• 한국의사학회지
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• 제26권1호
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• pp.27-39
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• 2013

The Theory of Meridian can be classified into early form of pre- and present form of after-. The representative early form of meridian is Eleven Meridians in Mawangdui scrolls(馬王堆帛書) which use Six Qi Diagnosis(六氣辨證). because it did not adopt Visceral Pattern Identification(臟腑辨證). The present form of meridian is Twelve Meridians of . It has developed to investigate relations between Visceral and disease with Five Phase Theory. Analyzing the name of the Six Meridians in the Shanghanlun(傷寒論)On Cold Damage, there are no hands, feet and visceral signs. and it is almost identical to Eleven Meridians in Mawangdui scrolls. According to , Eleven Meridians use only Six Foot Meridians(足六經) to classify diseases. This fact was applied identically to the Six Meridians in the Shanghanlun. Therefore many doctors, especially Hanzhihe(韓祗和) and Zhangzhicong(張志聰) mentioned that "I have never seen a book on Shanghanlun discuss about Hand Meridians(手經)."

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2018년도 춘계학술발표대회
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• pp.267-270
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• 2018

구제역으로 인하여 국내 축산업계 및 관련 산업분야는 매년 막대한 피해를 입고 있다. 구제역과 관련한 다양한 학술적 연구들이 현재 진행되고는 있으나, 구제역의 발병에 따른 사회적 파급효과에 관한 공학적 분석 연구는 매우 제한적이다. 본 연구에서는 구제역에 관한 일반 시민들의 감성적 반응을 텍스트 마이닝 방법론을 사용하여 분석하는 체계적인 방법론을 제안한다. 제안하는 시스템은 먼저, 트위터에 게시된 트윗 중 구제역과 관련된 데이터를 수집한 후, 감성사전을 기반으로 극성탐지 과정을 거친다. 둘째, 토픽 모델링의 대표적인 기법 중 하나인 LDA를 활용하여 트윗으로 부터 키워드들을 추출하고, 추출된 키워드들로부터 극성별 동시출현 키워드 네트워크를 구성한다. 셋째, 키워드 네트워크을 통해 각 구간별 구제역의 사회적 파급효과를 분석한다. 사례 분석으로써, 2010년 7월부터 2011년 12월까지 국내에서 발생한 구제역에 관한 일반 시민들의 감성적 변화를 분석하였다.

• 한국멀티미디어학회논문지
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• 제22권2호
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• pp.136-145
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• 2019

The crowded environment of a domestic pig farm is highly vulnerable to the spread of infectious diseases such as foot-and-mouth disease, and studies have been conducted to automatically analyze behavior of pigs in a crowded pig farm through a video surveillance system using a camera. Although it is required to correctly separate occluding pigs for tracking each individual pigs, extracting the boundaries of the occluding pigs fast and accurately is a challenging issue due to the complicated occlusion patterns such as X shape and T shape. In this study, we propose a fast and accurate method to separate occluding pigs not only by exploiting the characteristics (i.e., one of the fast deep learning-based object detectors) of You Only Look Once, YOLO, but also by overcoming the limitation (i.e., the bounding box-based object detector) of YOLO with the test-time data augmentation of rotation. Experimental results with two-pigs occlusion patterns show that the proposed method can provide better accuracy and processing speed than one of the state-of-the-art widely used deep learning-based segmentation techniques such as Mask R-CNN (i.e., the performance improvement over Mask R-CNN was about 11 times, in terms of the accuracy/processing speed performance metrics).

• Journal of Genetic Medicine
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• 제17권2호
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• pp.89-91
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• 2020

Charcot-Marie-Tooth (CMT) disease can be divided mainly into demyelination and axonopathy based on the results of the electrophysiological study. Mitofusin 2, encoded by MFN2 gene, has a crucial role in the fusion of mitochondria, which is known to associate with CMT type 2A as one of the axonal forms. We describe a 44-year-old man with progressive weakness on bilateral legs after noticing foot drop in his early teen. When we examined him at 45 years of age, he presented atrophy on entire legs and with distal muscle weakness on limbs. The nerve conduction study revealed severely decreased amplitude on motor nerve ranging from 0.2 to 4.5 mV, while conduction velocity remained more than 30.4 m/s. The whole-exome sequencing revealed a novel variant c.2228G>T in MFN2 by efficient genetic analysis tool, MutationDistiller. This report will not only expand the mutation spectrum of CMT2A but also introduce a time-saving genetic analysis tool.

• 대한의생명과학회지
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• 제26권4호
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• pp.302-309
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• 2020

Human Coxsackievirus B5 (HuCoxV-B5) infection has been associated with various diseases such as myocarditis, aseptic meningitis, hand-foot-and mouth-disease, and insulin-dependent diabetes. HuCoxV-B5 is a virus transmitted through the fecal-oral route and is detected in clinics, aquatic environments, food, shellfish, etc. and is one of the more important viruses in public health because of its incidence rate reported worldwide. In this study, a combination of SYBR Green-based real-time PCR primers for molecular diagnosis including monitoring of HuCoxV-B5 was selected and the optimal reaction conditions were established. Compared with the previously reported TaqMan probe-based real-time PCR method, assessments including a sample applicability test were performed. Results showed that the real-time PCR method developed in this study was suitable for a molecular diagnostic technique for detecting HuCoxV-B5. This study is expected to contribute to efforts in responding to safety accidents in public health because the proposed method facilitates rapid diagnosis of clinical patients. It can also be used as a specific monitoring tool of HuCoxV-B5 in non-clinical areas such as aquatic environments among others.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.80-85
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• 2022

The instep flap and medialis pedis flap are both originate based on the medial plantar artery. The medialis pedis flap is based from the deep branch and the instep flap is based from the superficial branch. To increase the axial rotation, it is acceptable to ligate the lateral plantar artery. However, this can partially affect the blood supply of the plantar metatarsal arch. We restored the blood flow with a vein graft between the posterior tibial artery and the ligated stump. From 2012 to 2020, 12 cases of heel reconstruction, including seven instep flaps and five medialis pedis flaps, were performed with ligation of the lateral plantar artery. The stump of the lateral plantar artery was restored with a vein graft and between the posterior tibial artery and the ligated stump. Patients were followed for 18 months. Long-term results showed the vascular restoration of the lateral plantar artery remained patent demonstrated by doppler ultrasonography. Restoring blood flow to the lateral plantar artery maintains good blood supply to the toes. If the patient in the future develops a chronic degenerative disease, with microvascular complications, bypass surgery can still be performed because of the patency of both branches.

• Journal of Plant Biotechnology
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• 제48권4호
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• pp.228-235
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• 2021

The amino acids found in plants play important roles in protein biosynthesis, signaling processes, and stress responses, and as components in other biosynthesis pathways. Amino acid degradation helps maintain plant cells' energy states under certain carbon starvation conditions. Branched-chain amino acid transferases (BCATs) play an essential role in the metabolism of branched-chain amino acids (BCAAs) such as isoleucine, leucine and valine. In this paper, we performed genome-wide RNA-seq analysis using CsBCAT7-overexpressing Arabidopsis plants. We observed significant changes in genes related to flowering time and genes that are germination-responsive in transgenic plants. RNA-seq and RT-qPCR analyses revealed that the expression levels of some BCAA catabolic genes were upregulated in these same transgenic plants, and that this correlated with a delay in their senescence phenotype when the plants were placed in extended darkness conditions. These results suggest a connection between BCAT and the genes implicated in BCAA catabolism.

• Clinical Pain
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• 제19권2호
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• pp.133-137
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• 2020

Bertolotti's syndrome (BS) is a disease that should be differentiated from low back pain (LBP) in young patients. BS shows an anatomical abnormality in which elongated transverse processes of the last lumbar vertebra articulate or fuse with varying degrees to the sacrum or ilium according to radiologic findings, which is associated with the clinical feature of LBP or radiating pain. In this case report, we describe various clinical features such as a waddling gait with severe foot and triceps surae muscle pain, in addition to the typical symptom of BS such as LBP. We report the various clinical symptoms and treatment progress in this case and review the literature.

• Korean Journal of Acupuncture
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• 제41권3호
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• pp.110-117
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• 2024

Objectives : The objective of this study is to report a case of a patient with a fracture of the 1st metatarsal bone, whose symptoms improved after receiving Complex Korean Medical treatment mainly focused on acupuncture. Methods : During admission treatment, the patient received 2 sessions of acupuncture treatment, 1 session of pharmacopuncture treatment, and electromoxibustion daily. To assess the patient's condition regarding the 1st metatarsal bone fracture, X-rays were performed on the affected area of the patient on a weekly basis, along with a daily follow up on the Numerical Rating Scale (NRS), degree of swelling (measured in cm via measuring tape), and the temperature of the affected area. The Foot Function Index (FFI) and Health Assessment Questionnaire (HAQ) were also used to add credibility in assessing the patient's current condition. Results : After 4 weeks of hospital admission treatment, the NRS of the pain in the affected area decreased from 4 to 1, with the night pain NRS of the affected area also being reduced from 8 to 0. There was a general improvement in the swelling and temperature of the affected area, as well as the FFI and HAQ of the patient. Conclusions : The study shows that complex Korean medical treatment can be effective in treating patients with bone fractures even without interventions involving traditional Korean herbal medicine.

• Journal of Veterinary Science
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• 제22권6호
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• pp.87.1-87.12
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• 2021

Background: African swine fever virus (ASFV), classical swine fever virus (CSFV), and porcine reproductive and respiratory syndrome virus (PRRSV) are still prevalent in many regions of China. Co-infections make it difficult to distinguish their clinical symptoms and pathological changes. Therefore, a rapid and specific method is needed for the differential detection of these pathogens. Objectives: The aim of this study was to develop a multiplex real-time quantitative reverse transcription polymerase chain reaction (multiplex qRT-PCR) for the simultaneous differential detection of ASFV, CSFV, and PRRSV. Methods: Three pairs of primers and TaqMan probes targeting the ASFV p72 gene, CSFV 5' untranslated region, and PRRSV ORF7 gene were designed. After optimizing the reaction conditions, including the annealing temperature, primer concentration, and probe concentration, multiplex qRT-PCR for simultaneous and differential detection of ASFV, CSFV, and PRRSV was developed. Subsequently, 1,143 clinical samples were detected to verify the practicality of the assay. Results: The multiplex qRT-PCR assay could specifically and simultaneously detect the ASFV, CSFV, and PRRSV with a detection limit of 1.78 × 10⁰ copies for the ASFV, CSFV, and PRRSV, but could not amplify the other major porcine viruses, such as pseudorabies virus, porcine circovirus type 1 (PCV1), PCV2, PCV3, foot-and-mouth disease virus, porcine parvovirus, atypical porcine pestivirus, and Senecavirus A. The assay had good repeatability with coefficients of variation of intra- and inter-assay of less than 1.2%. Finally, the assay was used to detect 1,143 clinical samples to evaluate its practicality in the field. The positive rates of ASFV, CSFV, and PRRSV were 25.63%, 9.36%, and 17.50%, respectively. The co-infection rates of ASFV+CSFV, ASFV+PRRSV, CSFV+PRRSV, and ASFV+CSFV+PRRSV were 2.45%, 2.36%, 1.57%, and 0.17%, respectively. Conclusions: The multiplex qRT-PCR developed in this study could provide a rapid, sensitive, specific diagnostic tool for the simultaneous and differential detection of ASFV, CSFV, and PRRSV.