• Journal of Biomedical Engineering Research
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• v.43 no.1
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• pp.35-44
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• 2022

Immersed boundary-Lattice Boltzmann Method (IB-LBM) is used for the analysis of flow over the circular cylinder in the concept of fluid-structure interaction analysis (FSI). Recently, IB-LBM has shown the enormous possibility for the application of various biomedical engineering fields, such as the movement of a human body or the behavior of the blood cells and/or particle-based drug delivery system in blood vessels. In order for the numerical analysis of the interaction between fluid and solid object, immersed boundary method and lattice Boltzmann method are coupled to analyze the flow over a cylinder for low Reynolds laminar flow (Re=10, 20, 40 and 100) with Zhu-He boundary condition at the boundary. With the developed IB-LBM, the flow around the cylinder in the uniform flow is analyzed for the laminar flow and the drag and lift coefficients and recirculation length are compared to the previous results.

• Journal of Environmental Impact Assessment
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• v.17 no.4
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• pp.243-253
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• 2008

The purpose of this study was to simulate the reduction effect of soil loss in the Yongdam reservoir watershed using SWAT model. To evaluate accuracy for flow and sediment yield of SWAT model, calibration was performed for the period from Jan. 2002 to Dec. 2003, and the verification for Jan. 2005 to Dec. 2005. The calibration and the verification were carried out using data observed at the Cheoncheon gaging station. The $R^2$ and EI values in terms of a flow were 0.8 and 0.78 respectively for calibration, whereas they for verification were 0.88 and 0.86 respectively. In terms of a sediment yield, they were 0.7 and 0.48 respectively for calibration, whereas for verification were 0.64 and 0.54 respectively. As a results from model simulation, annual mean soil loss rates in terms of forest, paddy and upland were 0.02 ton/ha/yr, 0.15 ton/ha/yr and 7.58 ton/ha/yr, respectively. The results show that the land use type of a upland has more significant impact on a total soil loss as well as a sediment yield than other types of land use. The sediment delivery ratio was determined to be about 0.35. In this study 2 land cover change scenarios for upland area were considered. These scenarios were used an input to SWAT model in order to evaluate their impact on soil loss and sediment delivery. The results show that a reduction of the upland area would reduce the soil loss and sediment yield.

• Journal of Pharmaceutical Investigation
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• v.40 no.1
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• pp.23-31
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• 2010

In our previous work on levodopa delivery at pH 2.5 using iontophoresis, we found that cathodal delivery showed higher permeation than anodal delivery and electroosmosis plays more dominant role than electrorepulsion. In this work, we studied the transdermal transport of levodopa at very low pH (pH=1.0) where all levodopa molecules are cations, and evaluated some factors which affect the transdermal transport. The transport study at pH 2.5 was also conducted for comparison. The contribution of electrorepulsion and electroosmosis on flux was also evaluated. Using stable aqueous solution, the effect of electrode polarity, current density, current type and drug concentration on transport through skin were studied and the results were compared. We also investigated the iontophoretic flux from hydroxypropyl cellulose (HPC) hydrogel containing levodopa. In vitro flux study was performed at $33^{\circ}C$, using side-by-side diffusion cell. Full thickness hairless mouse skin were used. Current densities applied were 0.2, 0.4 or $0.6\;mA/cm^2$. Contrary to the pH 2.5 result, anodal delivery showed higher flux, indicating that electrorepulsion is the dominant force for the transport, overcoming the electroosmotic flow which is acting against the direction of electrorepulsion. Cumulative amount of levodopa transported was increased as the current density or drug concentration was increased. When amount of current dose was constant, continuous current was more beneficial than pulsed current in promoting levodopa permeation. Similar transport results were obtained when hydrogel was used as the donor phase. These results indicate that iontophoretic delivery of zwitterion such as levodopa is much complicated than that can be expected from small ionic molecules. The results also indicate that, only at very low pH like pH 1.0, electrorepulsion can be the dominant force over the electroosmosis in the levodopa transport.

• Journal of Intelligence and Information Systems
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• v.13 no.1
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• pp.49-58
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• 2007

MDPDPTW (Multi-Depot Pickup and Delivery Problem with Time Windows) is a typical model among the optimization models based on the pickup and delivery flow in supply chains. It is based on multi-vehicles in multi-depots and does not consider moving vehicles near pickup and delivery locations. In ubiquitous environments, it is possible to obtain information on moving vehicles and their baggage. Providing the proper context from the perspective of moving vehicles and their baggage allows for more effective vehicle routings. This study proposes Integer Programming-based MDPDPTW including the information on moving vehicles and their baggage in a ubiquitous environment: u-MDPDPTW, and shows the viability and effectiveness of u-MDPDPTW through comparative experiments of MDPDPTW and u-MDPDPTW.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.383-386
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• 2002

This paper reports on the fluid flow simulation results of an active microvalve. The mechanical and fluidic analysis are done by finite element method. The designed structure is normally closed microvalve using buckling effect, which is consist of three separate structures; a valve seat die, an actuator die and a small piezoelectric actuator. It is confirmed that the complete laminar flow and the lowest flow leakage are strongly depend on the valve seat geometry. In addition, turbulent flow was occurs in valve outlet according to increase seat dimension, height and inlet pressure. From this, we was deducts the optimum geometry of the valve seat and diaphragm deflection that have an great influence fluid flow in microvalve. Thus, it is expected that our simulation results would be apply for constructing integrated chemical analyzing system or drug delivery system.

• International Journal of Fluid Machinery and Systems
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• v.9 no.1
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• pp.1-16
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• 2016

Behaviors of surges appearing near the stall stagnation boundaries in various fashions in systems of a single-stage compressor and flow-path systems were studied analytically and were tried to put to order. Deep surges, which enclose the stall point in the pressure-mass flow plane, tend to have either near-resonant surge frequencies or subharmonic ones. The subharmonic surge is a multiple-loop one containing, for example, in a (1/2) subharmonic one, a deep surge loop and a mild surge loop, the latter of which does not enclose the stall point, staying only within the stalled zone. Both loops have nearly equal time periods, respectively, resulting in a (1/2) subharmonic surge frequency as a whole. The subharmonic surges are found to appear in a narrow zone neighboring the stall stagnation boundary. In other words, they tend to appear in the final stage of the stall stagnation process. It should be emphasized further that the stall stagnation initiates fundamentally at the situation where a volume-modified reduced resonant-surge frequency becomes coincident with that for the stagnation boundary conditions, where the reduced frequency is defined by the acoustical resonance frequency in the flow-path system, the delivery flow-path length and the compressor tip speed, modified by the sectional area ratio and the effect of the stalling pressure ratio. The real surge frequency turns from the resonant frequency to either near-resonant one or subharmonic one, and finally to stagnation condition, for the large-amplitude conditions, caused by the non-linear self-excitation mechanism of the surge.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.7
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• pp.2354-2370
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• 2015

The advantages of employing SCTP-based Concurrent Multipath Transfer (CMT) have been demonstrated to be very useful for data delivery over multi-homed wireless networks. However, there is still significant ongoing work addressing some remaining limitations and challenges. The most important concern when applying CMT to data delivery is related to handling packet reordering and buffer blocking. Another concern on this topic is that current sender-based CMT solutions seldom consider balancing the overhead and sharing the load between the sender and receiver. This paper proposes a novel Receiver-driven Cooperation-based Concurrent Multipath Transfer solution (CMT-Rev) with the following aims: (i) to balance overhead and share load between the sender and receiver, by moving some functions including congestion and flow control from the sender onto receiver; (ii) to mitigate the data reordering and buffer blocking problems, by using an adaptive receiver-cooperative path aggregation model, (iii) to adaptively transmit packets over multiple paths according to their receiver-inspired sending rate values, by employing a new receiver-aware data distribution scheduler. Simulation results show that CMT-Rev outperforms the existing CMT solutions in terms of data delivery performance.

• Journal of Pharmaceutical Investigation
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• v.23 no.3
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• pp.19-30
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• 1993

The influence of emulsion type of tegafur, an oral anticancer agent, on lymphatic transport was studied in rats. The water-in-oil-type of emulsion and the oil-in-water-type emulsion of tegafur each in 50 mg, calculated in terms of tegafur, were prepared by adding tegafur aqueous solution to sesame oil containing hydrogenated castor oil following ultrasonic treatment, and then the prepared emulsions and aqueous solution as a comparative formulation were administered orally to rats (50 mg/5 ml/kg). The concentration levels of tegafur in plasma of femoral artery and lymph from thoracic duct cannula were measured simultaneously along a time course after administration and the pharmacokinetic parameters were investigated. At the same time, we examined the above described factors of 5-FU which is known as an active metabolite of tegafur. In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in w/o-emulsion but significantly decreased in o/w-emulsion. Lymph flow rates were similar in both solution and w/o-emulsion but half in o/w-emulsion. Ratios between area under the lymph and plasma concentration time curves were always less than 1 reflecting the passive lymphatic delivery after oral administration of the prepared tegafur emulsions, but those to the 5-FU in the case of w/o-emulsion were more than 1. These results suggested that lymphatic delivery of tegafur by w/o-emulsion was more effective than that by o/w-emulsion due to its differences of formation ability of chylomicrons.

• Journal of Pharmaceutical Investigation
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• v.31 no.3
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• pp.181-184
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• 2001

The purpose of this study was to develop transdermal drug delivery system (TDDS) for the combination of physostigmine and procyclidine. The effects of various pressure sensitive adhesives (PSA) on the percutaneous absorption of procyclidine across hairless mouse skin were evaluated to select an appropriate PSA. In addition, the influences of various vehicles on the percutaneous absorption of procyclidine from PSA matrix across hairless mouse skin were evaluated using flow-through diffusion cell system at $37^{\circ}C$. Physostigmine did not have any influence on the permeation rate of procyclidine. The flux of procyclidine was the highest in silicone and PIB and was relatively lower in SIS, Acryl, and SBS adhesive matrices, however, their use was limited by the crystallization of the drug in the matrix. Among acrylic adhesives, the permeability of procyclidine was the highest from poly (ethylene oxide) grafted acrylic adhesive. Some enhancers show different enhancing effect depending on the drug, however, many of the tested enhancers showed enhancing effect for the permeation of both procyclidine and physostigmine to some extent. $Crovol^{\circledR}$ EP 40 showed the highest enhancing effect on the permeation of both compounds. The size of TDDS to provide required permeation rate was estimated to be $35\;cm^2$ based on available information.

• Journal of the Korea Safety Management & Science
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• v.17 no.4
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• pp.247-258
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• 2015

The purpose of this study is to let the entire logistics system be managed in cyberspace by effectively sharing the logistics information between companies involved in the process, changing conventional commerce to electronic commerce. Most of the goods traded through electronic commerce are small goods involving small business transactions. This produces many problems in shipping and delivery and the leads an inefficient logistics system. Another problems is that there is no sharing of information that process the logistics flow and no systematic management of pick-up and delivery information. As a result, rise in logistics cost, longer delivery period and poor service quality are inevitable and these results are becoming an obstacle in the widespread usage of the electronic commerce. Companies that are part of logistics center can cooperate logistics business in Cyber space and share the entire logistics information through the cyber logistics center. This turns out in effective sharing of logistics information, and thus, allows efficient management of logistics, improves logistics service, and reduces logistics cost.