.214-234
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• 2000

This study was carried to identify whether acupuncture of several acupuncture points can affect the brain and to observe which aspects appear in EEG mapping, using electroencephalography. Those results are as follows ; 1. The pattern of resting computerized EEG map in intact human is appered normal 2. Each Acupuncture in Kwan Weon or Jog Sam Ri meridian points bring about the increase in $\theta,\;\alpha-wave$ activity and at various area of the cerebrium and the decrease in $\delta,\;\beta-wave$ activity. It strands to reason that brain function is elevated On the other hand , synchronous acupuncture bring about the decrease of brain function in view of the decrease of $\delta,\;\theta-wave$ activity at frontal area, and the unstable brain state in view of the increase of $\beta-wave$ activity. 3. Acupuncture in Hyeon Jong meridian point bring about the increase of $\delta,\;\theta-wave$ activity at frontal area and $\beta-wave$ activity at temporal area. From these we deduce that brain function is declined and brain is unstable. Synchronous acupuncture with other meridian points reversly showed that brain function is elevated. 4. Synchronous acupuncture in Kwan Weon , Jog Sam Ri, Hyeon Jong bring about the decrease of the brain function and the unstable brain state, showing the pattern of increased $\delta,\;\theta-wave$ activity at frontal, parietal area, and increased $\beta-wave$ activity at temporal area.

• 해양환경안전학회지
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• 제23권7호
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• pp.885-892
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• 2017

2017년 추계에 남해 전선역을 파악하고, 알칼리 인산분해 효소(Alkaline Phosphatase; APase) 활성을 이용하여 제한 영양염과 제한 영양염의 시간적인 변화를 평가하였다. 전선역이 형성된 인근해역의 경우, 용존무기인(dissolved inorganic phosphorus; DIP)의 농도와 용존무기질소(dissolved inorganic nitrogen; DIN): DIP 비가 각각 $0.2{\mu}M$ 이하와 최대 23.2로, DIP가 제한된 환경임에도 불구하고 Chlorophyll a(Chl.-a)가 $0.2{\mu}g/L$로 높은 생물생산력을 보였다. APase와 DIP는 중요한 역의 상관관계(r = -0.81; P<0.001)를 보여, DIP가 제한되어진 해역임을 알 수 있었으며, APase와 Chl-a 관계는 APase의 60 %가 식물플랑크톤, 40 %가 박테리아 기원인 것으로 평가되었다. 용존태 APase와 입자태 APase의 분포로부터 전선역은 장기간 DIP가 제한된 해역이며, 그 외의 해역은 최근에 DIP 제한이 해소된 것으로 판단되었다. 따라서 전선역에서 APase와 같이 가수분해효소의 측정은 제한 영양염의 시공간적인 변화 특성을 평가할 수 있으며, 전선역에서 생지화학 순환의 이해를 높일 수 있을 것으로 생각된다.

• Archives of Plastic Surgery
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• 제37권3호
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• pp.309-312
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• 2010

Purpose: An osteoma is one of the common benign tumors that penetrate the nasal portion, paranasal and frontal sinus. This tumor is mostly found by radiation test accidentally, however in rare cases; it can be found to be touched or with its symptoms as the tumor grows. We report this case since we found and healed the benign tumor which was affecting orbit and the both sides of fronal sinus. Methods: A 19 year old female patient visited to our hospital due to the mass on her forehead. The symptoms began 3 years ago but no special symptom was found except for touchable mass. She was diagnosed as the osteoma of superior orbital parts and both sides of frontal sinus using X-ray and CT scanning. The size of osteoma was $5{\times}2.5{\times}3.5\;cm$ and indicated the patterns penetrated to the right side of orbital region. The osteoma excision was conducted with coronal incision and wide area of defect part in frontal sinus and superior orbital part were reconstructed by cranial bone graft and resorbable fixation plates. Results: The patient recovered without any postoperative infections or complications and symptoms. Dysaesthesia was found on her frontal area but improved in 1 month after the surgery. Conclusion: The occurrences of osteoma in frontal sinus are rare and can be treated with conservative methods if there are no infections and symptoms. We report this case since we found the benign tumor, which was affecting orbit and the both sides of fronal sinus and healed it with coronal resectomy without any complications.

• Journal of Korean Neurosurgical Society
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• 제29권3호
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• pp.353-359
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• 2000

Objective : The fracture on the frontal bone in head-injured patients may be commonly encountered in the clinical situations. Biomechanical studies demonstrate that the anterior wall of the frontal sinus is intermediate in its ability to resist fracture on direct impact. If the frontal sinus is large and the anterior table is able to disperse the force of the impact over a greater area, the posterior table and intracranial contents usually can be spared. We analyzed the clinical features of the patients who presented with frontal skull fracture due to frontal blows. Patients and Methods : From January, 1992 to December, 1997, 172 patients with frontal skull fracture were selected among 1911 patients with head injury who were admitted to department of neurosurgery. Clinical records and radiological studies of all patients were reviewed and evaluated retrospectively. Results : The neurobehavioral changes was seen in 34 cases(19.8%) and showed statistical significances in case of facial bone fractures, acute subdural hematoma(SDH), and positive frontal lobe releasing sign(p<0.05). The good glasgow outcome score group(GOS, good recovery & moderate disability) at discharge was revealed in 77.3% of total patient population. The poor GOS group(severe disability & vegetative state & death) at discharge was revealed in 22.7%. The poor GOS group at discharge have statistical significances with acute epidural hematoma(EDH), traumatic intraventricular hemorrhage(t-IVH), traumatic intracranial lesion, poor initial glasgow coma scale(GCS) scores & Revised Trauma Score(RTS)(p<0.05). Conclusion : Because of their anatomical relationships and neurobehavioral patterns due to vulnerability of the frontal lobe, the frontal injury should be considered as complicated facial injuries. Therefore, these patients are more likely to have a cosmetic or neuropsychiatric problems.

• Biomaterials and Biomechanics in Bioengineering
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• 제3권1호
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• pp.47-57
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• 2016

Results from multiple high profile experiments on the parameters influencing the impacts that cause skull fractures to the frontal, temporal, and parietal bones were gathered and analyzed. The location of the impact as a binary function of frontal or lateral strike, the velocity, the striking area of the impactor, and the force needed to cause skull fracture in each experiment were subjected to statistical analysis using the JMP statistical software pack. A novel neural network model predicting skull fracture threshold was developed with a high statistical correlation ($R^2=0.978$) and presented in this text. Despite variation within individual studies, the equation herein proposes a 3 kN greater resistance to fracture for the frontal bone when compared to the temporoparietal bones. Additionally, impacts with low velocities (<4.1 m/s) were more prone to cause fracture in the lateral regions of the skull when compared to similar velocity frontal impacts. Conversely, higher velocity impacts (>4.1 m/s) showed a greater frontal sensitivity.