• 제목/요약/키워드: Food Science and Nutrition

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만성적인 에탄올 섭취로 인한 쥐의 위 조직 손상에서 방사무늬 김(Pyropia yezoensis)의 보호효과 (Protective Effects of Pyropia yezoensis Glycoprotein against Ethanol-induced Chronic Gastric Injury in the Rat)

  • ;최정욱;이민경;김영민;김인혜;남택정
    • 한국수산과학회지
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    • 제47권6호
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    • pp.765-769
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    • 2014

  • We examined the protective effects of Pyropia yezoensis glycoprotein (PYGP) against ethanol-induced gastric damage. The experimental animals were divided into four groups. They were treated with distilled water (control), ethanol alone (EtOH), ethanol + PYGP 150 mg/kg BW (EtOH+150), or ethanol + PYGP 300 mg/kg BW (EtOH+300). The groups were treated for 4 weeks. We measured mitogen-activated protein kinase (MAPK), the apoptotic signaling pathway, and PARP activity in gastric tissues obtained from the rats. Ethanol consumption increased apoptotic signal activity and ERK, JNK, and p38 phosphorylation. PYGP reduced the apoptotic signaling pathway activity and ERK, JNK, and p38 phosphorylation. Furthermore, PYGP regulated Bcl-2 family expression. In light of these findings, PYGP appears to prevent ethanol-induced gastric injury and oxidative stress.

  • https://doi.org/10.5657/KFAS.2014.0765 인용 PDF KSCI KPUBS HTML