• Applied Biological Chemistry
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• 제40권5호
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• pp.442-446
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• 1997

감도와 재현성이 높은 quinclorac 의 토양중 잔류분석방법 개발을 위해 $CO_2$를 이용한 초임계추출후 4-bromomethyl-7-methoxycoumarin 로 형광유도체화하여 HPLC 상에서 분석하는 방법을 개발하였다. 추출변수로 추출압력과 modifier인 methanol 의 함량을 변화시켜, 100 ppb 처리토양에서 7000 psi $(80^{\circ}C)$, 30% $(methanol/CO_2\;v/v)$) 조건을 이용하여 96% 의 회수율을 얻었다. 18-crown-6-ether 를 촉매로 한 형광유도체 반응은 상온에서 30분이내에 정량적으로 완결되었으며 HPLC-형광분석검출기를 이용하여 토양중 quinclorac의 최소검출 수준을 0.5 ppb까지 낮출 수 있었다. 이 방법은 기존의 방법에 비해 간편하고 감도가 높아 carboxylic acid를 함유한 농약의 잔류분석에 이용될 수 있다고 판단된다.

• 대한토목학회논문집
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• 제41권6호
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• pp.627-635
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• 2021

본 논문은 교량 하부에서 발생된 화재에 대한 강합성 교량 상부구조의 화재손상 및 구조성능평가를 위한 수치해석적 연구이다. 수치해석의 정확성 및 효율성을 높이기 위해 구성재료의 비선형 열적·열역학적 특성이 고려된 유체-구조 연성 화재해석 기법이 제안되고, 각각 ANSYS FLUENT 및 Mechanical solver에 연결되어 해석이 수행된다. 이는, 실제 강합성 교량 화재사고와 비교·검증되며, 검증된 해석기법을 통해 화원에서 교량 하부 플랜지까지 이격거리에 따른 화재별 부재의 온도분포 및 구조성능이 평가된다. 해석결과, 강합성 교량 상부구조의 콘크리트 슬래브 및 강재 거더 하부 플랜지의 경우 실제 화재사고에 대하여 임계온도를 초과하였다. 또한, 화원 이격거리가 13 m 이상일 경우 유조차 화재사고에 대한 강합성 교량 구조물의 화재손상이 안전한 것으로 나타났다.

• Toxicological Research
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• 제26권4호
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• pp.275-283
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• 2010

Placenta transfer study in non-human primate (NHP) is one of the crucial components in the assessment of developmental toxicity because of the similarity between NHP and humans. To establish the method to determine placenta transfer in non-human primate, toxicokinetics of valproic acid (VPA), a drug used to treat epilepsy in pregnant women, were determined in pregnant cynomolgus monkeys. After mating, pregnancy-proven females were daily administered with VPA at dose levels of 0, 20, 60 and 180 mg/kg by oral route during the organogenesis period from gestation day (GD) 20 to 50. Concentrations of VPA and its metabolite, 4-ene-VPA, in maternal plasma on GDs 20 and 50, and concentrations of VPA and 4-ene-VPA in placenta, amniotic fluid and fetus on GD 50 were analyzed using LC/MS/MS. Following single oral administration of VPA to pregnant monkeys, concentrations of VPA and 4-ene-VPA were generally quantifiable in the plasma from all treatment groups up to 4-24 hours post-dose, demonstrating that VPA was absorbed and the monkeys were systemically exposed to VPA and 4-ene-VPA. After repeated administration of VPA to the monkeys, VPA was detected in amniotic fluid, placenta and fetus from all treatment groups, demonstrating that VPA was transferred via placenta and the fetus was exposed to VPA, and the exposures were increased with increasing dose. Concentrations of 4-ene-VPA in amniotic fluid and fetus were below the limit of quantification, but small amount of 4-ene-VPA was detected in placenta. In conclusion, pregnant monkeys were exposed to VPA and 4-ene-VPA after oral administration of VPA at dose levels of 20, 60 and 180 mg/kg during the organogenesis period. VPA was transferred via placenta and the fetus was exposed to VPA with dose-dependent exposure. The metabolite, 4-ene VPA, was not detected in both amniotic fluid and fetus, but small amount of 4-ene-VPA was detected in placenta. These results demonstrated that proper procedures to investigate placenta transfer in NHP, such as mating and diagnosis of pregnancy via examining gestational sac with ultrasonography, collection of amniotic fluid, placenta and fetus after Caesarean section followed by adequate bioanalysis and toxicokinetic analysis, were established in this study using cynomolugus monkeys.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.813-820
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• 2001

The Safety depressurization System(SDS) of KNGR prevents RCS from overpressurization by discharging high pressure and temperature coolant through the I-sparger into the IRWST during an accident. If IRWST water temperature rise locally, around the sparger, beyond $200_{\circ}$2000 F by the discharged coolant, unstable steam condensation can cause large pressure load on the IRWST wall. To investigate whether this condition can be avoided for the design basis event IOPOSRV(Inadvertent Opening of one Pilot Operated Safety Relief Valve), the flow and temperature distribution of water in the IRWST is calculated by using CFX 4.3 computational fluid dynamic code. According to the results, since pool water temperature does not exceeds temperature limit within 50 seconds after the opening of one POSRV, it can be assured that the integrity of IRWST wall is maintained.

• 한국환경과학회지
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• 제19권12호
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• pp.1335-1341
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• 2010

Voltammetric diagnostics of pesticide thiram was studied in plant leafs in vivo fluid with DNA immobilized on a carbon nanotube electrode (DCE). Sensor properties of carbon nanotube (CE) and DNA immobilized nanotube were compared. DCE was more effective than CE in target detecting. The parameters such as pH strength, stripping accumulation, amplitude, and increment potential were examined to find the optimum condition for detection of pesticide thiram in a sesame leaf. The optimized conditions were as follows 550 Hz frequency, 0.15 V amplitude, 0.005 V increment potential, -1.2 V initial potential, 4.78 pH, 500 sec accumulation time. Under optimum condition, the detection limit of thiram was attained at 0.01ng/L.

• 대한기계학회논문집B
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• 제26권6호
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• pp.765-771
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• 2002

This Paper presents numerical solutions of two-dimensional Euler equations for supersonic steady and unsteady flows with heat addition in a convergent-divergent duct, The Van Leer FVS (flux vector splitting) method in generalized coordinates is employed in order to calculate the inviscid strong shock waves caused by thermal choking. We discuss on transient characteristics, start and unstart phenomena caused by thermal choking, limit of equivalence ratio to avoid thermal choking and fluctuation of specific thrust caused by thermal choking. We prove that thermal choking is a serious problem in view of engine performance.

• 대한수학회보
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• 제53권3호
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• pp.843-852
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• 2016

A vortex sheet is susceptible to the Kelvin-Helmhotz instability, which leads to a singularity at finite time. The vortex blob model provided a regularization for the motion of vortex sheets in an inviscid fluid. In this paper, we consider the blob model for viscous vortex sheets and present a linear stability analysis for regularized sheets. We show that the diffusing viscous vortex sheet is unstable to small perturbations, regardless of the regularization, but the viscous sheet in the sharp limit becomes stable, when the regularization is applied. Both the regularization parameter and viscosity damp the growth rate of the sharp viscous vortex sheet for large wavenumbers, but the regularization parameter gives more significant effects than viscosity.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2004년도 동계학술대회 논문집
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• pp.35-35
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• 2004

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2009년도 정보통신설비 학술대회
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• pp.391-394
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• 2009

In this paper, achieved rise temperature distribution about degradation phenomenon of 2 MVA distribution mold transformer using finite element method (FEM). Usually, life of transformer is depended on temperature distribution of specification region than thermal special quality of transformer interior. Specially, life of transformer by decline of dielectric strength decreases rapidly in case rise by strangeness transformer interior hot spot temperature value permits. Because calculating high-voltage winding and low-voltage winding of mold transformer and Joule's loss of core for improvement these life, forecasted heat source, and high-voltage winding and low-voltage winding of mold transformer and rise temperature distribution of core for supply of electric power and temperature distribution of highest point on the basis of the result Also, calculated temperature rise limit of mold transformer and permission maximum temperature using analysis by electron miracle heat source alculate and forecasted rise temperature distribution by heat source of thermal analysis with calculated result.

• 한국전산유체공학회지
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• 제15권3호
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• pp.81-86
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• 2010

In this paper, a three-dimensional numerical study on flow pattern in winter along connecting passageway of a composite building was conducted using a commercial CFD package. The incompressible Navier-Stokes equation coupled was solved by using SIMPLE algorithm in order to find steady solutions. It was shown that a upward flow is generated inside the building in winter due to buoyancy effect and that the air inside connecting passageway flows from the shorter building to the taller one regardless of the slope of the passageway. Further, it was found that the magnitude of air velocity inside connecting passageway increases as the uphill slope to the taller building increases and decreases as the downhill slope to the taller one increases, although the variation in the magnitude of fluid velocity is not substantial. Lastly, it was shown that the maximum air velocity inside connecting passageway is less than the allowable limit for all the cases considered in this study.