• Genomics & Informatics
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• v.14 no.1
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• pp.2-11
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• 2016

The advances in mass spectrometry-based proteomics technologies have enabled the generation of global proteome data from tissue or body fluid samples collected from a broad spectrum of human diseases. Comparative proteomic analysis of global proteome data identifies and prioritizes the proteins showing altered abundances, called differentially expressed proteins (DEPs), in disease samples, compared to control samples. Protein biomarker candidates that can serve as indicators of disease states are then selected as key molecules among these proteins. Recently, it has been addressed that cellular pathways can provide better indications of disease states than individual molecules and also network analysis of the DEPs enables effective identification of cellular pathways altered in disease conditions and key molecules representing the altered cellular pathways. Accordingly, a number of network-based approaches to identify disease-related pathways and representative molecules of such pathways have been developed. In this review, we summarize analytical platforms for network-based protein biomarker discovery and key components in the platforms.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.503-506
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• 2005

In this study, optimization design technique for control of solid-fluid coupled force (sloshing) using evolutionary method is suggested. Artificial neural networks(ANN) and genetic algorithm(GA) is employed as evolutionary optimization method. The ANN is used to analysis of the sloshing and the genetic algorithm is adopted as an optimization algorithm. In the creation of ANN learning data, the design of experiments is adopted to higher performance of the ANN learning using minimum learning data and ALE(Arbitrary Lagrangian Eulerian) numerical method is used to obtain the sloshing analysis results. The proposed optimization technique is applied to the minimization of sloshing of the water in the tank lorry with baffles under 2 second lane change.

• The KSFM Journal of Fluid Machinery
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• v.10 no.3 s.42
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• pp.39-46
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• 2007

This study presents a numerical procedure to optimize the shape of staggered dimple surface to enhance turbulent heat transfer in a rectangular channel. The RBNN method is used as an optimization technique with Reynolds-averaged Navier-Stokes analysis of fluid flow and heat transfer with shear stress transport (SST) turbulence model. The dimple depth-to-dimple print diameter (d/D), channel height-to-dimple print diameter ratio (H/D), and dimple print diameter-to-pitch ratio (D/S) are chosen as design variables. The objective function is defined as a linear combination of heat transfer related term and friction loss related term with a weighting factor. Latin Hypercube Sampling (LHS) is used to determine the training points as a mean of the design of experiment. The optimum shape shows remarkable performance in comparison with a reference shape.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2003.04a
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• pp.403-410
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• 2003

A new semiactive control strategy for seismic response reduction using a neuro-controller and a magnetorheological (MR) fluid damper is proposed. The proposed control system adopts a clipped algorithm which induces the MR damper to generate approximately the desired force. The improved neuro - controller, which was developed by employing the training algorithm based on a cost function and the sensitivity evaluation algorithm replacing an emulator neural network, produces the desired active control force, and then by using the clipped algorithm the appropriate command voltage is selected in order to cause the MR damper to generate the desired control force. The simulation results show that the proposed semiactive neuro-control algorithm is quite effective to reduce seismic responses. In addition, the semi-active control system using MR fluid dampers has many attractive features, such as the bounded-input, bounded-output stability and small energy requirements. The results of this investigation, therefore, indicate that the proposed semi-active neuro-control strategy using MR fluid dampers could be effectively used for control of seismically excited structures.

• 한국전산유체공학회:학술대회논문집
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• 2002.10a
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• pp.71-77
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• 2002

The grid technology is believed to be the next generation research tool for both computational and experimental scientists. With advanced network technologies and middleware, geographically distributed facilities can be tightly connected to provided a huge amount of resources or remote accessibility, In this paper, an overview of grid technology will be introduced with an emphasis in application to computational fluid dynamics. The computational fluid dynamics, which involves solution of partial differential equations, is basically limited by the computing power, With the grid technology, virtually unlimited resources are provided. The schematic structure of middleware and grid environment, as well as some preliminary results are presented.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2003.03a
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• pp.473-480
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• 2003

A new semiactive control strategy for seismic response reduction using a neuro-controller and a magnetorheological (MR) fluid damper is proposed. The proposed control system adopts a clipped algorithm which induces the MR damper to generate approximately the desired force. The improved neuro-controller, which was developed by employing the training algorithm based on a cost function and the sensitivity evaluation algorithm replacing an emulator neural network, produces the desired active control force, and then by using the clipped algorithm the appropriate command voltage is selected in order to cause the MR damper to generate the desired control force. The simulation results show that the proposed semiactive neuro-control algorithm is quite effective to reduce seismic responses. In addition, the semiactive control system using MR fluid dampers has many attractive features, such as bounded-input, bounded-output stability and small energy requirements. The results of this investigation, therefore, indicate that the proposed semiactive neuro-control strategy using MR fluid dampers could be effective used for control seismically excited structures.

• International Journal of Fluid Machinery and Systems
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• v.8 no.4
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• pp.264-273
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• 2015

This presentation describes an experimental approach for the detection of cavitation in hydraulic machines by use of ultrasonic signal analysis. Instead of using the high frequency pulses (typically 1MHz) only for transit time measurement different other signal characteristics are extracted from the individual signals and its correlation function with reference signals in order to gain knowledge of the water conditions. As the pulse repetition rate is high (typically 100Hz), statistical parameters can be extracted of the signals. The idea is to find patterns in the parameters by a classifier that can distinguish between the different water states. This classification scheme has been applied to different cavitation sections: a sphere in a water flow in circular tube at the HSLU in Lucerne, a NACA profile in a cavitation tunnel and two Francis model test turbines all at LMH in Lausanne. From the signal raw data several statistical parameters in the time and frequency domain as well as from the correlation function with reference signals have been determined. As classifiers two methods were used: neural feed forward networks and decision trees. For both classification methods realizations with lowest complexity as possible are of special interest. It is shown that two to three signal characteristics, two from the signal itself and one from the correlation function are in many cases sufficient for the detection capability. The final goal is to combine these results with operating point, vibration, acoustic emission and dynamic pressure information such that a distinction between dangerous and not dangerous cavitation is possible.

• International Journal of Fluid Machinery and Systems
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• v.9 no.4
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• pp.370-381
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• 2016

As a single-channel pump is used for wastewater treatment, this particular pump type can prevent performance reduction or damage caused by foreign substances. However, the design methods for single-channel pumps are different and more difficult than those for general pumps. In this study, a design optimization method to improve the hydrodynamic performance of a single-channel pump impeller is implemented. Numerical analysis was carried out by solving three-dimensional steady-state incompressible Reynolds-averaged Navier-Stokes equations using the shear stress transport turbulence model. As a state-of-the-art impeller design method, two design variables related to controlling the internal cross-sectional flow area of a single-channel pump impeller were selected for optimization. Efficiency was used as the objective function and was numerically assessed at twelve design points selected by Latin hypercube sampling in the design space. An optimization process based on a radial basis neural network model was conducted systematically, and the performance of the optimum model was finally evaluated through an experimental test. Consequently, the optimum model showed improved performance compared with the base model, and the unstable flow components previously observed in the base model were suppressed remarkably well.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.11 no.5
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• pp.94-98
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• 2012

Butterfly valves are usually used by the plumbing systems in plant engineering field. Valves are used for controlling the flow rate and pressure of fluid. In order to control the flow rate using butterfly valve, the position control of valve disc should be designed. However, since there are lots of uncertain disturbance in plumbing system, the robust control system should be considered. Therefore, the sliding mode control system using neural network algorithm is proposed in this paper. The proposed control system provides the estimating method using neural network for the unmeasurable disturbance in the plumbing system. The performance of the proposed control system is evaluated through computer simulations.

• 한국가시화정보학회:학술대회논문집
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• 2004.11a
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• pp.52-55
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• 2004

Thermo-chromic Liquid Crystal(TLC) particles were used as temperature sensor for thermal fluid flow. $1K\times1K$ CCD color camera and Xenon Lamp(500W) were used for the visualization of a Hele-Shaw cell. The characteristic between the reflected colors from the TLC and their corresponding temperature shows strong non-linearity. A neural network known as having strong mapping capability for non-linearity is adopted to quantify the temperature field using the image of the flow. Improvements of color-to-temperature mapping was attained by using the local color luminance (Y) and hue (H) information as the inputs for the constructed neural network.