• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.18 no.11
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• pp.888-895
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• 2006

The present study has been conducted to investigate the effects of Reynolds number on heat/mass transfer and pressure drop characteristics in a rotating smooth two-pass duct. For stationary cases, the heat/mass transfer and pressure drop Is decreased on turning region of both leading and trailing surfaces as Reynolds number increases. For rotating cases, increment of Reynolds number affects differently the heat/mass transfer and pressure drop on the leading and trailing surfaces. In the first pass, for example, the heat/mass transfer on the leading surface is greatly increased, though the heat/mass transfer on the trailing surface is almost the same. The reason is that effect of the main flow is more dominant than effect of secondary flow. In particular, it gave decrement of the heat/mass transfer and the pressure drop at turning region and upstream region of second pass for both non-rotating and rotating cases.

• Journal of Korean Society of Transportation
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• v.32 no.4
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• pp.389-400
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• 2014

This study finds a way to increase the usability of a subway commuter pass. Usability of the commuter pass on a probabilistic statistical model is calculated when the pass is allowed to used in a different mode(bus). A sunk cost of commuter pass is used to reduce the vehicle travels from public transit. 324 people aged 25 to 35 were surveyed and utilized to build a Nested Logit Model on STRADA 3.5 platform. Main results are as follows. First, commuter passes were issued in various forms. Second, the model turns out to be statistically significant in four explanatory variables (discount rate, inter-usablity between modes, forms of payment and periods). Lastly, the more valid on different modes, the more increased of the rail commuter pass.

• Journal of Pharmaceutical Investigation
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• v.35 no.2
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• pp.101-106
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• 2005

The pharmacokinetics of oral nifedipine (5 mg/kg) was studied in rabbits given after or simultaneously with naringin (1.5, 7.5 and 15 mg/kg, respectively). The area under the plasma concentration-time curve (AUC) and the peak concentration $(C_{max})$ of nifedipine coadministered or pretreated with naringin were significantly increased (p < 0.05, coad.; p < 0.01, pret.) compared with the control group. The absolute bioavailability (AB%) of nifedipine was significantly (p < 0.05, coad.; p < 0.01, pret.) higher by 22.3 - 28.1 % compared to the control (17.9%). The relative bioavailability (RB%) of nifedipine was higher by 1.24 - 1.43 times (coad.) and 1.32 -1.57 times (pret.) than those of the control, showing that preatreatrnent of naringin was more effective than that of the coadministration of naringin. Naringin did not show significant effect on the Tmax and $t_{1/2}$ of nifedipine. It is suggested that naringin may alter pharmacokinetic paramiters of nifedipine by inhibition of P-glycoprotein efflux pump and its first-pass metabolism. The dosage of nifedipine should be adjusted when it is administered with naringin in a clinical situation.

• YAKHAK HOEJI
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• v.51 no.3
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• pp.169-173
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• 2007

The aim of this study was to investigate the effect of morin on the pharmacokinetics of nifedipine in rats. The pharmacokinetic parameters of nifedipine were measured after the oral administration of nifedipine (5 mg/kg) in the presence or absence of morin (1.5, 7.5 and 15 mg/kg, respectively). Compared to the control groups, the presence of 7.5 mg/kg and 15 mg/kg of morin significantly (p<0.05) increased the area under the plasma concentration-time curve (AUC) of nifedipine by 48.5${\sim}$68.2%, and the peak concentration (C$_{max}$,) of nifedipine by 59.9~84.2%. The absolute bioavailability(AB%) of nifedipine was significantly (p<0.05) increased by 21.5${\sim}$24.5% compared to the control (14.5%). While there was no significant change in the time to reach the peak plasma concentration (T$_{max}$) and the terminal half-life (T$_{1/2}$) of nifedipine in the presence of morin. It might be suggested that morin altered disposition of nifedipine by inhibition of both the first-pass metabolism and p-glycoprotein (P-gp) efflux pump in the small intestine of rats. In conclusion, the presence of morin significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of morin or morin-containing dietary supplement with nifedipine should require close monitoring for potential drug interaction.

• Earthquakes and Structures
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• v.3 no.3_4
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• pp.341-363
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• 2012

The spectral representation method is a quick and versatile tool for the generation of spatially variable, response-spectrum-compatible simulations to be used in the nonlinear seismic response evaluation of extended structures, such as bridges. However, just as recorded data, these simulated accelerations require processing, but, unlike recorded data, the reasons for their processing are purely numerical. Hence, the criteria for the processing of acceleration simulations need to be tied to the effect of processing on the structural response. This paper presents a framework for processing acceleration simulations that is based on seismological approaches for processing recorded data, but establishes the corner frequency of the high-pass filter by minimizing the effect of processing on the response of the structural system, for the response evaluation of which the ground motions were generated. The proposed two-step criterion selects the filter corner frequency by considering both the dynamic and the pseudo-static response of the systems. First, it ensures that the linear/nonlinear dynamic structural response induced by the processed simulations captures the characteristics of the system's dynamic response caused by the unprocessed simulations, the frequency content of which is fully compatible with the target response spectrum. Second, it examines the adequacy of the selected estimate for the filter corner frequency by evaluating the pseudo-static response of the system subjected to spatially variable excitations. It is noted that the first step of this two-fold criterion suffices for the establishment of the corner frequency for the processing of acceleration time series generated at a single ground-surface location to be used in the seismic response evaluation of, e.g. a building structure. Furthermore, the concept also applies for the processing of acceleration time series generated by means of any approach that does not provide physical considerations for the selection of the corner frequency of the high-pass filter.

• The Journal of Fisheries Business Administration
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• v.53 no.2
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• pp.21-41
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• 2022

The effect of change in exchange rates on an economy is very important, especially, to a small open economy like South Korea. I explore whether Free Trade Agreements (FTAs) have positive influences on exchange rate-pass through import price of import market for fishery products in South Korea. Competition among FTA partners is enhanced after FTAs are effective. I expect that the extent to which are exchange rate pass-through (hereafter, ERPT) into import price of fishery products (in terms of Korea currency) would be reduced since the import market for fishery products in South Korea is an oligopolistic market. Specifically, I investigate two research questions with six South Korea's FTA partners-Norway, Thailand, Peru, U.S., China and Vietnam. First, whether the extent to which are exchange rate pass-through into import price of fishery products from six FTA partners would decrase in the post-FTA era; seconds, the size of reduction has a negative relation with the size of their market share in the import market for fishery products in South Korea if it decreases. The empirical results indicate that the degree of ERPT into import price from other FTA partners than Norway has been reduced after FTA, statistically and significantly; however, I do not find the evidence that the size of reduction is related to their market share. The findings in this study imply that FTAs have negative effects on producers' economic welfare in South Korea's fishery industry by reducing the extent to which are exchange rate pass-through as well as reducing tariff barriers.

• Journal of Biomedical Engineering Research
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• v.16 no.2
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• pp.209-216
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• 1995

Recently, a new tailored RF gradient echo (TRFGE) sequence was reported. This technique not only enhances the magnetic susceptibility effect but also allows us to measure local changes in brain oxygenation. In this study, a phantom and cat brain experiments were performed on a 4.7 Tesla BIQSPEC (BRUKER) instrument with a 26 cm gradient system. We have demonstrated that the signal intensity (SI) of the TRFGE sequence varies according to the concentration of susceptibility contrast agent. Three capillary tubes with different concentrations of Gd-DTPA (0.01, 0.05, 0.1 mMOI/l) were placed at the middle of a cylindrical water phantom. Using both TRFGE and conventional gradient echo (CGE) sequences, phantom images of the slices which contain all three tubes were obtained. For the animal experiment, cats were anesthetized and ventilated using halotane (0.5%) and a $N_2O/ O_2$ mixture (2:1), and blood pressure and heart rate were monitored and kept normal. For the observation of tue first pass of Gd- DTPA, imaging was started at t = 0. At t = 8 ~ 12s, 0.2 mMol/Kg Gd-DTPA was manually injected in the femoral vein. The imaging parameters were TRITE = 25/10 msec, flip angle = $30^{\circ}$, FOV = 10cm, image matrix size = $128{\times}128$ with 64 phase encodings and the image data acquisition window was 10 msec. SI-time curves were then obtained from a series of 30 images which were collected at 2 sec intervals using both CGE and TRFGE pulse sequences before, during, and following the contrast injection.

• Korean Journal of Radiology
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• v.24 no.2
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• pp.145-154
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• 2023

Objective: We aimed to evaluate the efficacy of EmboTrap II in terms of first-pass recanalization and to determine whether it could yield favorable outcomes. Materials and Methods: In this multicenter, prospective study, we consecutively enrolled patients who underwent mechanical thrombectomy using EmboTrap II as a front-line device. The primary outcome was the first pass effect (FPE) rate defined by modified Thrombolysis In Cerebral Infarction (mTICI) grade 2c or 3 by the first pass of EmboTrap II. In addition, modified FPE (mFPE; mTICI grade 2b-3 by the first pass of EmboTrap II), successful recanalization (final mTICI grade 2b-3), and clinical outcomes were assessed. We also analyzed the effect of FPE on a modified Rankin Scale (mRS) score of 0-2 at 3 months. Results: Two hundred-ten patients (mean age ± standard deviation, 73.3 ± 11.4 years; male, 55.7%) were included. Ninety-nine patients (47.1%) had FPE, and mFPE was achieved in 150 (71.4%) patients. Successful recanalization was achieved in 191 (91.0%) patients. Among them, 164 (85.9%) patients underwent successful recanalization by exclusively using EmboTrap II. The time from groin puncture to FPE was 25.0 minutes (interquartile range, 17.0-35.0 minutes). Procedure-related complications were observed in seven (3.3%) patients. Symptomatic intracranial hemorrhage developed in 14 (6.7%) patients. One hundred twenty-three (58.9% of 209 completely followed) patients had an mRS score of 0-2. Sixteen (7.7% of 209) patients died during the follow-up period. Patients who had successful recanalization with FPE were four times more likely to have an mRS score of 0-2 than those who had successful recanalization without FPE (adjusted odds ratio, 4.13; 95% confidence interval, 1.59-10.8; p = 0.004). Conclusion: Mechanical thrombectomy using the front-line EmboTrap II is effective and safe. In particular, FPE rates were high. Achieving FPE was important for an mRS score of 0-2, even in patients with successful recanalization.

• Journal of information and communication convergence engineering
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• v.13 no.4
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• pp.264-269
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• 2015

The chest X-ray image cannot be focused in the same manner that optical lenses are and the resultant image generally tends to be slightly blurred. Therefore, the methods to improve the quality of chest X-ray image have been studied. In this paper, the inherent noises of the input images are suppressed by adding the Laplacian image to the original. First, the chest X-ray image using an Gaussian high pass filter and an optimal high frequency emphasis filter has shown improvements in the edges and contrast of flat areas. Second, using fuzzy logic_histogram equalization, each pixel of the chest X-ray image shows the normal distribution of intensities that are not overexposed. As a result, the proposed method has shown the enhanced edge and contrast of the images with the noise canceling effect.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1799-1802
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• 2003

The commercial success of a new product is influenced by the time to market. Shorter product leadtimes are of importance in a competitive market. This can be achieved only if the product development process can be realized in a relatively small time period. New cutting inserts are developed by a time consuming trial and error process guided by empirical knowledge of the mechanical cutting process. The effect of previous cutting on chip formation and the surface residual stresses has been studied. The chip formation is not affected much. There is only a minor influence from the residual stress on the surface from tile first cutting on the second pass chip formation. Thus, it is deemed to be sufficient to simulate only the first pass. The influence of the cutting speed and feed on the residual stresses has been computed and verified by the experiments. It is shown that the state of residual stresses in the workpiece increases with the cutting speed. This paper presents experimental results which can be used for evaluating computational models to assure robust solutions. The general finite element code ABAQUS/Standard has been used in the simulations. A quasi-static simulation with adiabatic heating was performed. The path for separating the chip from the workpiece is predetermined. The agreement between measurements and calculation is good considering the simplifications introduced.