• The Journal of Advanced Prosthodontics
• /
• 제6권6호
• /
• pp.555-558
• /
• 2014

Focal epithelial hyperplasia (FEH) is a human papillomavirus (HPV)-induced alteration of the oral mucosa that presents with a clinically distinct appearance. While other HPV-infected lesions such as squamous papilloma, verruca vulgaris, and condyloma acuminatum involve the skin, oral mucosa, and genital mucosa, FEH occurs only in the oral mucosa. The affected oral mucosa exhibits multiple papules and nodules with each papule/nodule being flat-topped or sessile. The affected region resembles the normal color of oral mucosa rather than appearing as a white color since the epithelial surface is not hyperkeratinized. Almost all cases present with multiple sites of occurrence. This rare, benign epithelial proliferation is related to low-risk HPV, especially HPV-13 and -32, and is not transformed into carcinoma. We report a case of FEH that arose on the attached gingiva of an East Asian male adult related to prosthesis without detection of any HPV subtype in HPV DNA chip and sequencing.

• 대한소아치과학회지
• /
• 제29권4호
• /
• pp.581-585
• /
• 2002

Focal epithelial hyperplasia(FEH)는 구강편평상피의 국소적인 증식으로 사람유두종바이러스(Human papilloma virus)에 의해 유발되는 것으로 알려져 있다. 보통 어린 나이에 호발하며 종종 젊은 성인에서 발생하기도 한다. 협,순측 및 설측 점막에 호발하지만 치은이나 혀의 병소(lesions of tongue)도 보고된 바 있다. 이 병소는 전형적으로 다발성인 부드럽고 촉진 시 압통이 없는 편평한 구진이나 반의 형태를 갖는다. 종종 유두상의 표면을 보이기도 한다. 각각의 병소는 비교적 작고 분리되어 있으며 잘 경계지어진다. FEH의 조직학적 특징은 구강 상피의 유극세포증(acanthosis)이다. 그 밖에 바이러스에 의한 세포병리학적 변화를 나타내는 구멍세포(koilocyte)나 유사분열상 세포(mitosoid cell)가 관찰되기도 한다. 본 증례의 5세 여자환아는 치은의 돌기성 병소를 주소로 연세대학교 치과대학병원 소아치과에 내원하였다. 임상구강검사 결과 무경형의 유두상 구진(sessile papillary papules)이 상악 좌우측 제 2 유구치 협측 치은에서 관찰되었다. 촉진 시 동통은 없었다. 조직학적 검사를 위해 조직생검을 시행하였으며, 유극세포증이 관찰되었다. 이에 FEH로 진단되어 보고하는 바이다. FEH는 몇 달이나 몇 년 이내에 자발적으로 소멸하므로 일반적으로 치료는 불필요하다. 다만 진단적인 이유나 심미적인 이유로 보존적인 절제술을 시행하기도 한다. 이러한 치료 후 재발의 위험은 최소한이며, 악성 전이 가능성 역시 거의 없다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제25권6호
• /
• pp.441-452
• /
• 2022

Congenital diarrheal disorders (CDDs) with genetic etiology are uncommon hereditary intestinal diseases characterized by chronic, life-threatening, intractable watery diarrhea that starts in infancy. CDDs can be mechanistically divided into osmotic and secretory diarrhea. Congenital tufting enteropathy (CTE), also known as intestinal epithelial dysplasia, is a type of secretory CDD. CTE is a rare autosomal recessive enteropathy that presents with intractable neonatal-onset diarrhea, intestinal failure, severe malnutrition, and parenteral nutrition dependence. Villous atrophy of the intestinal epithelium, crypt hyperplasia, and irregularity of surface enterocytes are the specific pathological findings of CTE. The small intestine and occasionally the colonic mucosa include focal epithelial tufts. In 2008, Sivagnanam et al. discovered that mutations in the epithelial cell adhesion molecule (EpCAM, MIM# 185535) were the genetic cause of CTE (MIM# 613217). More than a hundred mutations have been reported to date. Furthermore, mutations in the serine peptidase inhibitor Kunitz type 2 (SPINT2, MIM# 605124) have been linked to syndromic CTE. In this study, we report the case of a 17-month-old male infant with congenital diarrhea. Despite extensive etiological workup, no etiology could be established before admission to our center. The patient died 15 hours after being admitted to our center in a metabolically decompensated state, probably due to a delay in admission and diagnosis. Molecular autopsy with exome sequencing revealed a previously reported homozygous missense variant, c.757G>A, in EpCAM, which was confirmed by histopathological examination.

• 한국어병학회지
• /
• 제28권3호
• /
• pp.145-155
• /
• 2015

The pathogenecity of atypical Aeromonas salmonicida was studied in healthy Oreochromis niloticus. Inoculum at concentration of $1.5{\times}10^8CFU/ml$ and $3{\times}10^8CFU/ml$ was injected into healthy fish through intramuscular and intraperitoneal injections. Experimentally infected Oreochromis niloticus showed ulceration at the dorsal musculature and trunk region in addition to black coloration, congested gills, exophthalmia, and ocular hemorrhage. Congested liver and kidney were recorded in post-mortem examination. Mortality of the experimentally infected Oreochromis niloticus reached 100% after intramuscular injection at concentration of $3{\times}10^8CFU/ml$. Histopathological investigation of infected organs was also performed. There was a focal area of bundles of skeletal musculature showing hyalinization. In addition, hyperplasia, congestion, and fusion were noticed in the gill lamellae. There was also congestion in the blood vessels in the ocular chamber. Severe congestion was also noticed in the central vein of liver associated with focal aggregation of the melanin pigmented cells in the parenchyma. Degenerative changes were noticed in the epithelial cells lining of kidney tubules. Plant extracts carvacrol and its biological precursor cymene were found to be effective in treating experimentally infected Oreochromis niloticus at concentration of 100 or 200 ppm.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권9호
• /
• pp.4491-4501
• /
• 2016

Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Apart from virus-associated lesions, VPLs harboring malignant potential or behaviour such as verrucous carcinoma, proliferative verrucous leukoplakia, oral verrucous hyperplasia (OVH), oral papillary squamous cell carcinoma (PSCC) and oral conventional squamous cell carcinoma with papillary features (CSCC) need to be further clarified for better understanding of their predictable biologic behavior and appropriate treatment. Current understanding of potentially malignant VPLs is perplexing and is primarily attributed to the use of confusing and unsatisfactory terminology. In particular, the condition referred to as oral verrucous hyperplasia (OVH) poses a major diagnostic challenge. OVH represents a histopathological entity whose clinical features are not well recognised and is usually clinically indistinguishable from a verrucous carcinoma and a PSCC or a CSCC. A consensus report published by an expert working group from South Asia as an outcome of the 'First Asian Regional Meeting on the Terminology and Criteria for Verruco-papillary Lesions of the Oral Cavity' held in Kuala Lumpur, Malaysia, recognised the clinical description of these OVH as a new entity named 'Exophytic Verrucous Hyperplasia'. Previously described clinical features of OVH such as the 'blunt' or 'sharp' variants; and the 'mass' or 'plaque' variants can now collectively fall under this newly described entity. This paper discusses in detail the application of the standardized criteria guidelines of 'Exophytic Verrucous Hyperplasia' as published by the expert group which will enable clinicians and pathologists to uniformly interpret their pool of OVH cases and facilitate a better understanding of OVH malignant potential.

• 한국어병학회지
• /
• 제20권3호
• /
• pp.291-297
• /
• 2007

양식 뱀장어(Anguilla japonica)의 사육 중 발생하는 아질산중독에 대한 aspirin(ASA)의 효과를 알아보기 위하여 인위적으로 메트헤모글로빈혈증을 유발시킨 다음 ASA, 식염, 식염과 ASA 및 1/2 환수시키고 24시간 동안 사육하였다. 각 처리군의 뱀장어에서 동맥구에서 말초혈액을 채취하여 헤마토크리트치, 혈구의 형태 변화, 혈장 중의 아질산의 농도 및 메트헤모글로빈의 농도와 아가미의 병리조직학적 변화를 조사하였다. ASA약욕군이 헤마토크리트치가 높고, 혈장중의 아질산 농도와 메트헤모글로빈의 농도가 낮을 뿐만 아니라 적혈구의 형태도 정상어와 유사하였다. 또한 아가미의 병리조직변화도 다른 처리군에서는 상피세포의 증생과 유착 및 모세혈관의 충혈 등이 확인되었지만, ASA처리군에서는 발견할 수 없었다. 이러한 결과로부터 ASA의 약욕이 뱀장어의 아질산의 독성저하에 효과적일 것으로 판단되었다.