• The Korean Journal of Physiology and Pharmacology
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• v.13 no.3
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• pp.215-220
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• 2009

Chlorpheniramine is a potent first-generation histamine $H_1$ receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of leading causes of acquired long QT syndrome, we investigated the acute effects of chlorpheniramine on hERG channels to determine the electrophysiological basis for its proarrhythmic potential. We examined the effects of chlorpheniramine on the hERG channels expressed in Xenopus oocytes using two-microelectrode voltage-clamp techniques. Chlorpheniramine induced a concentration-dependent decrease of the current amplitude at the end of the voltage steps and hERG tail currents. The $IC_{50}$ of chlorpheniramine-dependent hERG block in Xenopus oocytes decreased progressively relative to the degree of depolarization. Chlorpheniramine affected the channels in the activated and inactivated states but not in the closed states. The S6 domain mutations Y652A and F656A partially attenuated (Y652A) or abolished (F656A) the hERG current block. These results suggest that the $H_1$ antihistamine, chlorpheniramine is a blocker of the hERG channels, providing a molecular mechanism for the drug-induced arrhythmogenic side effects.

• The Journal of the Korea Contents Association
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• v.7 no.8
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• pp.191-198
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• 2007

Due to the growth of female movement after 1970s' and the resultant interest in female activity changed the type and degree of female crime and thus led to considerable interest and research. As a result, the relative difference between crime rates of sexes has been reduced, but the crime of male and female has been considerably decreased owing to sex role and concept of self-ego, more generally specking, the result of female movement. As countermeasure for the recently increasing frmale crime, this research presents first, enhancement of social education; second, arrangement of relevant institutions; third, activation of the system of female investigator; fourth, the necessity of victimology approach.

• Asia pacific journal of information systems
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• v.12 no.3
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• pp.1-20
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• 2002

For the last decade, some leading groups of corporations in Korea have integrated and managed their Information Systems(IS) functions. Each group established a separate System Management(SM) company to manage the IS and tried to get a synergy effect from the integration. These attempts, however, were not initiated by any one company. Rather they were group efforts. Moreover, the previous measuring tools evaluated IS with the scope of technical performance or quantitative user satisfaction using an absolute scale. Obscure criteria were used in an attempt to present improvements in IS function which were qualitatively weak. This study evaluates whether integration has been efficient and successful. For this purpose, we evaluate the performance efficiency of IS functions with Data Envelopment Analysis(DEA) methodology. In comparison with prior methods, DEA presents the rate of relative efficiency, the efficiency frontier for improving inefficiency, the degree of improvement(slack), and the guideline to construct any benchmark(reference set). For our DEA evaluation, this study selected a leading group of 23 companies in Korea. Our experimental results are as follows. First, efficiency was rated low on average. It also demonstrates that the motivation of performance efficiency of IS functions is deficient. Second, the result of the test to find the existence of economy of scale and scope shows that the growth of an organization and industrial characteristics do not affect IS performance efficiency from the perspective of user satisfaction. Finally, the comparison with other evaluation approaches informs us that DEA can be a complementary evaluation method which supports other measuring tools.

• Earthquakes and Structures
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• v.4 no.3
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• pp.299-324
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• 2013

The current research focuses on the seismic vulnerability assessment of typical Southern Europe buildings, based on processing of a large set of observational damage data. The presented study constitutes a sequel of a previous research. The damage statistics have been enriched and a wider damage database (178578 buildings) is created compared to the one of the first presented paper (73468 buildings) with Damage Probability Matrices (DPMs) after the elaboration of the results from post-earthquake surveys carried out in the area struck by the 7-9-1999 near field Athens earthquake. The dataset comprises buildings which developed damage in several degree, type and extent. Two different parameters are estimated for the description of the seismic demand. After the classification of damaged buildings into structural types they are further categorized according to the level of damage and macroseismic intensity. The relative and the cumulative frequencies of the different damage states, for each structural type and each intensity level, are computed and presented, in terms of damage ratio. Damage Probability Matrices (DPMs) are obtained for typical structural types and they are compared to existing matrices derived from regions with similar building stock and soil conditions. A procedure is presented for the classification of those buildings which initially could not be discriminated into structural types due to restricted information and hence they had been disregarded. New proportional DPMs are developed and a correlation analysis is fulfilled with the existing vulnerability relations.

• Natural Product Sciences
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• v.24 no.1
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• pp.71-78
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• 2018

The present study deals with the determination of optimal values of operating parameters such as the temperature of heating, the mass of the plant material and the volume of water leading to the best yield of electromagnetic induction (EMI) heating extraction of Algerian Thymus fontanesii essential oil. After an appropriate choice of the three critical variables, eight experiments leaded to a mathematical model as a first-degree polynomial presenting the response function (yield) in the relation to the operating parameters. From the retained model, we were able to calculate the average response, the different effects and their interactions. The maximum of essential oil recovery percentage relative to the initial mass of plant material was 1.69%, and was obtained at ($140^{\circ}C$, 250 g and 4.5 L). The chemical composition of the Algerian T. fontanesii essential oil under the obtained optimal conditions ($140^{\circ}C$, 250 g and 4.5 L), determined by GC/MS and GC/FID, reveled of the presence of major components such as: carvacrol ($70.6{\pm}0.1%$), followed by p-cymene ($8.2{\pm}0.2%$).

• Journal of Korea Society of Digital Industry and Information Management
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• v.7 no.3
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• pp.37-42
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• 2011

Nowadays software developers are moving from conventional software process technologies to the object-oriented paradigm. To develope the object-oriented softwares efficiently, various software metrics have been suggested. Coupling refers to the degree of independence between components of the system. It has long been well known that good software practice calls for minimizing coupling interaction. Many researches have been studied coupling metrics of the object- oriented systems. We review Chidamber and Kemerer's work & Li's work. In this paper, we study the coupling of the overall structures of object-oriented systems by analyzing the class diagram of UML. We propose four coupling metrics for object-oriented softwares. First, we use an established coupling metric for object- oriented systems as a basic coupling metric. Then we modify the basic coupling metric by including indirect coupling between classes, We also suggest two relative coupling metrics to measure coupling between subsystems. We investigate the theoretical soundness of the proposed metrics by the axioms of Briand et al. Finally, we apply the presented metrics to a practical case study. This coupling metric will be helpful to the software developers for their designing tasks by evaluating the coupling metric of the structures of object-oriented system and redesigning tasks of the system.

• Industrial Engineering and Management Systems
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• v.14 no.4
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• pp.347-371
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• 2015

A hybrid procedure based on multi-Criteria Satisfaction Analysis (MUSA) and a Network Data Envelopment Analysis (NDEA) is proposed to evaluate the relative efficiency of customer services in bank branches. First, a three-stage process including sub-processes such as customer expectations, customer satisfaction, and customer loyalty, is defined to model the banking customer services. Then, fulfillment of customer expectations, customer loyalty level, and the customer satisfaction degree are measured and quantified through a multi-dimensional questionnaire based on customers' perceptions analysis and MUSA method, respectively. The customer services scores and the other criteria such as mean of employee evaluation score, operation costs, assets, deposits, loans, number of accounts are considered in network three-stage DEA model. The proposed NDEA model is formed based on multipliers perspective, output-oriented, and constant return to scale assumptions. The proposed NDEA model quantifies and assesses the total efficiency of main process and assigns the efficiency to customer expectations, customer satisfactions, and customer loyalties sub-processes in bank branches. The whole procedure is applied on 30 bank branches in IRAN. The proposed approach can be used in other organizations such as airports, airline agencies, urban transportation systems, railway organizations, chain stores, chain restaurants, public libraries, and entertainment centers.

• Journal of Korean Society of Rural Planning
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• v.25 no.2
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• pp.35-45
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• 2019

This study revises current feasibility evaluation guideline for agricultural infrastructure improvement project considering recent changes in social and economic environment in rural area. We use an AHP(Analytic Hierarchy Process) approach to consider qualitative evaluation items in policy enforcement and balanced regional development as well as quantitative items in current economic analysis in the process of feasibility evaluation and decision making. The criteria system is composed of three level hierarchy. In the first level which consists of economic analysis, policy analysis, and regional development analysis, economic analysis was ranked top with relative weight of 0.45 and regional development analysis the lowest with 0.22. In the second level which consists of three evaluation items under policy analysis, consistency in policy enforcement, risk factors, and special evaluation factors, consistency in policy enforcement was ranked top. Finally, 13 detailed evaluation items in the third level were surveyed and ranked by using a comprehensive criticality vector. The result shows that the three most important evaluation items are 'degree of underdevelopment', 'spill-over effect of regional economy' and 'consistency with related planning and policy direction'.

• The Journal of Engineering Geology
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• v.33 no.3
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• pp.439-459
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• 2023

Numerical analysis has been adopted in nearly all modern scientific and engineering fields due to the rapid and ongoing evolution of computational technology, with the number of grid or mesh points in a given data field also increasing. Some values must be extracted from large data fields to evaluate and supplement numerical analysis results and observational data, thereby highlighting the need for a fast and effective interpolation approach. The quadrilateral irregular network (QIN) proposed in this study is a fast and reliable interpolation method that is capable of sufficiently satisfying these demands. A comparative sensitivity analysis is first performed using known test functions to assess the accuracy and computational requirements of QIN relative to conventional interpolation methods. These same interpolation methods are then employed to produce simple numerical model results for a real-world comparison. Unlike conventional interpolation methods, QIN can obtain reliable results with a guaranteed degree of accuracy since there is no need to determine the optimal parameter values. Furthermore, QIN is a computationally efficient method compared with conventional interpolation methods that require the entire data space to be evaluated during interpolation, even if only a subset of the data space requires interpolation.

• Structural Engineering and Mechanics
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• v.89 no.4
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• pp.383-397
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• 2024

To improve the vibration control performance and applicability of traditional particle tuned mass damper (PTMD) and realize the significant characteristic of lightweight design, this study proposes a novel particle tuned mass inerter system (PTMIS) by introducing inerter system (IS) to the PTMD. In the study, the motion equation of single degree of freedom (SDOF) structure attached with PTMIS is established first, then the variation law of the system's vibration reduction performance (VRP) is discussed through parameter analysis, and it is compared with the PTMD to analyze its VRP advantages. Finally, its vibration reduction (VR) mechanism from the perspective of core control force and energy analysis is explored, and its cavity relative displacement from the application perspective is analyzed. The results show that the PTMIS can remarkably improve the vibration control effectiveness of the PTMD. The reason is that the inerter can store energy and transfer the energy to the cavity and particles, which further stimulates the interaction between the two parts, thereby improving the nonlinear energy consumption effectiveness. Also, the IS can amplify the damping element's energy dissipation efficiency. In addition, the PTMIS can effectively reduce the working stroke of the PTMD, and through the analysis of the lightweight characteristics of the PTMIS, it is found that its lightweight advantage can reach nearly 100%.