• YAKHAK HOEJI
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• v.32 no.2
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• pp.112-116
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• 1988

The resolution of N-trifluoroacetyl (N-TFA) ter-isopropylesters of Ala, Ile, Leu, Val and Phe by gas chromatography on the (S)-5-isobutyl-$N^3$-phenyl-2-thiohydantoin as stationary phase was investigated. The phase was employed at several column temperatures $(140^{\circ}C{\sim}200^{\circ}C)$ and the separation factors were $1.18{\sim}1.45$ range for five amino acid enantiomers. The possible mechanism of chiral recognition was investigated by NMR technique and the association constant$(K_c)$ was calculated as 201.3(r=0.98) for alanyl derivative.

• Korean Journal of Child Studies
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• v.36 no.5
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• pp.37-58
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• 2015

This study explored the sandplay therapy case of an elementary school-aged boy who was mentally handicapped for the purposes of understanding his psyche. The goal of the therapy was to help him to adjust more appropriately to situations he commonly encountered within the free and protected space made possible during sandplay therapy. Fifty-five therapy sessions were held. The client showed a lack of fundamental care, which was accompanied with regression in the initial phase of therapy (1~14, my situations & regression). In the intermediate phase of therapy (15~52, rebirth), he experienced rebirth and grew psychologically with the death of both a spider and a king snake. In the final phase of therapy (53~55, the acquisition of treasure), he finished his journey with the acquisition of treasure in a free and protected space. By exhibiting a similar psyche with non-handicapped boys, this study confirmed an archetypal pattern existing even in a boy who was mentally handicapped.

• Journal of Power Electronics
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• v.19 no.5
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• pp.1162-1170
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• 2019

Finite-control-set model predictive control (FCS-MPC) is a promising control scheme for two-level voltage-source inverters (TL-VSIs). However, two main issues arise in the classical FCS-MPC method: an exponentially-increasing computational time and a low steady-state performance. To solve these two issues, a novel FCS-MPC method has been proposed for n-phase TL-VSIs in this paper. The basic idea of the proposed method is to carry out the FCS-MPC scheme of TL-VSIs for one leg by one leg, like a "pipeline". Based on this idea, the calculations are reduced from exponential time to linear time and its current waveforms are improved by applying more switching states per sampling period. The cases of three-phase and five-phase TL-VSIs were tested to verify the effectiveness of proposed method.

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.4
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• pp.237-248
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• 2015

"Dynamic stabilization" systems have been developed in recent years to treat degenerative disorders of the spinal column. In contrast to arthrodesis (fusion), the aim here is to conserve intervertebral mobility to maximize comfort. When developing innovative concepts, many mechanical tests need to be carried out in order to validate the different technological solutions. The present study focuses on the B Dyn$^{(R)}$ "dynamic stabilization" device (S14$^{(R)}$ Implants, Pessac, France), the aim being to optimize the choice of polymer material used for one of the implant's components. The device allows mobility but also limit the range of movement. The stiffness of the ring remains a key design factor, which has to be optimized. Phase one consisted of static tests on the implant, as a result of which a polyurethane (PU) was selected, material no.2 of the five elastomers tested. In phase two, dynamic tests were carried out. The fatigue resistance of the B Dyn$^{(R)}$ system was tested over five million cycles with the properties of the polymer elements being measured using dynamic mechanical analysis (DMA) after every million cycles. This analysis demonstrated changes in stiffness and in the damping factor which guided the choice of elastomer for the B Dyn$^{(R)}$ implant.

• Journal of the Korean Chemical Society
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• v.34 no.3
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• pp.248-254
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• 1990

Theoretical studies on the electrophilic substitution reactions of five-membered heteroaromatic compounds, furan, pyrrole and thiophene, with isopropyl cation were carried out using the MNDO method. The results indicated that site selectivities of ${\alpha},{\beta}$ and hetero-atoms are not controlled by electrostatic interactions but are determined mainly by charge trasfer stabilization between the HOMO of heteroaromatics and the LUMO of the electrophile. The reactivity order for ${\alpha}\;and\;{\beta}$ positions was pyrrole > furan > thiophene, in agreement with the solution-phase as well as the gas-phase experimental results.

• Journal of Power Electronics
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• v.16 no.6
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• pp.2099-2108
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• 2016

The cascaded multilevel converter is widely adopted to medium/high voltage and high power electronic applications due to the small harmonic components of the output voltage and the facilitation of modularity. In this paper, the operation principle of a T-type H-bridge topology is investigated in detail, and a carrier phase shifted pulse width modulation (CPS-PWM) based control method is proposed for this topology. Taking a virtual five-level waveform achieved by a unipolar double frequency CPS-PWM as the output object, PWM signals of the T-type H-bridge can be obtained by reverse derivation according to its switching modes. In addition, a control method for the T-type H-bridge based cascaded multilevel converter is introduced. Then a single-phase T-type H-bridge cascaded multilevel static var generator (SVG) prototype is built, and a repetitive controller based compound current control strategy is designed with the DC-link voltage balancing control scheme analyzed. Finally, simulation and experimental results validate the correctness and feasibility of the proposed modulation method and control strategy for T-type H-bridge based cascaded multilevel converters.

• JSTS:Journal of Semiconductor Technology and Science
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• v.16 no.4
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• pp.451-462
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• 2016

Photovoltaic energy conversion becomes main focus of many researches due to its promising potential as source for future electricity and has many advantages than the other alternative energy sources like wind, solar, ocean, biomass, geothermal etc. In Photovoltaic power generation multilevel inverters play a vital role in power conversion. The three different topologies, diode-clamped (neutral-point clamped) inverter, capacitor-clamped (flying capacitor) inverter and cascaded h-bridge multilevel inverter are widely used in these multilevel inverters. Among the three topologies, cascaded h-bridge multilevel inverter is more suitable for photovoltaic applications since each pv array can act as a separate dc source for each h-bridge module. This paper presents a single phase Cascaded H-bridge five level inverter for grid-connected photovoltaic application using sinusoidal pulse width modulation technique. This inverter output voltage waveform reduces the harmonics in the generated current and the filtering effort at the input. The control strategy allows the independent control of each dc-link voltages and tracks the maximum power point of PV strings. This topology can inject to the grid sinusoidal input currents with unity power factor and achieves low harmonic distortion. A PID control algorithm is implemented in Arm Processor LPC2148. The validity of the proposed inverter is verified through simulation and is implemented in a single phase 100W prototype. The results of hardware are compared with simulation results. The proposed system offers improved performance over conventional three level inverter in terms of THD.

• Bulletin of the Korean Chemical Society
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• v.21 no.12
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• pp.1202-1206
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• 2000

Transmission of substituent effects through 5-membered heteroaromatic rings is investigated theoretically at the RHF/6-31+G and B3LYP/6-31+G levels using the equilibria for the $OH^- addition to five-membered heteroaromatic aldehydes (5MHA). The transmission efficiency (S) in 5MHA(A) increases in the order NH>O>S>PH but the order exactly reverses in 5MHA($T^-$). This is originated by the delocalizability of the ${\pi}$ lonepair on Y, $$n_\pi$(Y)$. A better correlation is obtained with ${\sigma}_p^-$ in the Hammett plots with positive slope, $p_z$ > 0, indicating that the substituent (Z) effects are not transmitted by a direct conjugation. The magnitude of $p_z$ for Y=NH is the largest among the heteroaromatic systems, which is consistent with the largest transmission efficiency change $({\Delta}S)$. The equilibria for the addition processes are favorable in the gas phase $({\Delta}G^o<0)$, which reverses to unfavorable in aqueous solution $({\Delta}G^o>0)$ due to the relatively large salvation energy of $OH^-$ in the initial state in aqueous solution. The orders of ${\Delta}G^o$ and $p_z$ in the gas phase are almost maintained in solution.

• Biomedical Science Letters
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• v.28 no.2
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• pp.67-82
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• 2022

The prevalence of SARS-CoV-2 led to inconsistent public health policies that resulted in COVID-19 containment failure. These factors resulted in increased hospitalization and death. To prevent viral spread and achieve herd immunity, the only safe and effective measure is to provide to vaccinates. Ever since the release of the SARS-CoV-2 nucleotide sequence in January of 2020, research centers and pharmaceutical companies from many countries have developed different types of vaccines including mRNA, recombinant protein, and viral vector vaccines. Prior to initiating vaccinations, phase 3 clinical trials are necessary. However, no vaccine has yet to complete a phase 3 clinical trial. Many products obtained "emergency use authorization" from governmental agencies such as WHO, FDA etc. The Korean government authorized the use of five different vaccines. The viral vector vaccine of Oxford/AstraZeneca and the Janssen showed effectiveness of 76% and 66.9%, respectively. The mRNA vaccine of Pfizer-BioNTech and Moderna showed effectiveness of 95% and 94.1%, respectively. The protein recombinant vaccine of Novavax showed an effectiveness of 90.4%. In this review, we compared the characteristics, production platform, synthesis principles, authorization, protective effects, immune responses, clinical trials and adverse effects of five different vaccines currently used in Korea. Through this review, we conceptualize the importance of selecting the optimal vaccine to prevent the COVID-19 pandemic.

• Advances in nano research
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• v.13 no.3
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• pp.297-312
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• 2022

Coughing and breath shortness are common symptoms of nano (small) cell lung cancer. Smoking is main factor in causing such cancers. The cancer cells form on the soft tissues of lung. Deformation behavior and wave vibration of lung affected when cancer cells exist. Therefore, in the current work, phase velocity behavior of the small cell lung cancer as a main part of the body via an exact size-dependent theory is presented. Regarding this problem, displacement fields of small cell lung cancer are obtained using first-order shear deformation theory with five parameters. Besides, the size-dependent small cell lung cancer is modeled via nonlocal stress/strain gradient theory (NSGT). An analytical method is applied for solving the governing equations of the small cell lung cancer structure. The novelty of the current study is the consideration of the five-parameter of displacement for curved panel, and porosity as well as NSGT are employed and solved using the analytical method. For more verification, the outcomes of this reports are compared with the predictions of deep neural network (DNN) with adaptive optimization method. A thorough parametric investigation is conducted on the effect of NSGT parameters, porosity and geometry on the phase velocity behavior of the small cell lung cancer structure.