• Journal of Pharmaceutical Investigation
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• 제17권4호
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• pp.183-188
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• 1987

A new cephalosporin derivative, cefoperazone phthalidyl ester, were synthesized and investigated in terms of dissolution and absorption properties. In comparison with cefoperazone, its phthalidyl ester showed the following characteristics. The mean dissolution time and variance of retention time were more significantly prolonged in simulated intestinal fluid than those in simulated gastric fluid. After a single oral dosing of both cefoperazone and its ester to rabbits, serum concentrations of cefoperazone were measured by bioassay, and the results showed that the ester exhibited much higher and more sustained blood level than the parent drug. The total area under the curve of cefoperazone phthalidyl ester were 10.8 times greater than that of cefoperazone.

• Journal of Korean Biological Nursing Science
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• 제20권3호
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• pp.187-195
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• 2018

Purpose: The purpose of this study was to identify associations among the sleep disturbance, fatigue, job stress, and blood and body fluid (BBF) exposure of shift-work nurses. Methods: A total of 299 shift-work nurses from two tertiary hospitals were enrolled in this study. We used the Insomnia Severity Index (ISI), and the Fatigue Severity Scale (FSS), and the Korean Occupational Stress Scale-Short Form (KOSS-SF) to evaluate sleep disturbance, fatigue, and job stress, respectively. The data were analyzed using t-test or chi-squared test and Logistic regression analysis using the SPSS 23.0 program. Results: We found that 43.8% of participants reported BBF exposure over the past year. Splash or exposure to broken skin of BBF were most frequent (56.9%), and followed by needlestick injuries (30.4%) and sharp injuries (12.8%). Age, hospital, working period, level of stress, sleep disturbance ($ISI{\geq}15$), fatigue (FSS $score{\geq}4$), job demand and organizational climate subset in KOSS-SF were significantly associated with BBF exposure in shift-work nurses. In multivariate analysis after adjusting age and hospital, the risk factors of BBF exposure in shift-work nurses were the level of stress and fatigue (FSS $score{\geq}4$). Conclusion: Fatigue and job stress were related to BBF exposure in shift-work nurses. Our results suggest that management of sleep disturbance, fatigue, and high job stress in shift-work nurses is needed to reduce risk of BBF exposure.

• The Korean Journal of Physiology
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• 제11권1호
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• pp.21-26
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• 1977

Many cases have been reported that a post spinal headache can be relieved immediately by an epidural injection of saline; and autologous blood also has recently been used successfully instead of saline. The changes of the cerebrospinal fluid pressure in 40 cases were observed in the present study in support of the concept; that a continuous leakage in association with hypovolemia and hypotension of the cerebrospinal fluid is the primary cause of a post spinal headache. Subarachnoid pressure increased immediately with saline injection into the lumber epidural space. A spinal needle was inserted into the subarachnoid space at the level of $L2{\sim}3$ and opening pressure of the cerebrospinal fluid was read. An epidural Tuohy needle was insertad at the$L3{\sim}4$ and 25m1 of saline was injected into the epidural space and the cerebrospinal fluid pressure was read in the sitting position. $\underline{Sitting\;Position:}$ Mean pressure after injection $555{\pm}(110.9)mm\;H_2O$, Pressure rise rise (%) 51.3%, Mean opening pressure $366{\pm}(52.2)mm\;H_{2}O$, $\underline{Lateral\;position:}$ Mean pressure after injection $308{\pm}(70.8)mm\;H_{2}O$, Pressure(%) 86.7%, Mean opening pressure $165{\pm}(42.6)mm\;H_{2}O$. These pressure changes responded almost simultaneously as saline was injected. This pressure rise of 51.3% in the sitting position and 86.7% in the lateral position are clinically very significant. Therefore, it is most possible that the immediate relieve of post, spinal headache by injection of fluid into the epidural space is simultaneous with the increase of the cerebrospinal fluid pressure.

• 한국식품영양학회지
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• 제16권1호
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• pp.36-45
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• 2003

It is known as that onion is antioxidation effect, antibiotic effect, blood pressure decreasing effect and reducing serum cholesterol levels. This research about effect that onion concentrate gets blood cholesterol levels and body composition. Subject was 17 adult men of hyperlipidemia. Age distribution of investigation subjects were average 49.4 years old by 40~56 years old, and average height and weight were 167.6cm and 75.5kg each, BMI was 26.9kg/$m^2$, and BMR was 1,460.6$\pm$87.5㎉, and AMC was 25.0$\pm$1.05cm, and BCM was 41.0$\pm$2.79cm. In the meantime, the body muscle was 53.7$\pm$3.7kg, and fat mass was 18.7$\pm$3.8kg, and intracellular fluid was 26.6$\pm$1.8kg, and extracellular fluid was 12.8$\pm$0.9kg. The % body fat was 24.6$\pm$3.8%, and fat distribution was 0.9$\pm$0.0%, and the obesity degree was 125.4$\pm$8.2%. Vegetables, seaweeds, fruits and juices increased by change of dietary life and greasy foods, instants, breads, rices etc. decreased or there was no change, fast foods and eggs were no change. Also, subject previewed that guidance about stress, smoking, drinking and beverage intake need. If compared the nutrient intake amount with before onion concentrate allowance, it was similar level almost without significant. Energy, calcium and riboflavin are lower than the RDA for koreans. After 3 months, the levels of plasma total cholesterol, triglycerides had decreased significantly : 15.0%, 31.2% respectively. And the HDL-cholesterol and LDL-cholesterol levels also showed a marked reduction of 6.8%, 8.7% respectively. Plasma lipid level change by onion concentrate supplement would can know that case of triglyceride more greatly than plasma cholesterol. The pH and Na+ level of plasma were low significant since 8 weeks after, and $K^{+}$ level increase significant. While $Ca^{++}$ level was low significant after 1 month, there was no change since 2 months after, but nC $a^{++}$ level was low significantly. Plasma $Mg^{++}$ level was no change and nM $g^{++}$ level was low significant after intake.e.e.e.e.e.

• 한국수정란이식학회지
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• 제23권1호
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• pp.59-64
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• 2008

The objective of this study is to investigate the changes in concentrations of blood urea nitrogen (BUN) and sex steroid hormones, such as estrogen, progesterone, and testosterone in Korean cattle (Hanwoo) with reproductive disorders and to examine the relationship between BUN and body condition score (BCS) in Hanwoo. The concentration of BUN was 16.2 mg/dl, 17.8 mg/dl, 15.1 mg/dl, 17.9 mg/dl, and 28.3mg/dl in pregnancy, repeat breeding, follicular cyst, luteal cyst, and ovarian atrophy, respectively. In Hanwoo with BCS $2.0{\sim}2.9$, $3.0{\sim}3.5$ and $3.6{\sim}4.0$, the concentration of BUN was 15.8 mg/dl, 17.0 mg/dl, and 17.6 mg/dl, respectively. Fluoroimmunoassay showed that serum estrogen and progesterone levels were decreased in reproductive disorders Hanwoo, such as ovarian atrophy, endometritis, and weak estrus. The testosterone level was significantly decreased in Hanwoo with reproductive disorders compared to that in pregnant Hanwoo ($0.02{\sim}0.03\;ng/ml$ vs 0.13 ng/ml, p<0.05). The progesterone and estrogen concentrations in follicular fluid obtained from ovary with follicular cyst were significantly higher (p<0.05) than those in normal follicle fluid. These results show that there is no relationship between BUN and BCS in Hanwoo, and the concentration of sex steroid hormone in serum and follicular fluid are changed in reproductive disorders Hanwoo.

• The Korean Journal of Physiology and Pharmacology
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• 제20권6호
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• pp.621-628
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• 2016

Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8). The treatment was given via oral gavage for 8 weeks. The results showed that the weekly systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and aortic reactivity function were remarkably improved after 8 weeks of bacterial administration in SHR+LAB. These effects were mostly attributed by restoration of wall tension and tensile stress following the bacterial treatment. Although not statistically significant, the level of malondialdehye (MDA) in SHR+LAB serum was found declining. Increased levels of glutathione (GSH) and nitric oxide (NO) in SHR+LAB serum suggested that the bacterium exerted vascular protection through antioxidative functions and relatively high NO level that induced vasodilation. Collectively, Lb. casei strain C1 is a promising alternative for hypertension improvement.

• 대한관절경학회지
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• 제12권1호
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• pp.63-65
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• 2008

37세 남자의 슬개상 점액낭내 외상성 출혈을 치험하여 보고하고자 한다. 둔탁한 외상 후 슬개상 부종과 통증이 지속되었고, 방사선 사진에서 비정상 소견은 보이지 않았지만, 자기 공명 영상의 시상면 사진상 액체액체층이 있는 고립된 슬개상 낭종이 관찰되었다. 관절경적 검사에서 완전한 격막의 슬개상 추벽이 있었고 슬관절내에 활액막염의 소견은 없었으며 슬개상 추벽을 절제하자 점액낭에 고여있던 혈액이 새어 나왔다. 슬개상 점액낭 내에 색소성 융모 결절성 활액막염이나 다른 종양을 의심할 만한 병변은 없었다. 수술 후 증상은 소실되었고 추시 6개월째 재발은 없었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제21권1호
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• pp.65-68
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• 1999

Multiple facial trauma patient should be carefully treated because of severe bleeding on extraoral and intraoral wound, possibilty of airway obstruction and hypovolemic shock. Hypovolemic shock may be divided to hemorrhagic shock and non-hemorrhagic shock. Also hemorrhagic shock is divided to mild, moderate and severe shock according to the degree of blood volume depletion. Mild shock occurs in blood loss of less than 20% of blood volume and moderate shock does in blood loss of 20-40% of blood volume. And Severe shock occurs in blood loss of more than 40% of blood volume. The goal of emergency care of trauma patient is that respiration and perfusion should be recovered to satisfactory level and that normal vital sign is maintained. We reported the case of multiple facial trauma patient with severe bleeding and hopovolemic shock and metabolic acidosis who was treated with adequate supply of fluid transfusion, intubation, tracheostomy and emergency operation.

• 동의생리병리학회지
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• 제27권5호
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• pp.487-496
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• 2013

This article is a study on to which categories of modern diseases qi deficiency pattern types are assigned by reference to modern clinical papers to analyze and understand modern diseases with the perspective of Korean Medicine. Clinical papers were searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI) from 1994 to 2013. Conclusions are as follows. First, qi deficiency pattern types are roughly classified as qi deficiency pattern, qi-yin dual deficiency pattern and qi deficiency pattern related with viscera and bowels. Second, there are many patterns combined with static blood, qi stagnation, phlegm, dampness, heat, toxin, water or fluid deficiency and the level of pattern designation is more specific than pattern types in Korean Standard Classification of Diseases(KCD), which makes the pattern types more useful to clinical application. Third, static blood due to qi deficiency is the most frequent combined pattern and diseases related with blood circulation such as angina, atherosclerosis, hyperlipidemia and chronic obstructive pulmonary disease(COPD) were reported on that pattern. The detailed relation between modern diseases and pattern types can be an another topic.

• 한국환경농학회지
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• 제33권3호
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• pp.189-193
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• 2014

BACKGROUND: The aim of this study is to investigate the effects of Lycium chinense Miller fruit and its representative constituent betaine on reduction of immobility time and blood parameters in balb/c mice. METHODS AND RESULTS: We investigated the immobility time and the changes in aspects of blood biochemical parameters by the administration of L. chinense Miller fruit and its representative constituent betaine, after the forced swimming test. The immobility time was significantly reduced about 41.3% and 53.6%, respectively, in the animal of L. chinense Miller fruit and its representative constituent betaine-administrated group for 7 days, in comparison with that of the control group. The level of blood urea nitrogen was significantly decreased in L. chinense Miller fruit and its representative constituent betaine-treated group compared with the control group (P < 0.05), respectively. In addition, the interlukin-2 levels of mice in L. chinense Miller fruit and betaine treated group was increased compared with the control group. CONCLUSION: These results indicate that L. chinense Miller fruit and betaine might be helpful in the immune function improvement, enhance physical stamina, and fatigue recovery.