• Title/Summary/Keyword: Fluidic

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Nanochannels for Manipulation of DNA Molecule using Various Fabrication Molecule

  • Hwang, M.T.;Cho, Y.H.;Lee, S.W.;Takama, N.;Fujii, T.;Kim, B.J.
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.7 no.4
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    • pp.254-259
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    • 2007
  • In this report, several fabrication techniques for the formation of various nanochannels (with $SiO_2$, Si, or Quartz) are introduced. Moreover, simple fabrication technique for generating $SiO_2$ nanochannels without nanolithography is presented. By using different nanochannels, the degree of stretching DNA molecule will be evaluated. Finally, we introduce a nanometer scale fluidic channel with electrodes on the sidewall of it, to detect and analyze single DNA molecule. The cross sectional shape of the nanotrench is V-groove, which was implemented by thermal oxidation. Electrodes were deposited through both sidewalls of nanotrench and the sealing of channel was done by covering thin poly-dimethiysiloxane (PDMS) polymer sheet.

A Three-Dimensional Particle Focusing Channel Using the Positive Dielectrophoresis (pDEP) Guided by a Dielectric Structure Between Two Planar Electrodes (두 평면 전극 사이의 절연체 구조물에 의해 유도되는 양의 유전영동을 이용한 삼차원 입자 정렬기)

  • Chu, Hyun-Jung;Doh, Il;Cho, Young-Ho
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.33 no.3
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    • pp.261-264
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    • 2009
  • We present a three-dimensional (3D) particle focusing channel using the positive dielectrophoresis (pDEP) guided by a dielectric structure between two planar electrodes. The dielectric structure between two planar electrodes induces the maximum electric field at the center of the microchannel, and particles are focused to the center of the microchannel by pDEP as they flow from the single sample injection port. Compared to the previous 3D particle focusing methods, the present device achieves the simple and effective particle focusing function without any additional fluidic ports and top electrodes. In the experimental study, approximately 90 % focusing efficiency were achieved within the focusing length of 2mm, on both x-z plane (top-view) and y-z plane (side-view) for $2{\mu}m$-diameter polystyrene (PS) bead at the applied voltage over 15 Vp-p (square wave) and at the flow rate below 0.01 ${\mu}l$/min. The present 3D particle focusing channel results in a simple particle focusing method suitable for use in integrated microbiochemical analysis system.

Design and Fabrication of PZT Disc Actuated Micro Pump for Bio-Applications (II): Optimal Design & Fabrication of Embedding-type PZT Module (바이오용 압전디스크방식 마이크로 펌프 설계 및 제작 (II) -임베드방식의 압전모듈의 최적설계 및 제작-)

  • Kim, Hyung-Jin;Chang, In-Bae;Seo, Young-Ho;Kim, Byeong-Hee
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.21 no.3
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    • pp.362-367
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    • 2012
  • Though a micro pump is a crucial element in miniaturized bio-fluidic systems or drug delivery systems, most of the conventional micro pumps still have some limitations to miniaturize their controller system and to obtain the sufficient back pressure which can rise over the inner pressure of human body or experimental animals. In this paper, to overcome these limitation, a new PZT disc and its controller were designed and fabricated to get the sufficient flowrate and the back pressure with guaranteeing embeddability of the controller into pumping body. The amplitudes of the disc deflections were as large as 40 ${\mu}m$ at 200 V - 100 Hz condition. As results of experiments, the flow rate and the back pressure increase when the frequency increases. The obtainable maximum flow rate and back pressure are 5.2 ml/min at 95 Hz and 13.14 kPa at 90 Hz respectively.

Implantable Drug Delivery Systems-Design Process

  • Vincent, Croquet;Benolt, Raucent;Onori, Mauro
    • International Journal of Precision Engineering and Manufacturing
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    • v.7 no.4
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    • pp.40-46
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    • 2006
  • The market of programmable implantable pumps has bound to a monopolistic situation, inducing high device costs, thus making them inaccessible to most patients. Micro-mechanical and medical innovations allow improved performances by reducing the dimensions. This affects the consumption and weight, and, by reducing the number of parts, the cost is also affected. This paper presents the procedure followed to design an innovative implantable drug delivery system. This drug delivery system consists of a low flow pump which shall be implanted in the human body to relieve pain. In comparison to classical known solutions, this pump presents many advantages of high interest in both medical and mechanical terms. The first section of the article describes the specifications which would characterize a perfect delivery system from every points of view. This concerns shape, medication, flow, autonomy, biocompatibility, security and sterilization ability. Afterwards, an overview of existing systems is proposed in a decisional tree. Positive displacement motorized pumps are classified into three main groups: the continuous movement group, the fractioned translation group and the alternative movement group. These systems are described and the different problems which are specific to these mechanisms are presented. Since none of them fully satisfy the specifications, an innovation is justified.. The decisional tree is therefore extended by adding new principles: fractioned refilling and fractioned injection within the fractioned translation movement group, spider guiding system within the alternative translation movement group, rotational bearing guided device and notch hinge guided device in the alternative rotation movement group.

Performance Improvement and Validation of Advanced Safety Injection Tanks (신형안전주입탱크의 성능개선 및 검증)

  • Youn, Young Jung;Chu, In-Cheol;Kwon, Tae-Soon;Song, Chul-Hwa
    • Transactions of the Korean Society of Pressure Vessels and Piping
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    • v.7 no.1
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    • pp.1-8
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    • 2011
  • Advanced SITs of the evolutionary PWRs have the advantage that they can passively control the ECC water discharge flow rate. Thus, the LPSI pumps can be eliminated from the safety injection system owing to the benefit of the advanced SITs. In the present study, a passive sealing plate was designed in order to overcome the shortcoming of the advanced SITs, i.e., the early nitrogen discharge through the stand pipe. The operating principle of the sealing plate depends only on the natural phenomena of buoyancy and gravity. The performance of the sealing plate was evaluated using the VAPER test facility, equipped with a full-scale SIT. It was verified that the passive sealing plate effectively prevented the air discharge during the entire duration of the ECC water discharge. Also, the major performance parameters of the advanced SIT were not changed with the installation of the sealing plate.

Analysis of Flow Characteristics and Optimum Design of a Buckling Microvalve Using the Finite Element Method (유한요소법을 이용한 버클링 마이크로 밸브의 유동특성 해석 및 최적 설계)

  • Kim, Jae-Min;Lee, Jong-Choon;Chung, Gwiy-Sang;Yoon, Suk-Jin
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.11a
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    • pp.383-386
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    • 2002
  • This paper reports on the fluid flow simulation results of an active microvalve. The mechanical and fluidic analysis are done by finite element method. The designed structure is normally closed microvalve using buckling effect, which is consist of three separate structures; a valve seat die, an actuator die and a small piezoelectric actuator. It is confirmed that the complete laminar flow and the lowest flow leakage are strongly depend on the valve seat geometry. In addition, turbulent flow was occurs in valve outlet according to increase seat dimension, height and inlet pressure. From this, we was deducts the optimum geometry of the valve seat and diaphragm deflection that have an great influence fluid flow in microvalve. Thus, it is expected that our simulation results would be apply for constructing integrated chemical analyzing system or drug delivery system.

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Design of a Valveless Type Piezoelectric Pump for Micro-Fluid Devices

  • Kim, Hyun-Hoo;Oh, Jin-Heon;Yoon, Jae-Hun;Jeong, Eui-Hwan;Lim, Kee-Joe
    • Transactions on Electrical and Electronic Materials
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    • v.11 no.2
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    • pp.65-68
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    • 2010
  • The operation principle of a traveling wave rotary type ultrasonic motor can be successfully applied to the fluidic transfer mechanism of the micro-pump. This paper proposes an innovative valveless micro-pump type that uses an extensional vibration mode of a traveling wave as a volume transportation means. The proposed pump consists of coaxial cylindrical shells that join the piezoelectric ceramic ring and metal body, respectively. In order to confirm the actuation mechanism of the proposed pump model, a numerical simulation analysis was implemented. In accordance with the variations in the exciting wave mode and pump body dimension, we analyzed the vibration displacement characteristics of the proposed model, determined the optimal design condition, fabricated the prototype pump from the analysis results and evaluated its performance. The maximum flow rate was approximately $595\;{\mu}L/min$ and the highest back pressure was 0.88 kPa at an input voltage of $130\;V_{rms}$. We confirmed that the peristaltic motion of the piezoelectric actuator was effectively applied to the fluid transfer mechanism of the valveless type micro pump throughout this research.

Large Capacity Passive Flow Control Vortex Valve (대용량 피동형 유량제어 와류 밸브)

  • Choi, N. H.;Chu, I.-C.;Chung, C. H.;Cho, B. H.;Song, C.-H.
    • 유체기계공업학회:학술대회논문집
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    • 2004.12a
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    • pp.635-640
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    • 2004
  • The present paper provides the design specifications and working principle of flow controlling vortex valve which will be adopted in a Korean next generation reactor (APR1400). The vortex valve is installed inside the pressurized safety injection tank of APR1400, and it passively controls the water discharge flowrate from the tank. In the present study, the performance of the vortex valve have been evaluated throughout the repeated experiments in the full-scale test facility called VAPER(VAlve Performance Evaluation Rig). Based on the experimental results, it is confirmed that the currently developed vortex valve satisfies the major performance requirements of APR1400 plant design in view of the peak discharge flowrate, pressure loss coefficient, and total discharge duration time. To achieve the highest quality of the experimental results, a quality assurance program for vortex valve tests has been strictly applied.

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Flow Visualization in Porous Cylinder with Partial Slots (부분 슬롯을 가진 다공성 실린더의 내부 유동 가시화)

  • Son, Min;Kim, Dohun;Koo, Jaye;Chang, Hongbeen;Kang, Moonjung
    • Journal of Aerospace System Engineering
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    • v.8 no.3
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    • pp.1-5
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    • 2014
  • An inner flow of a porous cylinder with partial slots was visualized to study fluidic phenomena in a solid rocket motor. A high-pressure chamber and an air supply system for high flow rate were used. In order to visualize the inner flow, the smoke generator with a cam-driven pump and heaters and high speed camera were adopted. The results of the cylinder type and the partial slot type were compared. As a result, the injected smoke flow in the partial slot type had circumferential fluctuations unlike the cylinder type. It was found that the circumferential flow induced from the partial slots could be the cause of combustion instability and roll torque.

볼텍스챔버의 유동 특성에 관한 실험

  • Cho, Seok;Seo, Jeong-Sik;Song, Cheol-Hwa;Cheon, Se-Young;Jeong, Mun-Ki
    • Proceedings of the Korean Nuclear Society Conference
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    • 1998.05a
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    • pp.590-595
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    • 1998
  • 차세대 원자로(KNGR : Korea Next Generation Reactor)에는 새로운 안전개념으로서 피동형 안전주입탱크(Safety Injection Tank. SIT)의 도입을 고려하고 있는데, 이러한 피동형 유량조절기능은 안전주입탱크내의 유체기구(Fluidic device)인 볼텍스챔버(vortex chamber)에 의해 이루어진다. 볼텍스챔버는 내부에서 발생되는 와류강도에 따라 유동저항의 강도가 달라짐을 이용하여 유량을 피동적으로 조절할 수 있는 유체기구이다. 본 연구에서는 볼텍스챔버의 유동특성을 관찰하기 위하여 소규모 실험장치를 구축하고, 이를 이용하여 실험을 수행하였다. 본 연구는 두 단계로 수행되었다. 제1단계 실험에서는 볼텍스챔버의 기하학적 특성이 안전주입탱크의 안전주입수 방출특성에 미치는 영향에 대한 거시적 관점에서의 연구로서. 볼텍스챔버의 기하학적 변수(유입구 및 방출구의 직경)가 안전주입수의 방출과정에서 발생되는 SIT 내의수위 거동, 안전주입수의 방출유량 특성등에 미치는 영향에 대해 중점적으로 고찰하였다 제2단계 실험에서는 1단계 실험에서 관찰된 안전주입탱크의 여러 가지 방출특성과 볼텍스챔버 내부 유동장의 유동특성과의 관련성을 규명하기 위해 PIV (Particle Image Velocimetry)를 이용하여 볼텍스챔버의 기하학적 변수에 따른 유동장 내부의 국소 유속분포를 측정하였다.

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