• 한국동물위생학회지
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• 제42권1호
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• pp.25-30
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• 2019

The objective of this study was to assess the possibility of detecting Foot-and-Mouth Disease Virus (FMDV) from the herd-based oral fluids specimens collected by the cotton ropes from pig farms that were found as FMDV nonstructural protein (NSP) antibodies positive. The cotton ropes were applied to detect FMDV in the selected pig farms which NSP antibodies were continuously detected in 2016, including the one pig farm which FMDV antigen were detected at the specimens from the pigsty environment. As the result, FMDV antigen were not detected in the oral fluid specimens collected by the cotton ropes. Theoretically, to detect FMDV antigen from the pigs with NSP antibodies has very low possibility because FMDV antigen disappeared at the time when NSP antibodies were produced by FMDV. Therefore, in order to detect FMDV antigen from the oral fluids using the cotton rope, it would be more effective to be applied to target the FMDV infected pigs rather than the NSP antibodies positive pigs. The collected oral fluids using cotton rope could be useful test specimens to monitor high-density pig populations for FMDV infection. Then, oral fluids sampling using cotton rope will be used for the efficient FMDV surveillance to detect FMDV antigen.

• 대한한방소아과학회지
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• 제18권2호
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• pp.225-232
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• 2004

Objectives : Hand-Foot-Mouth disease is a highly contagious disease most often seen in children. It is caused most commonly by the coxsackievirus A16 and clinically characterized by vesicles appearing on the hands, feet and in the mouth. The purpose of this study is a approach to the oriental medical treatment of Hand-Foot-Mouth disease. Method : We studied the clinical literatures of traditional chinese medicine about Hand-Foot-Mouth disease after the year 2000. Result : Hand-Foot-Mouth disease are similar to epidemic febrile disease(溫病) dampwarm syndrome(濕溫), and epidemic disease(時疫) in Oriental Medicine. Conclusion : In oriental medical treatment is classified into the treatment of internal use, external use, and combination treatment of chinese and western medicine.

• Pediatric Infection and Vaccine
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• 제4권2호
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• pp.303-307
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• 1997

Hand-Foot-Mouth disease, which has a various enanthem-exanthem complex at the tongue, buccal mucosa, hands and feets and buttock area with febrile illness, is usually caused by Coxscakie virus type A(16). Generally, this disease shows self limited course and good prognosis without neurologic manifestations. However, enterovirus 71, which was newly discovered and reported in 1974, can cause the striking features of Hand-Foot-Mouth disease outbreaks and has neuropathogenic potentials of polio-like paralytic illness including aseptic meningitis, meningoencephalitis and respiratory disease. We experienced a case of Hand-Foot-Mouth disease with polyradiculitis manifestations, and a case of Hand-Foot-Mouth disease with meningoencephalitis. Therfore, we report these cases with brief review of related literatures.

• 한국동물위생학회지
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• 제42권1호
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• pp.31-37
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• 2019

There have been a total tenth FMD outbreaks in Korea and for the first time, type O and A were detected simultaneously in 2017, which led to difficulties in FMD control. For the effective prevention of FMD, the importance of discrimination of serotypes became greater. Therefore, the most urgent requirement in case of FMD outbreak is differential diagnosis of serotypes. In this study, we developed a PNA probe-mediated multiplex real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay using the peptide nucleic acid (PNA) probe, which is known to be stable to nucleotide mutation and that could specifically detect the all FMDV serotype A, FMDVA Yeoncheon strain which was occurred in Korea in 2017, and FMDV A viruses shown 96% similarity with FMDVA/Yeoncheon strain, at the same time. Therefore, It is believed that the newly introduced FMDVA will be effectively diagnosed using the PNA probe multiplex RT-PCR developed in this study, and ultimately contribute to the prevention of FMD.

• 한국운동역학회지
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• 제29권1호
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• pp.23-32
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• 2019

Objective: The aim of this study was to provide kinematic data on the characteristics of spinal disease patients by comparing and analyzing kinematic variables related to foot balance and gait pattern of spinal disease. Method: The subjects of the study included 40 adult men and 60 adult women who visited the hospital in Busan. Patients who were diagnosed with spinal disease by a physician through X-ray examination were selected as subjects for the diagnosis of vertebral disc herniation, spinal stenosis, spinal disease diagnosed with spinal disease and the general public. Left and right foot pressure and contact area were checked by Gaitview pro meter. X-ray photographs were taken with a Zen-2090 mobile fluoroscopy under physicians' direct participation. One-way ANOVA was performed to compare the differences between the kinematic variables and post-hoc was performed by the Duncan method. Results: The difference in contact area between the left foot and the right foot was $115.30{\pm}14.15cm^2$ in the left side and $124.25{\pm}13.65cm^2$ in the left side in the spinal disease patients. The difference in pressure between the left and right side of the spinal disease patients was wider than that of the general people. Especially, the right side of the spinal disease patients showed a larger area of left foot contact than the general population. Conclusion: Spinal disease patients have wider contact area of the left foot than those of the general population. In the case of right spinal disease, the left foot support area is widened due to pain. In the gait, women showed slightly more posterior body center than men, and the upper body muscle imbalance and immobilization due to the spinal disease caused imbalance of the muscles moving to the lower limb, It was analyzed to inhibit movement.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.411-412
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• 2022

최근 들어 잘못된 보행 습관과 신발 착용으로 족부 질환자들이 늘어나고 있다. 신발의 발달과 생활환경으로 누구나 족부질환으로부터 안심할 수 없다. 족부질환 환자가 정형 신발 구매시 신발디자인 특성이 만족도와 구매 의도에 어떠한 영향을 미치는지 연구한다. 신발 디자인 특성은 기능성, 편의성, 심미성으로 구성하였다. 사회활동 참여 빈도, 착용 목적, 족부 질환별 상태와 특징 등 다양한 관점에서 연구된다. 연구 결과를 통해 정형 경증 족부질환 환자들이 일상생활에서 유용하게 착용할 수 있는 정형 신발 디자인 개발과 현실적인 활용과 만족으로 이어지길 기대한다.

• 대한수의학회지
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• 제25권2호
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• pp.197-202
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• 1985

Incidence of foot disease of Korean native cattle (231 cases) and Holstein (310 cases) in slaughter house was observed from July August, 1984. 1. Incidence rate of foot disease was 9.09%, 12.90% and 11.27% for Korean native cattle, Holstein and total respectively. 2. Chronic necrotic pododermatitis showed the highest incidence among all foot disease and it's incidence rate was 6.47% in all cattle observes. 3. Topographical incidence rate of chronic necrotic pododermatitis was 25.7%, 60.0% and 14.3% for forefoot, hind foot and not specified respectively, so the disease showed high incidence rate in hind foot.

• 사상체질의학회지
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• 제34권4호
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• pp.81-88
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• 2022

Objectives The purpose of this case study is to report the improvement of hand foot and mouth disease after using Galgeunhaegi-tang Methods A Taeumin patient suffering from painful hand foot and mouth disease was treated with herb medicine Galgeunhaegi-tang, acupuncture and cupping therapy. Rhei radix et rhizoma was added or removed from herb medicine according to patient's stool condition. Severity of pain and general symptom was measured using Numerical Rating Scale(NRS), and the picture of patient's hand and foot was taken. Results & Conclusions After taking Galgeunhaegi-tang, symptoms including pain, rash, blisters, and general conditions improved as patient's stool condition improved from constipation to normal. In conclusion, this case report shows that Galgeunhaegi-tang can be effective to Taeumin hand foot and mouth disease patients.

• Asian-Australasian Journal of Animal Sciences
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• 제28권2호
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• pp.166-170
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• 2015

Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. Since FMD outbreaks have recently occurred in some Asian countries, it is important to understand the relationship between diverse immunogenomic structures of host animals and the immunity to foot-and-mouth disease virus (FMDV). We performed genome wide association study based on high-density bovine single nucleotide polymorphism (SNP) chip for identifying FMD resistant loci in Holstein cattle. Among 624532 SNP after quality control, we found that 11 SNPs on 3 chromosomes (chr17, 22, and 15) were significantly associated with the trait at the p.adjust <0.05 after PERMORY test. Most significantly associated SNPs were located on chromosome 17, around the genes Myosin XVIIIB and Seizure related 6 homolog (mouse)-like, which were associated with lung cancer. Based on the known function of the genes nearby the significant SNPs, the FMD resistant animals might have ability to improve their innate immune response to FMDV infection.

• Journal of Veterinary Science
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• 제23권5호
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• pp.32.1-32.11
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• 2022

Background: Classical swine fever (CSF) is a severe infectious disease of pigs that causes significant economic losses to the swine industry. Objectives: This study developed a solid-phase blocking enzyme-linked immunosorbent assay (spbELISA) method for the specific detection of antibodies against the CSF virus (CSFV) in porcine serum samples. Methods: A spbELISA method was developed based on the recombinant E2 expressed in Escherichia coli. The specificity of this established spbELISA method was evaluated using reference serum samples positive for antibodies against other common infectious diseases. The stability and sensitivity were evaluated using an accelerated thermostability test. Results: The spbELISA successfully detected the antibody levels in swine vaccinated with the C-strain of CSFV. In addition, the detection ability of spbELISA for CSFV antibodies was compared with that of other commercial ELISA kits and validated using an indirect immunofluorescence assay. The results suggested that the spbELISA provides an alternative, stable, and rapid serological detection method suitable for the large-scale screening of CSFV serum antibodies. Conclusions: The spbELISA has practical applications in assessing the vaccination status of large pig herds.