• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.141-144
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• 2000

Highly open porous polymer matrices are required for high density cell seeding, efficient nutrient, and oxygen supply to the cells cultured in the three dimensional matrices. However, there are severe problems of mass transfer limitations within the cell/scaffolds culture system. Thus we hypothesize that continuos-flow culture conditioning of cells with the scaffolds may improve the cell viability and the differentiated function. In this study, we fabricated porous PLGA scaffolds by using gas-foaming/salt-leaching method as previous described. Viscous PLGA gel paste contains ammonium bicarbonate particulates, acting as a gas-foaming agent as well as a salt-leaching porogen, were cast into Teflon mold and dried. Ammonium bicarbonate salt upon contact to an acidic aqueous solution evloves gaseous ammonia and carbon dioxide by itself. And we conjugated galactose moiety [AGA; $N-(aminobuty1)-O-{\beta}-D-galactopyranosyl-(1{\rightarrow}4)-D-glucoamide]$ to the terminal end group of a PLGA to increase the cell adhesion and matain the differentiated function of hepatocytes. Cell-seeded scaffolds were secured in a flow bioreactor chamber and exposed to continuous flow at 5 ml/min. As a result of our study, the high yield of hepatocytes attachment was accomplished by increasing the concentration of PLGA-AGA conjugate in polymer scaffolds and cells in the scaffolds under continuos flow condition maintained a high level of viability and albumin secretion rate of cultured hepatocytes showed a higher level that of control groups.

• The Journal of Korean Physical Therapy
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• v.22 no.5
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• pp.49-56
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• 2010

Purpose: The aim of this study was to evaluate a possible role for cranial artery velocity in cervicogenic headache. Methods: We studied 13 patients with cervicogenic headaches (M=9, F=4, age=$24.50{\pm}3.50\;y$) these were compared to 20 normal subjects (M=10, F=10, age=$23.30{\pm}2.90\;y$). Cervicogenic headache patients were divided into two groups (a myofascial relaxation group, a placebo group). Pain levels were measured using a visual analog scale (VAS). Transcranial Doppler (TCD) ultrasound recordings were used to measure blood flow velocity in the cranial artery. Results: Cervicogenic headache patients exhibited a significantly lower blood flow velocity in the middle cerebral artery. The patients who received an intervention had a significantly higher blood flow velocity in the left middle cerebral artery, right vertebral artery and basilar artery. Compared to the placebo group, the myofascial relaxation group exhibited a significantly decreased level of pain. Conclusion: Cervicogenic headache is pain referred to the head from a source in the cervical spine. Manual therapy affect to cervical spine and soft tissue as well as the passage of these vessels and nerves to recover because it is thought to be able to help.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.1554-1561
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• 2005

Geotextiles form one of the two largest groups of geosynthetics and it is consisted two major types of synthetic material (Woven, Non-woven). The functions of geotextiles are separation, reinforcement, filtration, drainage and as a moisture barrier. Within these functions, however, there are a large number of applications or use areas. Although the many research scholar and engineer developed and established the design criteria and construction methodology of geosynthetics filter layer, because the lack of suitable design terminology and uncertainty of long term durability, sustainable research still needed for optimum design methodology to the complicate field conditions. Especially, more intensive research needed about under the cyclic flow condition and fine silty sand base material. In this paper, the filter model test performed under cyclic flow with various boundary conditions (period and frequency of cyclic flow, types of geosynthetic filter material, surcharge etc.).

• Journal of computational fluids engineering
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• v.12 no.2
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• pp.1-7
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• 2007

To develop an aerodynamic performance, two groups of studies have been achieved widely. One is about the geometric design of vehicles and the other is about aerodynamic devices. Geometric design is a credible and stable method. However, it is not flexible and each part is related interactively. Therefore, if one part of geometry is modified, the other part will be required to redesign. On the other hand, the flow control by aerodynamic devices is flexible and modulized method. Even though it needs some energy, a relatively small amount of input makes more advanced aerodynamic performance. Synthetic jet is one of the method in the second group. The device repeats suctions and blowing motions in constant frequency. According to the performance, the adjacent flow to flight surface are served momentum. This mechanism can reduce the aerodynamic loss of boundary layer and separated flow. A synthetic jet actuator has several parameters, which influences the flow control. This study focuses on the parameter effects of synthetic jet - orifice geometry, frequency, jet speed and etc.

• Progress in Medical Physics
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• v.9 no.1
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• pp.23-28
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• 1998

We measured the flow at peripheral blood vessel of finger dorsum surface using noninvasive LDF(Laser Doppler Flowmeter). We investigated the flow properties between the normal and the diabetic with the Amplitude Spectral Densities of FFT analysis. We classified the diabetic as four groups of negative neuropathy, positive neuropathy, hyperthyroid and hypothyroid. And tested the neuropathic and thyroid effects of peripheral blood flow. As the results, the diabetic, the positive neuropathic and the hypothyroid respectively showed the abnormal blood flow properties on the contrary of the normal flow of negative neuropathic and hyperthyroid.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.835-840
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• 2009

In this paper, confined multiple slot jet impingement with exhaust ports is investigated numerically. A flow cell, defined as volume sectioned by the impingement and confinement surfaces and the centerlines of adjacent nozzle and exhaust port, is chosen for computational domain. The effects of Reynolds number and geometrical parameters on the heat transfer performance and the flow characteristics are studied. For turbulence, the Abe-Kondoh-Nagano version of the low-Reynolds k-$\varepsilon$ model is employed. The results showed that the local Nusselt number distribution is shifted down and show poor heat transfer performance for small Reynolds number and small ratio of the lateral and axial length of flow cell. The rest of range, except the range of the shift phenomenon, can be classified into three groups by heat transfer characteristics.

• Journal of the Korean Society of Physical Medicine
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• v.10 no.4
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• pp.9-14
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• 2015

PURPOSE: Low-intensity exercise with restriction of blood flow has been proposed as an alternative exercise to secure the disadvantage of a high-intensity resistance exercise. However, studies of how affects the muscle using functional exercise are lacking. Thus, the purpose of this study was to investigate knee extensor muscle strength during stair exercise of functional exercise with leg blood flow restriction. METHODS: Twenty two healthy young adults with no history of musculoskeletal or neurogical disorder were participated in this study. participant were randomized into either non-restriction group(11 subject) or restriction group (11 subject). The restriction blood cuff attached to the proximal end of the leg. Measurement of knee extensor strength was used by cybex dynamometer. Data analyzed in independent t-test and paired t-test. RESULTS: Knee extensor muscle strength was significantly different between groups. Also, there were significant differences in the strength of knee extensor within the group. CONCLUSION: This study found that stair exercise with restriction of blood flow did influence to knee extensor muscle strength. These results will also be able to promote the effect of increasing the muscle power applied to functional exercise. Henceforth, studies will be made in the intervention method that can be applied to health vulnerable person.

• Korean Journal of Acupuncture
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• v.25 no.3
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• pp.29-41
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• 2008

Objectives : The aim of this study is to examine the effects of SSP(silver-spike point) therapy, applied to acupuncture points, on the middle cerebral arteries blood flows of sample group(tention-type headache patients, n=12) and control group(non tension-type headache patients, n=12), and on the reduction of their headaches, when applied to acupuncture points. Methods : We stimulated 6 acupuncture points for headache with the SSP(three times a week for three weeks), and measured VAS(visual analogue scale) and the blood flow of the middle cerebral arteries with TCD(transcranial doppler ultrasonography). Results : The blood flow of the middle cerebral artery and VAS of the sample group and the control group were compared four times(initial, 1weeks, 2weeks, 3weeks) and significant differences in the measurements were found at 3 weeks(p<.05). The blood flow of the middle cerebral artery of the sample group was significantly increased, and VAS was significantly decreased in both groups. Conclusions : The silver-spike-point low-frequency electrical-stimulation treatment, applied to acupuncture points, can significantly increase the blood flow of the middle cerebral arteries in headache patients and can thus alleviate their headaches.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.9
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• pp.39-48
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• 2008

Recently, many multimedia services have emerged in Internet such as real-time and non- real time services. However, in this Internet environment, we have some limitations to satisfy each service feature. To guarantee the service features in Measurement-Based Admission Control(MBAC) based system on the flow-aware network, there is the method applying Dynamic Priority Scheduling(DPS) algorithm that gives a higher priority to an earlier incoming flow in all of the link bandwidth. This paper classifies all flows under several groups according to flow characteristics on per-flow MBAC algorithm based system. In each flow group, DPS algorithm is applied. This paper proposes two methods that are a DPS based bandwidth borrowing method and a bandwidth dynamic allocation method. The former is that if low priority class has available bandwidths, the flow of high priority class borrows the bandwidth of low priority class when high priority flow has insufficient bandwidth to connect a flow call. The later is that the each group has a minimum bandwidth and is allocated the bandwidth dynamically according to the excess rate for available bandwidth. We compare and analyze the characteristics of the two proposed methods through the simulation experiments. As the results of the experiment, the proposed methods are more effective than existing DPS based method on the packet loss and delay characteristics. Consequently the proposed two methods are very useful in various multimedia network environments.

• Journal of Ecology and Environment
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• v.30 no.2
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• pp.109-119
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• 2007

The effect of water flow on the growth of Gafrarium tumidum was studied in the field using open cages constructed with stainless steel net and perspex in which holes were drilled. Cages with different flows (25, 50 and 75% of the control) were made by varying the area of perspex being drilled. Reduction in flow rate was directly proportional to the undrilled area, and the mean flow rate of the different treatment groups varied from 3.12 cm/s for the 25% exposure to 12.48 cm/s for the control cages. At the end of the 3-month experiment, no significant differences in sediment characteristics were found among the treatments. Growth in shell length, shell weight and tissue dry weight was, however, positively correlated with flow rate. Percentage increases ranged from $3.0{\sim}8.3%$ for shell length, $9.9{\sim}23.1%$ for shell weight and $17.2{\sim}53.3%$ for tissue dry weight. Condition index of the clam was not significantly different among the treatments. Seston depletion effect could reduce growth in G. tumidum only when water flow was reduced to 25% of the control. G. tumidum also exhibited different responses in shell and tissue growth at low flow rates, in which shell growth continued to decrease as flow rate decreased whereas tissue growth was relatively independent of low flows at 25 and 50% of the control. It was suggested that when seston flux was reduced at slow flows, it would be a better strategy for G. tumidum to channel energy for gonad development instead of shell growth during the reproductive stage.