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검색결과 655건 처리시간 0.023초

Rapid Screening of Phospholipid Biomarker Candidates from Prostate Cancer Urine Samples by Multiple Reaction Monitoring of UPLC-ESI-MS/MS and Statistical Approaches

  • Lim, Sangsoo;Bang, Dae Young;Rha, Koon Ho;Moon, Myeong Hee
    • Bulletin of the Korean Chemical Society
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    • 제35권4호
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    • pp.1133-1138
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    • 2014
  • Ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI- MS/MS) provides a high-speed method to screen a large number of samples for small molecules with specific properties. In this study, UPLC-ESI-MS/MS with multiple reaction monitoring (MRM) was employed to screen urinary phospholipid (PL) content for biomarkers of prostate cancer. From lists of urinary PLs structurally identified using nanoflow LC-ESI-MS/MS, 52 PL species were selected for quantitative analysis in urine samples between 22 cancer-free urologic patients as controls and 45 prostate cancer patients. Statistical treatment of data by receiver operating characteristic (ROC) analysis yielded 14 PL species that differed significantly in relative concentrations (area under curve (AUC) > 0.8) between the two groups. Among PLs present at higher levels in prostate cancer urine, phosphatidylcholines (PCs) and phosphatidylinositols (PIs) constituted the major head group PLs (3 PCs and 7 PIs). For technical reasons, PL species of low abundance may be underrepresented in data from UPLC-ESI-MS/MS performed in MRM mode. However, the proposed method enables the rapid screening of large numbers of plasma or urine samples in the search for biomarkers of human disease.

나이팅게일 기장 수상자 박명자의 창조적이고 개척적인 간호업적 고찰 (Historical Review of Park Myungja, very Pioneering and Creative Registered Nurse who winned the Florence Nightingale Medal)

  • 이꽃메
    • 한국간호교육학회지
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    • 제21권3호
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    • pp.361-372
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    • 2015
  • Purpose: The purpose of this study is to present a model for R.N. and nursing students. Methods: Main primary sources were certificates, writings, news and articles. On the basis of them, her life was described over time and analyzed on the secondary sources. Results: Park Myungja faced Korean War as a nursing student and became the military officer of nursing. In 1950s and 1960s she worked hard to improve the operation room nursing. And she devoted herself to improve nursing education and help her students. Park Myungja became a military training teacher in 1972 and included first aid with the military training course. As a researcher of Korean National Open University, she tried to develop a course that R.N.s can receive a bachelor's degree in Nursing. Her last formal career was the head of a middle school, and she established the first nursery facility for the teachers. After the retirement, she devoted herself to the volunteer works, especially such as the hospice care, free clothes making, and Taichi teaching to arthritis patients. Conclusion: Park's life has been that of a R.N and volunteer. She has been very creative to find what she could do and pioneering to accomplish them.

디퓨져와 노즐을 이용한 열공압형 마이크로 펌프의 입력 전압과 주파수에 따른 펌핑 특성에 관한 실험적 연구 (An Experimental Study on the Pumping Characteristics of Diffuser-Nozzle Based Thermopneumatic Micropumps with Different Input Voltages and Frequencies)

  • 정진;채희문;김창녕
    • 설비공학논문집
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    • 제19권9호
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    • pp.654-661
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    • 2007
  • This study has been conducted to investigate the pumping characteristics of diffuser-nozzle based thermopneumatic micropumps with different input voltages and frequencies. In this study, the displacements of the membrane have been obtained changing the input voltage and frequency in load-free state because it is very difficult to measure the displacement of the membrane in an actual load state. It has been found that the amplitude of the membrane displacement increases as the input voltage increases. The pressure head of the thermopneumatic micropump increases almost linearly over some range of the input voltage and decreases almost linearly as the frequency increases. Also, the results show that the thermopneumatic micropump can pump the fluid over a certain input voltage. This study can be utilized as basic data for design and evaluation of thermopneumatic micropumps.

아동의 한국어 문장이해과정에 나타난 사건관련전위 연구 (A Study of Event-Related Brain Potentials in Children's Korean Sentence Comprehension)

  • 최인화;이순형
    • 대한가정학회지
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    • 제49권2호
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    • pp.37-49
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    • 2011
  • The present study investigated the semantic and syntactic processes in Korean children's sentence comprehension by measuring event-related brain potentials(ERPs). The subjects were 18 right-handed, healthy native Korean children(1st graders), who were free from any hearing problems. While the children listened to the auditory sentence stimuli, ERPs were recorded with the electrodes mounted in a 'Quik-Cap' on the subject's head. The ERP data were recorded and analyzed using the NeuroScan 4.3 and EEGLABv6.03b programs. For statistical analyses, descriptive statistics, three-way repeated measures ANOVA, and t-tests were performed using a SPSS 15.0 PC program. The results indicated that semantic violations elicited a negativity (N400) ranging from 300 to 500 msec. For syntactic violations, children displayed a positivity (P600) ranging from 900 to 1,100 msec. The discovery of N400 and P600 in semantic and syntactic processes respectively, confirmed the suggestion that Indo-European and Korean languages share a common mechanism for sentence comprehension.

A Hierarchical Time Division Multiple Access Medium Access Control Protocol for Clustered Underwater Acoustic Networks

  • Yun, Changho;Cho, A-Ra;Kim, Seung-Geun;Park, Jong-Won;Lim, Yong-Kon
    • Journal of information and communication convergence engineering
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    • 제11권3호
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    • pp.153-166
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    • 2013
  • A hierarchical time division multiple access (HTDMA) medium access control (MAC) protocol is proposed for clustered mobile underwater acoustic networks. HTDMA consists of two TDMA scheduling protocols (i.e., TDMA1 and TDMA2) in order to accommodate mobile underwater nodes (UNs). TDMA1 is executed among surface stations (e.g., buoys) using terrestrial wireless communication in order to share mobility information obtained from UNs which move cluster to cluster. TDMA2 is executed among UNs, which send data to their surface station as a cluster head in one cluster. By sharing mobility information, a surface station can instantaneously determine the number of time slots in a TDMA2 frame up to as many as the number of UNs which is currently residing in its cluster. This can enhance delay and channel utilization performance by avoiding the occurrence of idle time slots. We analytically investigate the delay of HTDMA, and compare it with that of wellknown contention-free and contention-based MAC protocols, which are TDMA and Slotted-ALOHA, respectively. It is shown that HTDMA remarkably decreases delay, compared with TDMA and Slotted-ALOHA.

한국 전통목가구 평상(平床) 연구 2 - 평상을 적용한 모듈화 다용도 침대 개발 - (A Study on Traditional Korean Furniture, PyeongSang II - Developing Modularized and Multi-useful Bed adopting PyeongSang -)

  • 김민경;문선옥
    • 한국가구학회지
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    • 제28권3호
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    • pp.145-155
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    • 2017
  • This study explores developing a piece of modularized and multi-useful bed adapting PyeongSang followed by the last issue, 'a study on traditional Korean furniture, PyeongSang I' for the understanding of the furniture from theory and history. Adopted From the joints and ornament, the modularized elements were designed and developed in order to compose the head board, the side board, the foot board, and the seat bottom. The joints are sambang miter, samae miter, dado, and mortise and tenon, which are strong in holding the bed. And the ornament is lattice patterns like geokjamun and manjamun, elephant eyes patterns like ansangmun from the traditional furniture. Using the elements, the bed is composed with six modules which make people free and easy to move and transform them. Hence, the bed is multi-useful by using the double, the twin the single, and various sofas by the way to display them such as two, three, four, five, and six modules. And the bed was made of bright zelkova tree and dark heat treated ash expressing contrast of black and white, the design concept modern and easy to make many people access to them.

외이도에 발생한 악성종양에서 유경근육피판을 이용한 결손 재건 (Utilizing Pedicled Muscle Flap for Defect Coverage after External Auditory Canal Cancer Resection)

  • 이강우;김은기
    • 대한두개안면성형외과학회지
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    • 제12권1호
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    • pp.37-42
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    • 2011
  • Purpose: Cancer arising from the external auditory canal is a rare disease. A lesion that seems harmless in someway, can be lethal when inadequately excised, the tumor may infiltrate nerves, the parotid and auditory tissues before re-invading the skin. Wide resection of the lesion surrounding the structure and reconstruction with an adequate plan is crucial for the treatment of this disease. Methods: Two patients with external auditory canal cancer were treated with muscle flaps and skin grafts. Lateral temporal bone resection (LTBR) was performed for complete resection of the cancer. The defect cavity was obliterated with highly vascularized tissue using pedicled sternocleidomastoid muscle, and temporalis muscle individually, combined with full thickness skin graft for covering the skin defect of the ear. Results: Clear resection margin was obtained, and both patients showed disease free survival during the follow up. There was no complications of hematoma, infection, flap loss, or wound problem in both patients. Both patient received radiation therapy, there was no osteoradionecrosis or any other complication related to radiation therapy. Conclusion: Utilizing pedicled muscle flaps for managing defects after wide resection of the external auditory canal cancer is an effective method for managing this difficult disease.

First Report of Two Plectus Species (Nematoda: Plectida) from Korea

  • Kim, Jiyeon;Yu, Jeong-Nam;Kim, Taeho
    • Animal Systematics, Evolution and Diversity
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    • 제36권3호
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    • pp.251-257
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    • 2020
  • The genus Plectus Bastian, 1865 represents a group of free-living freshwater nematodes belonging to the family Plectidae Örley, 1880. However, only one species has been reported thus far from Korea. Plectus aquatilis Andrássy, 1985 and Plectus cirratus Bastian, 1865 are reported for the first time from Korea, from sediments collected from the Nakdong River. Plectus aquatilis is distinguished from other Plectus species by its three longitudinal alae in the lateral field, thin and directed cephalic setae, continuous lip region (head not set-off), and rectangular shaped tail. Plectus cirratus is distinguished from other Plectus species by its large body, two longitudinal alae in the lateral field, larger stoma, and longer tail. Morphological characters and measurements of the specimens generally agree with the original descriptions of Plectus species. Here, the morphological characters (detailed morphometrics) of two species in the genus Plectus are fully redescribed and illustrated using optical microscopy. DNA barcode sequence information from the 18S rDNA gene is also provided for molecular species identification and compared with sequences from other Plectus species available on GenBank.

THE EFFECT OF NITROGEN ON THE MICROSTRUCTURE AND THE CORROSION RESISTANCE OF Fe-Hf-C-N THIN FILMS

  • Choi, J.O.;Han, S.H.;Kim, H.J.;Kang, I.K.
    • 한국자기학회지
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    • 제5권5호
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    • pp.641-644
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    • 1995
  • We have studied the effect of the nitrogen on the microstructure, thermomagnetic properties and corrosion resistance of Fe-Hf-C-N nanocrystalline thin films with high permeability and high saturation magnetization. These films were fabricated by reactive sputtering in $Ar+N_{2}$ plasma using an rf magnetron sputtering apparatus. As $P_{N2}$ increases, the microstructure changes from amorphous to crystalline $\alpha$-Fe phase and again returns to amorphous one. Spin wave stiffness constant increases with $P_{N2}$ until 5% $P_{N2}$, and then decreases with the further increase. This trend corresponds well with that of the microstructure with increasing $P_{N2}$. The Fe-Hf-C-N films with over 3% $P_{N2}$ show higher corrosion resistance than the N-free Fe-Hf-C films. The Fe-Hf-C-N films are considered to have high potentials for the head core materials suitable for high density recording systems, owing to their excellent soft magnetic properties and corrosion resistance.

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Measurement and Modeling of Personal Exposure to the Electric and Magnetic Fields in the Vicinity of High Voltage Power Lines

  • Tourab, Wafa;Babouri, Abdesselam
    • Safety and Health at Work
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    • 제7권2호
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    • pp.102-110
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    • 2016
  • Background: This work presents an experimental and modeling study of the electromagnetic environment in the vicinity of a high voltage substation located in eastern Algeria (Annaba city) specified with a very high population density. The effects of electromagnetic fields emanating from the coupled multi-lines high voltage power systems (MLHV) on the health of the workers and people living in proximity of substations has been analyzed. Methods: Experimental Measurements for the Multi-lines power system proposed have been conducted in the free space under the high voltage lines. Field's intensities were measured using a referenced and calibrated electromagnetic field meter PMM8053B for the levels 0 m, 1 m, 1.5 m and 1.8 m witch present the sensitive's parts as organs and major functions (head, heart, pelvis and feet) of the human body. Results: The measurement results were validated by numerical simulation using the finite element method and these results are compared with the limit values of the international standards. Conclusion: We project to set own national standards for exposure to electromagnetic fields, in order to achieve a regional database that will be at the disposal of partners concerned to ensure safety of people and mainly workers inside high voltage electrical substations.