• Journal of Ecology and Environment
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• v.42 no.4
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• pp.265-271
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• 2018

Background: Temperature-driven variation in pollinator assemblage and activity are important information, especially at high altitudes, where rising temperature trends exceed global levels. Temporal patterns of pollinators in a flowering season can be used as a proxy to predict the changes of high-altitude plants' mutualistic relationships. We observed a spring temperature change in one population of a high-altitude endemic species, Megaleranthis saniculifolia on Mt. Sobaeksan, and related it to pollinator assemblage and activity changes. Methods: This study was conducted at two sites, each facing different slopes (NE and NW), for two times in the spring of 2013 (early-flowering, April 27-28, vs. mid-flowering, May 7-8, 2013). We confirmed that the two sites were comparable in snowmelt regime, composition of flowering plants, and flower density, which could affect pollinator assemblage and activity. Pollinator assemblage and activity were investigated at three quadrats ($1m^2$ with 5-m distance) for each site, covering a total of 840 min observation for each site. We analyzed correlations between the temperature and visitation frequency. Results: Twelve pollinator species belonging to four orders were observed for M. saniculifolia at both sites during early- and mid-flowering times. Diptera (five species) and hymenopteran species (four species) were the most abundant pollinators. Pollinator richness increased at both sites toward the mid-flowering time [early vs. mid = 7 (NE) and 3 (NW) vs. 9 (NE) and 5 (NW)]. Compared to the early-flowering time, visitation frequency showed a fourfold increase in the mid-flowering time. With the progression of spring, major pollinators changed from flies to bees. Upon using data pooled over both sites and flowering times, hourly visitation frequency was strongly positively correlated with hourly mean air temperature. Conclusions: The spring temperature change over a relatively brief flowering period of M. saniculifolia at high altitudes can alter pollinator assemblages through pollinator dominance and visitation frequency changes. Thus, this study emphasizes information on intra- and inter-annual variations in the mutualistic relationship between pollinators and M. saniculifolia to further assess the warming impacts on M. saniculifolia's reproductive fitness.

• Biomolecules & Therapeutics
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• v.29 no.5
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• pp.506-518
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• 2021

The imprinted tumour suppressor NOEY2 is downregulated in various cancer types, including ovarian cancers. Recent data suggest that NOEY2 plays an essential role in regulating the cell cycle, angiogenesis and autophagy in tumorigenesis. However, its detailed molecular function and mechanisms in ovarian tumours remain unclear. In this report, we initially demonstrated the inhibitory effect of NOEY2 on tumour growth by utilising a xenograft tumour model. NOEY2 attenuated the cell growth approximately fourfold and significantly reduced tumour vascularity. NOEY2 inhibited the phosphorylation of the signalling components downstream of phosphatidylinositol-3'-kinase (PI3K), including phosphoinositide-dependent protein kinase 1 (PDK-1), tuberous sclerosis complex 2 (TSC-2) and p70 ribosomal protein S6 kinase (p70S6K), during ovarian tumour progression via direct binding to vascular endothelial growth factor receptor-2 (VEGFR-2). Particularly, the N-terminal domain of NOEY2 (NOEY2-N) had a potent anti-angiogenic activity and dramatically downregulated VEGF and hypoxia-inducible factor-1α (HIF-1α), key regulators of angiogenesis. Since no X-ray or nuclear magnetic resonance structures is available for NOEY2, we constructed the three-dimensional structure of this protein via molecular modelling methods, such as homology modelling and molecular dynamic simulations. Thereby, Lys15 and Arg16 appeared as key residues in the N-terminal domain. We also found that NOEY2-N acts as a potent inhibitor of tumorigenesis and angiogenesis. These findings provide convincing evidence that NOEY2-N regulates endothelial cell function and angiogenesis by interrupting the VEGFR-2/PDK-1/GSK-3β signal transduction and thus strongly suggest that NOEY2-N might serve as a novel anti-tumour and anti-angiogenic agent against many diseases, including ovarian cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.7
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• pp.2257-2285
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• 2022

Cyber-physical systems (CPS) have been growing exponentially due to improved cloud-datacenter infrastructure-as-a-service (CDIaaS). Incremental expandability (scalability), Quality of Service (QoS) performance, and reliability are currently the automation focus on healthy Tier 4 CDIaaS. However, stable QoS is yet to be fully addressed in Cyber-physical data centers (CP-DCS). Also, balanced agility and flexibility for the application workloads need urgent attention. There is a need for a resilient and fault-tolerance scheme in terms of CPS routing service including Pod cluster reliability analytics that meets QoS requirements. Motivated by these concerns, our contributions are fourfold. First, a Distributed Non-Recursive Cloud Model (DNRCM) is proposed to support cyber-physical workloads for remote lab activities. Second, an efficient QoS stability model with Routh-Hurwitz criteria is established. Third, an evaluation of the CDIaaS DCN topology is validated for handling large-scale, traffic workloads. Network Function Virtualization (NFV) with Floodlight SDN controllers was adopted for the implementation of DNRCM with embedded rule-base in Open vSwitch engines. Fourth, QoS evaluation is carried out experimentally. Considering the non-recursive queuing delays with SDN isolation (logical), a lower queuing delay (19.65%) is observed. Without logical isolation, the average queuing delay is 80.34%. Without logical resource isolation, the fault tolerance yields 33.55%, while with logical isolation, it yields 66.44%. In terms of throughput, DNRCM, recursive BCube, and DCell offered 38.30%, 36.37%, and 25.53% respectively. Similarly, the DNRCM had an improved incremental scalability profile of 40.00%, while BCube and Recursive DCell had 33.33%, and 26.67% respectively. In terms of service availability, the DNRCM offered 52.10% compared with recursive BCube and DCell which yielded 34.72% and 13.18% respectively. The average delays obtained for DNRCM, recursive BCube, and DCell are 32.81%, 33.44%, and 33.75% respectively. Finally, workload utilization for DNRCM, recursive BCube, and DCell yielded 50.28%, 27.93%, and 21.79% respectively.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1B
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• pp.119-124
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• 2006

The purpose of this study was the comparison of pollutants removal and the track study of the nitrogen and phosphorus, the estimation of the nitrification and denitrification rate, and the investigation of the nitrogen mass balance between intermittently aerated membrane bioreactor(IAMBR) and intermittently aerated bioreactor(IABR), thus it verified the validity of the membrane submergence. As a result, it had no difference of organic matter removal, however, IAMBR showed better efficiency than IABR in the nutrients. Also, $NO_3{^-}$-N concentration at the anoxic state in the reactor was lower in IAMBR, and the denitrified nitrogen of IAMBR was 40.9%, that of IABR was 10.7%, thus it found out that the denitrification capability of IAMBR was higher than IABR above fourfold. Therefore, it seems resonable to conclude that the membrane helps to improve the removal of pollutants, because of the high MLSS concentration and the available method of intermittent inflow/outflow.

• The korean journal of orthodontics
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• v.31 no.2 s.85
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• pp.271-281
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• 2001

The Purpose of this study was fourfold - to evaluate the general laws of friction applied to orthodontic conditions, to compare archwire materials under these controlled conditions, to compare ligation method, and to measure the effect of the artificial saliva on friction with these materials Three wire alloys (Cobalt-chromium, Nickel-titanium, Beta-titanium) in two size wires (.016" , .016" ${\times}$.022" ) were examined respect to the bracket (.018" ${\times}$.025" standard), and two ligature material (stainless steel, elastomeric) in dry and wet conditions The results were as follows, 1. The order of frictional force against alloy materials was Co-Cr (lowest), Ni-Ti, and ${\beta}$-Ti(highest) - with the exception of elastomeric ligation under wet conditions. 2. S.S. ligation gave rise to significantly greater friction than elastomeric ligation did. 3. Testing in the presence of saliva, rather than in dry conditions, decreased the frictional force for S.S. ligation with .016" Co-Cr, Ni-Ti, ${\beta}$-Ti. but, increased the frictional force for S.S. ligation with .016" ${\times}$ .022" Co-Cr, Ni-Ti, ${\beta}$-Ti. 4. .016" ${\times}$.022 " wire generated more friction than .016" wire.

• Journal of the Korean Magnetics Society
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• v.20 no.5
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• pp.173-177
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• 2010

The electronic structure of charge-density-wave (CDW) system $CeTe_2$ has been investigated by using angle-resolved photoemission spectroscopy (ARPES). The clearly dispersive band structures are observed in the measured ARPES spectra, indicating the good quality of the single-crystalline sample employed in this study. The four-fold symmetric patterns are observed in the constant energy (CE) mappings, indicating the $2{\times}2$ lattice deformation in the Te(1) sheets. The observed CE images are similar to those of $LaTe_2$, suggesting that Ce 4f states have the minor contribution to the CDW formation in $CeTe_2$. This study reveals that the carriers near the Fermi level should have mainly the Te(1) 5p and Ce 5d character, that the Te(1) 5p bands contribute to the CDW formation, and that the Ce 5d bands cross the Fermi level even in the CDW state.

• Journal of the korean academy of Pediatric Dentistry
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• v.43 no.2
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• pp.166-175
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• 2016

There is no genetic activity information with the functions of dental pulp and periodontal ligament in human. The purpose of this study was to identify the gene-expression profiles of, and the molecular biological differences between periodontal ligament and dental pulp obtained from human permanent teeth. cDNA microarray analysis identified 347 genes with a fourfold or greater difference in expression level between the two tissue types 83 and 264, of which were more plentiful in periodontal ligament and dental pulp, respectively. Periodontal ligament exhibited strong expression of genes related to collagen synthesis (FAP), collagen degradation (MMP3, MMP9, and MMP13), and bone development and remodeling (SSP1, BMP3, ACP5, CTSK, and PTHLH). Pulp exhibited strong expression of genes associated with calcium ions (CALB1, SCIN, and CDH12) and the mineralization and formation of enamel and dentin (SPARC/SPOCK3, PHEX, AMBN, and DSPP). Among these genes, SPP1, SPARC/SPOCK3, AMBN, and DSPP were well known in dental research. However, the other genes are the newly found and it may help to find a good source of regenerative therapy if further study is performed.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3131-3137
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• 2013

Background: Visual inspection of cervix with acetic acid (VIA) is offered at 252 centers in 64 districts of Bangladesh. VIA+ve women are managed at colposcopy clinics of Bangabandhu Sheikh Mujib Medical University (BSMMU) and 14 Medical College Hospitals (MCHs). This research work has been supported by 'UICC Cancer Prevention Campaign' programme. Objectives: This study explored the role of print materials and electronic media to improve cervical cancer screening in the present socio-cultural context of Bangladesh. Methods: This study was performed from January to August 2011 at two upazilas of Bangladesh (Singair with screening facility and Sonargaon without screening facility). Data were collected by focus group discussion (FGD) with women, husbands and community people before and after intervention. Information on cervical cancer screening and VIA camps was disseminated using advertisement through local cable line of the television, microphone announcement, service providers and leaflet throughout the week prior to a VIA camp. Three-day VIA camps were organized at the upazila health complex (UHC) of both upazilas. Quantitative data was gathered from women at the camps on source of information on VIA and the best method of awareness creation. Results: The population was aware of "cancer" and a notable number knew about cervical cancer. Baseline awareness on prevention and VIA was low and it was negligible where screening services were unavailable. Awareness was increased fourfold in both upazilas after interventions and half of the women and the majority of the community people became aware of screening and available facilities. Cable line advertisement (25.5%), microphone announcement (21.4%), and discussion sessions (20.4%) were effective for awareness creation on VIA. Television was mentioned as the best method (37.4%) of awareness creation. Conclusion: Television should be used for nation-wide awareness creation. For local awareness creation, cable line advertisement, microphone announcements and health education at Uthan Baithaks/ EPI sessions can easily be adopted by the government.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.4
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• pp.373-381
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• 2016

To investigate the influence of hand cream of domestic and foreign brands on the purchase tendency, a survey was conducted on hand cream application, purchase tendency, and perception of 105 women in a metropolitan area. Market research was then conducted to compare the hand cream cost, quantity, and total substance, and the hand creams were sorted according to high-price and low-price, and foreign brand and domestic brand, and a clinical demonstration was conducted by back-hand application on 17 recipients to analyze the moisture and skin oil differences and the moisture endurance. As a result, the percentage of subjects who perceived that the price and brand of hand cream affects the quality was higher than those who did not, and the hand cream prize per 1mg (g) varied as much as fourfold among the high-price and low-price, and among foreign and domestic brands. The result of the total substance comparison, glycerin the moisturizer and cetearyl alcohol the skin conditioner were included in all hand creams. As a result of the clinical demonstration, the difference in moisture and skin oil difference and moisture endurance between the high-price and low-price and foreign brand did not show a statistically significant difference. These results show that there are no relationships between skin moisture and sebeum of the brand. Therefore, considering that hand cream is a highly consumptive product that is used multiple times on a daily basis, these results might provide fundamental data that could contribute to the increase in hand cream product quality by determining the consumers' needs.

• Food Science and Preservation
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• v.14 no.3
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• pp.294-300
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• 2007

Three varieties of soy sauce were prepared using saps of bamboo, xylem and gorosoe, with sea salt and bamboo salt, in May. Soy sauce was fermented in the traditional manner. Homemade soy sauce was analyzed after 3 months of aging. The pH and amino-type nitrogen content of soy sauce fermented with xylem sap and sea salt were very high, and malic acid was dominant among four types of organic acid. The content of calcium in soy sauce fermented with bamboo sap and sea salt was fourfold greater than that of the control. The contents of total amino acids in the soy sauces fermented with xylem sap and gorosoe, with the addition of sea salt instead of water, were 2-fold and 1.4-fold greater than that of ordinary soy sauce, respectively. In the DPPH assay, the antioxidant effect of soy sauce fermented with bamboo sap and sea salt was higher than that of other samples. Sensory evaluation showed that the overall acceptability of soy sauce fermented with gorosoe and sea salt was best, among the samples tested.