• Proceedings of the KSMRM Conference
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• 2004.09a
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• pp.17-17
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• 2004

• Proceedings of the KSMRM Conference
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• 2005.09a
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• pp.26-26
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• 2005

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.112-112
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• 2001

Purpose： We developed the software for diffusion tensor imaging and evaluated its feasibility in norm brains. Method： Five normal volunteers, aged from 25 to 29 years, were examined on a 1.5 T MR system. the diffusion tensor pulse sequence used a SE-EPI with 6 diffusion gradie directions of (1, 1, 0), (-1, 1,0), (1, 0, 1), (-1, 0, 1), (0, 1, 1), (0, 1, -1) and also with no diffusion gradient. A b-factor of 500 sec/mm2 was used. Measurement parameter were as follows； TR/TE=10000 ms/99 ms, FOV=240 mm, matrix=128$\times$128, slice thickness/gap=6 mm/0 mm, bandwidth=91 kHz and the number of total slices=20. Four repeated axial diffusion images were averaged for diffusion tensor imaging. A total scan 11 of 4 min 30 sec was used. Six full diffusion tensor components of Dxx, Dyy, Dzz, Dxy, Dxz and Dyz were obtained using two-point linear regression model from 7 diffusion-weight images at each pixel and fractional anisotropy and lattice index images was estimated fr their eigenvectors and eigenvalues. Our program was written on a platform of IDL. W evaluated the qualities of fractional anisotropy and lattice index images of normal brains a knew whether our software for diffusion tensor imaging may be feasible.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.20-20
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• 2003

Purpose： To investigate the difference of fractional anisotropy (FA) values between 6- and 25-direction diffusion tensor images (DTI) in normal adult brain. Materials and Methods： DTI was peformed in 28 normal subjects (15 subjects with 6-direction, 13 subjects with 25-direction) in a 1.5 T MR system. DTI was done with SE-EPI sequence with TR/TE/NEX 10000/84/1, 5mm slice thickness and b=1000 s/mm2. FA values were measured from 8 different anatomical locations which included both cerebral peduncles, both posterior limbs of the internal capsules, both corona radiata, genu and splenium of the corpus callosum. Statistical difference of FA was tested between 6-and 25-direction DTI.

• Journal of Biomedical Engineering Research
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• v.37 no.2
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• pp.84-89
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• 2016

In this study, we proposed ameliorated method for region of interest (ROI) study to improve its accuracy using partial volume effect (PVE). PVE which arose in volumetric images when more than one tissue type occur in a voxel, could be used to reduce an amount of gray matter and cerebrospinal fluid within ROI of diffusion tensor image (DTI). In order to define ROIs, individual b0 image was spatially aligned to the JHU DTI-based atlas using linear and non-linear registration (http://cmrm.med.jhmi.edu/). Fractional anisotropy (FA) and mean diffusivity (MD) maps were estimated by fitting diffusion tensor model to each image voxel, and their mean values were computed within each ROI with PVE threshold. Participants of this study consisted of 20 healthy controls, 27 Alzheimer's disease and 27 normal-pressure hydrocephalus patients. The result showed that the mean FA and MD of each ROI were increased and decreased respectively, but standard deviation was significantly decreased when PVE was applied. In conclusion, the proposed method suggested that PVE was indispensable to improve an accuracy of DTI ROI study.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.439-445
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• 2004

Diffusion tensor image(DTI) exploits the random diffusional motion of water molecules. This method is useful for the characterization of the architecture of tissues. In some tissues, such as muscle or cerebral white matter, cellular arrangement shows a strongly preferred direction of water diffusion, i.e., the diffusion is anisotropic. The degree of anisotropy is often represented using diffusion anisotropy indices (relative anisotropy(RA), fractional anisotropy(FA), volume ratio(VR)). In this study, FA images were obtained using different gradient schemes(N=6, 11, 23, 35. 47). Mean values and the standard deviations of FA were then measured at several anatomic locations for each scheme. The results showed that both mean values and the standard deviations of FA were decreased as the number of gradient directions were increased. Also, the standard error of ADC measurement decreased as the number of diffusion gradient directions increased. In conclusion, different gradient schemes showed a significantly different noise performance and the schem with more gradient directions clearly improved the quality of the FA images. But considering acquisition time of image and standard deviation of FA, 23 gradient directions is clinically optimal.

• Journal of the Korean Society of Radiology
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• v.4 no.3
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• pp.13-18
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• 2010

Purpose : Diffusion tensor imaging(DTI) allows the visualization of fiber tract damage in patients with cerebral infarction. The purpose of this study is to evaluate the correlation between degree of NIH stoke scale and fractional anisotropy (FA) in patient with cerebral infarction. Material and Methods : 16 patients aged 36~77 years(male : 11, female : 5, mean age : 61y), diagnosed cerebral infarction by diffusion weighted imaging(DWI), underwent 24 directional diffusion tensor imaging(DTI). Patients had the DTI taken within 3days of stroke onset. Comparison of DWI, FA value on DTI were measured infarcted area and counter part of specific region of interest (ROI). And evaluation of differences between clinically improved patient group (n=9) and unimproved patient group (n=7) until 2 week follow up after development of cerebral infarction. Clinical status was scaled by NIH stroke scale. Results : Quantitative measurements of FA confirmed statistically the significant diffusion changes in the infarct compared with the matched-counter part region. In DWI, the infarcted area shows high signal intensity, however FA value on DTI was lower than normal brain parenchyma. The FA value of clinically improved patient by NIH stroke scale was 0.49, and the value of contralateral normal brain parenchyma was 0.41. On the contrary, FA value of infarcted area shows about 15% lower than normal brain parenchyma. But, the FA value of unimproved patient by NIH stroke scale represents a half those of contralateral normal brain parenchyma (0.28 on infarcted area vs. 0.56 on normal brain parenchyma). So, the FA value of unimproved patient group was considerably less than those of improved. Conclusion : It is concluded that the unimproved patient group after cerebral infarction showed much less FA value than that of normal brain parenchyma. The FA value of DTI may be one of the useful parameter to predict outcome of cerebral infarction patients.

• Journal of the Korean Society of Radiology
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• v.16 no.5
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• pp.575-583
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• 2022

Magnetic resonance diffusion tensor imaging (DTI) has revealed the disruption of brain white matter microstructure in normal aging and alcoholism undetectable with conventional structural MR imaging. we plan to analyze the FA measurements of the ROI of dangerous drinkers selected from Alcohol Use Disorders Identification Test (AUDIT) and Tract-Based Spatial Statics (TBSS) tool was used to extract FA values in the ROI from the image acquired through the pre-processing process. TBSS has a higher sensitivity of the FA value and MD value in the white matter than the brain gray matter, and has the advantage of quantitatively deriving the unlimited degree of brain nerve fibers, and more specialized in the brain white matter. We plan to analyze the fractional anisotropy (FA) measurement value for damage by selecting the center of the anatomical structure of the white matter region of the brain with high anisotropy among the brain neural networks that are particularly vulnerable to alcohol as the region of interest (ROI). In this study, we expected that alcohol causes damage to the brain white matter microstructure from FA value in various areas including both Choroid plexus. Especially, In the case of the moderate drunker, the mean value of FA in Lt, Rt. Choroid plexus was 0.2831 and 0.2872, whereas, in the case of the severe drunker, the mean value of FA was 0.1972 and 0.1936. We found that the higher the score on the AUDIT scale, the lower the FA value in ROI region of the brain white matter. Using the AUDIT scale, the guideline for the FA value of DTI can be presented, and it is possible to select a significant number of potentially severe drinkers. In other words, AUDIT was proved as useful tool in screening and discrimination of severe drunker through DTI.

• Investigative Magnetic Resonance Imaging
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• v.24 no.3
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• pp.174-177
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• 2020

Multiple studies have established that mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) exhibits reversible diffusion restriction in the white matter, including the splenium. There have been a few previous reports of the change in fractional anisotropy (FA) of MERS cases. Herein, we report the longitudinal changes in axial and radial diffusivity (AD and RD), and FA in a 15-year-old boy patient with MERS. Our case demonstrated that a MERS lesion had a significant drop of AD in the early period and gradual recovery. On the contrary, RD did not show any significant change.

• Journal of Biomedical Engineering Research
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• v.29 no.2
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• pp.114-121
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• 2008

Within 2 to 5 months after stroke, patients recover variable degrees of function, depending on the initial deficit. An impaired hand function is one of the most serious disability in chronic stroke patients. Therefore, to evaluate the extent of motor dysfunction in the hemiplegic hand is important in stroke rehabilitation. In this paper, motor recoveries in 8 chronic stroke patients with Fugl-Meyer (FM) and white matter changes before and after the training program with a designed bilateral symmetrical arm trainer (BSAT) system were examined. The training was performed at 1 hr/day, 5 days/week during 6weeks. In all patients, FM was significantly improved after the 6-week training. Diffusion tensor imaging (DTI) results showed that tractional anisotropy ratio (FAR) and fiber tracking ratio (FTR) in the posterior internal capsule were significantly increased after the training. It seemed that the cortical reorganization was induced by the 6 week training with the BSAT. In all parameters proposed this study, a significant correlation was found between these parameters (FAR and FTR) and motor recoveries. This study demonstrated that DTI technique could be useful in predicting motor recovery in chronic hemiparetic patients.