• The Journal of the Korean life insurance medical association
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• v.26
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• pp.3-12
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• 2007

Frailty는 노인에서 장애와 사망의 주된 원인이 되는데 근육 감소증, 근력 약화, 에너지/화동력/보행속도의 감소, 염증성 싸이토카인의 증가를 특징으로 한다. 비타민 D의 결핍 또는 저항증은 근육기능과 단백질 합성에 대한 효과, 염증성 싸이토카인의 표현 조절, 혈관계에 대한 영향, 중추신경계에 대한 영향을 통해 Fraity syndrome에 대한 원인인자가 될 수 있다. 따라서 만약 비타민 D 결핍이 이 증후군의 중요한 요인이라면 비타민 D 투여는 안전하고도 비용-효과적인 Frailty syndrome에 대한 예방 및 치료 방법이 될 수 있는 것이다.

• International Journal of Heart Failure
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• v.6 no.3
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• pp.93-106
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• 2024

Being commonly diagnosed in elderly women and associated with comorbidities as well as ageing-related cardio-vascular changes, heart failure with preserved ejection fraction (HFpEF) has been recently considered as a distinct cardiogeriatric syndrome. Frailty is another frequent geriatric syndrome. HFpEF and frailty share common underlying mechanisms, often co-exist, and represent each other's risk factors. A threshold of 65 years old is usually used to screen patients for both frailty and HFpEF in research and clinical settings. However, both HFpEF and frailty are very heterogenous conditions that may develop at younger ages. In this review we aim to provide a broader overview on the coexistence of HFpEF and frailty throughout the lifetime. We hypothesize that HFpEF and frailty patients' profiles (young, elderly, superaged) represent a continuum of the common ageing process modified by cumulative exposure to risk factors resulting to a presentation of HFpEF and frailty at different ages. We believe, that suggested approach might stimulate assessment of frailty in HFpEF assessment and vice versa regardless of age and early implementation of targeted interventions. Future studies of pathophysiology, clinical features, and outcomes of frailty in HFpEF by age are needed.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.2
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• pp.129-140
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• 2023

Purpose : This study was conducted to investigate and analyze the physical health of older Koreans with sarcopenia and locomotive syndrome and identify the related factors. Methods : In this study, the sarcopenia and locomotive syndrome evaluations were applied to 210 elderly people, and the sarcopenia group was 36, the locomotive syndrome group was 164, and the normal group was 10. After group selection, a physical health status survey was conducted. The physical health status was assessed via body composition analysis, physical characteristics survey including measurement of waist and calf circumference, investigation of diseases currently being diagnosed by a doctor, and frailty measurements. The collected data were statistically analyzed using one-way ANOVA, the Kruskal-Wallis test, and the Chi-square test. Results : There were significant differences between groups in all elements of physical characteristics including body mass index, waist circumference, and calf circumference. Among them, a consistent result was found that the normal group had the largest amount of muscle mass and the sarcopenia group had the least amount of muscle mass in the factors related to muscle mass. However, the factors relating to fat mass and obesity also showed significant differences between the groups, but the results were not consistent. Considering the group differences in current diseases, a significant difference was only detected for osteoporosis among 12 diseases. Moreover, those in the sarcopenia group had the highest rate of osteoporosis. And there was no significant difference between the groups in the total score of the frailty measurement, but there was a significant difference between the groups in the frailty measurement levels. Conclusion : This study on physical health status confirmed that muscle mass-related factors, osteoporosis, and frailty levels were significantly related to sarcopenia and locomotive syndrome.

• 한국체육학회지인문사회과학편
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• v.58 no.4
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• pp.423-433
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• 2019

The purpose of this review is to summarize current knowledge regarding animal sarcopenia and frailty models and their diagnosis indexes. In addition, we introduce the effects of exercise interventions on sarcopenia and frailty syndrome. Data collection and analysis (fifteen published articles from 2005~2017) were conducted by using keywords' sarcopenia index, frailty index, exercise and mice, and so on' in academic search engines such as Google scholar and Pubmed. Sarcopenia and frailty are the representative syndromes in elderly peoples which those symptoms can be effectively prevented or delayed by extremely adjusted long term exercise interventions (The combined oxidative and resistant exercise program might be ideal.).

• Korean Journal of Psychosomatic Medicine
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• v.32 no.1
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• pp.1-9
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• 2024

Frailty is a clinical syndrome as an increased vulnerability to stressors, leading to a decrease in physiologic reserves and a decline in the ability to maintain a good homeostasis. This condition leads to an increased risk of hospitalization, disability and mortality. Frailty occurs due to various causes and requires a multidimensional approach. It is also important to detect and manage it early. Frailty is also deeply related to neuropsychiatric problems such as pain and depression. In evaluating frailty, it is desirable to comprehensively consider not only physical areas such as disease, nutrition, movement, and sensory functions, but also psychosocial areas, and representative scales include Fried's physical frailty phenotype and Rockwood's frailty index. Physical activity and appropriate protein intake are important for frailty management, and inappropriate drug use should be reduced and oral care, cognitive function, and falls should also be noted. Frailty and pain can affect each other, and pain can promote frailty. Evidence has been published that hormone and protein abnormalities, immune system activity and inflammatory response, and epigenetic mechanisms work in common in the field of frailty and pain. More extensive and high-quality research should be conducted in the future, and the quality of life will be improved if the results are applied to the suppression and treatment of old age and pain.

• Journal of Nutrition and Health
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• v.54 no.6
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• pp.631-643
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• 2021

Purpose: Frailty is a clinical syndrome in older adults, and adequate nutrition is a modifiable factor in preventing the condition. The current study aims to investigate the association between frailty and dietary intake in the Korean elderly. Methods: This cross-sectional study included data from the 2018 Korean National Health and Nutrition Examination Survey of 1,268 subjects (535 men and 733 women) aged 65 years or older. Frailty was defined as having more than three of the following 5 modified Fried frailty phenotype criteria: unintentional weight loss, exhaustion, walking difficulties, weakness, and low physical activity. Dietary intake was assessed by applying the one-day 24-hour dietary recall. The association between frailty and dietary intakes were analyzed by multiple logistic regression. Results: Totally, 9.7% men and 21.9% women were classified as the frail group. Increasing levels of frailty were proportional to a decreased mean nutrient adequacy ratio in both genders. Moreover, the total food intake was significantly low in the frail elderly. In male subjects, multiple logistic regression analyses after adjusting covariates showed that the odds ratio (OR) of frailty in the highest tertile of the consumption of fruits (OR [95% confidence interval, CI] = 0.34 [0.13-0.93], p-trend = 0.021) were significantly lower than values obtained in the lowest tertile. In females, the highest tertile of fish and shellfish intake showed a significantly lower OR for frailty (OR [95% CI] = 0.55 [0.30-0.99], p-trend = 0.045), as compared with the lowest tertile. Conclusion: The present study indicates that high intake of fruits for men, and fish and shellfish for women, are probably linked with lowering the risk of frailty in the elderly.

• Journal of the Korean Applied Science and Technology
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• v.37 no.3
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• pp.625-634
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• 2020

The purpose of this study is not only to define and cause of sarcopenia and frailty due to aging, but also to explore prevention and delay through regular exercise and right nutrition. Sarcopenia and frailty are known to cause frailty, cachexia, osteoporosis, metabolic syndrome and early death due to decreased muscle mass and muscle function caused by aging. The two disease were related to nervous system damage and lack of protein synthesis within the muscles due to the increase in the amount of oxidative stress, and inadequate nutrition and lack of physical activity. It also emphasizes the role and importance of right nutrition and physical activity (such as aerobic exercise, resistance movement, etc) to prevent and improve such syndromes. Conclusions, it is in proposing the supply of high-quality protein, including regular exercise, as the most beneficial way to prevent and overcome aging-related sarcopenia and frailty.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.2
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• pp.1-14
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• 2007

Objective The purpose of this study is to work on the direction of the study with regard to the sarcopenic obesity. Methods We searched articles relative to sarcopenic obesity in the KyungHee University Meta-analysis database. We classified articles according to type of study and subject clinical characteristics, assessment, medical complications and treatment. Results and Conclusion Data from this pilot study showed that sarcopenic obesity is associated with metabolic abnormality, cancer, increased frailty, physical disability and inflammatory markers. Therefore, clinical studies are needed to demonstrate the effectiveness and safety of management for sarcopenic obesity.

• Journal of Korean Critical Care Nursing
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• v.8 no.2
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• pp.55-65
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• 2015

Purpose: The purpose of this study was to identify the attributes, antecedents, and consequences of post-intensive care syndrome. Methods: The study was conducted in accordance with Walker and Avant's conceptual analysis process. We searched the Medline, ProQuest, Google scholar, NANET (Korean National Assembly Library), and RISS (Korean Education and Research Information Service) databases resulting in 29 studies for in-depth review. Results: The attributes of post-intensive care syndrome include (1) new or worsening impairment persisting after discharge, (2) physical impairment, (3) psychological impairment, (4) cognitive impairment, and (5) symptom experience. The antecedents of the concept include a critical condition that requires intensive care, stressful events, immobility, sedation, delirium, insomnia, frailty, and invasive procedures. The consequences of post-intensive care syndrome are increased dependency in activities of daily life, decreased social interaction, delayed return to previous occupation, decreased quality of life, familial post-intensive care syndrome, and readmission/death. Conclusion: The concept of post-intensive care syndrome has multifaceted and integrative features. Further research needs to be conducted to develop a measurement tool that reflects the attributes of the concept and to develop multidisciplinary interventions to prevent post-intensive care syndrome.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.2
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• pp.1-11
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• 2022

Purpose : This study was conducted to assess the status of sarcopenia and locomotive syndrome in the Korean elderly population over 65 years of age by applying the recently updated screening tool for diagnostic evaluation of sarcopenia and locomotive syndrome. Methods : Sarcopenia and locomotive syndrome (LS) were diagnosed and evaluated in 210 Korean elderly people over 65 years of age. There were 36 patients in the "sarcopenia group", 164 in the "locomotive syndrome group", and 10 in the "normal group". The collected data were analyzed using the chi-square and Kruskal-Wallis tests. Results : The diagnostic evaluation of sarcopenia and LS showed the presence of sarcopenia in 9.05 % of males and 8.10% females among the Korean elderly population over 65 years of age. Prevalence of stage 1 locomotive syndrome (LS 1) was 95.24 %; stage 2, (LS 2) 36.19 %; and stage 3 (LS 3), 16.19 % among the study population. Both the sarcopenia diagnostic indicator and the LS evaluation indicators showed significant differences between the three groups. All the subjects in the sarcopenia group had LS; further, on comparison of the detailed composition ratio of each patient with LS, the prevalence of LS in the sarcopenia group was found to be: LS 1 41.67 %, LS 2 41.67 %, and LS 3 16.67 %, whereas in the LS group, it was found to be: LS 1 66.46 %, LS 2 16.46 %, and LS 3 17.07 %. The difference between the two groups was statistically significant. Conclusion : It was confirmed that sarcopenia is correlated with LS incidence. This suggests that the evaluation of motor LS can be used as a tool for the early diagnosis and prevention of sarcopenia in cases of functional decline due to aging in the elderly population.