• Archives of Pharmacal Research
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• v.16 no.4
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• pp.271-275
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• 1993

In order to prepare a novel human insulin analogue suhbstituted with homoserine at B$^{30}$ / position, (B$^{30}$ /-homoserine) human insulin, a synthetic gene was designed by linking directly a gene for B chain with that for A chain. This gene was constructed by enzymatic joining of 10 different synthetic oligonucleotides, and then inserted at the polylinker region of pUC19 plasmid. To achieve a high level of gene expression, the gene fusion technique region of pUC19 plasmid. To achieve a high level of gene expression, the gene fusion technique was employed using amino terminal regions of lacZ gene up to Clal or hpal, and either of them has been located under tac promoter. The chemical induction of these fused genes by isopropyl-.betha.-D-thiogalactopyranoside (IPTG) gave a satisfactory level of expression in Escherichia coli harboring the ocnstructed plasmids. It was observed that the fused gene product as a single chain insulin precusor was produced more than 30% of total cell protein of E. coli as a form of inclusion body.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2005.11a
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• pp.461-470
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• 2005

A dynamic supply chain that is composed of many different companies with different rent roles and interests allows free joining and secession. Buyers place orders simultaneously and manufacturers should compete each other for the orders. The purpose of our paper is how to find the optimal formation of supply chain ill a global viewpoint while allowing each member company to pursue his local goal The dynamic nature of supply chain formation causes the variation of cost depending on how many orders a manufacturer would accept. We propose a multi-agent based negotiation protocol that efficiently leads to the formation of optimal supply chain without giving up maximization of the individual profit in multi-agent environment of the make-to-order industry. The goal of the negotiation is to form a supply chain to minimize the overall sum of manufacturers' manufacturing cost, and earliness cost and tardiness cost based on SET model. We compare the negotiation protocol with Branch & Bound method. Finally, the validity and performance of buyer's negotiation has been tested experimentally.

• International Journal of Korean Welding Society
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• v.1 no.1
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• pp.17-22
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• 2001

Because the quantitative relationships between welding parameters and welding result are not yet blown, optimal values of welding parameters for $CO_2$ robotic arc welding is a difficult task. Using the various artificial data processing methods may solve this difficulty. This research aims to develop an expert system for $CO_2$ robotic arc welding to recommend the optimal values of welding parameters. This system has three main functions. First is the recommendation of reasonable values of welding parameters. For such work, the relationships in between the welding parameters are investigated by the use of regression analysis and fuzzy system. The second is the estimation of bead shape by a neural network system. In this study the welding current voltage, speed, weaving width, and root gap are considered as the main parameters influencing a bead shape. The neural network system uses the 3-layer back-propagation model and a generalized delta rule as teaming algorithm. The last is the optimization of the parameters for the correction of undesirable weld bead. The causalities of undesirable weld bead are represented in the form of rules. The inference engine derives conclusions from these rules. The conclusions give the corrected values of the welding parameters. This expert system was developed as a PC-based system of which can be used for the automatic or semi-automatic $CO_2$ fillet welding with 1.2, 1.4, and 1.6mm diameter the solid wires or flux-cored wires.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.78-78
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• 2020

The Se San and Srepok river basins (2S) are the two major tributaries of the Mekong River, both of which originate in the territory of Viet Nam and flow to Cambodia to meet at Stung treng with the Sekong river (originating in Lao PDR) to form the 3S river basin before joining the Mekong mainstream. In the territory of Viet Nam, the 2S river basins are located in the Central Highlands including 5 provinces, arranged by geographical location from north to south namely Kon Tum, Gia Lai, Dak Lak, Dak Nong and Lam Dong. This is a region with a very important strategic position in terms of economy, politics and defense for the whole country with many potential advantages for economic development. However, the limited and vulnerable basin water resources are under the pressure of socio-economic development in line with increasing water demands for various sectors. In order to overcome the water management challenges, a long-term water resources planning has conducted to support the 2S River Basin Committee (RBC) in effective planning and operation as part of the WB Mekong-Integrated Water Resources Management (IWRM) Project. This paper introduces the outline and progress of the river basin planning using analytical DSS toolkits to analyze, evaluate and formulate the planning options.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.677-686
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• 2016

A thermal power plant is the first CFBC (Circulating Fluidized Bed Combustion) power plant consisting of 2 boilers-1 turbine. The optimal height of a stack needs to be approximately 156 meters in the case of this thermal power plant; however, the thermal power plant sites satisfy a function and reduce the construction cost by using mountains in the sites after cutting the ground and locating an integrated office and chimney at an altitude of 70 meters thereby lowering the height of the stack to 86 meters. In addition, the integrated office, which has a combined stack style with a unique design, is constructed by connecting with 2 stacks and disposing the office and an observatory in the space between them. Therefore, this study examined the design concept that fulfils the structural, functional, and aesthetic factors, harmoniously by joining the integrated office and the stack, which are disparate, and investigated special construction methods (Slip Form, Steel Inner Flue & Lift-up) through which heterogeneous architectures are structurally, functionally, and aesthetically constructed.

• Journal of Welding and Joining
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• v.34 no.5
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• pp.33-40
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• 2016

The microstructures and the creep rupture properties of dissimilar welds between the Ni-based superalloy Inconel 740H and the non-stabilized austenitic stainless steel TP316H have been characterized. The welds were produced by shielded metal arc (SMA) welding process with the AWS A5.11 Class ENiCrFe-3 filler metal, commonly known as Inconel 182 superalloy. Postweld heat treatment at $760^{\circ}C$ for 4 hours was conducted to form ${\gamma}^{\prime}$ strengthener in Inconel 740H. The austenitic weld metal produced by Inconel 182 had a dendritic microstructure, and grew epitaxially from the both sides of Inconel 740H and TP316H base metals. Since both Inconel 740H and TP316H did not undergo any solid-state transformation during welding process, there were no heat-affected-zone (HAZ) sub-regions and the coarsoned grains near the weld interface were limited to a narrow region. The hardness of Inconel 182 weld metal was ~220 Hv. The gradual hardness decrease was detected at HAZ of TP316H, and the TP316H base metal displayed the lowest hardness value (~180 Hv) whilst the Inconel 740H showed the highest hardness value (~400 Hv). Fracture after creep occurred at the center of weld metal, regardless of creep condition. It was found that during creep the cracks initiated and propagated along interdendritic regions and grain boundaries at which Laves particles enriched in Nb, Si and Cr were present. The appropriate design of weld metal was discussed to suppress the creep-induced cracking of the present dissimilar weld.

• The Journal of Korean Academy of Prosthodontics
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• v.38 no.2
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• pp.200-213
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• 2000

Lasers have given dentistry a new rapid, economic, and accurate technique for metal joining. Although laser welding has been recommended as an accurate technique, there are some limitations with this technique. For example, the two joining surfaces must have a tight-fitting contact, which may be difficult to achieve in some situations. The tensile samples used for this study were made from a custom-made pure titanium and type III gold alloy plates. 27 of 33 specimens were sectioned perpendicular to their long axis with a carborundum disk and water coolant. Six specimens remained and served as the control group. A group of 6 specimens was posed as butt joints in custom parallel positioning device with a feeler gauge at each of three gaps : 0.00, 0.25. and 0.50mm. All specimens were then machined to produce a uniform cross-sectional dimension, none of the specimens was subjected to any subsequent form of heat treatment. Scanning electron microscopy was performed on representative tested specimens at fractured surfaces in both the parent metal and the weld. Vickers hardness was measured at the center of the welds with a micropenetrometer using a force of 300gm for 15 seconds. Measurement was made at approximately $200{\mu}m\;and\;500{\mu}m$ deep from each surface. One-way analysis of variance (ANOVA) and Scheffe's test was calculated to detect differences between groups. The purpose of this study is to compare the strength and properties of the joint achieved at various butt Joint gaps by the laser welding of type III gold alloy and pure titanium tensile specimens in an argon atmosphere. The results of this study were as follows : 1. When indexing and welding pure titanium, there was no decrease in ultimate tensile strength as compared with the unsectioned alloys for indexing gaps of 0.00 to 0.50mm, although with increasing gap size may come increased distortion (p>0.05). 2. When indexing and welding type III gold alloy, there were significant differences in ultimate tensile strength among groups with weld gaps of 0.00mm, 0.25 and 0.50mm, and the control group. Group with butt contact without weld gap demonstrated a significant higher ultimate tensile strength than groups with weld gaps of 0.25 and 0.50mm (p<0.05). 3. When indexing and welding the different metal combination of type III gold alloy and pure titanium, there were significant differences in ultimate tensile strength between groups with weld gaps of 0.00, 0.25, and 0.50mm. However, the mechanical properties of the welded joint would become too brittle to be acceptable clinically (p<0.05). 4. The presence of large pores in the laser welded joint appears to be the most important factor in controlling the tensile strength of the weld in both pure titanium and type III gold alloy.

• Journal of Korea Spatial Information System Society
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• v.10 no.4
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• pp.59-66
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• 2008

GeoSensor network means sensor network infra and related software of specific form monitoring a variety of circumstances over geospatial. And these GeoSensor network is implemented by mixing data stream with spatial attribute, spatial relation. But, until a recent date sensor network system has been concentrated on a store and search method of sensor data stream except for a spatial information. In this paper, we propose a definition of spatial data stream and its join strategy model at GeoSensor network, which combine data stream with spatial data. Spatial data stream s defining in this paper are dynamic spatial data stream of a moving object type and static spatial data stream of a fixed type. Dynamic spatial data stream is data stream transmitted by moving sensor as GPS, while static spatial data stream is generated by joining a data stream of general sensor and a relation with location values of these sensors. This paper propose joins of dynamic spatial data stream and static spatial data stream, and cost models estimating join cost. Finally, we show verification of proposed cost models and performance by join strategy.

• Journal of architectural history
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• v.14 no.3 s.43
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• pp.23-37
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• 2005

The purpose of this study is to clarify the characteristics of the ancient architectures of the Yuan Dynasty(元代). The result is expected to efficient for a basic data to research history of the Koryo(高麗) architectures. This study was focused on the architecture of the Yuan dynasty in Hancheng city, because the buildings of the Yuan Dynasty were remained in Hancheng city(韓城) of Shanxi province(陝西) in the largest numbers through all China territory. And the study was especially analyzed in the angle of the system of wooden structures among various architectural points. It was looked into, in large, views of form of whole structure and, in detail, joining method of detail parts. As a result of the study, the characteristics of architectures of the Yuan Dynasty in Hancheng city were summarized as follow a reduction of the unit size, a shifting of columns, a removal of columns and a simplicity of ornaments. These are different with architecture of other empire periods. Also, these are the characteristics of the Korean tradition at architectures. This study of the Yuan's architectures of Hancheng is expected to be the basis of the advanced study about the relationship between Koryo(高麗) architectures and Yuan(元) architectures.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.2
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• pp.89-94
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• 2018

Due to industrial advancement and environmental concerns, there is a demand for light-weight material parts with high-performance characteristics. In order to meet this demand, various studies have been conducted on developing high-performance castings to achieve composite features by coating only specific parts that require high performance, with dissimilar joining, rather than coating the entire material part. This study analyzed the possibility of forming a local composite layer on an aluminum alloy through evaporation pattern casting, and the effects of parameters on the aluminum alloy.