• Title/Summary/Keyword: Focusing manner

검색결과 191건 처리시간 0.038초

Simple and Robust Measurement of Blood Plasma Lysophospholipids Using Liquid Chromatography Mass Spectrometry

  • Ji, Dong Yoon;Lee, Chang-Wan;Park, Se Hee;Lee, Eun Jig;Lee, Do Yup
    • Mass Spectrometry Letters
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    • 제8권4호
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    • pp.109-113
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    • 2017
  • Single analytical procedure including extraction, liquid chromatography, and mass spectrometric analysis was evaluated for the simultaneous measurement of lysophospholipids (LPLs). LPLs, particularly, lysophosphatidic acids (LPA) and sphingosine 1-phosphate (S1P) are lipid messengers ubiquitously found in various biological matrix. The molecular species mediate important physiological roles in association with many diseases (e.g. cancer, inflammation, and neurodegenerative disease), which emphasize the significance of the simple and reliable analytical method for biomarker discovery and molecular mechanistic understanding. Thus, we developed analytical method mainly focusing on, but not limited by those lipid species S1P and LPA using reverse phase liquid chromatography-tandem mass spectrometry (RPLC-ESI-MS-MS). Extraction method was modified based on Folch method with optimally minimal level of ionization additive (ammonium formate 10 mM and formic acid). Reverse-phase liquid-chromatography was applied for chromatographical separation in combination with negative ionization mode electrospray-coupled Orbitrap mass spectrometry. The method validation was performed on human blood plasma in a non-targeted lipid profiling manner with full-scan MS mode and data-dependent MS/MS. The proposed method presented good inter-assay precision for primary targets, S1P and LPA. Subsequent analysis of other types of LPLs identified a broad range of lysophosphatidylcholines (LPCs) and lysophosphatidyl-ethanolamines (LPEs).

사교육서비스 분야에서의 BSC 모델 개발 및 전략실행방안에 관한 연구 (A Study on BSC development and Strategy execution plan for Private education service field)

  • 정민의;유성진
    • 품질경영학회지
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    • 제42권3호
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    • pp.425-444
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    • 2014
  • Purpose: This study aims to overcome the problem of private education market environment which is polarized into commercialized large private education institutions and small and medium sized private education institutions in a poor business environment, and develop systematic performance measurement model applicable for small and medium sized private education institutions. Methods: To develop the BSC which measures financial and non-financial indicator in a balanced manner and introduce the BSC into private education institutions that contain conflicting goals "EDUCATION" and "PROFIT". In particular, Utilizing the methodology of AHP, the priority of strategies and execution assignments are derived. Results: BSC model was developed and introduced by cooperating with executives of the private education institution. Moreover, the study permits to achieve the strategy, enterprise-wide vision and mission by deriving strategy map and applying it to the private education institution. To measure the performance of BSC model instruction, KPI corresponding to the strategic objectives of each perspective was derived. Conclusion: BSC model generally introduces to large-sized companies and public institutions. In this study, BSC model is developed by focusing on small and medium sized private institution. Furthermore, this study is more than simple model development, it makes a connection with achievement of strategic objectives, enterprise-wide vision and mission through strategy map and strategy execution method. Through the developed BSC model and strategy execution method, utilization plan in practice and customized model for private education institutions coexisting profit and non-profit objectives were developed, and academic implications were presented.

보건교사 배치기준의 변천과정 및 배치정책의 문제 연구 (A Study on the Change in Health Teacher Placement Standards and the Problems in the Placement Policy)

  • 김미경
    • 한국학교보건학회지
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    • 제26권3호
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    • pp.133-143
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    • 2013
  • Purpose: The purpose of this study is to provide basic data for a more reasonable health teacher placement policy sending teachers to more appropriate sites, by analyzing the change process of the health teacher placement standards and the problems caused by an unreasonable placement policy. Methods: This study mainly analyzed relevant research data and existing studies focusing on a literature analysis. Results: To date, the placement policy for health teachers has changed, going through expansion, reduction, and retrogression, since its establishment. The standard, placing health teachers only in elementary schools with more than 18 classes, was created in 1952. Despite the expansion of the role of health teachers and the revision of the school health law in 2007, this standard has been applied to date without modification. In the meantime, there have been many problems caused by inappropriate placement of health teachers. It was difficult for health teachers in large schools to carry out proper health education; and, in many schools, passive health management, such as first aid, health tests, and student health management, was mainly executed rather than active health management. Students in small schools were not even given an opportunity to receive health education and health management owing to the absence of health teachers. Also, compared to teachers teaching other subjects, health teachers have had very unfair placement standards. Conclusion: The placement policy for health teachers, which has been applied to the present, has never reflected social change, the increase of student health issues, and the demand from the school area. Although the role of health teachers expanded with the execution of health education, the current placement standards for health teachers are very unreasonable. Accordingly, it is necessary to review the health teacher placement policy in a reasonable manner and to revise the standards considering the reality.

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한국과 주요 외국의 안전보건교육제도에 관한 비교 연구 (A Comparative Study on the Safety and Health Education System between Korea and other Countries)

  • 정승래;박현진;장성록
    • 한국안전학회지
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    • 제31권5호
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    • pp.117-123
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    • 2016
  • After the Se-wol ferry disaster in Korea, the safety issue was highly spotlighted in a number of media, and consequently the ministry of public safety and security was newly established under the public attention. In addition to this, a recent earthquake in Gyeonju suggested the training issues for public such as evacuation and public safety. Regarding the industry, one of significant reasons causing the accidents were inadequate training, in execution of safety manual or inexperienced first response. Although the engineering or scientific study provided a basis of the industry safety and health in Korea a study focusing on the safety and health education system should be highlighted in that the law is the only way to execute the policy. In this manner, the goal of current study was to compare the safety and health education system in Korea to other countries including America, England and Germany. Especially, the law for training method, contents, supervision and punishment was analyzed. Result showed (1) lack of a structured training course for educating safety and health education trainer, (2) no training system of safety and health education to public or workers, and (3) less specific law for supervision and punishment as compared to the America, England and Germany.

How do Citrus Crops Cope with Aluminum Toxicity?

  • Arunakumara, K.K.I.U.;Walpola, Buddhi Charana;Yoon, Min-Ho
    • 한국토양비료학회지
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    • 제45권6호
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    • pp.928-935
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    • 2012
  • World Agriculture faces daunting challenges in feeding the growing population today. Reduction in arable land extent due to numerous reasons threatens achievement of food and nutritional security. Under this back ground, agricultural use of acidic soils, which account for approximately 40 % of the world arable lands is of utmost important. However, due to aluminum (Al) toxicity and low available phosphorous (P) content, crop production in acidic soils is restricted. Citrus, in this context, gains worldwide recognition as a crop adapted to harsh environments. The present paper reviewed Al toxicity and possible toxicity alleviation tactics in citrus. As reported for many other crops, inhibition of root elongation, photosynthesis and growth is experienced in citrus also due to Al toxicity. Focusing at toxicity alleviation, interaction between boron (B) and Al as well as phosphorus and Al has been discussed intensively. Al toxicity in citrus could be alleviated by P through increasing immobilization of Al in roots and P level in shoots rather than through increasing organic acid secretion, which has been widely reported in other crops. Boron-induced changes in Al speciation and/or sub-cellular compartmentation has also been suggested in amelioration of root inhibition in citrus. Despite the species-dependent manner of response to Al toxicity, many commercially important citrus species can be grown successfully in acidic soils, provided toxicity alleviation Agro-biological tactics such as addition of phosphorous fertilizers are used properly.

도시재생사업에서의 사회복지사업 유형 및 내용 분석 (A Study on Typology and Contents of Social Welfare Programs in Urban Regeneration Projects)

  • 강혜규;엄태영;류진아
    • 한국콘텐츠학회논문지
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    • 제17권7호
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    • pp.31-43
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    • 2017
  • 본 연구는 도시재생에 대한 기존의 물리적 접근의 한계를 극복하고자 추진 중인 최근 도시재생의 흐름속에서 사회복지적 접근의 실체를 파악하고 사회복지 기법의 정착과 확대에 필요한 제안 사항을 고찰하고자 하였다. 이를 위하여 도시재생 선도지역과 주거취약지역의 사업계획서에서 내용분석의 방법을 적용하여 사회복지 사업을 추출하였으며 사업들을 특성과 형태에 따라 유형화하였다. 분석 결과 도시재생 지역의 사회복지사업은 경제적 기반마련, 복지중심 주거환경개선, 지역사회통합추구, 사회서비스제공의 4가지 유형으로 나타났으며, 각 유형은 다시 12개의 세부 유형으로 분류되었다. 연구 결과를 토대로 향후 도시재생사업에 사회복지기법이 안정적으로 운영되기 위하여 지역특성에 맞는 일자리 연계, 사업수행과정에서 당사자의 적극적 참여, 지역사회통합을 위한 역량 강화, 사회서비스 확대 제공이 필요하다는 시사점을 제시하였다.

의사들의 의료정보추구행태에 관한 탐구 (Exploring Medical Doctors' Medical Information Seeking Behaviors)

  • 김나원;박지홍
    • 정보관리학회지
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    • 제26권3호
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    • pp.435-449
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    • 2009
  • 새로운 기술의 발달과 병행하는 정보이용환경의 급격한 변화는 정보원의 이용 및 정보서비스에 대한 새로운 고찰을 요구한다. 이용자 정보추구의 올바른 이해는 정보서비스의 향상에 핵심적인 역할을 하고 있으므로 변화하는 정보이용환경에 따라 이용자의 정보추구를 시기적절하게 새롭게 고찰할 필요가 있다. 많은 이전 연구들이 이용자 정보추구에 초점을 맞추고 있으나 의사들의 정보추구, 특히 진료정보 및 의학지식 추구를 동시에 대상으로 한 연구는 거의 없다. 이에 따라 본 연구는 진료와 의학연구를 동시에 수행하는 대학병원의 강사인 의사들의 정보추구행태를 탐구하는 것을 목적으로 하고 있다. 본 연구는 연세의료원 강사 12명을 대상으로 개방형 반구조화 형식의 심층 면접을 통하여 수집하였다. 면접 내용은 크게 연구 환경, 진료와 관련된 정보 추구 행태, 선호하는 정보원과 자료 유형, 검색과정과 만족도의 4가지 주제로 구성하였다. 응답 결과 연구 목적의 정보추구에 있어서는 PubMed를 통한 전자학술지 대한 신뢰도가 더 높았으나 진료 목적인 경우에는 인쇄형태의 교과서를 더 선호하는 것으로 나타났다. 이는 정보원에 대한 권위와 근거를 매우 중요시하는 의사들의 태도에서 그 원인을 찾을 수 있다.

Precedent based design foundations for parametric design: The case of navigation and wayfinding

  • Kondyli, Vasiliki;Bhatt, Mehul;Hartmann, Timo
    • Advances in Computational Design
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    • 제3권4호
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    • pp.339-366
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    • 2018
  • Parametric design systems serve as powerful assistive tools in the design process by providing a flexible approach for the generation of a vast number of design alternatives. However, contemporary parametric design systems focus primarily on low-level engineering and structural forms, without an explicit means to also take into account high-level, cognitively motivated people-centred design goals. We present a precedent-based parametric design method that integrates people-centred design "precedents" rooted in empirical evidence directly within state of the art parametric design systems. As a use-case, we illustrate the general method in the context of an empirical study focusing on the multi-modal analysis of wayfinding behaviour in two large-scale healthcare environments. With this use-case, we demonstrate the manner in which: (1). a range of empirically established design precedents -e.g., pertaining to visibility and navigation- may be articulated as design constraints to be embedded directly within state of the art parametric design tools (e.g., Grasshopper); and (2). embedded design precedents lead to the (parametric) generation of a number of morphologies that satisfy people-centred design criteria (in this case, pertaining to wayfinding). Our research presents an exemplar for the integration of cognitively motivated design goals with parametric design-space exploration methods. We posit that this opens-up a range of technological challenges for the engineering and development of next-generation computer aided architecture design systems.

국내 재난 주관방송사의 재난보도 프레임 분석 : 지카 바이러스 보도를 중심으로 (Analysis of Disaster News Frame of Host Broadcaster for Disaster Broadcasting Services : Focusing on Zika Virus News)

  • 최믿음;정희수
    • 한국콘텐츠학회논문지
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    • 제18권7호
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    • pp.609-619
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    • 2018
  • 국내 방송사업자는 재난 상황에서 국민을 보호하고 국민이 재난에 신속히 대처할 수 있도록 관련 재난정보를 빠르고 정확하고 제공할 의무를 지닌다. 특히 한국공영방송 KBS는 방송통신발전 기본법 제40조의2에 의하여 '재난방송 등의 주관방송사'로 지정되어 있기 때문에 다른 방송사보다도 빠르고 정확하게 재난방송을 송출할 의무를 가지고 있다. 이 연구는 재난주관방송사가 지카바이러스와 관련된 사회적 재난 보도를 어떻게 다루고 있는지 살펴보고, 재난 대응에 도움이 되는 프레임을 시의적절하게 활용하였는지 평가하였다. 분석 결과, 재난이 발생한 사실을 단순히 알리는 역할을 하는 '사실 전달 프레임'의 비중이 가장 많았다. 반면 지카 바이러스의 원인 및 예방법을 소개하거나 지카 바이러스 감염 시 목격되는 증상과 진단 및 검사방법 등에 대한 정보를 제공하는 기사, 즉 '정보성 프레임'을 활용한 기사와 대책 마련에 대한 '책임 프레임'은 상대적으로 적은 것으로 나타났다. 이 연구는 이와 같은 분석 결과를 바탕으로 재난 보도의 효율성과 신뢰도를 제고하기 위한 방안에 대한 실무적 함의를 제시하였다.

공공도서관의 리모델링을 위한 타당성 연구 - 부산광역시교육청 공공도서관을 중심으로 - (A Feasibility Study of Public Libraries Remodeling: Focusing on Busan Metropolitan City)

  • 노지현;이은주;조용완
    • 한국도서관정보학회지
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    • 제48권4호
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    • pp.209-233
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    • 2017
  • 1970, 80년대 건립된 도서관들은 시설 노후화로 인한 안전문제와 도서관 시설 이용에 대한 이용자 불만 및 불편이 지속적으로 제기되고 있어 이를 해소하기 위한 시설 현대화(리모델링)가 시급히 필요한 상황이다. 이에 지난 2014년에 발표된 "제2차 도서관발전종합계획(2014~ 2018)"에서는 '노후 도서관의 시설 개선'을 주요 정책 과제로 설정한 바 있고, 각 지역에서도 지역 도서관 발전을 위한 시행 계획에 '노후 도서관의 리모델링'을 포함하고 있다. 본 연구는 부산광역시교육청 공공도서관 14개관을 대상으로 하여 리모델링의 타당성을 객관적으로 분석하고, 리모델링의 우선순위와 추진방향, 범위를 제안하는데 목적을 두고 있다. 연구에 필요한 데이터는 문헌연구, 현장실태조사, 설문조사, 전문가 자문 등을 통해 수집하였다. 본 연구의 결과는 부산지역 공공도서관의 리모델링을 추진하는 근거자료로서, 더불어 타 지역에서 리모델링 사업의 근거자료를 확보하는데 기초자료로 활용할 수 있을 것이다.