• Geomechanics and Engineering
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• 제8권2호
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• pp.283-303
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• 2015

To research and analyze the differential settlements of foundations specifically, site investigations of existing railways and metro were firstly carried out. Then, the centrifugal test was used to observe differential settlements in different position between foundations on the basis of investigation. The theoretical model was established according to the stress diffusion method and Fourier method to establish an analytical solution of embankment differential settlement between different foundations. Finally, theoretical values and experimental values were analyzed comparatively. The research results show that both in horizontal and vertical directions, evident differential settlement exists in a limited area on both sides of the vertical interface between different foundations. The foundation with larger elastic modulus can transfer more additional stress and cause relatively less settlement. Differential settlement value decreases as the distance to vertical interface decreases. In the vertical direction of foundation, mass differential settlement also exists on both sides of the vertical interface and foundation with larger elastic modulus can transfer more additional stress. With the increase of relative modulus of different foundations, foundation with lower elastic modulus has larger settlement. Meanwhile, differential settlement is more obvious. The main error sources in theoretical and experimental values include: (a) different load form; (b) foundation characteristics differences; (c) modulus conversion; (d) effect of soil internal friction.

• 공학교육연구
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• 제21권2호
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• pp.51-59
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• 2018

The author investigated the momentum of the maker movement and its educational implications with the following four research questions: 1. What is the maker movement? 2. What is the nature of our societal interest in the maker movement? 3. Which learning theories are associated with the maker movement? 4. What are the educational implications of the maker movement? The author reviewed the history of education in terms of the maker movement and concluded that Papert's learning-by-making approach provided a theoretical foundation of the maker movement. The maker movement aims to engage participants in Do-It-Yourself(DIY) activities, the spirit of tinkering, and a hands-on approach. Also, the maker movement meets the educational demands of fostering students' 21st-century abilities and technological literacy. Lastly, the author anticipated the issues that may arise following the introduction of the maker movement in K-12 schools. In conclusion, the author discussed the challenges of the school maker education movement and suggested the bottom-up approach to utilize the school resources of technology and engineering education.

• 대한간호
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• 제10권2호통권52호
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• pp.23-28
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• 1971

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• 한국병원경영학회지
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• 제25권2호
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• pp.25-44
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• 2020

Purposes: This study was to analyze the effects of organizational culture attributes on organizational effectiveness in newly established general hospital. Method: For this purpose, this study sampled 981 hospital employees working for E hospital opened on Apr. 1, 2019 in Seoul. A total of 981 questionnaires were distributed to them, and 888 ones responded to the survey, which had been conducted from Oct. 17, through Oct. 25, 2019. 793 responses were used for the final analysis. The data collected were processed using the SPSS 19.0K for descriptive statistics, T-test, ANOVA, Pearson's correlation coefficient and regression analysis. Findings: First, The type of organizational culture perceived most by hospital employees was 'hierarchy-oriented' (3.53) followed by 'relation-oriented'(3.33), 'task-oriented'(3.23), 'innovation-oriented'(3.19) and job satisfaction scored 3.13, organizational commitment scored 3.28 on their order. Second, 'Relation-oriented', 'task-oriented' and 'innovation-oriented' was positively correlated with job satisfaction and organizational commitment. hierarchy-oriented' was negatively correlated with job satisfaction and organizational commitment. Third, Factors that significantly influencing on organizational effectiveness in a newly established general hospital were as follows. Factors influencing job satisfaction included 'innovation-oriented', 'relation-oriented' and factors influencing organizational commitment included 'relation-oriented', 'innovation-oriented' and age. Practical Implications: In order to increase the organizational effectiveness of the E-General Hospital, it is necessary to gradually move from a hierarchica l-oriented culture to an innovation-oriented and relationship-oriented culture. Since age also affects organizational commitment, it is necessary to promote stability and growth by promoting the mentor-menti system for new members with a low level of experience and experience.

• 대한지구과학교육학회지
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• 제5권2호
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• pp.189-196
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• 2012

This study was conducted using the phenomenological research method to collect and analyze high school students' opinions about fusing "science" textbook that reflect the 2009 Revised Curriculum. Ninety six students were chosen to be participants from 32 high schools that selected by city and province. The data collection was carried by individual interviews and group discussions. The results are as follow; students' opinions were summarized to 50 themes, and then classified to 9 theme clusters and 2 categories. Students' opinions were divided into a positive position - "it is good because interesting material associated with life", "the structure of textbook is good", "teachers' efforts make class interesting", and "it will help in career choices"- and negative position - "the content is difficult to understand", "the configuration is complex", "I have less interest about it because it doesn't related College Scholastic Ability Test", "teacher's explanation is insufficient", and "it is not associated with career choice"-. The living-related material and story-telling configuration received good reviews from students. On the other hand, the configuration of topics makes many concepts to use, so students have difficulty understanding the content and pointed out the lack of teachers' explanations about unfamiliar areas. In order to solve the difficulties, variety teaching material for fusing "science" will be developed.

• 분석과학
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• 제36권4호
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• pp.180-190
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• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• 분석과학
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• 제37권1호
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• pp.25-38
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• 2024

The study aimed to investigate a novel approach by utilizing liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) to separate, identify and characterize very nominal quantities of degradation products (DPs) of balsalazide along with its process related impurities without isolation from their reaction mixtures. The impurities along with balsalazide were resolved on spherisorb ODS2 (250×4.6 mm, 5.0 ㎛) column at room temperature using 0.2 M sodium acetate solution at pH 4.5 and methanol in the ratio of 55:45 (v/v) as mobile phase pumped isocratically at 1.0 mL/min as mobile phase and UV detection at 255 nm. The method shows sensitive detection limit of 0.003 ㎍/mL, 0.015 ㎍/mL and 0.009 ㎍/mL respectively for impurity 1, 2 and 3 with calibration curve liner in the range of 50-300 ㎍/mL for balsalazide and 0.05-0.30 for its impurities. The balsalazide pure compound was subjected to stress studies and a total of four degradation products (DPs) were formed during the stress study and all the DPs were characterized with the help of their fragmentation pattern and the masses obtained upon LC-MS/MS. The DPs were identified as 3-({4-[(E)-(4-hydroxyphenyl) diazenyl]benzoyl}amino)propanoic acid (DP 1), 4-[(E)-(4-hydroxyphenyl)diazenyl] benzamide (DP 2), 5-[(E)-(4-carbamoylphenyl)diazenyl]-2-hydroxybenzoic acid (DP 3) and 3-({4-[(E)-phenyldiazenyl]benzoyl}amino)propanoic acid (DP 4). Based on findings, it was concluded that, the proposed method was successfully applicable for routine analysis of balsalazide and its process related impurities in pure drug and formulations and also applicable for identification of known and unknown impurities of balsalazide.

• International Journal of Advanced Culture Technology
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• 제9권4호
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• pp.52-60
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• 2021

This study is conducted with the aim of redefining the university-based lifelong education support system for developmental disabled. The research method consisted of procedures in parallel with literature analysis and expert meetings. As for the contents of the study, a composition system that recognized the problems and solutions of lifelong education for the developmental disabled based on universities was primarily presented. Through this, it was suggested that universities can form an academic foundation for the establishment of a lifelong education support system for the developmental disabled along with the convergence field. In addition, a structural model related to this was presented along with the aspect that universities could develop a curriculum for lifelong education for the developmental disabled according to the school foundation. Also, a composition system was suggested that universities can develop lifelong education curriculum for people with developmental disabilities to lead the cooperation of local related organizations such as welfare centers for the disabled and lifelong education centers for the developmentally disabled. As a result of the study, it was analyzed that leadership in the university-based lifelong education support system for developmental disabled can contribute to fostering professional manpower qualifications and establishing cooperation with local related organizations in an integrated composition system.

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 2005년도 춘계 학술발표대회 논문집
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• pp.228-229
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• 2005

• 디자인학연구
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• 제11권1호
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• pp.199-207
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• 1998

지금의 독일 디자인이 지니고 있는 이미지 형성에 있어 바우하우스로부터 현재에 이르는 독일의 산업 디자인 기초 교육은 중요한 역할을 담당하였다. 현 시대가 요구하고 있는 산업디자인 기초 교육과정에서는 조형 개념을 이해할 수 있도록 하여야 함은 물론이고, 과학과 문화의 통합적 개념에서 산업디자인에 접근할 수 있어야 한다. 본 논문에서는 독일 산업디자인 발전에 지대한 공헌을 한 조형대학의 시대적 설립배경을 분석하여, 독일 조형대학들간의 기본적인 산업디자인 기초 교육을 이해하고자 하였다. 또한 바우하우스, 울름 조형대학과 현재의 독일 조형대학에서의 산업디자인 기초 교육과정의 결과물과 독일 디자인의 이미지를 대표하는 제품의 조형적 의미를 비교 분석하여 디자인 기초 교육의 역할에 대한 중요성 인식과 우리의 산업디자인 기초 교육과정을 위한 기본방향을 제시하였다.