• Proceedings of the Korea Information Processing Society Conference
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• 2011.04a
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• pp.300-303
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• 2011

이미지 어노테이션 기법은 효과적인 이마지 공유 및 검색을 위하여 활발하게 연구되고 있는 연구분야 중 하나로서, 최근에는 사용자들에 의하여 제작되는 방대한 양의 이미지 데이터 및 태그 정보를 제공하는 Flick와 같은 소셜 이마지 데이터베이스를 활용함으로써 이미지 어노테이션 및 이미지 검색을 효과적으로 수행하고자 하는 다양한 연구들이 시도되고 있다. 본 논문에서는 이미지 지식정보의 관리 및 공유를 위한 온톨로지와 소셜 이마지 데이터베이스를 활용하여 이미지 어노테이션을 수행하기 위한 시스템을 제안한다. 본 논문에서 제안하는 시스템은 소셜 이미지 데이터베이스를 활용하여 의미 있는 개념들을 이미지 어노테이션에 활용하며, 지식 관리 체계인 온툴로지를 이용하여 이미지 데이터베이스 내의 이미지 및 개념간에 존재하는 의미적 관련성을 기반으로 보다 효율적인 이미지 검색을 수행하고자 한다.

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.674-678
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• 2010

The effects of medetomidine on the degree of analgesia and sedation in rats were evaluated. The rats were randomly divided into six groups: saline, 1 mL/kg (group 'Saline'); butorphanol, 2.0 mg/kg; medetomidine, 0.2, 0.4, 0.8 or 1.6 mg/kg (group 'MED0.2', 'MED0.4', 'MED0.8' and 'MED1.6', respectively). The degree of analgesia was measured in the $50^{\circ}C$ hot-water tail-flick latency test, and the degree of sedation was evaluated using the numerical sedation score (NSS) and the righting reflex. All doses of medetomidine, except MED0.2, significantly increased the analgesic effect compared to the Saline group. Variables in the MED0.4 and MED0.8 groups, but not in the MED1.6 group, were significantly increased compared to those in the MED0.2 group. However, analgesia with all doses of medetomidine was not significantly different compared to that with butorphanol. Saline and butorphanol treatments did not induce sedation and loss of righting reflex during the recording period. NSS in the MED0.4, MED0.8 and MED1.6 groups were significantly higher than that in the MED0.2 group. NSS in the MED0.8 and MED1.6 groups were not significantly different from that in the MED0.4 group. The latency to loss of righting reflex in the MED0.8 and MED1.6 groups decreased significantly compared to that in the MED0.2 group. Thus, 0.4 and 0.8 mg/kg of medetomidine provided not only reliable analgesia but also sedation to rats. In conclusion, 0.4 to 0.8 mg/kg medetomidine could be a useful chemical restraint method in rats.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.43 no.6 s.312
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• pp.26-33
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• 2006

Film restoration is to detect the location and extent of defected regions from a given movie film, and if present, to reconstruct the lost information of each region. It has gained increasing attention by many researchers, to support multimedia service of high quality. In general, an old film is degraded by dust, scratch, flick, and so on. Among these, the most frequent degradation is the scratch. So far techniques for the scratch restoration have been developed, but they have limited applicability when dealing with all kinds of scratches. To fully support the automatic scratch restoration, the system should be developed that can detect all kinds of scratches from a given frame of old films. This paper presents a neurual network (NN)-based texture classifier that automatically detect all kinds of scratches from frames in old films. To facilitate the detection of various scratch sizes, we use a pyramid of images generated from original frames by having the resolution at three levels. The image at each level is scanned by the NN-based classifier, which divides the input image into scratch regions and non-scratch regions. Then, to reduce the computational cost, the NN-based classifier is only applied to the edge pixels. To assess the validity of the proposed method, the experiments have been performed on old films and animations with all kinds of scratches, then the results show the effectiveness of the proposed method.

• Journal of Acupuncture Research
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• v.21 no.2
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• pp.115-129
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• 2004

Objectives : To investigate the analgesic effect and its cholinergic mechanism of electroacupuncture(EA) in the rat model of collagen-induced arthritis(CIA). Methods : Immunization of male Sprague-Dawley rats with bovine typeII (CII) collagen emulsified in Freund's incomplete adjuvant, followed by a booster injection 14 days later, leads to development of arthritis in more than 70% of rats by 21 days postinjection. After three weeks of first immunization, EA stimulation(2 Hz, 0.07 mA, 0.3 ms) was delivered into Jogsamni($ST_{36}$) for 30 minutes. Analgesic effect was evaluated by tail flick latency(TFL). We compared the analgesic effect of EA with TFLs between pretreatment of normal saline and pretreatment of Atropine (1 mg/kg, intraperitoneal) and Neostigmine ($100{\mu}g/kg$, intraperitoneal) in CIA. Results : 1. TFLs were gradually decreased in CIA as increasing severity of arthritis. 2. Jogsamni($ST_{36}$) EA stimulation in CIA increased TFLs and the effect lasted for 60 minutes. 3. Increased TFLs with Jogsamni($ST_{36}$) EA stimulation were inhibited with pretreatment of atropine in CIA 4. Increased TFLs with Jogsamni($ST_{36}$) EA stimulation did not show an obvious synergistic effect with pretreatment of neostigmine in CIA. Conclusions: Jogsamni($ST_{36}$) EA showed analgesic effects in CIA. The analgesic effects of Jogsamni($ST_{36}$) EA were inhibited by atropine pretreatment and combined application of Jogsamni(ST36) EA and neostigmine did not show an synergistic effect. These observations suggest that intrinsic muscarinic cholinergic pathways represent an important modulating system in pain perception of inflammatory pain in CIA It is suggested that, the active mechanism of analgesic effect in EA may involve the release of acetylcholine in the spinal cord.

• 한국HCI학회:학술대회논문집
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• 2009.02a
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• pp.1059-1063
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• 2009

모바일 폰의 메뉴 구조는 하이퍼텍스트 형태로 정보를 제공하며 링크의 연결로 페이지 정보를 전달하거나 하부 카테고리로 연결하는 역할을 한다. 모바일 폰 사용자는 메뉴 조작을 통해 기능을 실행하며, 이 과정에서 선형구조, 계층형 구조, 대화형 구조, 데이터베이스 구조, 혼합구조와 같은 다양한 형태를 경험하게 된다. 사용자는 모바일 폰의 다양한 기능을 사용하면서 추상적 개념의 공간 인지를 구체적인 공간으로 이해하려 한다. 즉 UI, GUI에서 제시하고 있는 Label이나 방향표시를 따라 상하좌우라는 공간적 개념으로 은유하여 이해하는 것이다. 하드키 단말의 경우는 상하좌우키를 이용하여 공간을 이해했다면 최근에는 터치 및 제스처 동작 인식이 가능한 폰이 등장하면서 좌우 flick, 상하 flick 등과 같은 구체적인 행동으로 디바이스 화면에서 공간이 이동하는 것으로 이해하고 있다. 본 논문에서 사용자의 공간 은유를 이해하기 위해 상위 depth로 이동하는 [이전] 키의 기능을 중심으로 살펴보고자 한다. 첫째, 기능을 수행하기 위해 순차적으로 진행하는 방법보다는 [취소]를 이용하여 depth를 이동하는 것이 사용자의 모바일 폰의 공간 은유 파악에 더욱 도움을 줄 수 있을 것이라고 예상되기 때문이다. 둘째, [이전], [취소]라는 Label이 가지고 있는 모호성 때문이다. 모바일 폰의 다양한 기능 중에서 [이전]는 전체 사용에 있어 아주 작은 요소에 불과하지만 사용자는 정해진 순서의 process에 따라 기능을 수행할 때와는 다르게 역 방향 Process를 사용하면서 모바일 폰의 구조를 이해하고 모바일 공간을 인지하는 중요한 요소로 사용될 수 있을 것이라고 예상된다. 본 논문에서는 이전으로 돌아가는 [이전]의 기능을 통해 사용자가 메뉴의 층위 구조 및 공간 인지에 영향을 미칠 수 있을 것이다라는 가설을 설정하여 이를 실험을 통해 증명하고자 한다. 실험을 위해 모바일 폰을 자주 사용하고 있는 20~30대 남녀 10명의 피험자에게 전화번호부, 앨범, 문자메시지의 목록화면과 상세보기 화면을 제시한 후 마지막 상세보기 화면에서 실험에서 제시하는 제시어를 보고 어느 화면으로 이동하게 될 것인지를 예상하는 질문을 하였으며, 그러한 이유에 대해서는 인터뷰를 통해 확인하였다. 이 실험을 통해 사용자의 모바일 폰 공간인지는 동일한 레벨의 단계 즉 상세보기의 경우는 수평의 관계라고 보고 있으며, 목록화면과 상세화면의 관계는 상하의 관계라고 이해하고 있다. 이러한 이유를 인터뷰를 통해 질문하였을 때, 상세화면에서 좌우 방향표시가 존재하기 때문이라는 응답이 높았으며, 상세보기 화면이 좌우라고 인식하면 목록화면은 상하의 관계로 이해하고 있다고 응답하였다. 즉 하나의 정해진 공간인지를 통해 다른 공간을 유추하여 생각하고 있다고 볼 수 있다. 또한 결과적으로 실제 단말에서 [이전] 기능을 상위 depth로 이동하도록 설계하였다면 [한단계위]라는 Label 또는 e번과 같은 상위의 개념을 포함한 아이콘을 사용한다면 혼란을 줄일 수 있는 방법으로 활용될 수 있을 것으로 예상된다. 현재 논문에서는 [이전]라는 기능으로만 사용자의 공간 개념을 예측할 수 있었지만, 터치스크린의 등장과 함께 플릭과 같은 다양한 제스처에 의한 인터렉션이 가능한 현 시점에서 추상적인 공간은 방향성을 가진 제스처에 의해 구체적인 물리적 공간으로 인식하는 경향이 더욱 뚜렷이 나타나고 있다. 이러한 시점에서 사용자의 공간인지에 도움을 줄 수 있는 Label과 방향성 표시는 더욱 절실히 요구되고 있는 시점이며, 이후 모바일 환경에서 사용자의 공간인지에 대한 구체적인 연구가 필요하리라고 예상된다.

• Journal of Acupuncture Research
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• v.18 no.1
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• pp.76-87
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• 2001

Objective : Zusanli(ST36) and Hoku(Li4) are analgesic acupuncture points frequently used for acupuncture in Oriental medicine. The present study was conducted to see the antinociceptive effects produced by electroacupuncture combined two frequencies(Low, High) and two different acupuncture points(LI4, ST36) in the rat tail flick test. Method : In this study the Rats (Sprague-Dawley, 250-300g) were partially anesthetized with thiopental sodium(40mg/kg, i.p.). The basal reaction time for the tail-flick was 3${\pm}$0.5 sec. Low frequency(3Hz, 5V, biphasic) and high frequency(100Hz, 5V, biphasic) were applied to the inserted needle for the period of insertion(twenty minutes). Experimental groups are divied as follow; a) electroacupuncture stimulation groups at Hoku with or high frequency(L-EA, H-EA), b) electroacupuncture stimulation groups at Zusanli with low or high frequency(1-EA, h-EA), c) low frequency at Hoku and Zusanli(LIEA), d) low frequency at Hoku and high frequency at Zusanli(LhEA), e) high frequency at Hoku and low frequency at Zusanli(HIEA), f) high frequency at Hoku and Zusanli(HhEA) Results : The individual stimulation at either Hoku or Zusanli with low frequency has stronger and longer analgesic effect than high frequency stimulation. In addition, the combined stimulation at Hoku and Zusanli with low frequency has superior effect to individual stimulation with low frequency. LhEA and LIEA have superior effect to other stimulation groups among the combined groups. In order to determine the involvement of opioid system on the different antinociceptive effects, Naloxone, an opioid antagonist, was used in the combined groups. LIEA is the most sensitive when naloxone was administrated among study groups. HhEA is the least sensitive in the administration of naloxone. Conclusion : From results, this study confirmed that the opioid system is involved in analgesic effect of low frequency stimulation of acupuncture point, and we also can suggest the stronger analgesic effect of combining stimulation points is due to the theory of spatial summation in the nervous system.

• Toxicological Research
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• v.20 no.3
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• pp.251-261
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• 2004

A large number of chemical pollutants including phthalates, alkylphenolic compounds and organochlorine pesticides have the ability to disrupt endocrine function in animals, and alter cog-nitive function. Because hormone mediated events play an important role in central nervous system development and function, the changes in cognitive function seem to be mediated by the endocrine-like action of these chemicals. The present study therefore was designed to investigate effect of bisphenol A (BPA), an endocrine disrupting chemical on neuro-behavial patterns, and expression of estrogen receptors and tyrosine hydroxylase, a limiting enzyme of dopamine synthesis pathway. BPA was treated orally for 3 weeks into 3 week old mice, and then the neuro-behavial patterns (stereo-type behaviors such as jumping rearing and forepaw tremor, climbing behavior, tail flick, rotarod and locomotor activity), and the expression of estrogen receptors and tyrosine hydroxylase were deter-mined every 3 week for 9 weeks. During the treatment of BPA, the food uptake and body weight increase were not significantly changed. BPA resulted in the increased stereotype behaviors (jump-ing, rearing and forepaw tremor) 6 or 9 weeks after treatment. The time response to tail flick and locomotor activity were decreased by the treatment of BPA, whereas the time for rotarod was increased by the treatment of BPA. The expression of estrogen receptor alpha and beta was increased in the brain and pituitary gland. Maximum expression was found in the brain after 9 week of 100 mg/kg BPA treatment and in the pituitary gland after 6 week of 100 mg/kg BPA treatment. Tyrosine hydroxylase was increased in dose and time dependent manners in the brain but no change was found in the pituitary gland. The present data show that exposure of BPA in the young mice could alter expression of estrogen receptors and dopamine synthesis pathway, thereby modulate neuro-behavial patterns (increase of stereotype behaviors but decrease locomotor activity).

• The Korean Journal of Pharmacology
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• v.29 no.1
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• pp.33-41
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• 1993

Central analgesic effect of capsaicin was assessed by the tail flick reflex (TFR) test, using male Sprague-Dawley rats under anesthesia with pentobarbital sodium (induction with 40 mg/kg and maintenance with $4{\sim}8\;mg/kg/hr$). Level of norepinephrine in the spinal cord was also measured. Capsaicin, $35{\sim}150\;{\mu}g$, was injected intrathecally, and the TFR latency was measured before, 10, 30, and 60 minutes after the drug administration. TFR latency was increased 100% or more immediately by intrathecal capsaicin, from 2.9 seconds to the maximum of 7.0 seconds at 10 minute after the drug; P<0.01. The increase in TFR latency was maintained during the course of experiment of 2 hours. Concomitant reduction of NE content in the spinal cord was observed; from 16 ng/mg protein to 7 ng/mg protein. On the other hand, subcutaneous injection of capsaicin of 50 mg/kg did not change the TFR latency although the NE content reduced similarly to the case of intrathecal injection. Pretreatment of the animal with 0.5 mg/kg of MK-801 reversed the increase of TFR latency and NE reduction induced by intrathecal capsaicin. These results suggest that capsaicin causes analgesia at the spinal cord level by activating the excitatory amino acid-NE-dorsal horn interneurons axis of the descending inhibitory pain modulation pathway.

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.99-108
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• 2005

Objective : The aim of this study is to investigate the analgesic effect and its mechanism of bee venom acupuncture on collagen-induced arthritis(CIA) rats. Methods : Bee venom (1 mg/kg) was subcutaneously punctured into Choksamni (ST36) of CIA Analgesic effect was evaluated by using the tail flick latency (TFL). Opioid and ${\alpha}2$-adrenergic neurotransmitter system were examined by naloxone as an opioid receptor antagonist and yohimbine as ${\alpha}2$-adrenoceptor antagonist prior to bee venom cupuncture. Results : The results were as follows; 1. The TFL for the CIA rat was decreased as time went by. 2. The TFL in CIA rat was increased in bee venom acupuncture group compared with control group (no treatment). 3. Analgesic effect of bee venom acupuncture was not abolished by naloxone pre-treatment in the CIA rat. 4. Analgesic effect of bee venom aqua-acupuncture was abolished by yohimbine pre-treatment in the CIA rat. 5. Two weeks bee venom acupuncture had the continous analgesic effect for 4 weeks. Conclusions : Bee venom acupuncture has an analgesic effect on the CIA rat and has an antinociception mediated by ${\alpha}2$-adrenergic system.

• YAKHAK HOEJI
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• v.43 no.2
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• pp.263-273
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• 1999

When glutamate was infected intrathecally, the result is similar to those produced by TPA injected. The involvement of protein kinase C (PKC) in the nociceptive responses in rat dorsal horn neurons of lumbar spinal cord was studied. In test with formalin, a PKC inhibitor (chelerythrine) inhibited dose-dependently the formalin-induced behavior response. Neomycin also inhibited it significantly. But, a PKC activator (12-O-tetradecanoylphorbol-13-ester, TPA) showed reverse effect. When gluatamate was injected intrathecally, we observed the result is smilar to those produced by TPA injection. On the other hand, intrathecal injection of glutamate induced thermal and mechanical hyperalgesia. In Tail-flick test, we examined the involvement of PKC on the glutamate-indeced thermal hyperalgesia. Chelerythrine showed an inhibitory effect and TPA enhanced thermal response. Glutamate decreased the mechanical threshold significantly. A pretreatment of chelerythrine and neomycin inhibited glutamate-induced mechanical hyperalgesia, but the effect of neomycin was not significant. TPA had little effect on the mechanical nociceptive response. These results suggest that the PKC activation through metabotropic receptor at postsynaptic region of spinal cord dorsal horn neurons may influence on the persistent nociception produced by chemical stimulation with formalin, thermal and mechanical hyperalgesia induced by glutamate.