• Korean Journal of Clinical Laboratory Science
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• v.46 no.2
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• pp.59-63
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• 2014

The death toll of Colorectal Carcinoma in Korea was 1,826 and 7,721 in the years 1992 and 2011, respectively. This rate of increase was shown to be more than 4.23 times higher than that of any other form of cancer. Therefore, Colorectal Carcinoma requires various diagnostic methods, and Microsatellite Instability (MSI) was applied as a new diagnostic tool. From this study with several microsatellite markers, only marker #13 was detected and observed D13S160 13% (4/30), D13S292 13% (4/30), D13S153 10% (3/30) in order. From the results of amplication with microsatellite marker, D13S292 37% (11/30), D13S153 33% (10/30), D13S160 33% (10/30) in order were shown. The appearance of a genetic mutation, which depends on the loci of Colorectal Carcinoma, was shown amplication from rectal cancer (3.77) which was higher than that of right Colorectal Carcinoma (2.08) (p<0.018). The genetic mutation with lymph node (4.13) appeared higher than normal (1.93) (p<0.001). There were no great differences in the genetic mutation dependent on disease, histological classification and increased group of serum CEA. Accordingly, it is suggested that the correct primers, which can evaluate MSI well from colorectal carcinoma, should be chosen and that MSI be considered a good prognosis and quality control tool.

• Journal of the Korea Society of Computer and Information
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• v.22 no.4
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• pp.41-49
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• 2017

Word sense disambiguation(WSD) that determines the exact meaning of homonym which can be used in different meanings even in one form is very important to understand the semantical meaning of text document. Many recent researches on WSD have widely used NNLM(Neural Network Language Model) in which neural network is used to represent a document into vectors and to analyze its semantics. Among the previous WSD researches using NNLM, RNN(Recurrent Neural Network) model has better performance than other models because RNN model can reflect the occurrence order of words in addition to the word appearance information in a document. However, since RNN model uses only the forward order of word occurrences in a document, it is not able to reflect natural language's characteristics that later words can affect the meanings of the preceding words. In this paper, we propose a WSD scheme using Bidirectional RNN that can reflect not only the forward order but also the backward order of word occurrences in a document. From the experiments, the accuracy of the proposed model is higher than that of previous method using RNN. Hence, it is confirmed that bidirectional order information of word occurrences is useful for WSD in Korean language.

• Journal of Korea Multimedia Society
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• v.6 no.1
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• pp.97-104
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• 2003

The appearance of various portal web sites that have individual customers, customizing information operate importantly upon a content. But most current portal sites that has a goal for international electronic commerce use information for customer to a simply individual profile and don't create more and new information that customizing. In this paper, we propose a system that generates a new customizing information with classification and analysis in detail and provides automatically to individual customers. The goal of our research is the development of personalizing auto generation agent that composed form of e-mail from preference of each individual user using open rate and mouse event Information for e-mail.

• Journal of Microbiology and Biotechnology
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• v.25 no.2
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• pp.302-306
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• 2015

VvpM, one of the extracellular metalloproteases produced by Vibrio vulnificus, induces apoptotic cell death via a pathway consisting of ERK activation, cytochrome c release, and activation of caspases-9 and -3. VvpM-treated cells also showed necrotic cell death as stained by propidium iodide (PI). The percentage of PI-stained cells was decreased by pretreatment with Necrostatin-1, indicating that VvpM-mediated cell death occurs through necroptosis. The appearance of autophagic vesicles and lipidated form of light-chain-3B in rVvpM-treated cells suggests an involvement of autophagy in this process. Therefore, the multifarious action of VvpM might be one of the factors responsible for V. vulnificus pathogenesis.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.89-98
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• 2007

1. Objectives This study aims to evaluate newly developing Sasang Constitution Diagnosis Questionnaire for accuracy and efficiency. 2. Methods Three hundred and twenty eight patients from 4 multi centers are involved in this study. Excluding 16 constitution-unidentified patients and 2 Taeyang-in patients, 310 patients' questionnaires are analyzed statistically by their constitutions. 3. Results Sixty one questions are statistically significant in whole 229 questions of Sasang Constitution Diagnosis Questionnaire. We have selected 30 questions from 61 questions by comparing total data from 4 multi centers with those of each center. Thirty questions are made up of 10 body shape questions, 10 appearance questions, 5 character questions and 5 symptom questions. 3. Conclusions There might be needs for revision of character and symptom questions. From results, we suggest to diagnose Sasang Constitution for screening by short-form questionnaire consisted of questions on body shapes and appearances.

• Journal of the Korean Society of Food Culture
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• v.26 no.3
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• pp.283-294
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• 2011

The purpose of this study was to determine the optimal mixing conditions for three different amounts of mulberry juice, sugar, and agar powder for Yanggaeng prepared with mulberry juice. The experiment was designed according to the central composite design for estimating the response surface, which demonstrated 16 experimental points including 2 replicates for mulberry juice, sugar and agar powder each?? The mechanical and sensory properties of test materials were measured, and these values were applied to the mathematical models. A canonical form and perturbation plot showed the influence of each ingredient on the final product mixture. Measurement results of the mechanical properties showed a significant increase or decrease?? in pH, sugar content, water content, viscosity, l-value, a-value, b-value, hardness, springiness, chewiness, gumminess, cohesiveness. Also the sensory measurements showed a significant improvement?? in appearance, flavor, color, sweetness, texture, overall quality. As a result, the optimum formulation by numerical and graphical methods was calculated as mulberry juice 41.99 g, sugar 90.00 g, agar powder 3.18 g.

• Journal of Fashion Business
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• v.7 no.5
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• pp.54-65
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• 2003

To accomplish the above goal of this study, I have taken the statistics about wearing behavior and design preference for Saenghwal Hanbok. This is surveyed by 354 women having jobs 20-50years old-in Daegu. The result of the study is summarized as follows. People prefer to put on Saenghwal Hanbok same as the Korea Traditional Dress in the traditional holidays and the active style that they can dress as casual clothes having the Korea Traditional Dress's characteristics as well. Form a viewpoint of appearance, people prefer Jugori have a bit spare width, the length comes near to the waist line, the type of Korean Traditional Dress's sleeve, and the round type that is linked body and sleeve in waist section and length is between knee and the calf of leg.

• Journal of Veterinary Clinics
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• v.39 no.6
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• pp.384-389
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• 2022

A 12-year-old Shetland sheepdog with dyschezia was presented to the clinic. Dyschezia was considered to have been caused by rectal stricture due to a perianal mass containing the distal colon, rectum, and anus. Considering the histological findings and gross appearance of the perianal mass, an aggressive form of adenocarcinoma was diagnosed and a poor prognosis was expected. An endon colostomy was successfully performed to improve quality of life, which had been decreased by the dyschezia. Postoperative fecal evacuation was well-managed by the owner using a disposable colostomy bag in addition to a previously reported flange and drainable pouch. The dog survived for three months and had a satisfactory quality of life. Surgery and postoperative management in such cases will be helpful in the treatment of defecation disorders in animals.

• Journal of the Speleological Society of Korea
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• no.66
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• pp.45-57
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• 2005

This Paper is a study on the duality of speleothem that appeared in 'Hyeob Jae Cave' which is designated as the natural monumen. No.236. It is located at Hyeob Jae Ri, Hanrim Eub, Bug Je-ju Gun, Je-judo. The findings are as follows. 1. The distribution range of the shelly sand which has maximum thickness of $10m{\pm}$ and average of $3m{\pm}$ was $3.2m^2$. 2. The desert hollow acted to promote the speleothem deposits in the lava tunnel with lava mound formed by lavapilz and artificial breaksand wall. 3. The main component of the pseudo limestone cavern was carbonate Calcium from shelly sand. And the deposition of speleothem in the Cave was accelerated after the volcanic erupsion of Biyang island in 1002. A.D. 4. The secondary depositions of Calcite recognized as speleothem up to now it can be used for the pseudo karst in general. 5. It seems that the variety of the cave deposits is decided depending upon the geology, land form, climate, vegetations and the structural environmental factors. 6. It seems that the wondering development of accretionary deposits caused by encrusting has a close relation with intermittent seepage of ground water. 7. Finally, we can acknowledge the coexistent duality of speleothem by shelly sand along with the joint and the lava stalactites formed at the same time with the lava tunnel on the ceiling where there was no seepage.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.