• Development and Reproduction
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• v.17 no.3
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• pp.289-297
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• 2013

Bisphenol A (BPA) is an estrogenic endocrine disrupter. However, depending on a way of treatment, the harmful effects of BPA have not been confirmed. Also, trans-generational effects of BPA on male reproduction are still controversial. Because the reabsorption of testicular fluid in the efferent ductules (ED) and initial segment (IS) is important for sperm maturation, the present study was designed to determine trans-generational effect of BPA administrated orally on expression of water transport-related molecules in the mouse ED and IS. Ethanol-dissolved BPA was diluted in water to be 100 ng (low), $10{\mu}g$ (medium), and $1mg/m{\ell}$ water (high). BPA-containing water was provided for two generations. Expression of ion transporters and water channels in the ED and IS were measured by relative real-time PCR analysis. In the ED, BPA treatment caused expressional increases of carbonic anhydrase II, cystic fibrosis transmembrane regulator, $Na^+/K^+$ ATPase ${\alpha}1$ subunit, and aquaporin (AQP) 1. No change of $Na^+/H^+$ exchange (NHE) 3 expression was detected. BPA treatment at medium dose resulted in an increase of AQP9 expression. In the IS, the highest expressional levels of all molecules tested were observed in medium-dose BPA treatment. Generally, high-dose BPA treatment resulted in a decrease or no change of gene expression. Fluctuation of NHE3 gene expression by BPA treatment at different concentrations was detected. These findings suggest that trans-generational exposure to BPA, even at low dose, could affect gene expression of water-transport related molecules. However, such effects of BPA would be differentially occurred in the ED and IS.

• Journal of the Korean Society of Safety
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• v.14 no.3
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• pp.101-109
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• 1999

This study attempts to analyse the solid mixing in the feeder and the packing effect for pressure fluctuations in the fluidized bed. To study the mixing characteristics of solid in vibrating feeder for the stable operations of fluidized combustion, the system consisted of two groups of particles such that fine particles were located on the top of the coarse particles before vibratory mixing had started. The effects of packing materials on the pressure fluctuations in a fluidized bed were analysed by using a statistical method to interpret the behavior of fluidized bed. The experiments were carried out in a fluidized bed of 6.7cm-ID, and the experimental variables were particle sizes, of 115 to 1,015$\mu\textrm{m}$ in diameter and the multi-sized particles haying Rosin-Rammler and Gaussian distributions. The settled bed heights of particles to diameter ratios (L/D) were ranged from 0.5 to 2.0. And fluidizing of particles was carried out by air. The packing materials used were screen packing, and the properties of the pressure fluctuations in the fluidized bed were measured by a differential pressure transducer. The properties of the pressure fluctuations calculated were the mean, the standard deviation, and the major frequency of the power spectral density functions. From the characteristics of fluidizing, it was found that the standard deviation of pressure fluctuations could be effectively used to explain the fluidized phenomena, and the packing materials affected severely the properties of the pressure fluctuations. As a result, from the interpretation by spectral analysis, the effects of measuring radius of pressure fluctuations on standard deviation were constant in the case of the fluidized bed with and without packing materials. However, the effects of measuring the height of pressure fluctuations on standard deviations were linear increasing for the fluidized bed with packing materials, but were constant for the fluidized bed without packing materials at 4.5cm above the gas distributor. The major frequency of pressure fluctuations was found to be nearly independent of fluidized system. Also, the major frequency of pressure fluctuations decreased with increasing packing size, and it had maximum value at 10% of the packing amount.

• Journal of the Korean association of regional geographers
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• v.18 no.4
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• pp.414-432
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• 2012

Land price is a kind of text to read urban spatial structure. The purpose of this paper is to inquire into the characteristics of Daegu's urban structure and its change in time through exploring spatio-temporal variations of land price with a detailed spatial and temporal resolution. To achieve this, land value surfaces were represented using the officially assessed land price every other year from 1995 to 2011. Through mapping and exploring spatio-temporal patterns and fluctuation rates of land price for this period, changes in urban structure, the effects of local decision makings such as Greenbelt adjustment, housing site development, and gentrification, and the effects of business fluctuations or policies at global or national scales could be caught. In addition, the trends for suburbanization and multi-centric urban form could be examined from the results of a negative exponential model explaining the effect of distance from an urban center on spatial variation of land price. These results demonstrate that urban analysis using land price mirroring spatial decision making at various scales could deepen understanding for internal structure and change of a city and provide useful information for establishing regional and urban development policies and evaluating their effects.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.12
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• pp.1035-1044
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• 2013

Because of the high specific stiffness and strength inherent in the sandwich structure composed of facesheet that resists in-plane loads and a core that resists out-of-plane loads, it is often used for large and light-weighted structures. However, inevitably the increased flexibility allows greater deformation-based disturbances in the structures. Thus, it is necessary to analyze the structural safety. To obtain more accurate analytical results, the input disturbances must more closely simulate real load conditions; to improve accuracy, non-linear elements such as gust effects were considered. In addition, the structural safety was analyzed for the iso-grid sandwich panel structure using fluid-structure interactions. For a more realistic simulation, flow velocity fields, which consider the effects of irregular gust fluctuation, were generated and the coupled field was analyzed by mapping the pressure and displacement.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.1
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• pp.47-52
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• 2003

The prostate gland contains numerous neuroendocrine cells that are believed to influence the function of the prostate gland. Our recent study demonstrated the expression of both ${\alpha}1$- and ${\alpha}2$-ARs, signaling the release of stored $Ca^{2+}$ and the inhibition of N-type $Ca^{2+}$ channels, respectively, in rat prostate neuroendocrine cells (RPNECs). In this study, the effects of NA on the resting membrane potential (RMP) of RPNECs were investigated using a whole-cell patch clamp method. Fresh RPNECs were dissociated from the ventral lobe of rat prostate and identified from its characteristic shape; round or oval shape with dark cytoplasm. Under zero-current clamp conditions with KCl pipette solution, the resting membrane potential (RMP) of RPNECs was between -35 mV and -85 mV. In those RPNECs with relatively hyperpolarized RMP (＜-60 mV), the application of noradrenaline (NA, $1{\mu}M$) depolarized the membrane to around -40 mV. In contrast, the RPNECs with relatively depolarized RMP (＞-45 mV) showed a transient hyperpolarization and subsequent fluctuation at around -40 mV on application of NA. Under voltage clamp conditions (holding voltage, -40 mV) with CsCl pipette solution, NA evoked a slight inward current (＜-20 pA). NA induced a sharp increase of cytosolic $Ca^{2+}$ concentration ($[Ca^{2+}]_c$), measured by the fura-2 fluorescence, and the voltage clamp study showed the presence of charybdotoxin-sensitive $Ca^{2+}$-activated $K^+$ currents. In summary, adrenergic stimulation induced either depolarization or hyperpolarization of RPNECs, depending on the initial level of RMP. The inward current evoked by NA and the $Ca^{2+}$-activated $K^+$ current might partly explain the depolarization and hyperpolarization, respectively.

• Structural Engineering and Mechanics
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• v.52 no.3
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• pp.485-505
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• 2014

This study aimed to develop an approach to accurately predict the wind models and wind effects of large wind turbines. The wind-induced vibration characteristics of a 5 MW tower-blade coupled wind turbine system have been investigated in this paper. First, the blade-tower integration model was established, which included blades, nacelle, tower and the base of the wind turbine system. The harmonic superposition method and modified blade element momentum theory were then applied to simulate the fluctuating wind field for the rotor blades and tower. Finally, wind-induced responses and equivalent static wind loads (ESWL) of the system were studied based on the modified consistent coupling method, which took into account coupling effects of resonant modes, cross terms of resonant and background responses. Furthermore, useful suggestions were proposed to instruct the wind resistance design of large wind turbines. Based on obtained results, it is shown from the obtained results that wind-induced responses and ESWL were characterized with complicated modal responses, multi-mode coupling effects, and multiple equivalent objectives. Compared with the background component, the resonant component made more contribution to wind-induced responses and equivalent static wind loads at the middle-upper part of the tower and blades, and cross terms between background and resonant components affected the total fluctuation responses, while the background responses were similar with the resonant responses at the bottom of tower.

• 한국연소학회:학술대회논문집
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• 2006.10a
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• pp.86-94
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• 2006

This paper investigates the effects of acoustic forcing on NOx emissions and mixing process in the near field region of turbulent hydrogen nonpremixed flames. The resonance frequency was selected to force the coaxial air jet acoustically, because the resonance frequency is effective to amplify the forcing amplitude and reduce NOx emissions. When the resonance frequency is acoustically excited, a streamwise vortex is formed in the mixing layer between the coaxial air jet and coflowing air. As the vortex develops downstream, it entrains both ambient air and combustion products into the coaxial air jet to mix well. In addition, the strong vortex pulls the flame surface toward the coaxial air jet, causing intense chemical reaction. Acoustic excitation also causes velocity fluctuations of coaxial air jet as well as fuel jet but, the maximum value of centerline fuel velocity fluctuation occurs at the different phases of $\Phi$=$180^{\circ}$ for nonreacting case and $\Phi$=$0^{\circ}$ for reacting case. Since acoustic excitation enhances the mixing rate of fuel and air, the line of the stoichiometric mixture fraction becomes narrow. Finally, acoustic forcing at the resonance frequency reduces the normalized flame length by 15 % and EINOx by 25 %, compared to the flame without acoustic excitation.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.2
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• pp.259-266
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• 2009

An experimental study was conducted to investigate the effects of forcing amplitude on the flow structure near the nozzle exit of forced jet diffusion flames. The jet was excited up to the blowout occurrence by a considerable large amplitude with a periodic velocity fluctuation at the tube resonating frequency. In the attached flame regime, we disclosed the very interesting result newly that adding of a moderate forcing amplitude caused the jet flame to become longer in spite of being forced. Particular attention is focused on the turnabout mechanism of vortex roll-up around the elongated flame, which has not been reported previously, and on the inner coherent structure of the forced jet in the attached flame regime. From the velocity and flow visualization results, it was ascertained that the surrounding air due to the occurrence of negative velocity parts was suck into the fuel nozzle. To aid in understanding the rotating phenomenon of coherent structure, we present a schematic diagram of the turnabout mechanism of vortex roll-up. The mechanism of vortex turnabout phenomenon can be easily understood by considering the positive and negative velocity amplitudes about the instantaneous velocity of the forcing flow, as shown in this diagram.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.4
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• pp.314-339
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• 1982

Fluctuating climate is still most important environmental constrain, although improved modem agricultural technology has succeeded to increase crop production in the world. To stabilize the food production under fluctuating weather conditions, it is very needed to obain the quantitative information of interactions between crops and climate. The main purpose of this paper is three hold. Using the JIBP-data, the dry matter accumulation of rice crops is studied in relation to weather indexes (\SigmaTa and \SigmaSt). Temperature dependence of the yield index of rice is analyzed as to air temperature and water temperature. \SigmaT$_{10}$ -fluctuations are studied using meteorological data at various stations. The possible shift of \SigmaT$_{10}$ -isopleths due to climate fluctuation is evaluated. The second interest is in the plant climate of rice crops. Using results of canopy photosynthesis, it is pointed that the canopy structure has most important implication in plant climate. Leaf-air, stomatal, and mesophyll resistances of rice crops are described in relation to weather conditions. The change in light condition and aerodynamical property of rice crops with the growth is illustrated. The energy partition is also studied at different growing stages. Third point is to show in more detail effective countermeasures against cold irrigation water and cool summer. Heat balance of warming pond and polyethylene tube as a heat exchanger is studied to make nomo-grams for evaluating the necessary area and necessary length. Effects of windbreak net on rice crops are illustrated by using experimental and simulation results.lts.

• Journal of Environmental Science International
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• v.4 no.2
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• pp.181-194
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• 1995

Flocculation kinetics using ferric nitrate as a coagulant to coagulate kaolin clay in water was examined as a tool to investigate the effect of low temperature under tightly controlled treatment conditions. Both the particle size distribution data obtained from Automatic Image Analysis (AIA) system and the on-line measurement of the degree of turbidity fluctuation in a flowing suspension by Photometric Dispersion Analyzer (PDA) were used to measure flocculation kinetics. Results show that cold water temperature had a pronounced detrimental effect on flocculation kinetics. For improving flocculation kinetics at low water temperature, maintaining constant pOH to adjust water chemistry for temperature changes was found to be partially effective only in the more acidic pH range studied.