• Title/Summary/Keyword: Frequency of resistance

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Effector Memory CD8+ and CD4+ T Cell Immunity Associated with Metabolic Syndrome in Obese Children

  • Yang, Da-Hee;Lee, Hyunju;Lee, Naeun;Shin, Min Sun;Kang, Insoo;Kang, Ki-Soo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.24 no.4
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    • pp.377-383
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    • 2021
  • Purpose: We investigated the association of effector memory (EM) CD8+ T cell and CD4+ T cell immunity with metabolic syndrome (MS). Methods: Surface and intracellular staining of peripheral blood mononuclear cells was performed. Anti-interleukin-7 receptor-alpha (IL-7Rα) and CX3CR1 antibodies were used to stain the subsets of EM CD8+ T cells, while anti-interferon-gamma (IFN-γ), interleukin-17 (IL-17), and forkhead box P3 (FOXP3) antibodies were used for CD4+ T cell subsets. Results: Of the 47 obese children, 11 were female. Children with MS had significantly higher levels of serum insulin (34.8±13.8 vs. 16.4±6.3 µU/mL, p<0.001) and homeostasis model assessment of insulin resistance (8.9±4.1 vs. 3.9±1.5, p<0.001) than children without MS. Children with MS revealed significantly higher frequencies of IL-7Rαlow CD8+ T cells (60.1±19.1% vs. 48.4±11.5%, p=0.047) and IL-7RαlowCX3CR1+ CD8+ T cells (53.8±20.1% vs. 41.5±11.9%, p=0.036) than children without MS. As the serum triglyceride levels increased, the frequency of IL-7RαlowCX3CR1+ and IL-7RαhighCX3CR1- CD8+ T cells increased and decreased, respectively (r=0.335, p=0.014 and r=-0.350, p=0.010, respectively), in 47 children. However, no CD4+ T cell subset parameters were significantly different between children with and without MS. Conclusion: In obese children with MS, the changes in immunity due to changes in EM CD8+ T cells might be related to the morbidity of obesity.

A Linkage between NGOs and Government in Resettlement Assistance for Defecting North Korean Residents (NGO와 정부의 연결관계의 모색: 탈북자 정착지원의 경우)

  • Lee, Ki-Young
    • Korean Journal of Social Welfare
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    • v.37
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    • pp.327-355
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    • 1999
  • This study analyzes the relationship between NGOs and government assisting defecting North Korean residents and seeks a desirable model of a linkage between the two sectors. The factors used in this study for an analysis of the relationship between NGOs and government are frequency and direction of interaction between NGOs and government, government's acceptance or resistance of institutional pluralism. the degree of formality of the relationship, and the relative power balance in the relationship. Also, Coston's typology(l998) of NGO-government relationships is applied for the analysis. Results of the analysis indicates that, in resettlement assistance for defecting North Korean residents, Korean NGOs and government have a cooperative relationship at minimal level, which means that there is a low linkage, informal relationship, and asymmetrical power-relationship between the two sectors. Also, government's acceptance of institutional pluralism seems to be superficial and a tendency of one-way direction of interaction is identified. Based on the findings, this study suggests a more collaborative relationship or partnership between NGOs and the government to arrange more effective assistance programs and activities. Discussion of some controversial issues related to achieving the collaboration and suggestion of a possible model of linking government to the NGOs are followed in conclusion.

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HVPE growth of Mg-doped AlN epilayers for high-performance power-semiconductor devices (고효율 파워 반도체 소자를 위한 Mg-doped AlN 에피층의 HVPE 성장)

  • Bae, Sung Geun;Jeon, Injun;Yang, Min;Yi, Sam Nyung;Ahn, Hyung Soo;Jeon, Hunsoo;Kim, Kyoung Hwa;Kim, Suck-Whan
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.27 no.6
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    • pp.275-281
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    • 2017
  • AlN is a promising material for wide band gap and high-frequency electronics device due to its wide bandgap and high thermal conductivity. AlN has advantages as materials for power semiconductors with a larger breakdown field, and a smaller specific on-resistance at high voltage. The growth of a p-type AlN epilayer with high conductivity is important for a manufacturing an AlN-based applications. In this paper, Mg doped AlN epilayers were grown by a mixed-source HVPE. Al and Mg mixture were used as source materials for the growth of Mg-doped AlN epilayers. Mg concentration in the AlN was controlled by modulating the quantity of Mg source in the mixed-source. Surface morphology and crystalline structure of AlN epilayers with different Mg concentrations were characterized by FE-SEM and HR-XRD. XPS spectra of the Mg-doped AlN epilayers demonstrated that Mg was doped successfully into the AlN epilayer by the mixed-source HVPE.

Study on the Contamination of Methicillin-Resistant Staphylococcus (MRS) in a High School Environment (일개 고등학교 환경에서 메치실린 내성 포도알균의 오염도 조사)

  • Hong, Seung Bok;Baek, Yun Hee
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.4
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    • pp.420-426
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    • 2017
  • Methicillin-resistant Staphylococcus (MRS) can be colonized in various body sites and is more frequently isolated in healthcare associated persons. This study aimed to evaluate the contamination rate of MRS in a high school environment, those living with closed life style. Staphylococcus aureus was isolated from only the hands of 2 students among a sample of 28 students, and S. aureus were susceptible to methicillin antibiotics. Coagulase negative Staphylococci (CoNS) were isolated from the hands of 26 students (26/28, 92.9%), and among them, 14 (53.8%) isolates were methicillin-resistant CoNS (MRCoNS). Among the 14 MRCoNS, S. warneri was the most common (8/14, 57%) and susceptible to most $non-{\beta}-lactam$ antibiotics, such as clindamycin, erythromycin, ciprofloxacin, tetracycline, gentamicin, and vancomycin. In a culture of 31 desks, S. aureus was not isolated but CoNS were isolated from 26 desks (26/31, 83.6%), which did not harbor the mecA gene. The other bacteria isolated from the hands and desks were Micrococcus and Bacillus spp. In conclusion, methicillin-resistant S. aureus was not isolated from the hands and desks of high school students. However, the frequency of MRCoNS harboring mecA gene were high in the hands of high school students. Therefore, to prevent and to control the transfer of infection, intensifying preventive education, such as hand washing, and active surveillance systems, such as an investigation of contamination or carrier rate of resistant bacteria are necessary.

A Study on the Resistance of Stress Corrosion Cracking due to Expansion Methods for Steam Generator Tubes in Nuclear Power Plants (원전 증기발생기 전열관의 확관방법에 따른 응력부식균열 저항성 연구)

  • Kim, Young Kyu;Song, Myung Ho
    • Journal of Energy Engineering
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    • v.23 no.2
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    • pp.149-157
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    • 2014
  • The steam generator tubes of nuclear power plants have various types of corrosion failures during the plant operation. The stress corrosion cracking which occurs on the outer surface of tube is called the secondary side stress corrosion cracking and mainly occurs in the expansion-transition area of tube. The causes are the concentration of impurities by the sludge pile-up related to the geometry of its region and the residual stress by tube expansion in the process of steam generator manufacturing. Especially the directionality and sizes of residual stresses are differed according to the tube expansion methods and the direction and the frequency of tube cracks depend on their characteristics. In bases on the plant experiences, it is notified that circumferential cracks of tubes expanded with explosive expansion method are dominantly occurred compared to those of tubes done with hydraulic expansion one. Therefore in this study, according to tube expansion methods frequencies and sizes of tube cracks with specific direction are compared by means of accelerated immersion test and also the crack morphology and the specific chemicals from water-chemistry environment are observed through the fracture surface examination.

Investigation of wearing behaviors and consumer's needs for summer golf wear (하절용 골프웨어의 착용실태 및 소비자 요구도)

  • Kim, Jeong-Hwa;Lee, Sun-Young;Lee, Jung-Soon
    • Science of Emotion and Sensibility
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    • v.10 no.2
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    • pp.177-186
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    • 2007
  • The purposes of this study were to investigate consumer's needs for golf wear and to suggest a direction of product development and planning, based on the analysis of golfer's needs. The subjects used for the research were 150 male and female golfers who were in golf practice fields. The data were analyzed by frequency analysis, factor analysis, ANOVA, t-test and Duncan test. In summary, the results of this study were as followers; Dimensions of consumer's needs for golf wear were extracted from factor analysis as following properties; fashion/design property, textile property, hygiene property, body-shaped property. The most important consumer's need for golf wear was "wearing comfort" and second one was "moisture absorbency" Respondents evaluated that wearing comfort, stretchability, tactile, size of golf wear were very important but price, pilling, shrinkage or color-fading after laundry of golf wear were relatively less important. The evaluation of consumer's needs for golf wear according to demographic information had significant difference. The female golfers were found to consider that fiber characteristics, easy-to-laundry, wrinkle resistance, stretchability, sewing quality were relatively more important, when compared with the male golfers. Also, There were significant differences on the evaluation of consumer's needs for golf wear on fiber characteristics, stretchability, brand name between age groups.

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Development of an Automatic Comprehensive Condition Diagnosis System for Inductive Loop Detector Using Magnetic Field (자기장을 이용한 루프검지기 자동진단시스템 개발)

  • Kim, Nam-Sun;Lee, Seung-Hwan;Oh, Young-Tae;Lee, Choul-Ki;Kang, Jeung-Sik
    • Journal of Korean Society of Transportation
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    • v.23 no.5 s.83
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    • pp.123-134
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    • 2005
  • This research aims at developing a new method which can replace the existing method. known as the quality factor(Q factor) method by an L-R-C test for use in the performance test of inductive loop detectors(ILD) being installed and maintained. In this study, a sensor to detect a magnetic field in terms of frequency and intensity, a method to collect field data, the method of analysis, and the method of diagnosis were developed. An automatic diagnosis system which was developed to overcome those drawbacks has the following features : First, field data is collected automatically by a test vehicle equipped with magnetic field sensors that is running can be said to along the roadway and. thus, the new system completely overcome the roadway and, thus, the new system can be said to completely overcome the inefficiency of the existing method second, since the magnetic fold generated from the ILD is the final output of the whole system of ILD, the existing problem has been solved. third. since each of the detection area by height is collected by the magnetic sensors installed by height. a basic for the identification of the vehicle types to be detectable and the setting of adjustment factors has been made. For the automatic diagnosis system developed during in this study, a reliability test was carried out by comparing vehicle times of ILD installed ideally.

Development of Estimation Method for Velocity Pressure Exposure Coefficient of Buildings Based on Spatial Information (공간정보기반 건축물의 풍속고도분포계수 산정 방법 개발)

  • SEO, Eun-Su;CHOI, Se-Hyu
    • Journal of the Korean Association of Geographic Information Studies
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    • v.20 no.2
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    • pp.32-46
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    • 2017
  • Recent rapid urban expansion and crowding of various industrial facilities has affected the features of a significant part of downtown area, resulting in areas having buildings with a wide range of height and the foothills. To compute a velocity pressure exposure coefficient, namely the design wind speed factor, this study defines ground surface roughness by utilizing concentration analysis for the height of each building. After obtaining spatial data by extracting a building layer from digital maps, the study area was partitioned for the concentration analysis and to allow investigation of the frequency distribution of building heights. Concentration analysis by building height was determined with the Variation-to-Means Ratio (VMR) and Poisson distribution analysis using a buildings distribution chart, with statistical significance determined using Chi-square verification. Applying geographic information systems (GIS) with the architectural information made it possible to estimate a velocity pressure exposure coefficient factor more quantitatively and objectively, by including geographic features, as compared to current methods. Thus, this method is expected to eliminate inaccuracies that arise when building designers calculate the velocity pressure exposure coefficient in subjective way, and to help increase the wind resistance of buildings in a more logical and cost-effective way.

Studies on the Electrofusion Applied to the Yeast to Produce High Quantity of Organic Germanium (전기융합법을 이용한 게르마늄 강화 효모의 균주개발)

  • Oh, Sun-Woo;Lee, Sung-Hee;Lee, Hyun-Joo;Han, Eun-Sook
    • Korean Journal of Food Science and Technology
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    • v.38 no.5
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    • pp.712-716
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    • 2006
  • Saccharomyces cerevisiae and Zygosaccharomyces rouxii were electrofused and fermented in germaniumfortified nutrients to produce high-yield, organic germanium. The conditions for the preparation of protoplasts from both strains and for electrofusion were studied. The protoplasts of both cells formed long pearl chains and the cell membranes were lysed and fused through cellulase and high frequency voltage $(450{\sim}750V/128{\sim}512\;{\mu}sec)$. The fusants with the fastest growth were selected, and then characterized for their carbohydrate usage and tolerance to glucose and salts. The glucose tolerance of the fusants was better than that of S. cerevisiae and similar to that of Z. rouxii. The fusants appeared to have resistance to 12% NaCl. The cell size of the fusants was greater than that of the parental strains. The fusant cells contained more gemlanium than the parental cells did. The electrofusion of S. cerevisiae and Z. rouxii increased the cell capacity and accumulation of germanium in the yeasts. This method was proved to be effective to produce a high quantity of organic germanium.

Status of Infection Control in Jeju-area General Hospitals (제주특별자치도 종합병원의 감염관리 현황)

  • Chong, Moo Sang;Lee, Kyutaeg
    • Korean Journal of Clinical Laboratory Science
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    • v.48 no.2
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    • pp.130-136
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    • 2016
  • The aim of this study was to examine and analyze the infection management status of Jeju-area general hospitals, and in order to convey the importance of infection management, and to determine role plans of medical technologists as infection management staff, the infection management status was examined through surveys targeting 7 general hospitals located in Jeju Special Self-Governing Province. The infection management of Jeju-area medical institutions showed excellence in that all institutions operated an infection management room, there was dedicated manpower, and hospital infection management guidelines were established and executed. However most institutions were operating their infection management room with only 1 nurse, reporting many difficulties in securing dedicated manpower, microbe-related culture deciphering, frequency of multiple-resistance bacteria, infection statistics, and details on microbe testing. Accordingly, it is believed that the medical technologist who can perform the practical tasks of infection management has sufficient qualification and experience in infection management as per the medical law enforcement regulations, and in operation of an infection management room. If medical technologists (infection control microbiological technologist) with expert knowledge on microbes and infection control nurses can execute the tasks as dedicated personnel, the operation of the infection management room will be more advanced. In addition, for proper infection management in the future, the introduction of a medical system specialized in infection management and full support for infection management of vulnerable small/medium hospitals in addition to general hospitals across the country is considered important.