• Journal of Pharmaceutical Investigation
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• v.40 no.3
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• pp.167-173
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• 2010

Repeated oral administration of hydrochlorothiazide, a loop diuretic, due to transient high blood levels, may cause adverse effects such as gastric disturbance, nausea, high blood sugar, and hyper lipidemia. Transdermal administration could avoid some of these systemic side effects and gastric disorders. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible material, for transdermal delivery of hydrochlorothiazide. Drug solubility was highest at 40% PEG-400 volume fraction. Drug release increased as concentration increased with a linear relationship between the release rate and the square root of loading dose. Increasing temperature increased drug release from the EVA matrix. The activation energy, measured from the slope of log P versus 1000/T, was 11.9 kcal/mol for a 2.5% loading dose from EVA matrix. Diethyl phthalate had the highest plasticizing effects on the release of hydrochlorothiazide. To increase the skin permeation of hydrochlorothiazide from the EVA matrix, enhancers such as the saturated fatty acids, the unsaturated fatty acids, and the non-ionic surfactants were added to the EVA matrix, and skin permeation was evaluated using a modified Keshary-Chien diffusion cell fitted with intact excised rat skin. Polyoxyethylene 23-lauryl ether showed the highest enhancing effects. In conclusion, transdermal delivery of hydrochlorothiazide could be improved from an EVA matrix containing plasticizer and permeation enhancer.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.5
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• pp.619-624
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• 2013

A bendable electronic module is developed. In this module, thin silicon electronic chips are embedded in a polymer-based encapsulating adhesive between flexible copper-clad polyimide layers. During the qualification test of a harshly thermal-hygroscopic complex loading condition, delaminations occur inside the module layers. A finite element model is developed for the module. To investigate the effect of hygroscopic stress on delamination, the results of the thermal and thermal-hygroscopic loads are compared. The analysis results reveal that the hygroscopic effect more strongly affects delamination than does the thermal effect. The potential failure mechanisms of the module are investigated based on the stress analysis.

• Structural Engineering and Mechanics
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• v.74 no.5
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• pp.679-698
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• 2020

In this paper, the meshless local Petrov-Galerkin (MLPG) method is developed for dynamic analysis of non-symmetric nanocomposite cylindrical shell equations of elastic wave motion with nonlinear grading patterns under shock loading. The mechanical properties of the nanocomposite cylinder are obtained based on a micro-mechanical model. In this study, four kinds of grading patterns are assumed for carbon nanotube mechanical properties. The displacements can be approximated using shape function so, the multiquadrics (MQ) Radial Basis Functions (RBF) are used as the shape function. In order to discretize the derived equations in time domains, the Newmark time approximation scheme with suitable time step is used. To demonstrate the accuracy of the present method for dynamic analysis, at the first a problem verifies with analytical solution and then the present method compares with the finite element method (FEM), finally, the present method verifies by using the element free Galerkin (EFG) method. The comparison shows the high capacity and accuracy of the present method in the dynamic analysis of cylindrical shells. The capability of the present method to dynamic analysis of non-symmetric nanocomposite cylindrical shell is demonstrated by dynamic analysis of the cylinder with different kinds of grading patterns and angle of nanocomposite reinforcements. The present method shows high accuracy, efficiency and capability to dynamic analysis of non-symmetric nanocomposite cylindrical shell, which it furnishes a ground for a more flexible design.

• Journal of Biosystems Engineering
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• v.40 no.1
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• pp.35-46
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• 2015

Purpose: To present a flexible and accurate autonomous solution for creating any desired row spacing value between the hydroponic gullies in multilayer growing units, and evaluate the capabilities and performance of the relevant automated system through the use of virtual prototyping technique. Methods: To build the virtual prototype of the system, CAD models of its different parts, including an autonomous vehicle and the mechanical mechanisms embedded in the multilayer growing unit, were developed and imported into the RecurDyn simulation software. In order to implement the automated row spacing operation, three spacing modes with different loading cycles and working steps were defined, and the operation of the system was simulated to obtain the target row spacing values specified for each of these modes. Results: Motion profiles related to the horizontal displacement of: 1) the lower and upper sliding bars installed in the cultivation layers, and 2) the hydroponic gullies, during the simulation of the system operation, were generated and analyzed. No deviation from the specified target spacing values was observed at the end of simulations for all spacing modes. Conclusions: The results of the motion analysis obtained by simulating the system operation confirm the effectiveness of the control scheme proposed for automated row spacing of gullies. It was also found that proper sequencing of the loading cycles and the precision of the working strokes of the upper bars are the critical factors for establishing a certain row spacing value. Based on the simulation results, precise control of the back and forth motions of the upper bars is highly necessary for sound operation of the real system.

• Nuclear Engineering and Technology
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• v.55 no.8
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• pp.2723-2733
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• 2023

Transuranic nuclides (such as ²³⁸Pu, ²⁵²Cf, ²⁴⁹Bk, etc.) have a wide range of application in industry, medicine, agriculture, and other fields. However, due to the complex conversion chain and remarkable fission losses in the process of transuranic nuclides production, the generation amounts are extremely low. High flux reactor with high neutron flux and flexible irradiation channels, is regarded as the promising candidate for producing transuranic nuclides. It is of great significance to increase the conversion ratio of transuranic nuclides, resulting in higher efficiency and better economy. In this paper, we perform an optimization design evaluation of producing transuranic nuclides in high flux reactor, which includes optimization design of irradiation target and influence study of reactor core loading. It is demonstrated that the production rate increases with appropriately determined target material and target structure. The target loading scheme in the irradiation channel also has a significant influence on the production of transuranic nuclides.

• Magazine of the Korean Society of Agricultural Engineers
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• v.30 no.3
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• pp.69-81
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• 1988

The Repeated Load Triaxial and Oedometer Tests to the weathered granite & silty clay soil have been fulfilled to investigate their dynarnic characteristics. The results obtained are summarized as follows ; 1. In the relation between the repeated triaxial compression and the oedometer test, the recoverable strain of weathered granite soil showed a tendency to decrease by the increase of the repeated loads number(N), and that of silty clay showed approximately constant values while the total strain increased continuously. 2. The changes of plastic strain was dependent to the level of deviator stress which is the most important element in the calculation of soil deformation under repeated load condition. And there was a significance of 10% between the level of stress and plastic strain. 3. When the soil was aimost dried or saturated to 100%, the deformation by the repeated loads was small. However the deformation showed peak around the saturation of 50%. 4. When the deformation was predicted by the repeated triaxial load tests of a laboratory, it is desirable to introduce the threshold stress concept in the calculation of deformation of subgrade of the pavement. 5. The improved design equation (Eq. 16) introducing the modulus of conversion(Fo), which is based on the Boussineq' s theory, is considered to be rational in the design of flexible pavement. From the above results, the deformation to the repeated traffic loads could be predicted by the repeated triaxial tests on the pavement materials or undisturbed soil layers, therefore it is think that the durable and econornic pavement could be constructed by reflecting that to the design.

• International Journal of Highway Engineering
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• v.16 no.2
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• pp.61-71
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• 2014

PURPOSES : The first generation of wide base tires introduced in the early 1980s was found to cause a significant increase in pavement damage compared to dual-tire assemblies. However, wide base tires have evolved considerably, and a new generation of wide base tire is thought to be comparable to conventional dual tires for pavement damage. A challenge associated with using wide base tires is the accurate quantification of pavement damage induced by these tires. The objective of this study was to investigate the responses of flexible pavement to continuously moving vehicular loading under various tire configurations. METHODS : The comparison of the strain/stress responses of full-depth pavement caused by conventional dual tire assembly and new generation of wide-base tires was performed. The FE model incorporates linear viscoelasticity of asphalt material and continuous moving load using implicit dynamic analysis. RESULTS AND CONCLUSIONS : The result demonstrates that the new wide-base tires caused slightly more fatigue damage and less primary rutting damage in HMA layer than a dual-tire assembly, but caused more secondary rutting damage in subgrade than a dual tire assembly.

• Structural Engineering and Mechanics
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• v.73 no.2
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• pp.123-132
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• 2020

Steel spherical hinged bearings have high loading capacity, reliable load transfer, flexible rotation with universal hinge and allowance of large displacement and rotation angle. However, bearings are in complex forced states subject to various load combinations, which lead to the significant influence on integral structural safety. Taking the large-tonnage complex steel spherical hinged bearings of Terminal 2 of Guangzhou Baiyun International Airport as an example, full-scale rotation and shear behaviour tests of the bearings subject to axial tensile load are carried out, and the corresponding finite element simulation analyses are conducted. The results of experiments and finite element simulations are in good agreement with the coincident development tendency of stress and deformation. In addition, the measured rotational moment is less than the calculated moment prescriptive by the code, and the relationship between horizontal displacement and horizontal shear force is linear. Finally, based on these results, the rotation and shear stiffness models of bearings subject to axial tensile load are proposed for the refinement analysis of integral structure.

• Wind and Structures
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• v.25 no.5
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• pp.459-474
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• 2017

In this study an analytical expression is derived for the natural frequency of the wind turbine towers supported on flexible foundation. The derivation is based on a Euler-Bernoulli beam model where the foundation is represented by a stiffness matrix. Previously the natural frequency of such a model is obtained from numerical or empirical method. The new expression is based on pure physical parameters and thus can be used for a quick assessment of the natural frequencies of both the real turbines and the small-scale models. Furthermore, a relationship between the diagonal and non-diagonal element in the stiffness matrix is introduced, so that the foundation stiffness can be obtained from either the p-y analysis or the loading test. The results of the proposed expression are compared with the measured frequencies of six real or model turbines reported in the literature. The comparison shows that the proposed analytical expression predicts the natural frequency with reasonable accuracy. For two of the model turbines, some errors were observed which might be attributed to the difference between the dynamic and static modulus of saturated soils. The proposed analytical solution is quite simple to use, and it is shown to be more reasonable than the analytical and the empirical formulas available in the literature.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.18 no.3
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• pp.307-314
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• 2009

Large area micro pattern replication has promising application potential in many areas. Rolling imprint process has been demonstrated as one of the most competitive processes for such micro pattern replication, because it has advantages in low cost, high throughput and high efficiency. In this paper, we developed a prototype of roll-to-flat(R2F) thermal imprint system for large area micro pattern replication process, which is one of the key processes in the fabrication of flexible displays. Experimental tests were conducted to evaluate the feasibility of system and the parameters' effect on the process, such as flat mold temperature, loading pressure and rolling speed. 100mm $\times$ 100mm stainless steel flat mold and commercially available polycarbonate sheets were used for the tests. The experimental results showed that the developed R2F system is suitable for fabrication of various micro devices with micro pattern over large area.