• Genomics & Informatics
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• v.16 no.2
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• pp.22-29
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• 2018

Incorporation of unique barcodes into fission yeast gene deletion collections has enabled the identification of gene functions by growth fitness analysis. For fine tuning, it is important to examine barcode sequences, because mutations arise during strain construction. Out of 8,708 barcodes (4,354 strains) covering 88.5% of all 4,919 open reading frames, 7,734 barcodes (88.8%) were validated as high-fidelity to be inserted at the correct positions by Sanger sequencing. Sequence examination of the 7,734 high-fidelity barcodes revealed that 1,039 barcodes (13.4%) deviated from the original design. In total, 1,284 mutations (mutation rate of 16.6%) exist within the 1,039 mutated barcodes, which is comparable to budding yeast (18%). When the type of mutation was considered, substitutions accounted for 845 mutations (10.9%), deletions accounted for 319 mutations (4.1%), and insertions accounted for 121 mutations (1.6%). Peculiarly, the frequency of substitutions (67.6%) was unexpectedly higher than in budding yeast (~28%) and well above the predicted error of Sanger sequencing (~2%), which might have arisen during the solid-phase oligonucleotide synthesis and PCR amplification of the barcodes during strain construction. When the mutation rate was analyzed by position within 20-mer barcodes using the 1,284 mutations from the 7,734 sequenced barcodes, there was no significant difference between up-tags and down-tags at a given position. The mutation frequency at a given position was similar at most positions, ranging from 0.4% (32/7,734) to 1.1% (82/7,734), except at position 1, which was highest (3.1%), as in budding yeast. Together, well-defined barcode sequences, combined with the next-generation sequencing platform, promise to make the fission yeast gene deletion library a powerful tool for understanding gene function.

• Journal of Dental Rehabilitation and Applied Science
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• v.26 no.1
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• pp.39-46
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• 2010

To assess the stress distribution of implant prosthesis induced by intentional misfit using photoelastic model. Stress was measured at the surrounding bone after applying vertical load to the implant. Three implants were placed in each of three photoelastic resin blocks. No misfits were used for the control group, while for the experimental group $100{\mu}m$ misfit after cutting the crown was used. The photoelastic stress analysis was performed. In control group, stress concentration was not shown when the load was not applied, whereas stress concentration was shown only in the loaded part even when load was applied and the stress was distributed in anterior-posterior direction when applying a load in the middle. When intentional misfits were given, stress around the fixture was incurred when tightening the screw even if load was not applied. If the load was applied, stress was concentrated around the implants including areas where the load was applied. In particular, the prosthesis made of UCLA showed more stress concentration as compared with a conical abutment. In the UCLA case, concentration was shown from the apex following through the axis to the cervical area. Prosthesis with misfit makes the stress concentrated though the load was not applied and it induces even more severe stress concentration when the load was applied. This founding demonstrates the importance of the correct prosthesis production.

• Journal of Digital Convergence
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• v.18 no.2
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• pp.175-182
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• 2020

The study aims to verify the effects of volleyball programs on the fitness and attention-intensive abilities of students with intellectual disabilities in middle school. Physical strength and attention concentration were analyzed to verify the effectiveness of the volleyball program. The volleyball program was applied to the experimental group three times a week, 90 minutes a week, a total of 36 times for 12 weeks. To verify the effectiveness of physical strength and attention concentration, the PPS-D intellectual disability student test and ATA concentration test were used to verify the effectiveness of attention concentration The six-minute walking figure related to cardiopulmonary functions was improved compared to those with intellectual disabilities who did not participate in the volleyball program, the report showed. We can see improvements in muscular function-related sit-ups and flexibility-related sit-ups compared to those with intellectual disabilities who did not participate, and significant changes have been seen in the distance of the place-wide jump related to net worth. We could also confirm that it had a positive effect on the improvement of selective attention concentration, and that the change in self-control, continuous attention, and selective attention among middle school students had a positive effect on the improvement.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.3
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• pp.124-131
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• 2016

Baseline correction is very important due to influence on performance of spectral analysis in application of spectroscopy. Baseline is often estimated by parameter selection using visual inspection on analyte spectrum. It is a highly subjective procedure and can be tedious work especially with a large number of data. For these reasons, it is an objective and automatic procedure is necessary to select optimal parameter value for baseline correction. Asymmetrically reweighted penalized least squares (arPLS) based on penalized least squares was proposed for baseline correction in our previous study. The method uses a new weighting scheme based on the generalized logistic function. In this study, we present an automatic selection of optimal parameter for baseline correction using arPLS. The method computes fitness and smoothness values of fitted baseline within available range of parameters and then selects optimal parameter when the sum of normalized fitness and smoothness gets minimum. According to the experimental results using simulated data with varying baselines, sloping, curved and doubly curved baseline, and real Raman spectra, we confirmed that the proposed method can be effectively applied to optimal parameter selection for baseline correction using arPLS.

• Journal of the Korea Society of Computer and Information
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• v.27 no.2
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• pp.43-51
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• 2022

In this paper, we suggest the method to improve the existing method leaning context-free grammar(CFG) using tabular representation(TBL) as a chromosome of genetic algorithm in grammatical inference and show the more efficient experimental result. We have two improvements. The first is to improve the formula to reflect the learning evaluation of positive and negative examples at the same time for the fitness function. The second is to classify partitions corresponding to TBLs generated from positive learning examples according to the size of the learning string, proceed with the evolution process by class, and adjust the composition ratio according to the success rate to apply the learning method linked to survival in the next generation. These improvements provide better efficiency than the existing method by solving the complexity and difficulty in the crossover and generalization steps between several individuals according to the size of the learning examples. We experiment with the languages proposed in the existing method, and the results show a rather fast generation rate that takes fewer generations to complete learning with the same success rate than the existing method. In the future, this method can be tried for extended CYK, and furthermore, it suggests the possibility of being applied to more complex parsing tables.

• Journal of Wetlands Research
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• v.17 no.3
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• pp.251-263
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• 2015

This study suggested a novel approach of estimating the optimal probability density function (OPDF) of the annual maximum rainfall time series (AMRT) combining the L-moment ratio diagram and the geographical information system. This study also reported several interesting geographical characteristics of the AMRT in Korea. To achieve this purpose, this study determined the OPDF of the AMRT with the duration of 1-, 3-, 6-, 12-, and 24-hours using the method of L-moment ratio diagram for each of the 67 rain gages in Korea. Then, a map with the Thiessen polygons of the 67 rain gages colored differently according the different type of the OPDF, was produced to analyze the spatial trend of the OPDF. In addition, this study produced the color maps which show the fitness of a given probability density function to represent the AMRT. The study found that (1) both L-skewness and L-kurtosis of the AMRT have clear geographical trends, which means that the extreme rainfall events are highly influenced by geography; (2) the impact of the altitude on these two rainfall statistics is greater for the mountaneous region than for the non-mountaneous region. In the mountaneous region, the areas with higher altitude are more likely to experience the less-frequent and strong rainfall events than the areas with lower altitude; (3) The most representative OPDFs of Korea except for the Southern edge are Generalized Extreme Value distribution and the Generalized Logistic distribution. The AMRT of southern edge of Korea was best represented by the Generalized Pareto distribution.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.46 no.3
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• pp.202-208
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• 2001

Under the constant daylength of 13 hours and growth temperatures of 15$^{\circ}C$ to 27$^{\circ}C$, the final number of loaves (FNL) on the main culm was constant as 15 regardless of temperature in rice variety 'Kwanganbyeo'. Leaf appearance rate (LAR) increased with rising temperature and decreased with phenological development. Threshold temperature (T$_{o}$) was not constant across growth stages, but increased with phenological development. Effective accumulated temperature (EAT), which is calculated by the summation of values subtracting T0 from daily mean temperature, is closely related with number of leaves appeared (LA). LA was fitted to bilinear, quadratic, power and logistic function of EAT. Among the functions, logistic function had the best fitness of which coefficient of determination was $R^2$=0.995. Therefore, LAR prediction model was established by differentiating this function in terms of time: (equation omitted). where dL/dt is LAR, T$_1$ is daily mean temperature, L is the number of leaves appeared, and a, b, and c are constants that were estimated as 41.8, 1098.38, and -0.9273, respectively. When predictions of LA were made by LAR prediction model using data independent of model establishment, the observed and predicted LA showed good agreement of $R^2$$\geq$0.99.

• Journal of the Korea Society of Computer and Information
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• v.16 no.12
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• pp.23-31
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• 2011

The simple bacteria cooperative optimization (sBCO) algorithm that we developed as one of optimization algorithms has shown relatively good performances, but their performances were limited by step-by-step movement of individuals at a time. In order to solve this problem, we proposed a new method that assigned a speed to each individual according to its rank and it was confirmed that it improved the performances of sBCO in some degree. In addition to the assigning of speed to the individuals, we employed a new mutation operation that most existing evolutionary algorithms used in order to enhance the performances of sBCO in this paper. A specific percent of bad individuals are mutated within an area that is proportion to the rank of the individual in the mutation operation. That is, Gaussian noise of large standard deviation is added as the fitness of individuals is low. From this, the probability that the individuals with lower ranks can be located far from its parent will be increased. This causes that the probability of falling into local optimum areas is decreased and the probability of fast escaping the local optimum areas is increased. From experimental results with four function optimization problems, we showed that the performances of sBCO with mutation operation and individual speed were increased. If the optimization function is quite complex, however, the performances are not always better. We should devise a new method for solving this problem as a further work.

• Journal of Industrial Convergence
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• v.21 no.7
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• pp.51-63
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• 2023

This study aimed to verify the effects of a 4-week program of ankle-strengthening exercise and toe-taping walk exercise on the basic lower body strength and walking to examine the benefits of the two exercises. The subjects involved 30 women in their 20s enrolled in university A. The subjects were equally divided into three groups - ankle-strengthening exercise group, toe-taping walk exercise group, and control group. The subjects were instructed to massage and do ankle-strengthening exercises using a towel, massage ball, and CRT, for 60 minutes, 3 times a week. They also taped their hallux valgus using a kinesiology tape and walked for 20 minutes with white tape applied. To sum up, the 4-week ankle-strengthening exercise and toe-taping walk exercise were identified to have a partial statistical significance on the basic lower body strength (muscular strength, power, and balance) and walking (length of gait line, plantar pressure, and COP) of women in their 20s. Therefore, the study confirmed the effects of ankle-strengthening exercises and toe-taping walk exercise on the lower body exercise function, and it is considered that further studies should be conducted on more various effects of the exercises by subdividing them into different pain locations and orthomechanic findings.

• Journal of Dental Rehabilitation and Applied Science
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• v.31 no.4
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• pp.371-377
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• 2015

Oral lichen planus (OLP) is a common mucocutaneous disease, which presents as bilateral or multiple lesions. The several factors are implicated in etiology of OLP such as dental restorations, systemic disease, drugs and stress. Especially the influence of dental restorations and plaque control for OLP has been the interest in dentistry. This case is about OLP patient having poor contoured and ill-fitting metal ceramic restorations. The patient in this study has suffered from OLP for a long time, particularly after restoration of metal ceramic restorations on both posterior teeth of maxilla and mandible. This study reported that OLP lesion recovered effectively by improving the contour and fitness of restorations with plaque control.