• The Korean Journal of Urological Oncology
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• 제15권3호
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• pp.178-186
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• 2017

Purpose: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. Materials and Methods: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein isothiocyanate dextran (FD, MW 4 kDa) as a fluorescent probe were prepared by the cold method with different concentrations of the polymer (20, 25, and 30 w/w%). The gel-forming capacities were characterized in terms of gelation temperature (G-Temp), gelation time (G-Time), and gel duration (G-Dur). Homogenous dispersion of the probe throughout the hydrogel was observed by using fluorescence microscopy. The in vitro bladder simulation model was established to evaluate the retention and drug release properties. P407Gels in the solution state were administered to nude mice via urinary instillation, and the in vivo retention behavior of P407Gels was visualized by using an in vivo imaging system (IVIS). Results: P407Gels showed a thermo-reversible phase transition at $4^{\circ}C$ (refrigerated; sol) and $37^{\circ}C$ (body temperature; gel). The G-Temp, G-Time, and G-Dur of FD-free P407Gels were approximately $10^{\circ}C-20^{\circ}C$, 12-30 seconds, and 12-35 hours, respectively, and were not altered by the addition of FD. Fluorescence imaging showed that FD was spread homogenously in the gelled P407 solution. In a bladder simulation model, even after repeated periodic filling-emptying cycles, the hydrogel formulation displayed excellent retention with continuous release of the probe over 8 hours. The FD release from P407Gels and the erosion of the gel, both of which followed zero-order kinetics, had a linear relationship ($r^2=0.988$). IVIS demonstrated that the intravesical retention time of P407Gels was over 4 hours, which was longer than that of the FD solution (<1 hour), even though periodic urination occurred in the mice. Conclusions: FD release from P407Gels was erosion-controlled. P407Gels represent a promising system to enhance intravesical retention with extended drug delivery.

• Korean Journal of Construction Engineering and Management
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• v.15 no.1
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• pp.70-77
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• 2014

Collaborative processes among team members including communication, coordination, and information-handling processes either during pre-construction or project execution are required in order to accomplish the objectives of construction projects. However, current construction management practice does not explicitly take the effect of organizational aspects on project performance into account. This paper introduces a method to understand collaborative processes in an explicit and systematic fashion. An agent-based simulation of collaborative working processes within construction project teams was designed from game theory perspective and implemented. The simulation produced both individual behavior and network dynamics. Individuals represented as agents made efforts to improve performance by communication and coordinating with other members, and overall team network was emerged as a result of interactions among members. Interestingly, it was found that the tendency of forming cohesive subgroups increased when sustaining relations with between-group partners incurs higher cost. The primary contribution of this paper is that it presented an explicit approach to examining collaborative working processes in construction project teams and it extended existing computational organization and network studies by integrating individual behavior models and network models.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.10a
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• pp.245-249
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• 2009

According to the increase of intelligent vehicles many automotive electric components are installed. The wire harness which connects those also increases. The crimping process for compressing the copper wire bundle into the terminal is a key process to assure the good quality of wire harness. For the case of inadequate forming condition many shape failures such as less-filling, over-filling are happen in the crimping process. Even though the quality of crimping shape is satisfactory the quality check for electrical resistance of wire harness is sometime not satisfied the qualification due to large variation of electrical resistance of wire harness under climate test. This large variation is thought to be related with the malfunction automotive electric system and caused by the internal stress of wire, which occurred during the crimping process. In this paper we develop the 3D-FEM simulation scheme and design methodology of optimum terminal shape. Also the effect of terminal shape on the residual stress is discussed.

• Journal of Ocean Engineering and Technology
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• v.12 no.1
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• pp.10-22
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• 1998

In the present work the elastic-plastic FE formulations using dynamic explicit time integration schemes are used for numerical analysis of a large auto-body panel stamping processes. For analyses of more complex cases with larger and more refined meshes, the explicit method is more time effective than implicit method, and has no convergency problem and has the robust nature of contact and friction algorithms while implicit method is widely used because of excellent accuracy and reliability. The elastic-plastic scheme is more reliable and rigorous while the rigid-plastic scheme require small computation time. In finite element simulation of auto-body panel stamping processes, the roobustness and stability of computation are important requirements since the computation time and convergency become major points of consideration besides the solution accuracy due to the complexity of geometry conditions. The performnce of the dynamic explicit algorithms are investigated by comparing the simulation results of formaing of complicate shaped autobody parts, such as a fuel tank and a rear hinge, with the experimental results. It has been shown that the proposed dynamic explicit elastic-plastic finite element method enables an effective computation for complicated auto-body panel stamping processes.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.3
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• pp.64-73
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• 2005

This paper is concerned with the simulation-based parameter determination for the tool design in the stamping process of the complicated auto-body member. The CAE procedure of the stamping process is proposed so that troubles such as wrinkle, springback and excess metal be eliminated with changing parameters such as the blank size, the restraining force of the draw-bead and the embossing shape in the die face. The selected indicators of failure during forming are wrinkling. the amount of spring after unloading of the tool, the amount of excess metal developed .The proposed analysis scheme is applied to the tool and process parameter design for the front side member of a RV car. The simulation results show that the scheme can produce sound product from the viewpoint of thickness distribution, the contact condition between tools and the blank, the shape accuracy and so on.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1327-1332
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• 2003

In this paper, an ATC(Automated Transfer Crane) control system is required rapid transportation to get highest productivity with low cost. Therefore, the container paths should be built in terms of the least time and least sway when container is transferred from the initial coordinate to the finial coordinate. So we applied the best-first search method for forming the container path, and calculated the anti-collision path for avoiding collision in its movement to the finial coordinate. And we constructed the neural network two degree of freedom PID (TDOFPID) controller to control the precise navigation. For simulation, we constructed the container profiles so that we analyzed the state of formed path and the performance of TDOFPID controller to the formatted path. Then we compared the performance of ES-tuned PID controller with our proposed controller in terms of trolley position, anti-sway, path change, disturbance, and the load of containers. The computer simulation results show that the proposed controller has better the other on the various conditions.

• Korean Journal of Materials Research
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• v.19 no.2
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• pp.79-84
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• 2009

A series of experiments demonstrated that an addition of Ag into $(Cu_{0.5}Zr_{0.5})_{100-x}Ag_{x}$ amorphous alloys alters the plasticity of the alloys in a systematic manner. Energy dispersive x-ray spectroscopy (EDS) conducted on the $(Cu_{0.5}Zr_{0.5})_{100-x}Ag_{x}$ alloys exhibited the presence of compositional modulation, indicating that compositional separation had occurred. The presence of compositional modulation was also validated using a combined technique of molecular dynamics and Monte Carlo simulation. In this study, the effect of Ag on the compositional separation in $(Cu_{0.5}Zr_{0.5})_{100-x}Ag_{x}$ bulk amorphous alloys was investigated to understand the role played by the phase-separating element on the plasticity of the amorphous alloys.

• Journal of electromagnetic engineering and science
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• v.18 no.1
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• pp.20-28
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• 2018

The time synchronization of each sub-unit of a pulsed generator is important to generate an output high-power radio frequency (RF) signal. To obtain the time synchronization between an input RF signal fed by an external source and an electron beam produced by an electric pulse generator, the influence of different charging voltages on a delay and a rise time of the output pulse waveform in the electric pulse generator should be carefully considered. This paper aims to study the timing characteristics of the delay and the rise time as a function of different charging voltages with a peak value of less than -35 kV in the high-voltage pulse generator, including a trigger generator (TG) and a pulse-forming line (PFL). The simulation has been carried out to estimate characteristics in the time domain, in addition to their output high-voltage amplitude. Experimental results compared with those obtained by simulation indicate that the delay of the output pulses of the TG and PFL, which are made by controlling the external triggering signal with respect to different charging voltages, is getting longer as the charging voltage is increasing, and their rise times are inversely proportional to the amplitude of the charging voltage.

• Journal of the Korean Vacuum Society
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• v.5 no.2
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• pp.113-118
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• 1996

Aligning a cathode tip at the center of a gate hole is important in gated filed emission devices. We have fabricated a silicon field emitter using a following process so that a cathode and a gate hole are automatically aligned . After forming silicon tips on a silicon wafer, the wafer was covered with the $SiO_2$, gate metal, and photoresistive(PR) films. Because of the viscosity of the PR films, a spot where cathode tips were located protruded above the surface. By ashing the surface of the PR film, the gate metal above the tip apex was exposed when other area was still covered with the PR film. The exposed gate metal and subsequenlty the $SiO_2$ layer were selectively etched. The result produced a field emitter in which the gate film was in volcano shape and the cathode tip was located at the center of the gate hole. Computer simulation showed that the volcano shape and the cathode tip was located at the center of the gat hole. Computer simulation showed that the volcano shape emitter higher current and the electron beam which was focused better than the emitter for which the gate film was flat.

• Transactions of Materials Processing
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• v.15 no.4 s.85
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• pp.295-303
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• 2006

Optimization is carried out to determine process parameters which reduce the amount of springback and improve shape accuracy of a deep drawn product in sheet metal forming process. The study uses the amount of stress deviation along the thickness direction in the deep drawn product as an indicator of springback instead of springback simulation. The scheme incorporates with an explicit elasto-plastic finite element method for calculation of the final shape and the stress deviation The optimization method adopts the response surface method in order to seek for the optimum condition of process parameters such as the blank holding force and the draw-bead force. The present scheme is applied to design of the variable blank holding force in an U-draw bending process and the application is further extend ε d to the design of draw-bead force in a front side member formed with advanced high strength steel (AHSS) sheets of DP60. Results show that design of process parameter is well performed to decrease the stress deviation through the thickness and to reduce the amount of springback. The present analysis provides a guideline in a design stage for controlling the springback based on the finite element simulation of the complicated parts.