• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권1호
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• pp.1-6
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• 2009

DNA double-strand breaks (DSBs) occur commonly in the all living and in cycling cells. They constitute one of the most severe form of DNA damage, because they affect both strand of DNA. DSBs result in cell death or a genetic alterations including deletion, loss of heterozygosity, translocation, and chromosome loss. DSBs arise from endogenous sources like metabolic products and reactive oxygen, and also exogenous factors like ionizing radiation. Defective DNA DSBs can lead to toxicity and large scale sequence rearrangement that can cause cancer and promote premature aging. There are two major pathways for their repair: homologous recombination(HR) and non-homologous end-joining(NHEJ). The HR pathway is a known "error-free" repair mechanism, in which a homologous sister chromatid serves as a template. NHEJ, on the other hand, is a "error-prone" pathway, in which the two termini of the broken DNA molecule are used to form compatible ends that are directly ligated. This review aims to provide a fundamental understanding of how HR and NHEJ pathways operate, cause genome instability, and what kind of genes during the pathways are associated with head and neck cancer.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2009년도 추계학술발표대회 논문집
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• pp.55-58
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• 2009

Traditional pile-buildings in Southeast Asia has high utility. Their floors are lifted above the ground to stave off humidity in the house, increase the amenity and hygienic condition, fend off fierce animals or harmful animals like rat, and protect the house from being submerged in flood waters. Such traditional pile-buildings have Austronesian saddle-backed roof commonly, and are built through various techniques such as joining and mortising, without use of nails. The roof has a considerably large proportional appearance, and for this formal characteristics, the roof is symbolized as boat on occasions. The roof has dual structures or is lifted in some cases to facilitate the ventilation, and the wall is formed to maximize the ventilation. This housing types the hierarchy of foundation, housing space, and roof, which implies religious symbolism that human is above animal and God is above human. However, housing types in Southeast Asia have very different detailed form and culture, depending on the ethnic and religious characteristics. As explained above, this study examines the common aspects and diversity based on the form and culture of traditional housing of Southeast Asia and provides useful basic academic data.

• 한국자동차공학회논문집
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• 제6권6호
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• pp.40-52
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• 1998

A good grasp of the failure mechanisms of resistance spot weld, widely used in joining the auto-panels, in essential to the structural/crashworthy analyses and integrity assessment of the whole auto-body. In this study, We provide an estimative model describing the failure behavior of resistance spotf weld, and apply the model to the finite element analysis of crashworthiness. First, in "Part 1-Failure Criteria", to be used for the finite element analysis of spot-welded structural panels of an auto-body, (i) a methodology for quantifying the spot weld failure and the accompanying failure criteria are presented, and (ii) the coefficients of the failure equation are determined by a munimum number of appropriate experimental tests. To achieve these, we derive the functional form of the failure envelop by limit analysis, and correlate it with the form in PAM-$CRASH^{TM}$ code, and also investigate the effect of the failure coefficients on the failure envelop form. An estimative model obtained in this Part1, as spot weld failure criteria is applied to the Macroscopic finite element analysis of autobody structural panels using PAM-$CRASH^{TM}$ code in Part 2.

• Journal of Welding and Joining
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• 제15권4호
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• pp.109-115
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• 1997

Laser cladding is a technique for modification of metal surface. In this laser cladding experiment a metal powder feeding system was developed for more efficient laser cladding. This system can reduce processing time and be used simpler than the conventional method. The feeding of metal powder has given a rise to the process for sequential buildup of bulk rapidly solidified materials in the form of fine powder stream to the laser cladding process. The parameters of laser cladding have been investigated using this experimental equipment. Bronze on aluminum alloy and copper on aluminum alloy were experimented by using defocused beam, powder feeding system, and gas shielding. Good cladding was achieved in the range of beam travel speed of 2.25m/min. In the case of copper/aluminum and bronze/aluminum substrate, the absorption of laser beam was too high to produce low diluted clad. In the case of copper/1050 aluminum, the optimal laser cladding condition was of laser power of 2.8kW, powder feed rate of 0.31g/s and beam travel speed of 2.25m/min. In the case of bronze/aluminum the optimal condition is of laser power of 2.5kW, powder feed rate of 0.31g/s, and beam travel speed of 2.36m/min.

• Genomics & Informatics
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• 제12권3호
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• pp.80-86
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• 2014

Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as $180^{\circ}$ and the intertwining of two double helixes within each other's major groove to form an intercoil with a diameter of 2.2 nm. FBI DNA has been suggested to mediate intra-molecular homologous recombination of a deletion and inversion. Inter-molecular homologous recombination, known as site-specific insertion, on the other hand, is mediated by the direct perpendicular approach of the FBI DNA tip, as the attP site, onto the target DNA, as the attB site. Transposition of DNA transposons involves the pairing of terminal inverted repeats and 5-7-bp tandem target duplication. FBI DNA configuration effectively explains simple as well as replicative transposition, along with the involvement of an enhancer element. The majority of diverse retrotransposable elements that employ a target site duplication mechanism is also suggested to follow the FBI DNA-mediated perpendicular insertion of the paired intercoil ends by non-homologous end-joining, together with gap filling. A genome-wide perspective of transposable elements in light of FBI DNA is discussed.

• Journal of Welding and Joining
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• 제8권1호
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• pp.31-42
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• 1990

Arc must be stable during welding first of all other factors for obtaining sound weldment, especially in the automation of welding process. Arc stability is somewhat sophisticated phenomenon which is not clearly defined yet. In consumable electrode welding, the voltage and current variation due to metal transfer enables to assess arc stability. Recently, statistical analyses of the voltage and current waveform factors are performed to assess the degress of arc stability which is assessed and controlled by operator's own experience by now. But, considering the increasing need and the trend of automation of welding process, it is necessary to monitor arc stability in real-time. In this sutdy, the modified stability index composed of two voltage and current wvaeform factors (arc time and short circuit time) reduced from four factors (arc time, short circuit time, average arc current and average short circuit current) in Mita's index by the welding electrical circuit modeling is proposed and verified by experiments to be well estimating arc stability in the static sense. Also, the recursive calculation form estimating present arc stability in the dynamic sense is developed for real-time estimation. The results of applying the recursive index during welding show good estimation of arc stability in real-time. Therefore, the results of this study offers the mean for real-time control arc stability.

• Journal of Welding and Joining
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• 제24권5호
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• pp.22-28
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• 2006

A spacer grid assembly, which is an interconnected array of slotted grid straps and is welded at the intersections to form an egg crate structure, is one of the main structural components of the nuclear fuel assembly for Pressurized Water Reactors (PWRs). The weld quality of spacer grids in PWRs fuel is extremely important for the fuel assembly performance in the nuclear renter. The spacer grid welds are currently evaluated mainly by the metallographic examination although it reveals only cross-points which are welded by the laser beam. This experiment is also to compare the weldability of Zircaloy-4 spacer grids using by the GTA and LB. The effect of node geometries of spacer grids for the GTAW and LBW has been studied and optimum conditions of spacer grid welding have been found. Microstructures and micro-hardness of the GTA and LB welded zones have been also compared.

• Journal of Welding and Joining
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• 제33권5호
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• pp.14-19
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• 2015

This study has been performed to investigate the adhesive slag at GTAW weld zone after FCAW multi-pass welding. The cause of adhesive slag formation was examined using optical microscope, field emission scanning electron microscope(FE-SEM) and XRD analysis. The results obtained in this experiment are summarized as follows. Slag of GTAW weld zone surface during welding were formed by mixing the presence of slag in FCAW weld zone. While the slag cools, Cr-spinel phase were formed due to reactions in slag/metal interface. Also, a Cr moves form the weld metal to the slag to strong affinity between oxide atoms and Cr atoms. Hence, detachability of slag was exacerbated by decreasing the interfacial tensions between slag and weld metal.

• Journal of Welding and Joining
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• 제11권2호
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• pp.74-85
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• 1993

Effect of Si metal powders addition with the plasma transferred arc(PTA) overlaying process on characteristics of the alloyed layer in aluminum alloy(A5083) has been investigated. The overlaying conditions were 175-250A in plasma arc current, 500mm/min in travel speed, the 5-20g/min in powder feeding rate. Main results obtained are summarized as follows. 1)Sufficient size of molten pool on surface of base metal was required for forming an alloyed layer; in a fixed travel, the formation of alloyed layer with clear and beautiful surface depend upon the plasma arc current and powder feeding rate; the greater plasma arc current and the smaller powder feeding rate were, the better bead was formed. Optimum alloyed conditions by which an excellent alloyed bead obtained was 225A in plasma arc current. PTA process made it possible to form an alloyed layer with up to 67wt% Si. 2)Microstructure in the alloyed layer was in accord with prediction from the Al-Si phase diagram 3)The hardness of the alloyed layer increased in proportion to Si content. 4)As volume fraction of primary Si increased, the specific wearness of the alloyed layer was significantly improved. However, no further improvement was found when the volume fraction was greater than about 30%. 5)Utilizing the PTA process, a crack free alloyed layer with maximum hardness of about Hv 310 could be obtained.

• Journal of Welding and Joining
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• 제17권4호
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• pp.53-59
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• 1999

Amorphous alloys have also been called glassy alloys or non-crystalline alloys. They are made by the rapid solidification. The solidification occurs so rapid that the atoms are frozen in their liquid configuration. There are unique magnetic, mechanical, electrical and corrosive behaviors which result form their amorphous structure. In the study. amorphous coatings were manufactured with Ni-Cr-B-Si powders by flame spray. Measurement of hardness, were resistance, corrosion resistance and observation of microstructures and XRD, DSC were performed to investigate characteristics of amorphous coatings. The experimental results obtained as follow: 1) Amorphous powders could not be manufactured with the spraying in the spraying in the liquid nitrogen. But, amorphous coatings could be manufactured with the rotation cooling method by liquid nitrogen. In the fabrication of amorphous coatings, major factor was the rapid cooling by rotation of the substrate. 2) Hardness of coatings was obtained Hv 960 by formation of amorphous phase. But, wear resistance decreased. That was due to porosity in the coatings by the rapid cooling. 3) In the case of corrosion resistance, amorphous coatings were superior to air-cooled coatings. That was due to formation of amorphous phase. 4) After amorphous coatings were heat-treated at 520℃ for 1hr. hardness increased 80% and wear resistance increased 30% comparing with air cooled coatings. These were due to crystallization of amorphous phase and decrease of porosity by heat-treatment.