• 디지털콘텐츠학회 논문지
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• 제18권2호
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• pp.403-410
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• 2017

본 논문에서는 스마트 NFC 통신과 실시간 소화기 압력 측정을 이용한 소화기 유지관리 및 모니터링 시스템을 제안하였다. 제안하는 시스템 구성은 소화기를 식별하기 위해 스마트 기기와 소화기용 모듈 간 NFC 통신으로 인식하는 단계, 소화기의 외관 점검과 실시간 소화기 압력 측정 단계 및 소화기 점검 상태 정보를 관리서버로 전송하고 관리 프로그램에서 통합 관리하는 단계로 구성된다. 특히 스마트 기기를 이용한 실시간 소화기 압력 측정은 정상 압력을 의미하는 녹색 영역과 색상 패턴 기반 검출된 지시바늘의 위치 각도간의 거리 계산으로 최종 압력을 검출하였다. 실험 결과, 제안하는 소화기 유지관리 시스템이 설계 규격대로 수행됨을 확인할 수 있었고, 제안하는 시스템은 관리자가 효과적으로 소화기 안전 점검 상태 정보를 통제할 수 있는 결과를 보였다.

• 대한전자공학회논문지
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• 제10권5호
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• pp.16-20
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• 1973

많은 검지방식중 어떠한 방식에 의하든 간에 교통류에 관한 정보수집이 선행되어야하고, 그 다음에 정상주기방식이든 전술제어등 비정주기방식이든 간에 교통신호등의 신속제어시에 그 최적신호주기설정을 전제로 하고서 신호주기에 포함되어 있는 발진지연현상에 관하여 분석검토치 않으면 안된다. 선상에서 차의 속도별 및 앞뒤차간의 간격등으로 분포교통량의 개개가 일률적인 인자라 볼 수 없는 것은 사실이나 좀더 구체적으로 그 요인을 제어공학적 해석방법으로써 분석하여 이들을 각각 외란들로 간주하고 나아가 합성외란을 입력과 출력의 차인 오차로 간주했다. 외란은 시간의 함수이므로 첫째 환경조건으로써 도로의 상태 및 기후, 둘째 차량자체의 구조 및 성능으로부터 오는것, 세째 운전자(입간)의 정신적 신체적조건등으로 구분하여 검토하고 본논문은 기존환경조건을 최대로 활용하는 견지에서 첫째의 경우를 일정하다고 보고, 다만 차와 운전자에 대한것만 요인으로 취하였다. 안정화 대책으로써 오차요소별 최소화를 시도했으며, 그 결과 신원최적제어주기설정을 위한 방안이 구체적으로 제시되었고, 주로 외란의 요인을 제거하므로써 최적제어가 가능케됨을 입증해주고 있다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.408-413
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• 2004

Numerical and experimental investigation were car-ried out to clarify the flow structure of underexpanded jet from a square nozzle. The square nozzle rep-resents one of the clustered combustors of a linear aerospike engine. From the numerical results, the three-dimensional shock wave of the underexpanded square jet was found to be composed of two shocks. One is the intercepting shock which corresponds to the shock observed in two-dimensional planar jet. The other is the recompression shock divided into two types. The expansion fans coming from the nozzle edges interact with each other at the comers of the nozzle exit, and overexpanded regions are generated. Therefore one of the two recompression shocks is formed at the comers of the nozzle exit behind the overexpanded regions. As the jet goes downstream, the overexpanded regions grow larger to coalesce at the symmetry planes. Then, the other type of the recompression shock is generated. The three-dimensional shock structure formed by the intercepting shock and the recompression shocks dominates the expansion of the jet boundary. The shock detection algorithm us-ing CFD results was developed to reveal the relation between the shock waves and the jet boundary, and it was found that the cross-sectional jet shape becomes cross-shape. The key features observed in the numerical investigation were verified by the experimental results. The shock structure at the diagonal plane was in good agreement with the experimental schlieren images. Moreover, the cross-sections visualized by the Mie scattering method confirmed that the cross-section of the jet becomes cross-shape.

• Archives of Pharmacal Research
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• 제24권3호
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• pp.207-210
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• 2001

A fully automated high performance liquid chromatography with column-switching was developed for the simultaneous determination of KR60436, a new reversible proton pump inhibitor, and its active metabolite O-Demethyl-KR60436 from rat plasma samples. Plasma sample (50$\mu$l) was directly introduced onto a Capcell Pak MF Ph-1 column ($10{\times}4$ mm I.D.) where primary separation was occurred to remove proteins and concentrate target Substances Using acetonitrile-Potassium Phosphate (PH 7, 0.1 M) (2 : 8, v/v). The drug molecules eluted from MF Ph-1 column were focused in an intermediate column ($10{\times}2$ I.D.) by the valve switching step. The substances enriched in intermediate column were eluted and separated on a Vydac 218MR53 column ($250{\times}3.2$ I.D.) using acetonitrilepotassium phosphate (pH 7, 0.02 M) (47:53, v/v) at a flow rate of 0.5 ml/min when the valve status was switched back to A position. The method showed excellent sensitivity (detection limit of 2 ng/ml) with small volume of samples ($50{\mu}$l), good precision and accuracy, and speed (total analysis time 24 min) without any loss in chromatographic efficiency. The response was linear ($r^2{\geq}0.797$) over the concentration range of 5-500 ng/ml.

• Archives of Pharmacal Research
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• 제19권6호
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• pp.529-534
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• 1996

A high-performance liquid chromatographic (HPLC) assay has been developed for the determination of ketorolac in human serum using a new extraction method with a good recovery. Human serum samples (1.0 ml) spiked with known concentrations of ketorolac tromethamine and 10${\mu}g$ of ketoprofen as the internal standard (IS) were acidified with 200${\mu}l$ of 1 N HCl and extracted with 7 ml of n-hexane-ether (7:3 v/v). Extracts were centrifuged and organic layer was back-extracted with 400${\mu}l$ of 0.1% tromethamine solution. Twenty .mu.l of centrifuged aqueous layer was injected onto a reversed-phase octyl column and eluted with a mixture of acetonitrile, water, methanol, and triethylamine [35:55:10:0.1 (v/v), pH 3.0] at a flow rate of 1.0 ml/min. Ultraviolet detection of ketorolac and IS was carried out at 300 nm. The calibration curve obtained using peak area ratios showed a good linearity (in concentration range 10-150 ng/ml $r^2$=O.9944; in range 50-2000 ng/ml, r$^{2}$=0.9998). The mean intra-day accuracy and precision for this HPLC method were found to be 3.6 and 3.7%, respectively. The mean inter-day accuracy and precision were found to be 4.0 and 3.7%, respectively, in the concentration range 50-2000 ng/ml. The recovery of ketorolac from serum was 92.0 $({\pm}5.7)$ % at the concentration of 100 ng/ml. This method proved to be readily applicable to the assay of ketorolac in human serum.

• Archives of Pharmacal Research
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• 제19권6호
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• pp.554-558
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• 1996

High-performance liquid chromatographic method was developed for the determination or LB 20304 (compound 1) in the plasma of rats and dogs. The analyte was deproteinized with 1 volume of methanol and 1/2 volume of 10% zinc sulfate, and the supernatant was injected onto a reversed-phase HPLC column. The mobile phase was a mixture of 24 parts of acetonitrile and 76 parts of 0.1% trifluoroacetic acid. The flow rate was 1 ml/min, and the effluent was monitored by fluorescence detector at an excitation wavelength of 337 nm and an emission wavelength of 460 nm. The retention time of compound 1 was 6.3 min. The assay of compound 1 was linear over the concentration range of 0.2-100.mu.g/ml in the plasma of rats and dogs. The lower limit of quantification was 0.2.mu.g/ml using 100.mu.l of plasma with a 97-99% accuracy and a 12-14% precision. In the 0.5, 5, and 50.mu.g/ml quality control samples, the intra- and inter-day accuracy were 88-95% and 88-97%, whereas intra- and interday precision were 0.5-6.6% and 0.2-9.3%, respectively, in the plasma of rats and dogs. The recoveries were 68-71% independent of concentration and species in the plasma. No interferences from endogenous substances were observed. Taken together, the above HPLC assay method by deproteinization and fluorescence detection was suitable for the determination of compound 1 in the preclinical pharmacokinetics.

• IMMUNE NETWORK
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• 제11권6호
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• pp.383-389
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• 2011

Background: EY-6 is one of the newly synthesized indoledione derivatives to induce tumor cell-specific cell death. In this study, we investigated the mechanism of immunological death induced by EY-6 at mouse colon cancer cell as well as at the normal immune cell represented by dendritic cell. Methods: C57BL/6 mouse syngeneic colon cancer cell MC38 was treated with EY-6, and analyzed by MTT for viability test, flow cytometry for confirming surface expressing molecules and ELISA for detection of cytokine secretion. Normal myeloid-dendritic cell (DC) was ex vivo cultured from bone marrow hematopoietic stem cells of C57BL/6 mice with GM-CSF and IL-4 to analyze the DC uptake of dead tumor cells and to observe the effect of EY-6 on the normal DC. Results: EY-6 killed the MC38 tumor cells in a dose dependent manner (25, 50 and $100{\mu}M$) with carleticulin induction. And EY-6 induced the secretion of IFN-${\gamma}$ but not of TNF-${\alpha}$ from the MC38 tumor cells. EY-6 did not kill the ex-vivo cultured DCs at the dose killing tumor cells and did slightly but not significantly induced the DC maturation. The OVA-specific cross-presentation ability of DC was not induced by chemical treatment (both MHC II and MHC I-restricted antigen presentation). Conclusion: Data indicate that the EY-6 induced tumor cell specific and immunological cell death by modulation of tumor cell phenotype and cytokine secretion favoring induction of specific immunity eliminating tumor cells.

• 한국군사과학기술학회지
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• 제20권6호
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• pp.767-773
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• 2017

Infrared stealth is an important technology for naval ships. This technology helps improve the anti-detection performance and survivability of naval ships. In general, the infrared signature of naval ships are categorized into internal and external heat source. External signature are generated by ship surface heating by solar flux as well as the complicated heat transfer process with the surrounding weather condition. Modern naval ships are equipped with seawater injection nozzles on the outside for nuclear, biological and, chemical, and these nozzles are used to control external signature. Wide nozzle placement intervals and insufficient injection pressure, however, have reduced seawater dispersion area. To address this problem, nozzle installation standards must be established. In this study, an actual-scale experimental system was implemented to provide the evidence for nozzle installation standards in order to reduce the infrared signature of naval ships. In addition, the environmental conditions of the experiment were set up through computational fluid dynamics considering the ocean climate data and naval ship management conditions of South Korea. The dispersion distance was measured using a high-resolution thermography system. The flow rate, pipe pressure, and dispersion distance were analyzed, and the evidence for the installation of seawater injection nozzles and operation performance standards was suggested.

• Journal of Pharmaceutical Investigation
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• 제34권6호
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• pp.453-457
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• 2004

Atenolol and related compounds found in raw materials and commercial products were analyzed by reversed-phase high-performance liquid chromatography. A mixed solution of phosphate buffer (3.4 g/l, pH 3.0), tetrahydrofurane and methanol (800:20:180, v/v/v) including sodium octanesulfonate (1 g/l) and tetrabutylammonium-hydrogensulfate (0.4 g/l) was used as mobile phase at the flow rate of 0.25 ml/min. Detection was carried out at UV 226 nm. Atenolol related compounds, such as bis ether, tertiary amine and blocker acid were identified by comparing the retention time of the standard. The within-day and between-day precisions of the separated compounds were less than 1.2% and 3.4%, respectively. The contents of related compounds of the tested samples were under the limit prescribed in the European Pharmacopoeia. The pattern of the related compounds showed that atenolol raw materials and products could be classified in three different groups, indicating that the materials originated from different source or treated in different way.

• 센서학회지
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• 제6권4호
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• pp.307-315
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• 1997

본 논문에서는 센서교환이 용이하고 소량의 샘플을 요구하는 ISFET 센서용 전해질 분석기의 샘플챔버(sample chamber)를 설계하였으며, 이를 이용한 2점 교정방식의 4채널 전해질 분석기를 구현하였다. 샘플과 교정용액들의 사용을 최소화하기 위한 샘플의 로딩상태 감지회로를 제안하였으며 이를 실현하였다. 구현된 전해질 분석기는 제어계통과 액류흐름계통으로 구성되어 있으며 전해질 분석기의 효과적인 제어를 위하여 측정루틴, 교정루틴 및 세척루틴의 시스템 소프트웨어를 각각 개발하였다.