• Biotechnology and Bioprocess Engineering:BBE
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• 제11권3호
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• pp.179-186
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• 2006

End-Labeled Free-Solution Electrophoresis (ELFSE) is a new technique that is a promising bioconjugate method for DNA sequencing (or separation) and genotyping by both capillary and microfluidic device electrophoresis. Because ELFSE enables high-resolution electrophoretic separation in aqueous buffer alone (i.e., without a polymer matrix), it eliminates the need to load viscous polymer networks into electrophoresis microchannels. To achieve microchannel DNA separations with high performance, ELFSE requires monodisperse perturbing entities (i.e., drag-tags), which create a large amount of frictional drag when pulled behind DNA during free-solution electrophoresis, and which have other properties suitable for microchannel electrophoresis. In this article, the theoretical concepts of ELFSE and the required characteristics of the drag-tag molecules for the ultimate performance of ELFSE are reviewed. Additionally, the merits and limitations of current drag-tags are also discussed in the context of recent experimental data of ELFSE separation (or sequencing).

• Structural Engineering and Mechanics
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• 제61권3호
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• pp.335-345
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• 2017

Free vibration analysis for continuous bridge under any number of vehicles is conducted in this paper. Calculation strategy for natural frequency and mode shape is proposed based on Euler-Bernoulli beam theory and numerical assembly method. Firstly, a half-car planar model is adopted; equations of motion and displacement functions for bridge and vehicle are established, respectively. Secondly, the undermined coefficient matrices for wheels, vehicles, intermediate support, left-end support and right-end support are derived. Then, the numerical assembly technique for conventional finite element method is adopted to construct the overall matrix of coefficients for whole system. Finally, natural frequencies and corresponding mode shapes are determined based on iterative method and overall matrix solution. Numerical simulation is presented to verify the effectiveness of the proposed method. The results reveal that the solutions of present method are exact ones. Natural frequencies and associate modal shapes of continuous bridge under different conditions of vehicles are investigated. The influences of vehicle parameters on natural frequencies are also demonstrated.

• 소음진동
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• 제3권4호
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• pp.331-339
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• 1993

The main purpose of this paper is to present an analytical method for free vibration of arches with thickness varying in a discontinuous fashion. The ordinary differential equations governing the free vibration of these arches are derived as nondimensional forms including the effect of rotatory inertia. The governing equation are solved numerically for the circular and sinusoidal arches with hinged-hinged-hinged end clamped-clamped end constraints. As the numerical results, the effect of rotatory inertia on the natural frequencies is reported. The lowest four natural frequencies are presented as the functions of four nondimensional system parameters; the rise to span length ratio, the slenderness ratio, the section ratio and the ratio of discontinuous section.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 추계학술대회논문집 II
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• pp.1000-1004
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• 2001

This study explores the free vibrations of tapered column with hinged end restricted by rotational spring. The ordinary differential equation governing the free vibration of such column is derived as nondimensional form in which three kinds of cross-sectional shape are considered. In order to obtain the natural frequencies of column, the governing differential equation is solved by numerical procedures. Numerical results are compared with existing solutions by other methods. It is expected that the results obtained herein can be practically utilized in the structural and the vibration control fields.

• Steel and Composite Structures
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• 제33권3호
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• pp.403-432
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• 2019

Axially functionally graded (AFG) beams are a new class of composite structures that have continuous variations in material and/or geometrical parameters along the axial direction. In this study, the exact analytical solutions for the free vibration of AFG and uniform beams with general elastic supports are obtained by using Euler-Bernoulli beam theory. The elastic supports are modeled with linear rotational and lateral translational springs. Moreover, the material and/or geometrical properties of the AFG beams are assumed to vary continuously and together along the length of the beam according to the power-law forms. Accordingly, the accuracy, efficiency and capability of the proposed formulations are demonstrated by comparing the responses of the numerical examples with the available solutions. In the following, the effects of the elastic end restraints and AFG parameters, namely, gradient index and gradient coefficient, on the values of the first three natural frequencies of the AFG and uniform beams are investigated comprehensively. The analytical solutions are presented in tabular and graphical forms and can be used as the benchmark solutions. Furthermore, the results presented herein can be utilized for design of inhomogeneous beams with various supporting conditions.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2009년도 세계 도시지반공학 심포지엄
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• pp.1415-1424
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• 2009

Measuring dynamic properties of gravel-sized materials demands large specimens. Due to the difficulties in experiment as well as equipment, the dynamic properties of gravel-sized material has rarely been investigated. To realize free-free end condition more properly and stabilize specimen during testing with new specimen support system, a free-free resonant column testing device, which is capable of testing gravel-sized materials and constraining a specimen in free-free boundaries, is developed. We report the calibration of the equipment and preliminary testing results on Jumunjin sand. The testing data are compared with the previous data obtained from the existing fixed-free resonant column test.

• 대한교통학회지
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• 제19권1호
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• pp.115-129
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• 2001

본 연구에서는 평균지체시간을 최소화하는 변동주기 (Cycle fee) 기반의 동적 신호시간 결정모형을 유전자 알고리즘을 이용하여 개발하였다. 본 모형은 실시간으로 변화하는 각 접근로의 차량 도착분포를 토대로 이동류별 지체시간을 산정하고, 교차로의 지체시간을 최소화하는 신호주기의 길이와 이동류별 녹색시간을 산출한다. 개발모형은 4개 교차로로 구성된 간선도로를 대상으로 적용하였으며, 교차로 교통상황의 변화에 따라 신호주기별로 변동하는 신호주기의 길이, 이동류별 녹색시간 그리고 교차로간 변동 연동값을 각각 산출하였다. 모형의 적용결과 산출된 변동 신호주기와 이동류별 녹색시간은 비포화상태와 포화상태 모두 TRANSYT-7F나 PASSER-II에 의하여 산출된 정주기식 신호시간보다 대기차량수, 통과교통량, 그리고 지체시간에서 있어서 더 좋은 결과를 나타내었다. 또한 본 모형은 기존모형과는 달리 연동값을 고정 값으로 설정하지 않고 각 주기가 종료되는 시점마다 교차로 지체시간을 최소화하는 주기 및 이동류별 녹색시간을 산정하므로 연동값도 신호주기별로 변동하였다. 시공도 분석결과, 본 모형에서는 모형의 결과를 산출되는 변동 연동값을 통하여 주방향 이동류의 연동효과를 나타내었다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.467-468
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• 2006

• 대한치과보철학회지
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• 제32권4호
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• pp.526-552
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• 1994

The extent and direction of movement of removable partial dentures during function are influenced by the nature of the supporting structures and and the design of the prosthesis. Since forces are transmitted to the abutment teeth through occlusal rests, guide planes and direct retainers during functional movements, proper design based on the avaialble research data will maintain the health of abutment teeth and their supporting structures. The purpose of this in vitro study is evaluating stress distribution clinically around the abutment teeth prepared following 4-type clasping systems for unilateral free-end removable partial dentures. Three-Dimensional Photoelastic Stress Analysis method was used because it shows a visual display of stresses of the simulated abutment teeth and residual ridges and reveals stress concentration that can be read at any given points in terms of direction and magnitude. For this study, the author fabricated 4 mandibular photoelastic epoxy models missing left 1st and End molar. Epoxy models were duplicated and 4 unilateral removable partial dentures were construe- ted in accordance with 4-type direct retainers. Unilateral free-end removable partial dentures were positioned on their own models. 6kg force was loaded on the every removable partial dentures of the epoxy model on the central fossa of mandibular left 1st molar vertically by the loading device. After the stress was frozen in a stress freezing furnace, 6 specimens of 6-mm thickness were made from every epoxy model and examined with the circular polariscope. The results were as follows : 1. Generally I-bar clasp revealed the most favorable stress distribution around the abutment teeth. 2. At the end portion of the free-end ridge, Back action clasp showed the highest stress concentration at the bucco-lingual and top portions of the residual alveolar ridge. 3. At the distal area of the abutment teeth, Akers clasp and Roach clasp showed higher stress concentration bucco-lingually and apically than the others. 4. To the abutment tooth, I-bar clasp showed the least stress distribution bucco-lingually but the others showed irregular stress distribution. 5. At the mesial area of the abutment teeth, the order of effective stress distribution was I-bar clasp, Back-action clasp, Akers clasp and Roach clasp. There was big difference of stress distribution between them. 6. At the right 2nd premolar and 1st molar, the stress concentration of Akers clasp was a little high but that of I-bar clasp was low.

• Journal of Chest Surgery
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• 제37권10호
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• pp.839-844
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• 2004

배경 및 목적: 속가슴동맥 편과 유리 노동맥 편의 Y-복합이식편은 관상동맥우회 술에 많이 이용된다. 이 연구의 목적은 속가슴동맥 편의 혈류를 증가시킬 수 있는 방법을 찾고 Y-복합이식편의 혈류역학을 알고자 함이다. 대상 및 방법: 관상동맥우회 술을 받은 15예에서 속가슴동맥 편을 두 가지 방법으로 처치하여 속가슴동맥 혈류량을 측정하였다. 7예에서는 혈관 외부에만 파파베린 액을 처치하였고 8예에서는 혈관 내로 파파베린 액을 주입하였다. 다른 18예에서는 속가슴동맥 편과 유리 노동맥 편으로 Y-복합이식편을 만들어 사용하였고 그 자유 혈류량과 두 분지의 혈류 변화를 조사하였다. 결과: 속가슴동맥 편의 혈관 내로 파파베린을 주사한 경우는 혈관외부에 파파베린을 처치한 경우보다 약 2배의 자유혈류량을 얻을 수 있었다(47.7$\pm$9.6 mL/min와 100.8$\pm$26.3 mL/min, p<0.001). Y-복합이식편의 양측을 다 연 상태에서 총 자유혈류량은 속가슴동맥 측만을 열었을 때나 노동맥 측만을 열었을 경우보다 훨씬 많았다(173.3$\pm$45.3 mL/min와 121.1$\pm$34.3 mL/min 혹은 117.5$\pm$42.8 mL/min, 각각 p<0.001). Y-복합이식편의 양 분지를 다 연 경우 양측의 혈류량은 차이가 없었다(85.4$\pm$27.8 mL/min와 87.9$\pm$42.4 mL/min, p=0.772). Y-복합이식편에서 한 측의 혈류량은 다른 측을 열 때보다 막을 때 훨씬 많았다. 결론: 속가슴동맥 편의 혈관 내에 파파베린 액을 주입하는 방법은 자유혈류량을 올릴 수 있는 매우 효과적인 방법이다. 속가슴동맥 편과 유리 노동맥 편의 Y-복합이식편은 속가슴동맥의 단독이식편보다 더 많은 자유혈류량을 보이며, Y-복합이식편의 한 측의 혈류량은 다른 측의 혈류량의 변화에 따라 변할 수 있다.