• Applied Microscopy
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• v.47 no.3
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• pp.165-170
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• 2017

Gas vesicles are intracellular gas-filled protein-shelled nanocompartments. The structures are spindle or cylinder-shaped, and typically $0.1{\sim}2{\mu}m$ in length and 45~250 nm in width. A variety of prokaryotes including photosynthetic bacteria and halophilic archaea form gas vesicles in their cytoplasm. Gas vesicles provide cell buoyancy as flotation devices in aqueous habitats. They are used as nanoscale molecular reporters for ultrasound imaging for biomedical purposes. The structures in halophilic archaea are poorly resolved due to the low signal-to-noise ratio from the high salt concentration in the medium. Such a limitation can be overcome using focused ion beam-thinning or inelastically scattered electrons. As the concentric bodies (~200 nm in diameter) in fungi possess gas-filled cores, it is possible that the concept of gas vesicles could be applied to eukaryotic microbes beyond prokaryotes.

• Journal of Korean Neurosurgical Society
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• v.61 no.3
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• pp.343-351
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• 2018

Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene aberrations, genetic driver mutations and methylation changes, which have resulted in molecular and phenotypic subgrouping. However, many of the underlying mechanisms of DIPG oncogenesis remain unexplained. It is hoped that more representative in vitro and preclinical models-using both xenografted material and genetically engineered mice-will enable the development of novel chemotherapeutic agents and strategies for targeted drug delivery. This review provides a clinical overview of DIPG, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery.

• Journal of Biomedical Engineering Research
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• v.31 no.5
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• pp.335-343
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• 2010

This article presents a review of technologies for an endoscope. The classification according to the clinical applications and the imaging modalities are summarized. The major parts are focused on describing the gastrointestinal endoscope's structures and mechanisms. The details of the image enhanced endoscopic techniques, such as NBI (narrow band imaging), OCT (optical coherence tomography), and EUS (endoscopic ultrasound), are also explained. Finally, the trend of NOTES (natural orifice transluminal endoscopic surgery) which is new fusion technology in the field of endoscopic diagnosis and surgery is introduced.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2003.05a
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• pp.369-388
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• 2003

This research has been focused upon and analyzing Medison, once a leading New Technology-Based Firm (NTBF) in Korea with exceptionally advanced technology in 3D ultrasound diagnostic imaging devices (UDIDs) (armored with 23 subsidiaries at its peak expansion), from the perspective if Dynamic Firm Capability(DFC). The underlying hypothesis is that the various problems from its pointless pursuit of the business styles or precedents of the existing large firms might be traced to its specific characteristics as an NTBF, which should have more preferably been based upon the distinctive competences such as differentiated technologies, institutional linkages, organizational routines, and complementary assets, etc. In conclusion, for the NTBFs with different DFC domains from those of the large firms, the optimal external linkages and comprehensive integration efforts (Process) under their specific organizational characteristics and constraints (Path) are highly recommended for the continuous accumulation of their core capabilities based upon the technological assets (Position).

• Journal of Biomedical Engineering Research
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• v.33 no.3
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• pp.114-127
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• 2012

Recent technical advancement allows noninvasive measurement of blood glucose. In this literature, we reviewed various noninvasive techniques for measuring glucose concentration. Optical or electrical methods have been investigated. Optical techniques include near-infrared spectroscopy, Raman spectroscopy, optical coherence technique, polarization, fluorescence, occlusion spectroscopy, and photoacoustic spectroscopy. Electrical methods include reverse iontophoresis, impedance spectroscopy, and electromagnetic sensing. Ultrasound, detection from breath, or fluid harvesting technique can be used to measure blood glucose level. Combination of various methods is also promising. Although there are many interesting and promising technologies and devices, there need further researches until a commercially available non-invasive glucometer is popular.

• Journal of Korea Technology Innovation Society
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• v.6 no.2
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• pp.228-252
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• 2003

This research has been focused upon and analyzing Medison, once a leading New Technology-Based Finn (N1BF) in Korea with exceptionally advanced technology in 3D ultrasound diagnostic imaging devices (UDIDs) (armored with 23 subsidiaries at its peak expansion), from the perspective of Dynamic Finn Capability(DFC). The underlying hypothesis is that the various problems from its pointless pursuit of the business styles or precedents of the existing large firms might be traced to its specific characteristics as an NTBF, which should have more preferably been based upon the distinctive competences such as differentiated technologies, institutional linkages, organizational routines, and complementary assets, etc. In conclusion, for the NTBFs with different DFC domains from those of the large firms, the optimal external linkages and comprehensive integration efforts (Process) under their specific organizational characteristics and constraints (path) are highly recommended for the continuous accumulation of their core capabilities based upon the technological assets (Position).

• Journal of the Korean Institute of Telematics and Electronics B
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• v.28B no.10
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• pp.822-830
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• 1991

In this paper, we propose a new process for ultrasonic B-mode image considering the sound field effects of a concave circuit focused transducer, and aim to remove the speckle pattern which cause the blurring on boundary in ultrasonic B-mode image. We discuss in detail the conception of speckle pattern generation, and the frequency compounding method which is applied to the process for getting a speckle reduced B-mode image. Through the computer simulation, we define the meaning of speckle region, and show the results of reduced speckle pattern. It is discovered in the results that the frequency compounding method is very effective for boundary detection and that the application of the method is limited by various conditions.

• Progress in Medical Physics
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• v.31 no.3
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• pp.35-53
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• 2020

The authors congratulate the cerebrations for the 30 years of the Korean Society of Medical Physics (http://www.ksmp.or.kr/). The paper is published to recognize the anniversary. Geon-Ho Jahng invited Professor Z. H. Cho to join to submit this manuscript because he has been one of the leaders in the field of magnetic resonance imaging (MRI) during the last 40 years. In this review, we describe the development and clinical histories of MRI internationally and domestically. We also discuss diffusion and perfusion MRI, molecular imaging using MRI and MR spectroscopy (MRS), and the hybrid systems, such as positron emission tomography-MRI (PET-MRI), MR-guided focused ultrasound surgery (MRgFUS), and MRI-guided linear accelerators (MRI-LINACs). In each part, we discuss the historical evolution of the developments, technical developments, and clinical applications.

• Journal of the Korean Burn Society
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• v.23 no.2
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• pp.64-67
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• 2020

High-intensity focused ultrasound (HIFU) has been regarded as a non-invasive uterine-preserving treatment for women with uterine myoma. Numerous studies have reported that it is a relatively safe and effective treatment for uterine myoma. However, severe complications, such as deep thermal burn injuries, bowel perforation, and bladder injury, were reported on rare occasions. We report a case of a 4th degree burn on the lower abdomen after HIFU treatment for uterine myoma. Physicians must consider the possibility of deep thermal burn injuries when managing uterine myoma with HIFU.

• Korean Journal of Radiology
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• v.25 no.6
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• pp.559-564
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• 2024

Incidental pancreatic cystic lesions are a common challenge encountered by diagnostic radiologists. Specifically, given the prevalence of benign pancreatic cystic lesions, determining when to recommend aggressive actions such as surgical resection or endoscopic ultrasound with sampling is difficult. In this article, we review the common types of cystic pancreatic lesions including serous cystadenoma, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm with imaging examples of each. We also discuss high-risk or worrisome imaging features that warrant a referral to a surgeon or endoscopist and provid several examples of these features. These imaging features adhere to the latest guidelines from the International Consensus Guidelines, American Gastroenterological Association (2015), American College of Gastroenterology (2018), American College of Radiology (2010, 2017), and European Guidelines (2013, 2018). Our focused article addresses the imaging dilemma of managing incidental cystic pancreatic lesions, weighing the options between imaging follow-up and aggressive interventions.