• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.31 no.4
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• pp.214-224
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• 2020

Objectives: This study aimed to examine the trend in diagnostic prevalence of psychiatric disorders in children and adolescents. Methods: Individuals aged 0-18 years were included in the study based on the National Health Insurance Claims Data. To investigate the trends in diagnosis and diagnostic prevalence of psychiatric disorders reflecting the decrease in the birth rate, data were analyzed from 2010 as a reference year to 2015. Results: The number of patients diagnosed with psychiatric disorder decreased annually, from 23,412 on 2010 to 18,821 on 2015. The most common disorder was hyperkinetic disorder in male and depressive episode in female. Although there was no significant change in overall diagnostic prevalence rate of psychiatric disorders, age groups <10 years and some disorders had significant changes in prevalence rate. This study classified the diagnostic prevalence by age into two unique patterns: group in which the diagnosis rate increases with age and group in which the diagnosis rate peaks at a certain age and then decreases. Conclusion: Diagnostic prevalence of psychiatric disorders was different according to age and sex. These patterns should be reflected in the formulation of policies related to mental health and in medical practice for pediatric patients. It is urgent to identify how these patterns change in young adults.

• Journal of the Korean Applied Science and Technology
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• v.32 no.2
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• pp.202-214
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• 2015

Stimuli-responsive biomaterials that alter their function through sensing local molecular cues may enable technological advances in the fields of drug delivery, gene delivery, actuators, biosensors, and tissue engineering. In this research, pH-responsive hydrogel which is comprised of dimethylaminoethyl methacylate (DMAEMA) and 2-hydroxyethyl methacrylate (HEMA) was synthesized for the effective delivery of doxorubicin (Dox) to breast cancer cells. Cancer and tumor tissues show a lower extracellular pH than normal tissues. DMAEMA/HEMA hydrogels showed significant sensitivity by small pH changes and each formulation of hydrogels was examined by scanning electron microscopy, mechanical test, equilibrium mass swelling, controlled Dox release, and cytotoxicity. High swelling ratios and Dox release were obtained at low pH buffer condition, low cross-linker concentration, and high content of DMAEMA. Dox release was accelerated to 67.3% at pH 5.5 for 6-h incubation at $37^{\circ}C$, while it was limited to 13.8% at pH7.4 at the same time and temperature. Cell toxicity results to breast cancer cells indicate that pH-responsive DMAEMA/HEMA hydrogels may be used as an efficient matrix for anti-cancer drug delivery with various transporting manners. Also, pH-responsive DMAEMA/HEMA hydrogels may be useful in therapeutic treatment which is required a triggered release at low pH range such as gene delivery, ischemia, and diabetic ketoacidosis.

• Smart Structures and Systems
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• v.16 no.6
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• pp.1049-1068
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• 2015

In the paper, the authors propose the application of operational deflection shapes (ODS) for the detection of structural changes in technical objects. The ODS matrix is used to formulate the spatial filter that is further used for damage detection as a classical modal filter (Meirovitch and Baruh 1982, Zhang et al. 1990). The advantage of the approach lies in the fact that no modal analysis is required, even on the reference spatial filter formulation and other components apart from structural ones can be filtered (e.g. harmonics of rotational velocity). The proposed methodology was tested experimentally on a laboratory stand, a frame-like structure, excited from two sources: an impact hammer, which provided a wide-band excitation of all modes, and an electro-dynamic shaker, which simulated a harmonic component in the output spectra. The damage detection capabilities of the proposed method were tested by changing the structural properties of the model and comparing the results with the original ones. The quantitative assessment of damage was performed by employing a damage index (DI) calculation. Comparison of the output of the ODS filter and the classical modal filter is also presented and analyzed in the paper. The closing section of the paper describes the verification of the method on a real structure - a road viaduct.

• Journal of Fashion Business
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• v.21 no.3
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• pp.29-42
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• 2017

This study investigates the impact of female consumer self-image on pursued fashion style. A survey was carried out among 717 women between the ages of 20 and 60 living in Seoul, Incheon, and Gyeonggi. Analysis was conducted in the following manner: SPSS 18.0 was used to perform an Exploratory Factor Analysis (descriptive analysis, principal factor analysis, Pearson correlation analysis, frequency analysis, and reliability analysis) and AMOS 21.0 was used to carry out a Confirmatory Factor Analysis. Based on a Structure Equation Model, results show that ideal self-image and realistic self-image, which are factors derived from psychology, affect pursued fashion style. By contrast, social self-image - derived from social contexts - does not. Therefore, the female consumers' self-image influences pursued fashion style; this is opposed to the relationship between the realistic self-image and ideal self-image of women, which is more unconscious and self-satisfying. The presented results indicate that we should respond to changes in the fashion industry and develop a deeper understanding of consumer niches to discover the factors that predict purchasing behavior. This knowledge can then be applied to establish market strategies. This study contributes to the literature by producing preliminary data that can help support such strategy formulation in the fashion and clothing industry.

• Journal of Pharmaceutical Investigation
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• v.41 no.2
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• pp.75-82
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• 2011

LB71350 is an HIV protease inhibitor with poor aqueous solubility and extensive first pass effect. The purpose of the present study was to test the feasibility of solid dosage form of LB71350 with improved bioavailability utilizing solid dispersion. Three different compositions with varying ratio of (LB71350: Gelucire 44/14: Tween 20) were studied. Capsule filling of these solid dispersion compositions was tested using a semi-automatic capsule filling system. Oral bioavailability in dog was tested. Chemical and physical stability at 4, 25 and $40^{\circ}C$ was monitored by HPLC assay, dissolution test, powder XRD and microscopy. The capsule filling system yielded uniform products of drug loading up to 10%. Oral bioavailability in dog was improved compared to the aqueous suspension of crystalline LB71350. Capsules were chemically stable for up to 6 months at $40^{\circ}C$. However, there were temperature and composition dependent physical changes. Decrease in dissolution rates after storage at $40^{\circ}C$ was due to the polymorphic change. In conclusion, manufacturing process, bioavailability, and physico-chemical stability have been considered to propose a solid dispersion capsule formulation for the HIV protease inhibitor with poor physico-chemical properties. A new less soluble crystalline form identified during the physical stability test warrants further study.

• Journal of Information Technology Services
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• v.12 no.3
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• pp.151-163
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• 2013

It is no doubt that information technology is the key factor of national safety. Information technology is positively useful for national security such as crime prevention and detection, criminal investigation, disaster management, and national defense. However, it might be a threat to the security as we saw in the examples such as '3.4 DDoS attacks' and 'Nong-hyup Computer Network Failure.' Although the effect that information technology makes upon the national security is immense, the current legal system does not reflect these changes well. National security should be kept during 'prevention-response-recovery' process regardless it is in the online on offline. In addition, public administration for national security should be based on laws. However, the current legal system is lack of legislative basis on cyber and physical disaster, and the laws on the response to disaster might cause confusing. Therefore, this study examines the limitation of the current legal system on national security, and suggests directions for the development of the system based on the new establishment of the legal concept for 'national security'.

• YAKHAK HOEJI
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• v.44 no.6
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• pp.588-594
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• 2000

To investigate the effects of iota-carrageenan (CAR) and/or alum on the adjuvancity as well as the structural difference of oligosaccharide on the IgG2b in the adjuvant effect, C57BL/6 mice were immunized twice with fetuin as a model antigen. CAR alone showed no significant effect on induction of antibody except IgG1. In contrast, Alum-CAR (after mixing of antigen-Alum, CAR adjuvant was prepared) and CAR-Alum (after formulation of antigen-CAR, Alum adjuvant was prepared) enhanced production of antibody, especially, IgG2b. After separation of IgG2b, changes of glycosylation were investigated using enzymelinked lectin assay. High affinity of IgG2b to N-acetylneuraminic acid, galactose and mannose-specific lectin were induced by CAR-Alum adjuvant, however, the affinity of IgG2b induced by CAR-Alum to GlcNAc and GalNAc-specific lectin were much less than that induced by Alum-CAR.

• Advances in Traditional Medicine
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• v.7 no.1
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• pp.94-99
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• 2007

The present study is aimed at finding the effect of B-20 drops, a homoeopathic formulation, in streptozotocin (STZ) induced diabetic rats. B-20 drops comprises of the constituents derived from plants and other natural sources, and are generally prescribed by the homoeopathic physician, in cases of hyperglycemia and diabetes. The elevated levels of fasting blood glucose and pancreatic lipid peroxides observed in rats treated with STZ were significantly reduced by the treatment of B-20 drops. The reduced liver glycogen contents were also brought back to near normal level by B-20 drops treatment in STZ diabetic rats. STZ induced histopathological changes in pancreas and liver was also partially reversed by B-20 drops. The findings indicate that B-20 drops help in improving the glycogen stores in the liver and prevents STZ induced damage through free radicals by decreasing the pancreatic lipid peroxides levels.

• Structural Engineering and Mechanics
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• v.58 no.1
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• pp.143-161
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• 2016

Utilization of mineral and chemical admixtures in concrete technology has led to changes in the formulation and mix design in recent decades, which has, in turn, made the concrete stronger and more durable. Lightweight concrete is an excellent solution in terms of decreasing the dead load of the structure, while self-compacting concrete eases the pouring and removes the construction problems. Combining the advantages of lightweight concrete and self-compacting concrete is a new and interesting research topic. Considering its light weight of structure and ease of placement, self-compacting lightweight concrete may be the answer to the increasing construction requirements of slender and more heavily reinforced structural elements. Twenty one laboratory experimental investigations published on the mix proportion, density and mechanical properties of lightweight self-compacting concrete from the last 12 years are analyzed in this study. The collected information is used to investigate the mix proportions including the chemical and mineral admixtures, light weight and normal weight aggregates, fillers, cement and water. Analyzed results are presented in terms of statistical expressions. It is very helpful for future research to choose the proper components with different ratios and curing conditions to attain the desired concrete grade according to the planned application.

• Structural Engineering and Mechanics
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• v.61 no.5
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• pp.663-674
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• 2017

The determination of the fundamental period of vibration of a structure is essential to earthquake design. Current codes provide formulas for the approximate estimation of the fundamental period of earthquake-resistant building systems. These formulas are dependent only on the height of the structure or number of storeys without taking into account the presence of infill walls into the structure, despite the fact that infill walls increase the stiffness and mass of the structure leading to significant changes in the fundamental period. Furthermore, such a formulation is overly conservative and unable to account for structures with geometric irregularities. In this study, which comprises the companion paper of previous published research by the authors, the effect of the vertical geometric irregularities on the fundamental periods of masonry infilled structures has been investigated, through a large set of infilled frame structure cases. Based on these results, an attempt to quantify the reduction of the fundamental period due to the vertical geometric irregularities has been made through a proposal of properly reduction factor.