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Effect of the new needle-free injection system on pain perception and dental anxiety during anesthesia: randomized controlled split-mouth study

  • Melek Belevcikli;Halenur Altan;Osman Demir
    • Journal of Dental Anesthesia and Pain Medicine
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    • 제23권1호
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    • pp.1-8
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    • 2023
  • Backgrounds: Pain management is one of the most important factors affecting the success of pediatric dentistry. Therefore, new needle- and pain-free local anesthesia techniques have been developed in parallel with technological advancements. The purpose of this study is to compare the pain perception and dental anxiety levels associated with a needle-free injection system (Comfort-inTM) and the classic needle method during treatment-required infiltration anesthesia in children. Methods: This randomized controlled crossover split-mouth clinical study included 94 children who required dental treatment with local anesthesia using a dental needle or needle-free injection system for the bilateral primary molars. The Wong-Baker Scale (WBS) was used to measure pain perception at different times, and the Modified Child Dental Anxiety Scale (MCDAS) was used to measure the anxiety level of the child. A statistical software package was used to process the data. Statistical significance was set at P < 0.05. Results: There was no significant difference between the needle-free injection system and dental needle method during the induction stage for filling and pulpotomy (P > 0.05). "Pain on postoperative 1st day" was similar in both types of anesthesia (P = 0.750). Conclusions: The needle-free injection system was as effective as the dental needle method. The Comfort-inTM system was an acceptable alternative for patients during the postoperative period. Understanding how pain management may be provided during local anesthesia administration and a child's fear and anxiety regarding the dentist may lead to better dental compliance.

Confirmation of Male Specific Fetal Free RNA in Maternal Plasma and Comparison of Accuracy on the Sex Determination using Real-time PCR Method in Korean Native Cattle

  • Lee, Sang-Ho;Park, Chul-Ho;Park, Jun-Tae;Park, Sang-Guk;Lee, Jin-A;Suh, Guk-Hyun;Oh, Ki-Seok;Son, Chang-Ho
    • 한국수정란이식학회지
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    • 제28권4호
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    • pp.343-348
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    • 2013
  • Cell-free fetal RNA has been highlighted as useful tools for the fetal sex determination or other genetic inherent disorder. However, there is no knowledge about the sex determination using cell free fetal RNA in bovine field. Thus, the present study aimed to evaluate the presence of transcripts of DDX3Y, USP9Y and ZRSR2Y genes in maternal plasma of pregnant cows to determine the sex of the fetus using real-time quantitative polymerase chain reaction assay, and verify its accuracy, sensitivity and specificity compared with the molecular testing and the calf sex at birth. Transcripts of USP9Y and DDX3Y genes were expressed in the all plasma of males and females both the control group and the experimental group. However, ZRSR2Y gene was matched up with the molecular testing and the true sex in control group and has an overall accuracy of 82.6%, a sensitivity of 75%, and a specificity of 100% in experimental group. Therefore, these results indicated that real time PCR technique, as a noninvasive and cost-efficient method, is possible to determination fetal sex in the bovine species using circulating cell free RNA in maternal plasma and especially ZRSR2Y gene could be a good candidate for the RNA based sex determination work.

초음속 주유동 환경에서의 막냉각 특성 시험 연구 (An Experimental Study of Film Cooling Characteristics at Supersonic Free Stream Conditions)

  • 김만식;이동민
    • 한국항공우주학회지
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    • 제45권4호
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    • pp.342-348
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    • 2017
  • 본 연구에서는 초음속 주유동 환경에서의 막냉각 특성에 대해 적외선 열상법을 적용한 시험을 수행하였다. 막냉각 시험은 수축형 막냉각 노즐을 갖는 쐐기형 막냉각 시편을 이용해 마하수 3.0, 단위 길이 당 레이놀즈수 $42.53{\times}10^6$$69.35{\times}10^6$ 인 조건을 구현한 자유-제트 시험 설비에서 수행하였다. 모사 탐색창에 해당하는 PEEK의 표면 온도를 계측하여 막냉각 효율을 산출하였고 받음각 및 분사율이 막냉각 효율에 미치는 영향을 분석하였다. 막냉각을 적용하지 않는 경우와 비교할 때, 막냉각을 적용할 경우 측정된 PEEK의 표면 온도가 크게 감소하였다. 막냉각의 유용성은 시간에 따른 PEEK의 표면 온도로부터 산출한 열유속 특성으로도 확인할 수 있다. 분사율이 증가할수록 보호되는 PEEK의 영역이 주유동과 막냉각 유동의 흐름 방향으로 확장되었다.

Reduction in Lesion Incidence in Pork Carcass Using Transdermal Needle-free Injection of Foot-and-Mouth Disease Vaccine

  • Ko, Eun Young;Cho, Jaesung;Cho, Jin Ho;Jo, Kyung;Lee, Seung Hwan;Chung, Yoon Ji;Jung, Samooel
    • 한국축산식품학회지
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    • 제38권6호
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    • pp.1155-1159
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    • 2018
  • Foot-and-mouth disease (FMD) is an infectious disease affecting pigs. The control of FMD in swine husbandry is very important because its outbreak results in a vast economic loss. FMD vaccination has effectively controlled FMD; however, it results in economic loss associated with the incidence of lesions in the pork meat at the injection site. The objective of this study was to investigate the effects of transdermal needle-free injection (NFI) of the FMD vaccine on the incidence of lesions at the injection site. Pigs (n=493) in the control group were vaccinated with the FMD vaccine using a commercial syringe needle, while 492 pigs in the transdermal NFI group received the FMD vaccine using a needle-free gas-powered jet injector. After the slaughter of the pigs, the incidence of lesions at the injection site of all pigs was checked by plant workers. The result of this study showed that the incidence of lesions in the pork ham from pigs vaccinated with NFI was 14.82% lower than that in control pigs (p<0.01). In addition, lesions generated in the NFI group were found just in the subcutaneous tissue. Therefore, the incidence of lesions at the injection site in pork from pigs vaccinated with the FMD vaccine can be effectively reduced by using transdermal NFI rather than a conventional syringe needle.

금속분말 연소기의 slag 제거기법 개념 설계 및 Water Film 형성 조건 기초실험 (Conceptual Design of the Slag Removal Method in the Metal Powder Combustor and Condition Tests for the Water Film Formation)

  • 김광연;;고현;이성웅;조용호
    • 한국추진공학회:학술대회논문집
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    • 한국추진공학회 2011년도 제37회 추계학술대회논문집
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    • pp.554-557
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    • 2011
  • 금속분말을 연료로 하는 연소기 개발에 있어 발생하는 문제점 중에 하나는 알루미나 slag 처리이다. 연소기 내부에 Water film을 형성시킴으로써 금속분말 연소기의 문제점을 해결할 수 있을 것으로 기대한다. 이를 위한 선행연구로 water film의 형성 조건에 대한 실험을 수행하였다. 실험 모델에 대하여 물 분사 속도가 증가할수록 원형 모델에 대한 water fim 각도가 작아져, 약 10 m/s이상에서 완전한 water film이 형성되는 것을 알 수 있었다.

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Studies on Conditioned Media in Human Cells: Evaluation Using Various Cell and Culture Conditions, Animal Disease Models

  • Kim, Keun Cheon;Lee, Eun Ju
    • 한국수정란이식학회지
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    • 제33권1호
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    • pp.41-48
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    • 2018
  • In the last several decades, cell therapy research has increased worldwide. Many studies have been conducted on cell therapy, and have revealed that transplanted cells did not survive for long, and implanted cells remained inactive causing immune rejection depending on the patient's condition. Therefore, studies on cell-free therapy need to be conducted. To overcome these limitations, an alternative is the use of supernatant from cells, called "conditioned media (CM)." During in vitro cell culture, culture media supply nutrients to maintain cell characteristics and viability. In the culture, cells not only consume nutrients but also release beneficial proteins and substances, which are called "secretome." CM from cells can be stored for a long time and is easy to handle. Moreover, secretome in CM can also be measured; exact amount of secretome is important to set the standard value for disease treatment. Here, we reviewed studies on CM and confirmed that various secretomes from CM were identified in these studies. Moreover, these findings could benefit cell and animal studies in future. In conclusion, CM could be a potential candidate for an alternative to cell therapy.

Radiation Shielding Property of Concrete Using the Rapidly Cooled Steel Slag from Oxidizing Process in the Converter Furnace as Fine Aggregate

  • Kim, Jin-Man;Cho, Sung-Hyun;Kwak, Eun-Gu
    • 한국건축시공학회지
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    • 제12권5호
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    • pp.478-489
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    • 2012
  • Each year, about four million tons of steel slag, a by-product produced during the manufacture of steel by refining pig iron in the converter furnace, is generated. It is difficult to recycle this steel slag as aggregate for concrete because the reaction with water and free-CaO in steel slag results in a volume expansion that leads to cracking. However, the steel slag used in this study is atomized using an air-jet method, which rapidly changes the melting substance at high temperature into a solid at a room temperature and prevents free-CaO from being generated in steel slag. This rapidly-cooled steel slag has a spherical shape and is even heavier than natural aggregate, making it suitable for the aggregate of radiation shielding concrete. This study deals with the radiation shielding property of concrete that uses the rapidly-cooled steel slag from the oxidizing process in the converter furnace as fine aggregate. It was shown that the radiation shielding performance of concrete mixed with rapidly-cooled steel slag is even more superior than that of ordinary concrete.

급냉 제강 슬래그 대체율과 폴리머 수지에 따른 폴리머 콘크리트의 유동특성에 관한 실험적 연구 (An Experimental Study on the fluidity properties of Polymer Concrete According to Replacement Ratio of Rapidly-Chilled Steel Slag and polymer resin)

  • 최덕진;김재원;선정수;김하석;황의환;김진만
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2007년도 추계 학술논문 발표대회
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    • pp.75-78
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    • 2007
  • The steel slag, a by-product which is produced by refining pig iron during the manufacture of steel, is mainly used as road materials after aging. It is necessary to age steel slag for long time in air because the reaction with water and free-CaO in steel slag could make the expansion of volume. This problem prevents steel slag from being used as aggregate for concrete. However, steel slag used in this study was controled by a air-jet method which rapidly cools substance melted at a high temperature. The rapidly-chilled method would prevent from generation of free-CaO in steel slag. Also, Molten steel slag rapidly-chilled by air in high speed becomes a fine aggregate of nearly spherical shape. This study dealt with the influence of the using rate of rapidly-chilled steel slag and polymer resin on fluidity of polymer concrete, as a results Since RCSS has spherical shape and high density, up to replacement ratio of 100%, increases concrete fluidity under same polymer content and decrease polymer content in order to secure the same fluidity

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제어법칙 개발을 위한 소프트웨어 전환장치 설계에 관한 연구 (A Study on the Design of Software Switching Mechanism for Develops the Flight Control Law)

  • 김종섭;조인제;안종민;신지환;박상선
    • 제어로봇시스템학회논문지
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    • 제12권11호
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    • pp.1130-1137
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    • 2006
  • Relaxed Static Stability(RSS) concept has been applied to improve aerodynamic performance of modern version supersonic jet fighter aircraft. Therefore, the flight control systems are necessary to stabilizes the unstable aircraft and provides adequate handling qualities. The initial production flight control system are verified by flight test and it's always an elements of danger because of flight-critical nature of control law function and design error due to model base design method. These critical issues impact to flight safety, and it could be lead to a loss of aircraft and pilot's life. Therefore, development of an easily modifiable RFCS(Research Flight Control System) capable of reverting to a PFCS(Primary Flight Control System) of reliable control law must be developed to guarantee the flight safety. This paper addresses the concept of SSWM(Software Switching Mechanism) using the fader logic such as TFS(Transient Free Switch) based on T-50 flight control law. The result of the analysis based on non-real time simulation in-house software using SSWM reveals that the flight control system are switching between two computers without any problem.

주유동의 난류강도가 막냉각홀 주위의 열/물질전달 특성에 미치는 영향 (Effect of Free Stream Turbulence Intensity on Heat/Mass Transfer Characteristics Around a Film Cooling Hole)

  • 이동호;김병기;조형희
    • 한국추진공학회지
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    • 제2권2호
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    • pp.56-63
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    • 1998
  • 본 논문에서는 주유동의 난류강도 변화에 따른 복합각도로 분사되는 단일 막냉각홀 주위에서의 국소 열/물질전달계수 특성을 살펴보기 위하여 실험을 수행하였다. 단일 막냉각홀 시편은 평면에 대하여 $30^{\cire}$의 경사각을 가지고 있으며, 횡방향으로는 주유동에 대해 $45^{\cire}$의 각도로 분사하여 복합각도 분사시 주유동의 난류강도 변화에 따른 효과를 살펴보았다. 또한 막냉각제트의 분사율을 0.5에서 2.0까지 변화시켜가며, 주유동의 높은 난류강도조건에서 분사율 변화시 막냉각홀 주위의 열/물질전달특성에 미치는 효과를 살펴보았다. 주유동의 난류강도를 변화시키기 위하여 막냉각홀 상류에 난류발생격자를 설치하였다. 격자를 설치하지 않은 경우, 주유동의 난류강도는 0.5%이며, 난류발생격자의 종류 및 설치위치를 달리하여 난류강도를 3%에서 10%까지 변화시켜가며 실험하였다. 막냉각홀 주위에서 국소적인 열/물질전달계수 값을 얻기 위하여 물질전달 실험방법인 나프탈렌 승화법을 사용하였다. 주유동의 난류강도가 낮은 경우 분사홀 주변에서 막냉각제트 혹은 주유동에 의한 열/물질전달 촉진영역이 뚜렷한 경계를 갖지만, 난류강도가 증가하면서 전 영역에 걸쳐 열/물질전달이 촉진되었으며 주유동과 막냉각제트의 활발한 혼합작용으로 인해 영역의 구분이 점차 소멸되었다. 또한 주유동의 높은 난류강도 효과는 막냉각제트의 분사율이 높은 경우 뚜렷이 나타났다.

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