• 혜화의학회지
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• 제8권1호
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• pp.793-825
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• 1999

For the development of drugs for alzheimer,s disease, the study was done to review the oriental pathology, clinical data, recent trends for research and strategy for future study. The results were as follows: 1. The medical term Chi-dsi implying alzheimer,s disease was referred for the first time in a medical book, Hwatasheneubijeon written by Hwa-Ta and its differentiation and treatment were studied more in Ming or Ching dynasties. Chi-dai can be differentated as weak(虛) syndrome and Shi(實) syndrome. This can be caused by deficiencies of renal Yin, renal Yang, cardiac Yin and hepatic blood, while that by deficiencies of pathological fluid(痰飮) and clotted blood(瘀血). 2. Dementia can be roughly classified as alzheimer's disease and multi-infarct disease. Its causes were known to be cholinergic transmitter, C-peptide, amyloid-${\beta}$, apolipoprotein, APP(amyloid precursor protein), TGF, MMP-9 and free radical. 3. In Korea experimental studies were chiefly done for the elimataion of C-peptide, amyloid-${\beta}$, apolipoprotein, APP for alzheimer's disease, for the development of drug inhibiting degerative change following CVA and loss of memory and also administrative measure was done by support of government. 4. Drugs of dimentia developed so far were Chi-Dai dan, extracts from aloe, mushroom, green tea, Ganoderma and also folic acid, vitamin C, DHEA and silk amino acid were reported to be effective in dimenta. 5. Future strategic research had better be done on dementia-inducing factors such as acetylcholine, C-peptide, amyloid-${\beta}$, apolipoprotein, APP, TGF, MMP-9 and free radical, development of animal model for dimentia, clinical study, epidemiology, nursing and administrative studies and also consortium for dimentia research should be formed so that repeated investment be avoided.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.1951-1956
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• 2004

The transient nature and complex flow geometries of two-phase gas-liquid flows cause fundamental difficulties when measuring flow velocity using an electromagnetic flowmeter. Recently, a current-sensing flowmeter was introduced to obtain measurements with high temporal resolution (Ahn et $al.^{(1)}$). In this study, current-sensing flowmeter theory was applied to measure the fast velocity transients in slug flows. To do this, the velocity fields of axisymmetric gas-liquid slug flow in a vertical pipe were obtained using Volume-of-Fluid (VOF) method and the virtual potential distributions for the electrodes of finite size were also computed using the finite volume method for the simulated slug flow. The output signal prediction for slug flow was carried out from the velocity and virtual potential (or weight function) fields. The flowmeter was numerically calibrated to obtain the cross-sectional liquid mean velocity at an electrode plane from the predicted output signal. Two calibration parameters are required for this procedure: a flow pattern coefficient and a localization parameter. The flow pattern coefficient was defined by the ratio of the liquid resistance between the electrodes for two-phase flow with respect to that for single-phase flow, and the localization parameter was introduced to avoid errors in the flowmeter readings caused by liquid acceleration or deceleration around the electrodes. These parameters were also calculated from the computed velocity and virtual potential fields. The results can be used to obtain the liquid mean velocity from the slug flow signal measured by a current-sensing flowmeter.

• 대한기계학회논문집B
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• 제35권8호
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• pp.861-868
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• 2011

관로를 통과하는 유체의 양을 측정하기 위해 설치된 유량계는 주기적인 교정과 비교측정을 통하여 측정의 정확도와 신뢰성을 확보하고 있다. 이때 사용되는 기준기는 휴대용 즉 센서가 관로의 외벽에 부착되는 건식 초음파유량계이며 사용되는 측정센서의 수량에 따라 1회선, 2회선, 4회선으로 구분된다. 본 연구의 대상은 K-water에서 주로 사용하고 있는 유량계를 선정한 후 직관거리가 충분히 확보된 상태에서 실험대상 유량계가 갖는 고유오차와 유동교란인자인 2중 곡관 후단에서의 직관거리별 오차에 대한 특성실험을 실시하였다. 실험결과를 기준으로 허용오차를 만족하는 센서위치 즉, 관로외부에 부착하는 각도와 곡관 후단으로부터의 이격거리 및 최적의 회선수를 제시하여 유량측정기술 향상을 통한 수처리 공정관리 및 유수율 제고기반을 마련하였다.

• 대한기계학회논문집B
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• 제32권6호
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• pp.446-454
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• 2008

The purpose of this paper is to analyze two-phase flows of the hydrogen recirculation system. Two-phase flow modeling is one of the great challenges in the classical sciences. As with most problems in engineering, the interest in two-phase flow is due to its extreme importance in various industrial applications. In hydrogen recirculation systems of fuel cell, the changes in pressure and temperature affect the phase change of mixture. Therefore, two-phase flow analysis of the hydrogen recirculation system is very important. Two-phase computation fluid dynamics (CFD) calculations, using a commercial CFD package FLUENT 6.2, were employed to calculate the gas-liquid flow. A two-phase flow calculation was conducted to solve continuity, momentum, energy equation for each phase. Then, the mass transfer between water vapor and liquid water was calculated. Through an experiment to measure production of liquid water with change of pressure, the analysis model was verified. The predictions of rate of condensed liquid water with change of pressure were within an average error of about 5%. A comparison of experimental and computed data was found to be in good agreement. The variations of performance, properties, mass fraction and two-phase flow characteristic of mixture with resepct to the fuel cell power were investigated.

• 대한조선학회논문집
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• 제28권2호
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• pp.146-158
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• 1991

2차원 날개 단면 주위의 유동을 레이저 유속계측장치(LDV)를 이용하여 계측하였다. 레이저 유속계측장치는 주위 유동에 영향을 주지 않으면서 물체 주위의 유속을 정밀하게 계측할 수 있는 장비로서 본 논문에서는 2W Ar-Ion 레이져 광선을 이용한 2색 3선형 레이저 시스템을 사용하여 2방향 속도를 동시에 계측하였다. 레이저유속 계측장치를 사용하여 NACA0012 단면 주위의 유동을 계측한 후 난류경계층, 박리현상(Separation) 및 날개 뒷날에서의 유동 현상등에 대한 해석을 수행하였다. 계측된 유동장의 해석 결과를 Head의 운동량 적분법에 의한 계산결과와 비교하였다. 입사각이 작고 레이놀드수가 비교적 큰 경우에는 계측결과에 의한 경계층 특성과 운동량 적분법에 의한 계산결과가 잘 일치함을 보였다. 2차원 날개단면 주위 유동을 정밀 계측하여 수치계산 방법에 의한 결과와의 비교를 위한 유동계측 자료를 확보하였으며 캐비테이션 특징 및 양력특성이 우수한 새로운 날개단면 개발에 응용될 수 있는 2차원 단면시험법을 개발하였다.

• 설비공학논문집
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• 제23권7호
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• pp.528-534
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• 2011

In this paper, thermal characteristics of cylindrical grooved wick heat pipes with water-based MWCNT nanofluids as working medium are experimentally investigated. Volume fractions of nanoparticles are varied with 0.1% to 0.5%. Transient hot wire method developed in house is used to measure the thermal conductivity of nanofluids. It is enhanced by up to 29% compared to that of DI water. The thermal resistances and temperature distributions at the surface of the heat pipes are measured at the same evaporation temperature. The experimental results show that the thermal resistance of the heat pipes with water-based MWCNT nanofluids as working fluid is reduced up to 35.2% compared with that of heat pipe using DI water. The reduction rate of thermal resistance is greater than the enhancement rate of thermal conductivity. Finally, based on the experimental results, we present the reduction of the thermal resistances of the heat pipes compared with conventional heat pipes cannot be explained by only the thermal conductivity of water-based MWCNT nanofluids.

• 드라이브 ㆍ 컨트롤
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• 제12권3호
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• pp.52-59
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• 2015

An electro hydraulic poppet valve (EHPV) and a variable orifice poppet are assembled in a single block, which is referred to as a RHINO but is also generally called a pilot-operated flow control valve. In this study, we analyzed the structure and the operating principle for a RHINO applied in a 21-ton electric excavator system. The RHINO was experimentally tested to measure the dynamic responses and the pressure energy loss. In this test, we investigated the variation in the conductance coefficient according to the increase in the supply pressure under a constant current and a variation in the flow rate according to the increase in the current. Then, the geometrical shapes and the spring stiffness of the RHINO were considered to develop an analysis model. The characteristics (current-force and hysteresis) for the solenoid based on the experimental data were reflected in the analysis model that was developed, and the reliability of the analysis model was also verified by comparing the experimental and analytical results. The developed model is thus considered to be reliable for use in a wide range of applications, including optimum design, sensitivity analysis, parameter tuning, etc.

• 드라이브 ㆍ 컨트롤
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• 제14권4호
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• pp.1-8
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• 2017

The Down-the-Hole hammer is one of the pneumatic drill equipment used for grinding, drilling, and mining. One the advantages of which is that a reduction work efficiency at deep site are relatively small compared to other drilling methods. Due to the large vibration in the underground area, it is difficult to measure the performance of the hammer, and hammer testing requires substantial production cost and operating expenses so research on the development of the hammer is insufficient. Therefore, this study has developed a dynamic simulation model that apprehends the operating principles of an 8-inch DTH hammer and calculates performance data such as performance impact force, piston speed, and BPM. By using the simulation model, design factors related to strike force and BPM were selected, and the influence of each design factors on performance was analyzed through ANOVA analysis. As a result, be the most important for BPM and the strike force are position of upper port that push the piston in the direction of the bit and in BPM, the size of the empty space between the bits and the piston is the second most important design factor.

• Nuclear Engineering and Technology
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• 제42권4호
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• pp.339-364
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• 2010

Following a joint OECD/NEA-IAEA-sponsored meeting to define the current role and future perspectives of the application of Computational Fluid Dynamics (CFD) to nuclear reactor safety problems, three Writing Groups were created, under the auspices of the NEA working group WGAMA, to produce state-of-the-art reports on different aspects of the subject. The work of the second group, WG2, was to document the existing assessment databases for CFD simulation in the context of Nuclear Reactor Safety (NRS) analysis, to gain a measure of the degree of quality and trust in CFD as a numerical analysis tool, and to take initiatives to extend the existing databases. The group worked over the period of 2003-2007 and produced a final state-of-the-art report. The present paper summarises the material gathered during the study, illustrating the points with a few highlights. A total of 22 safety issues were identified for which the application of CFD was considered to potentially bring real benefits in terms of better understanding and increased safety. A list of the existing databases was drawn up and synthesised, both from the nuclear area and from other parallel, non-nuclear, industrial activities. The gaps in the technology base were also identified and discussed. In order to initiate new ways of bringing experimentalists and numerical analysts together, an international workshop -- CFD4NRS (the first in a series) -- was organised, a new blind benchmark activity was set up based on turbulent mixing in T-junctions, and a Wiki-type web portal was created to offer online access to the material put together by the group giving the reader the opportunity to update and extend the contents to keep the information source topical and dynamic.

• 에너지공학
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• 제27권4호
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• pp.70-79
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• 2018

한국중부발전 제주화력본부에서 방류되는 온배수로부터 열원을 회수하여 약 3 km의 원거리에 위치하고 있는 신촌백합영농조합법인의 시설온실에 냉온수를 공급하기 위한 300 RT 용량의 열펌프 시스템을 구축하였다. 원거리 시설로 온배수열을 공급하기 위한 최적화 방안을 도출하였고, 수송관로의 온도와 누수여부를 모니터링하기 위한 설비들이 설치되었다. 본 논문에서는 제주 시설온실 냉난방을 위한 발전소 온배수 활용 열펌프 시스템의 구성과 주요기기에 대해 기술하였다. 2018년 하절기에 열펌프 시스템의 냉방성능을 평가하기 위한 실증운전을 수행하였다. 냉방운전 시 열펌프 시스템의 주요 위치에서 측정된 유체의 온도와 유량, 그리고 냉방 성능계수를 분석하여, 구축된 열펌프 시스템의 안정성과 냉방성능을 검증하였다.