• The Korean Journal of Pain
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• v.34 no.4
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• pp.427-436
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• 2021

Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient's hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.

• Journal of the Korean Institute of Gas
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• v.25 no.4
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• pp.36-42
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• 2021

When the landfill gas generated at the landfill site is released into the atmosphere, methane gas with a high global warming potential is emitted, which adversely affects climate change. When methane contained in landfill gas is used as fuel for internal combustion engines and burned to generate electricity, it is emitted into the atmosphere in the form of carbon dioxide, which can contribute to lowering the global warming potential. Therefore, in order to use the landfill gas as fuel for power generation using an internal combustion engine, it is important to increase the thermal efficiency of the engine. Thus, it is necessary to use a fuel supply system in which gas is injected using an electronically controlled injector at an intake port for each cylinder rather than a fuel supply technology using the conventional mixer technology. In order to use the electronically controlled gas injection method, it is important to accurately measure the mass flow rate according to the conditions of using landfill gas. For this, a study was conducted to measure the injection amount and calculate them in order for the intake port gas injection of landfill gas.

• Ocean and Polar Research
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• v.43 no.4
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• pp.279-293
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• 2021

To investigate the effect of seasonal marine environment conditions on the cyanobacteria abundance and diversity in the South Sea, four-seasonal surveys were conducted along the 127.5°E survey transect line in the central South Sea using flow cytometry and 16S-23S ITS on the Miseq platform from August 2016 to May 2017. The average abundance of Synechococcus varied from 3.3 × 10³ to 7.4 × 10⁴ cells ml^-1. The abundance was the highest in the summer and the lowest in the winter, and the abundance fluctuated according to water temperature. The abundance was high in the outer sea affected by TWC. However, in summer, the Coastal areas affected by the Yangtze River were more populated than the outer sea. Prochlorococcus was rare and could not penetrate into coastal areas due to the fronts, but showed its dominance in the waters influenced by the TWC. Synechococcus clades II, VII, IX, CRD1, and CRD2 were predominant in the outer sea area affected by the TWC. In the coastal area, clades I and IV showed higher dominance whereas clades V, VI, WPC1, and 5.3-MS3 with euryhaline characteristics, showed a high dominance rate in the water masses affected by the low-salinity water of the Yangtze River in the summer. Clade XVI, XVII, CB1, CB5, and 5.3-I/II showed high dominance in nutrient-rich waters in the summer with increased water temperature. The abundance and community composition of cyanobacteria changed in the South Sea due to the influence of the TWC and stratification. In the summer, the abundance and the community composition differed, and were mainly affected by the general influence of the TWC in addition to the influence of the Yangtze River low-salinity water.

• Ecology and Resilient Infrastructure
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• v.8 no.4
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• pp.165-178
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• 2021

We studied driftwood behaviors including generation and deposition in a tsunami using a numerical simulation. We used an integrated two-dimensional numerical model, which included a driftwood dynamics model. The study area was Sendai, Japan. Observation data collected by Inagaki et al. (2012) were used to verify the simulation results by comparing them with driftwood deposition patterns. A simplified model was developed to consider the threshold of driftwood generation by the drag force of water flows. To consider the volume of driftwood generated, we estimated the total wood number in the study area using Google Earth. Therefore, we simulated more than 13,000 pieces of driftwood that were generated and transported inland from approximately 300,000 trees that were growing in the forest. The final distribution of the driftwood was similar to the observation data. The reproducibility of the generation and deposition patterns of driftwood showed good agreement in terms of longitudinal deposition pattern. In the future, a sensitivity analysis on driftwood parameters, such as the size of the wood, boundary conditions, and grid size, will be implemented to predict the travel patterns of driftwood. Such modeling will be a useful methodology for disaster prediction based on water flow and driftwood.

• Journal of Korean Society of Disaster and Security
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• v.12 no.2
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• pp.47-56
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• 2019

Recently, in order to overcome the difficulty of entering a fire source due to the occurrence of a large amount of smoke in the event of a fire in a parking lot, it has used that a method of discharge smoke using air supply, exhaust fans and jet fans installed for ventilation of parking lots. In this study, the variation of flow in the smoke layer was observed using CCTV under two conditions, in which only the air supply fan operates and the manned fan operates together, and the temperature around the plume was compared to Albert eq. to assess its suitability as a parking lot ventilation performance evaluation method. As a result, it was found that the smoke layer could be disturbed if the Jet Fan was operated at the same time, which could lead to the possibility of an initial evacuation disturbance. However, the additional operation of the Jet Fan has been confirmed by the observation CCTV that the emission performance is improved, which is believed to help conduct the suppression operation. The temperature around the plume was measured and compared to Alpert eq, and was analyzed to be about $2^{\circ}C$ lower at the center axis of the plume and $9.0^{\circ}C$ higher at 8 m in the direction of the discharge of smoke. The results of temperature measurements around the plume were lower than the maximum temperature expected in AS 4391 and did not exceed the expected temperature risk caused by the experiment. As with these results, the temperature risk from the progression of hot smoke tests is foreseeable, so it will be available as one of the general evaluation methods for assessing smoke control performance in a parking lot without relevant criteria.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.456-463
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• 2019

Micro climatic conditions within the livestock facility are affected by various factors such as ventilation, cooling, heating, insulation and latent and sensible heat generation from animals. In this study, numerical BES method was used to simulate energy flow inside the poultry house. Based on the BES method and THI concept, degree of thermal stress of poultry was evaluated according to the locations in South Korea. Comparison of THI values within the poultry house was also carried out according to the stocking densities to reflect recent animal-welfare issue. Significant decrease in thermal stress of poultry was observed when the stocking density of $30kg/m^2$ was applied in the change of the seasons(p<0.05) however, there was no statistically significant difference in summer season(p>0.05). It meant that installation of proper cooling system is urgently needed. For Iksan city of Jeollabuk-do province, total 252 hours of profit for thermal stress was found according to decrease in the stocking density.

• Journal of Life Science
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• v.28 no.11
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• pp.1321-1331
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• 2018

The aim of this study was to separate the photosensitizer that induces apoptosis of U937 and SK-HEP-1 cells from Nostoc commune. Dried N. commune was extracted with $CH_2Cl_2/MeOH$ (1:1) to separate the photosensitizer using various chromatographic techniques. The isolated compound was identified as pheophytin a ($C_{55}H_{74}N_4O_5$) with a molecular weight of 870. Its photodynamic activities were assessed under different irradiation conditions (light and non-light) at the same concentration range of $1.15-23.0{\mu}M$. The apoptosis inducing activity in U937 or SK-HEP-1 cells appeared only in the light. The mechanisms underlying the pheophytin a-mediated photodynamic inhibition of cancer cells were further investigated by examining cell morphology changes, cytotoxicity, caspase-3/7 activity, fluorescence staining, flow cytometry analysis, and DNA fragmentation in these two cell lines. The positive control and the light irradiation group showed typical apoptotic responses, including morphological changes, cytotoxicity, caspase activity, nucleus shrinkage owing to chromatin condensation, DNA laddering, and the presence of apoptotic bodies. Cytotoxicity markedly increased in a dose-dependent manner after a 12 hr exposure. Caspase-3/7 activity was higher in U937 cells than in SK-HEP-1 cells. Apoptosis induction therefore appeared to be both concentration- and light-dependent. In conclusion, pheophytin a, isolated from the blue green alga N. commune, had a photodynamic apoptosis-inducing effect on U937 and SK-HEP-1 cells. The findings reported here can be used as basic data for the development of next-generation photosensitizers from N. commune.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.6
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• pp.133-143
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• 2018

Roundabouts are generally installed at which traffic and pedestrian volume is relatively small intersections, and hence traffic can flow one direction around a circular island without traffic lights. A number of researches for roundabout signal metering have been processing ways to deal with operation efficiency drops in conditions of unusual traffic and pedestrian volume increases. However, there is still a shortcoming exists in previous operation algorithm does not consider the hidden vehicles between yield lines and detectors and queueing vehicles in circular lanes. These queueing vehicles between them can be cleared by introducing the queue clearance time. The purpose of this research is developing a real time signal metering operation algorithm by considering the vehicle queue clearance time. The results of varying queue clearance time application show that there is a substantial average vehicle delay reduction in VISSIM Com-Interface simulation. When the total number of entering vehicle is 3,200~4,800 vehicle/hour with varying queue clearance time application 21~50 seconds gives average delay reduction per vehicle by 16.1~71.7%.

• Journal of agriculture & life science
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• v.52 no.6
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• pp.1-12
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• 2018

This study was conducted to analyze the openness of erosion control dams situated near mountain stream. The ecological functions of erosion control dams analyzed by such openness for adequately protect and manage the diversity of species and to prevent disasters. The obtained results were as follows. When structurally modifying or changing non-permeable, gravity type dams with a passing rate of less than 1% into open-type dams, the passing rate increased by about 77 times more from 0.72% to 55.8%. Except for closed, gravity type erosion control dams that are constructed with a special purpose such as creating sand deposits and reservoirs, there is a need to construct and improve the dams into permeable type dams that can relatively satisfactorily perform various functions such as carrying soil and sand to the downstream region and create a ecological corridor upstream and downstream for fish and amphibians. The openness based on the blocking height of the erosion control dam varies depending upon the height of the base part and the depth of the substructural part. It must be designed based on the on-site conditions and the purpose of the construction. The functional types of erosion control dams based on the open form of the cross-section as follows: the fish traffic type, flood control type, reservoir type for forest fire control), non-permeability type for soil and rock blocking, net type for blocking the rock flow and the particle screen type.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.1
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• pp.183-194
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• 2019

In recent years, the risk of external flooding of major national facilities has increased significantly since 2000 due to the increase in local heavy rainfall events. For important domestic national facilities, it is necessary to analyze the risk of external flooding as flooding in major sites due to heavy rain can cause functional paralysis in major facilities and ultimately lead to massive trouble events. In order to manage the safety of main facilities and its related facilities at a high level, it is necessary to analyze the degree of disaster such as flood depth, flood flow rate, flood time and flood intensity when extreme floods (LIP) are introduced. In addition, the degree of vulnerability of these related facilities should be assessed and risk assessments should be reassessed through linkage analysis that combines the degree of disaster and vulnerability. By calculating a new flood hazard curve for the flood depth and flood intensity in major national facilities under the heavy rainfall conditions through this study, it is expected to be a basis for the waterproof design of important SOC facilities, flood prevention function design, advancement of flood prevention measures and procedures and evaluation of flood mitigation functions.