• 대한지역사회영양학회지
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• 제9권5호
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• pp.555-565
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• 2004

The objective of this study was conducted to investigate growth and development status of infants fed soy-based formulas over 3 months. The height and weight were measured and Z-scores were calculated by using standard of the same age groups. Their mothers were interviewed using questionnaires including general and environmental characteristics, total food intakes, soy based formula intakes and Ewha infant development screening test. Main results were as follows: 1) Nutrient intake levels of subjects were similar to or more than the level of Korean Recommended Dietary Allowances except for intakes of vitamin E (79.89% RDA), and the average status of nutrient intakes of infants were fairly good. 2) Z-scores of height for age (HAZ) and Z-scores of weight for age (WAZ), Kaup index, WLI and Ewha Infant Developmental Screening Test score of subjects were in the normal growth range. 3) There were no significant differences among soy based formula intake percentile groups in HAZ, WAZ, Kaup index, WLI and Ewha Infant Developmental Screening Test score. 4) Total energy intake was positively correlated with HAZ (p < 0.00, WAZ (p <0.00, and WLI (p < 0.05) in infants less than 12 month. Also, soy based formula energy intake was positively correlated with HAZ (p < 0.05) in infants less than 12 month. However, energy and soy based formula intake levels of infants over 12 month were not significant among variables. Considering results of this study, infants fed soy-based formulas over 3 months showed normal growth and development status. Further studies are needed to evaluate longterm growth and development in infants fed soy based formulas.

• Child Health Nursing Research
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• 제26권1호
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• pp.90-97
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• 2020

Purpose: The purpose of this study was to investigate the effects of a breastfeeding support program (BSP) on the prevalence of exclusive breastfeeding and growth in late-preterm infants. Methods: A quasi-experimental study was conducted. The participants were 40 late preterm infants (LPIs), of whom 20 were assigned to the experimental group and 20 to the control group. For the mothers in the experimental group, a BSP was provided prior to the LPIs' discharge and reinforced once a week for 4 weeks. Information on the feeding type was collected by observation and the LPIs' body weight was measured. Results: There were significant differences in feeding type by group and time. Exclusive breastfeeding was 5.18 times more common in the experimental group than in the control group (odds ratio=5.18, 95% confidence interval=1.11~16.70). However, weekly weight gain did not show a significant relationship with group and time (F=0.40, p=.712). Conclusion: The BSP was helpful for increasing the rate of exclusive breastfeeding in LPIs. Furthermore, the LPIs in the experimental group, which had a higher likelihood of being exclusively breastfed, showed an equivalent amount of weight gain as the LPIs in the control group, in which infants were more likely to be formula-fed.

• 대한한의학방제학회지
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• 제21권1호
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• pp.111-118
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• 2013

Objectives : Traditional medicine Oryeong-san (ORS) has been prescribed for a long time to treat light fever, thirst, dysuria, and accompanying edema. However, the acute toxicity and safety were not reported. In this study, we evaluated the potent acute toxicity and safety of ORS. Methods : ICR mice were used to evaluate acute toxicity and safety by oral administration of 0, 500, 1,000, 2,000mg/kg of ORS. Mortality, body weight, and clinical symptoms were observed, and organ weight and blood biochemical parameters were analyzed after necropsy. Results : We found no mortality and no toxic or abnormal clinical symptoms by administration of ORS. Comparing with control group, no significant alterations in organ weight and blood biochemical parameters were observed. Conclusions : ORS recognized as safe and non-toxic medicinal material, and median lethal dose considered to be over 2,000 mg/kg in both male and female ICR mice.

• 대한한의학회지
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• 제35권2호
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• pp.28-33
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• 2014

Background: Samul-tang (Si-Wu-Tang, SMT) is a traditional herbal formula, which has been widely used to treat various diseases such as menstrual irregularity, bleeding and leucorrhea. Although many studies have investigated the pharmacological properties of SMT, its toxicity information has not yet been fully elucidated. Methods: Five Sprague Dawley (SD) rats of each sex were given a single dose (5000 mg/kg) of SMT by gavage; control rats received the vehicle only. After the single administration, mortality, clinical signs, body weight changes and gross findings were monitored for 15 days in accordance with Good Laboratory Practice (GLP) principles. Results: In a single oral dose toxicity study, there was no adverse effect on mortality, clinical sign, body weight change or gross finding in any treatment group. Conclusions: The results indicate that SMT did not induce toxic effects at a dose level up to 5000 mg/kg in rats and its median lethal dose ($LD_{50}$) was considered to be over 5000 mg/kg/day body weight for both genders.

• Biomolecules & Therapeutics
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• 제15권4호
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• pp.245-251
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• 2007

The object of this study was to evaluate the single dose toxicity of Kong-Jin-Dan (KJD), a polyherbal formula in male and female mice. KJD was administered to female and male ICR mice as an oral dose of 2000, 1000 and 500 mg/kg (body wt.) according to the recommendation of KFDA Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy, organ weight and histopathology of 12 principle organs were examined. As results, we could not find any mortality, clinical signs, and changes in the body and organ weight except for increases of lymphoid organ weights in KJD-dosing groups. These increases of lymphoid organ weights considered that related to the immune modulate effect of KJD not toxicological signs. In addition, no KJD-treatment related abnormal gross findings and changes in histopathology of principle organs were detected except for some sporadic accidental findings. The results obtained in this study suggest that the KJD does not cause any toxicological signs. The $LD_{50}$ and approximate LD of KJD extracts in both female and male mice were considered as over 2000 mg/kg.

• 동의생리병리학회지
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• 제28권1호
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• pp.53-58
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• 2014

The object of this study was to evaluate the single dose toxicity of Choweseuncheng-tang (CWS), a polyherbal formula have been traditionally used as prevention or treatment agent for various diseases as Tae-eumin prescription on Korean medicinal theory, Sasang-euihak, in male and female mice. Aqueous extracts of CWS (yield = 11.00%) was administered to female and male mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 14 principle organs were also examined. As results, we could not find any CWS treatment related mortality and clinical signs, changes in the body and organ weights, gross findings and changes in histopathology of principle organs, except for some dose-independent accidental findings. The results obtained in this study suggest that the 50% lethal dose and approximate lethal dose of CWS aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines, and can be safety used in clinics.

• 대한한의학방제학회지
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• 제9권1호
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• pp.319-334
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• 2001

Objective: The present study has been undertaken to investigate the effects of Korean Carthami Semen and Estradiol-Carthami Semen co-treatment on osteoporosis in ovariectomized rats. Method: In this experiment, the rats were ovariectomized. Rats were administered 3 kinds of medicine, Korean Carthami Semen, Estradiol, and Estradiol-Carthami Semen, which were taken orally. The levels of bone mineral density, osteocalcin, estradiol, ALP, phosphorus, calcium in serum, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured. Results: These experimetal results, it appears that the only Carthami Semen have more less efficacy on osteoporosis but $E_2$-Carthami Semen co-treated group showed more effective on osteoporosis. Conclusions: Further west-east medicine combination study should be conducted to illustrate in depth the curing osteoporosis.

• 대한화장품학회지
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• 제24권3호
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• pp.89-95
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• 1998

The aim of this study is to elucidate the anti-microbial activity and anti-oxidative activity of water-soluble chitosan with a molecular weight of 5,000-200,000. Water-soluble chitosans have demonstrated a regular anti-microbial activity on the tested strians by the paper disk method. In the MIC (Minimum Inhibitory Concentration) test, CC-01 (MW=5,000) with the lower MW showed the higher MIC value than the higher MW chitosan. The MW of chitosan increase, the MIC decreases. MICs of 4 chitosans(CC-02∼CC-05) against S. aureusTCC 65389, E coli ATCC 8739, p. aeruginosa, ATCC 9027 and C. albicans ,ATCC 10231 were 7.0-39.O$\mu\textrm{m}$, whereas MICs of chitosans against A. niger were over 2.OmM. Formula containing chitosan showed higher anti-microbial activities than the formula made with the chemical preservatives(Methylparaben 0.2％ and Imidazolidinyl Urea 0.3％). Among 5 water-soluble chitosans, CC-03(MW=92,163) showed the most potent anti-oxidative activity (IC$\sub$50/ : 0.2mM). In conclusion, the water-soluble low molecular weight chitosan could be served as natural preservatives and antioxidant in cosmetics.

• Journal of Nutrition and Health
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• 제23권2호
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• pp.124-134
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• 1990

본 연구는 미숙아들의 영양공급 및 성장상태를 조사하기 위하여 출생시 체중이 2500g이하이며 在胎期間이 37주 미만인 신생아중 20일이상 입원한 미숙아를 대상으로 그들의 역학적 조사, 영양 섭취량과 공급 방식, 체위의 변화, 혈액학적 검사등을 비교 분석한 그 결과는 다음과 같다. 1) 출생체중별 在胎期間과 apgar score를 보면 1499g이하 미숙아군은 31주, 4/7(1min/5min)이며 1500~1999g, 2000~2500g 미숙아군은 각각 33주, 8/9(1min/5min)이었다. 2) 미숙아들의 체중별 1일 kg당 열량과 수분 섭취량을 평균적으로 보면 1499g 이하 미숙아군은 102.0Kcal, 150.2ml이며 1500~1999g 미숙아군은 119.3Kcal, 136.4ml이며 2000~2500g 미숙아군은 101.7Kcal, 141.5ml이었다. 3) 1999g이하 미숙아군의 영양 공급 빈도 중 dextrose와 dextrose/hyperal 공급시일 즉 관주입법으로 공급한 시일을 평균적으로 보면 1499g이하 미숙아군은 7.7일이여 1500~1999g 미숙아군은 3.8일이었다. dextrose/formula와 dextrose/hyperal/formula공급시일은 1499g이하 미숙아군은 평균 14.2일, 1500~1999g 미숙아군은 10.9일이었다. 4) 미숙아들의 초기 체중 감소율을 보면 1499g이하 미숙아군은 5.4%, 1500~1999g 미숙아군은 6.4%, 2000~2500g 미숙아군은 11.4%로 출생체중이 높은 미숙아군의 감소율이 높게 나타났다. 5) 혈액학적 검사시 1499g 이하 미숙아군의 10일째 Hb은 12.1g/dl, Hct은 36.7%, MCHC는 33.2%이며 1500~1999g 미숙아군의 수치는 15.4g/dl, 46.7%, 33.8%이며 2000~2500g 미숙아군은 14.3g/dl, 42.5%, 351.1%로 조사기간중 20일째까지 Hb과 Hct수치는 점차 감소하였다. 6) Amino acid 투여의 영향을 보면 amino acid투여군의 초기 체중 감소율이 9.0%로 amino acid투여 안한군(9.4%)보다 단백질과 열량을 적게 섭취하였음에도 초기 체중 감소율의 유의적 차이는 없었다.

• 한국전산구조공학회논문집
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• 제25권3호
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• pp.245-258
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• 2012

압출공법(incremental launching method)은 교대 배후에 거더 제작장소를 설치하고, 콘크리트를 이어쳐서 교량거더를 제작하고, 이것을 잭(jack)으로 밀어내는 가설방법이다. 이 공법에 의해 시공되는 교량의 상부단면은 시공 중에 지간의 중앙부와 지점부에 일시적이나마 모두 위치하게 된다. 따라서 단면들은 자중에 의해 발생되는 최대 정모멘트와 최대 부모멘트, 그리고 최대 전단력을 모두 경험하게 되는 구조적 특성을 가지고 있다. 한편 거더의 캔틸레버 작용을 감소시키기 위하여 거더의 선단에 압출추진코(launching nose)를 부착시킨다. 이때 상부단면에 발생하는 일시적인 응력의 크기는 압출추진코의 단면특성에 따라 달라진다. 이 연구에서는 압출추진코와 상부단면의 상호작용에 관한 해석식의 정확성을 유지하고, 활용도를 높이기 위해서 압출추진코를 유사등단면(강성;등단면, 중량;변단면)으로 가정하여 단순화된 해석식을 제안하였고, 압출추진코의 단면이 등단면으로 가정한 기존 해석식의 정확성을 향상시키기 위해서 다이아프램의 중량을 집중하중으로 치환시켜 변형된 등단면 해석식을 제안하였다. 그리고 제안된 2개의 해석식의 정확성과 활용성을 판단하기 위해 실제 ILM 교량 설계자료들을 통해 전산구조해석 프로그램과, 기존 해석식들과 비교 분석하였다.