• 한국유변학회:학술대회논문집
• /
• 한국유변학회 2001년도 Australian-Korean Rheology Conference 2001
• /
• pp.154.4-154
• /
• 2001

(No abstract, see full-text)

• 한국임상약학회지
• /
• 제2권1호
• /
• pp.1-9
• /
• 1992

Protective effect of urokinase on reperfusion were studied followed by global ischemia in the isolated perfused rat heart. Separately, anti-platelet aggregation effect of urokinase also investigated. Urokinase exhibited positive effect for the protection of rat heart function by increasing the LV dp/dt, coronary flow(CF) and the Tate pressure product(RPP), and by decreasing the LVEDP on reperfusion. Urokinase also decreased arrhythmia by $74.7\%(P<0.05) induced by global ischemia in the rat heart. In the platelet aggregation study, urokinase did not show the inhibitory effect of ADP or collagen induced platelet aggregation inviuo and exvivo.

• 대한기계학회논문집B
• /
• 제40권6호
• /
• pp.365-372
• /
• 2016

전산유체역학(CFD)을 이용하여 테일러 반응기 내 입자간 응집과 분해반응을 고려한 유동해석을 수행하였다. 입자크기분포를 파악하기 위하여 모멘트 적분법(QMOM)을 이용하여 집합체 균형방정식(Population Balance Equation)을 계산하였다. 초기 여섯 개의 모멘트를 이용하였으며, 응집커널은 Brownian kernel 과 turbulent kernel의 합을, 그리고 분해커널은 멱법칙 커널(power-law kernel)을 사용하였다. 입자의 초기 부피분율에 따른 최종 입자크기를 예측하였다. 그 결과, 초기 부피분율이 증가할수록 입자의 크기와 초기 성장속도가 증가하는 것을 확인하였다.

• 한국환경과학회지
• /
• 제28권2호
• /
• pp.259-266
• /
• 2019

Two main sources of data, meteorological data and land surface characteristics, are essential to effectively run a distributed rainfall-runoff model. The specification and averaging of the land surface characteristics in a suitable way is crucial to obtaining accurate runoff output. Recent advances in remote sensing techniques are often being used to derive better representations of these land surface characteristics. Due to the mismatch in scale between digital land cover maps and numerical grid sizes, issues related to upscaling or downscaling occur regularly. A specific method is typically selected to average and represent the land surface characteristics. This paper examines the amount of flooding by applying the FLO-2D routing model, where vegetation heterogeneity is manipulated using the Manning's roughness coefficient. Three different upscaling methods, arithmetic, dominant, and aggregation, were tested. To investigate further, the rainfall-runoff model with FLO-2D was facilitated in Yongdam catchment and heavy rainfall events during wet season were selected. The results show aggregation method provides better results, in terms of the amount of peak flow and the relative time taken to achieve it. These rwsults suggest that the aggregation method, which is a reasonably realistic description of area-averaged vegetation nature and characteristics, is more likely to occur in reality.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2007년도 춘계학술대회B
• /
• pp.2879-2884
• /
• 2007

Dynamic responses of electrorheological (ER) fluids in steady pressure flow to stepwise electric field excitations are investigated experimentally. The transient periods under various applied electric fields and flow velocities were determined from the pressure behavior of the ER fluid in the flow channel with two parallel-plate electrodes. The pressure response times were exponentially decreased with the increase of the flow velocity, but increased with the increase of the applied electric field strength. In order to investigate the cluster structure formation of the ER particles, it was verified using the flow visualization technique that the transient response of ER fluids in the flow mode is assigned to the densification process in the competition of the electric field-induced particle attractive interaction forces and the hydrodynamic forces, unlike that in the shear mode determined by the aggregation process.

• 정보처리학회논문지D
• /
• 제14D권6호
• /
• pp.597-604
• /
• 2007

스트림 데이터는 끊임없이 고속으로 생성되는 데이터로써 최근 이러한 데이터를 분석하여 부가가치를 얻고자 하는 노력이 활발히 진행 중 이다. 본 연구에서는 스트림 데이터의 다차원적 분석을 위해 큐브를 고속으로 계산하는 방법을 제안한다. 스트림 데이터는 비즈니스 데이터와는 달리 정렬되지 않은 채로 도착하며, 데이터의 끝에 도달하지 않은 상태에서는 집계 결과를 낼 수 없어서, 고속으로 집계하는 과정에서 저장 공간의 낭비를 심하게 초래한다. 또한 큐브에 속한 집계 테이블들을 모두 생성하는 것은 시간/공간 측면에서 비효율적이라는 점이 지적되고 있다. 이러한 문제를 해결하기 위해 본 연구에서는 기존 연구들과 마찬가지로 큐브에 포함시킬 집계 테이블들을 사용자가 미리 정하도록 하였고, 정렬되지 않은 스트림 데이터를 고속으로 집계하는 과정에서 배열과 AVL 트리들로 구성된 자료구조를 집계 테이블의 임시 저장소로 사용하였다. 제안한 알고리즘은 생성하려는 큐브가 메모리에 상주할 수 없을 정도로 큰 경우에도 집계 연산을 수행할 수 있다. 이론적 분석과 성능 평가를 통해 제안한 큐브 계산 알고리즘이 실용적임을 입증하였다.

• Journal of Ginseng Research
• /
• 제47권6호
• /
• pp.706-713
• /
• 2023

Background and objective: The ability to inhibit aggregation has been demonstrated with synthetically derived ginsenoside compounds G-Rp (1, 3, and 4) and ginsenosides naturally found in Panax ginseng 20(S)-Rg3, Rg6, F4, and Ro. Among these compounds, Rk3 (G-Rk3) from Panax ginseng needs to be further explored in order to reveal the mechanisms of action during inhibition. Methodology: Our study focused to investigate the action of G-Rk3 on agonist-stimulated human platelet aggregation, inhibition of platelet signaling molecules such as fibrinogen binding with integrin α_IIbβ₃ using flow cytometry, intracellular calcium mobilization, dense granule secretion, and thromboxane B₂ secretion. In addition, we checked the regulation of phosphorylation on PI3K/MAPK pathway, and thrombin-induced clot retraction was also observed in platelets rich plasma. Key Results: G-Rk3 significantly increased amounts of cyclic adenosine monophosphate (cAMP) and led to significant phosphorylation of cAMP-dependent kinase substrates vasodilator-stimulated phosphoprotein (VASP) and inositol 1,4,5-trisphosphate receptor (IP₃R). In the presence of G-Rk3, dense tubular system Ca²⁺ was inhibited, and platelet activity was lowered by inactivating the integrin αIIb/β₃ and reducing the binding of fibrinogen. Furthermore, the effect of G-Rk3 extended to the inhibition of MAPK and PI3K/Akt phosphorylation resulting in the reduced secretion of intracellular granules and reduced production of TXA₂. Lastly, G-Rk3 inhibited platelet aggregation and thrombus formation via fibrin clot. Conclusions and implications: These results suggest that when dealing with cardiovascular diseases brought upon by faulty aggregation among platelets or through the formation of a thrombus, the G-Rk3 compound can play a role as an effective prophylactic or therapeutic agent.

• 대한수의학회지
• /
• 제36권4호
• /
• pp.873-886
• /
• 1996

For better understanding the interrelationship of hemorrhage and aggregation mechanism, cyclopiazonic acid(CPA) known as promoting the aggregation of platelet, aflatoxin $B_1(AFB_1)$ inhibiting platelet aggregation were used as toxic mycotoxins in these studies. In order to investigate the potential role of prostaglandin metabolism on the platelet aggregation, a variety of prostaglandin metabolites such as $PGF_{2{\alpha}}$, $PGE_2$ and $TXB_2$ were measured in homogenized rabbit platelets by TLC and LSC. And the role of $Ca^{{+}{+}}$ on the platelet aggregation was investigated by flow cytometer. Finally, the morphological effects of mycotoxins on platelet were determined by transmission electron microscope. The results and conclusions obtained from these studies are: 1) CPA induced no changes but $AFB_1$ increased $PGE_2$ and $TXB_2$. 2) CPA promoted ADP, collagen, thrombin, A.A., and PAF-induced $Ca^{{+}{+}}$ release. $AFB_1$, however, decreased $Ca^{{+}{+}}$ level except collagen-induced $Ca^{{+}{+}}$ release. When the calcium blocker, verapamil, was used, CPA decreased thrombin-induced $Ca^{{+}{+}}$ release and increased collagen, ADP, PAF and A.A.-induced $Ca^{{+}{+}}$ release. $AFB_1$ in contrast decreased the all factors induced $Ca^{{+}{+}}$ release. 3) $AFB_1$ did not induce any ultrastructural changes except large vacuole formation in a few platelets. And CPA also did not induce any changes except moderate shape change, indicator of platelet activation. In conclusion, CPA promoted platelet aggregation by the increases of $Ca^{{+}{+}}$ release but had no changes in A.A. metabolites. Antiaggregating effects of $AFB_1$ may be due to decreases of $Ca^{{+}{+}}$ release and increases of $PGE_2$ and $PGF_{2{\alpha}}$ formation. These data provide the basis for the future study of mobilization and function of $Ca^{{+}{+}}$ in platelet aggregation.

• Laboraroty Animal Research
• /
• 제33권2호
• /
• pp.105-113
• /
• 2017

insenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% $FeCl_3$-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the $FeCl_3$-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as $Rg_3$ improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.

• 콘크리트학회지
• /
• 제4권2호
• /
• pp.119-126
• /
• 1992

고강도 시멘트 복합체의 유동성 손실을 감소시키기 위한 연구의 일환으로 시멘트계 입자에 대한 고성능감수제의 흡착특성, 현탄액 속에서의 응집특성을 관찰하여 시멘트풀과 모르터의 유동성과 관련시켜 고찰하였다. 본 연구결과 알루미네이트계 화합물이 많이 함유된 보통포틀랜드 시멘트의 흡착률이 가장 크며, 시멘트풀 및 모르처의 유동성 손실이 작았으며 나프탈린계 고성능 감수제가 유동성 손실면에서 얼마간 유리하였다.