• Journal of Sasang Constitutional Medicine
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• v.9 no.2
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• pp.203-225
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• 1997

Jihwangbakhotang(地黃白虎楊) is made by Li Je Ma, the creator of the Four Constitutional Medicine. Single and 13 weeks oral repeated dose toxicity studies were conducted in Sprague Dawley rats of both sexes to elucidate the potential acute and subchronic toxicity of JBT extract and reversibility of any effects. In the single dose study, JBT extract was administered orally to rats with the dose of 2 g/kg and 8 g/kg. In the long term administration of 13 weeks, the JBT extract of 125 mg/kg/day, 500 mg/kg/day, 2000 mg/kg/day was administered to rats. The change of blood weight, urine volume, electrolyte in urine, hematological change, the change of blood chemistry, autopsy finding, and histological observation were researched, the results were as follows; 1. The lethal dose of JBT extract seems to be over 10 g/kg, the single administration of JBT extract 8 g/kg showed no toxical signs except little increase of urine volume. 2. The change of body weight had the trend of decrease in the group of, but has no significance, and also the consumption of food and water had no changes. 3. The hematological changes induced by the 13 weeks administration of JBT extract showed the significance in the item of Hb, MCH, MCV, WBC in the group of 125 mg/kg/day. 4. In the test of blood chemistry, total cholesterol showed little decrease and A/G ratio showed little increase, but the change was not clear, and the standard error was large. So the result was obtained insignificantly and the toxicity of JBT extract was not observed. 5. In the male group after recovery period, the level of cholesterol and triglyceride decreased slightly, but the result was not significant. 6. In the urine test, the little change of electrolyte was appeared, but it seemed not to be the result induced by the toxicity of JBT extract. 7. In each group of male and female rats, the weight change of organ and the serum histological changes was observed, but the result did not showed the dose dependent toxicity. So the toxicity of JBT extract was not regarded. In the conclusion, the toxicity of JBT extract was not observed in the single dose treatment and long term repetitive administration of JBT extract.

• Journal of Positioning, Navigation, and Timing
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• v.4 no.2
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• pp.43-55
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• 2015

In the case of satellite navigation positioning, the shielding of satellite signals is determined by the environment of the region at which a user is located, and the navigation performance is determined accordingly. The accuracy of user position determination varies depending on the dilution of precision (DOP) which is a measuring index for the geometric characteristics of visible satellites; and if the minimum visible satellites are not secured, position determination is impossible. Currently, the GLObal NAvigation Satellite system (GLONASS) of Russia is used to supplement the navigation performance of the Global Positioning System (GPS) in regions where GPS cannot be used. In addition, the European Satellite Navigation System (Galileo) of the European Union, the Chinese Satellite Navigation System (BeiDou) of China, the Quasi-Zenith Satellite System (QZSS) of Japan, and the Indian Regional Navigation Satellite System (IRNSS) of India are aimed to achieve the full operational capability (FOC) operation of the navigation system. Thus, the number of satellites available for navigation would rapidly increase, particularly in the Asian region; and when integrated navigation is performed, the improvement of navigation performance is expected to be much larger than that in other regions. To secure a stable and prompt position solution, GPS-GLONASS integrated navigation is generally performed at present. However, as available satellite navigation systems have been diversified, finding the minimum satellite constellation combination to obtain the best navigation performance has recently become an issue. For this purpose, it is necessary to examine and predict the navigation performance that could be obtained by the addition of the third satellite navigation system in addition to GPS-GLONASS. In this study, the current status of the integrated navigation performance for various satellite constellation combinations was analyzed based on 2014, and the navigation performance in 2020 was predicted based on the FOC plan of the satellite navigation system for each country. For this prediction, the orbital elements and nominal almanac data of satellite navigation systems that can be observed in the Korean Peninsula were organized, and the minimum elevation angle expecting signal shielding was established based on Matlab and the performance was predicted in terms of DOP. In the case of integrated navigation, a time offset determination algorithm needs to be considered in order to estimate the clock error between navigation systems, and it was analyzed using two kinds of methods: a satellite navigation message based estimation method and a receiver based method where a user directly performs estimation. This simulation is expected to be used as an index for the establishment of the minimum satellite constellation for obtaining the best navigation performance.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.9
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• pp.825-830
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• 2009

Pharmaceutical compounds enter the water environment through the diverse pathways. Because their concentration in the water environment was frequently detected in the level of ppt to ppb, the monitoring system should be optimized as much as possible for finding appropriate management policies and technical solutions. One Factor At a Time (OFAT) approach approximating the response with a single variable has been preferred for the optimization of LC-MS/MS operational conditions. However, it is common that variables in analytical instruments are interdependent. Therefore, the best condition could be found by using the statistical optimization method changing multiple variables at a time. In this research, response surface analysis (RSA) was applied to the LC-MS/MS analysis of emerging antibiotic compound, sulfamethoxazole, for the best sensitivity. In the screening test, fragmentation energy and collision voltage were selected as independent variables. They were changed simultaneously for the statistical optimization and a polynomial equation was fit to the data set. The correlation coefficient, $R^2$ valuerepresented 0.9947 and the error between the predicted and observed value showed only 3.41% at the random condition, fragmentation energy of 60 and collision voltage of 17 eV. Therefore, it was concluded that the model derived by RSA successfully predict the response. The optimal conditions identified by the model were fragmentation energy of 116.6 and collision voltage of 10.9 eV. This RSA can be extensively utilized for optimizing conditions of solid-phase extraction and liquid chromatography.

• Journal of the Korean Society for Nondestructive Testing
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• v.25 no.5
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• pp.391-399
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• 2005

Laser-generated ultrasonic inspection system is a non-contact scanning inspection device with high spatial resolution and wide bandwidth. The amplitude of laser-generated ultrasound is varied according to the energy of pulse laser and the surface conditions of an object where the CW measuring laser beam is pointing. In this paper, we correct the generating errors by measuring the energy of pulse laser beam and correct the measuring errors by extracting the gain information of laser interferometer at each time. h dynamic stabilizer is developed to stably scan on the surface of an object for an laser-generated ultrasonic inspection system. The developed system generates ultrasound after adaptively finding the maximum gain time of an laser interferometer and processes the signal in real time after digitization with high speed. In this paper, we describe hardware configuration and control algorithm to build a stable laser-generated ultrasonic inspection system. Also, we confirmed through experiments that the proposed correction method for the generating errors and measuring errors is effective to improve the performance of a system.

• Journal of Preventive Medicine and Public Health
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• v.37 no.2
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• pp.111-119
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• 2004

Purpose : To identify those factors influencing the post-operative satisfaction in myopia patients receiving laser in situ keratomileusis (LASIK) Methods : This study included 288 consecutive patients who received LASIK between July and December 2001 from two eye clinics located in Seoul and Pusan. Factors that were considered to influence post-operative satisfaction included pre-operative baseline characteristics, pre-operative expectation for treatment outcomes, and treatment outcomes. Before undergoing LASIK, study subjects were asked to rate the degree of their expectation for the improvement of visual functions and symptoms after LASIK on a 5-point Likert-type scale: where 1 referred to 'somewhat worse,' 2 to 'no change,' 3 to 'somewhat improved,' 4 to 'improved,' and 5 to 'very improved.' Self-administered questionnaire was used to evaluate baseline visual functions and symptoms on a 5-point scale before LASIK. At 6 months after LASIK, the evaluation was repeated to measure treatment outcomes in terms of the difference in the score before and after LASIK. Post-operative satisfaction was also measured at 6 months on a 5-point scale. Multiple regression analysis was performed to examine the independent relationship between influencing factors and postoperative satisfaction. Results : A total of 171 patients (59.4%) participated in the 6-month follow-up investigation. The average expectation scores for the improvement in visual functions and symptoms were 3.8 and 3.4, respectively. The average score for the 7 questions assessing satisfaction was 4.0. The results of the regression analysis showed that the post-operative satisfaction increased with improvement in the visual function ($\beta$=0.16, p<0.05) and symptoms ($\beta$=0.25, p<0.05), the degree of preoperative refractive error ($\beta$ =0.26-0.67, p<0.05) and in male patients ($\beta$=0.31, p<0.1). The pre-operative expectation was not a statistically significant factor in explaining postoperative satisfaction in the regression model. Conclusion : The finding from this study was that patients with very severe myopia tended to be more satisfied with the treatment than those with mild myopia, which implies that LASIK can be more beneficial to those suffering from a severe visual condition. Patient satisfaction was also significantly affected by the treatment outcomes experienced after LASIK. This suggests that improving the clinical outcome is the most fundamental requirement for the improvement of patient satisfaction.

• Journal of the Korean Society of Marine Environment & Safety
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• v.26 no.6
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• pp.644-655
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• 2020

This study focuses on the margin of human error when a navigator is embarrassed by the psychological fear of collision in a close-quarter situation (CQS) and is unable to perform as per the prescribed collision avoidance measures. The purpose of the study is to identify the effects of the navigator's personal characteristics or factors in relation to on-board career (OC), license rating (LR), and age on the perceived collision risk (PCR) in CQSs. In order to obtain quantified data regarding the collision risk perceived by the navigator in four typical CQSs between their own ship and a target ship, this study measured and collated the heart rate variability of 30 navigators on their own ship when two ships approached each other at a speed of 10 knots from 2.5 nautical miles to a collision situation. According to a multiple regression analysis of the measured values, the navigators' OC and LR factors had negative effects on the PCR, while the age factor had no significant effect on PCR. The t-test results showed that the PCR value was significantly higher for navigators with an OC ≤ 4 years than for those with an OC ≥ 5 years, and the LR factor was significantly higher for a class 4~6 group than for a class 2~3. This finding may be applied to the development of collision risk warning systems, particularly for navigators.

• Environmental and Resource Economics Review
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• v.17 no.4
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• pp.813-843
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• 2008

This paper investigates the presence of long-run and short-run price asymmetries in weekly gasoline prices from January 1997 to July 2008. In accordance with distribution channels, wholesale and retail stages are analyzed separately. An approach based on TAR and M-TAR cointegration tests, which entail matching asymmetric ECMs, is employed. For wholesale prices, asymmetries in the links with crude oil prices and exchange rates are found for both ECMs in the long-run and short-run. Exchange rates appear to play more significant role than crude oil prices in explaining the short-run price asymmetry. The rise in crude oil prices or exchange rates has statistically significant major impact on the increase of wholesale prices on the second week, not immediately as expected in the concept of 'rockets and feathers'. And asymmetrically, the fall does not have any statistically significant effect on the same period. The finding seems to be somewhat unusual. However, for retail prices, asymmetry m connection with wholesale prices is only revealed in the long-run. A symmetric price adjustment can be assumed in the short-run. Contrary to the long-run asymmetry found in the wholesale stage, in the retail stage, the speed of adjustment for negative deviations toward long-run equilibrium is faster than for positive ones, which is a phenomenon not favorable to consumers.

• Journal of KIISE:Software and Applications
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• v.33 no.5
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• pp.508-524
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• 2006

We present our experience of combining, in a realistic setting, a static analyzer with a statistical analysis. This combination is in order to reduce the inevitable false alarms from a domain-unaware static analyzer. Our analyzer named Airac(Array Index Range Analyzer for C) collects all the true buffer-overrun points in ANSI C programs. The soundness is maintained, and the analysis' cost-accuracy improvement is achieved by techniques that static analysis community has long accumulated. For still inevitable false alarms (e.g. Airac raised 970 buffer-overrun alarms in commercial C programs of 5.3 million lines and 737 among the 970 alarms were false), which are always apt for particular C programs, we use a statistical post analysis. The statistical analysis, given the analysis results (alarms), sifts out probable false alarms and prioritizes true alarms. It estimates the probability of each alarm being true. The probabilities are used in two ways: 1) only the alarms that have true-alarm probabilities higher than a threshold are reported to the user; 2) the alarms are sorted by the probability before reporting, so that the user can check highly probable errors first. In our experiments with Linux kernel sources, if we set the risk of missing true error is about 3 times greater than false alarming, 74.83% of false alarms could be filtered; only 15.17% of false alarms were mixed up until the user observes 50% of the true alarms.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.2
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• pp.67-78
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• 2006

Local governments began to construct geographic information system to improve government productivity and performance. In support, central government organized a national commission for GIS. The master plan by NGIS has been the base for local government to participate in the construction of GIS at the local level in the under ground facilities management including water and sewers. The challenge faced by sewer facility managers includes controlling 'data accuracy'. The input for sewer data handling for efficient performance in local government requires accurate data. However data manipulation to get the 'good quality' data can be burdensome. Thus, the aim of this research is to provide the appropriate tool to guarantee the high quality of digital data in sewer facility management. It is helpful to pass the data examination by government as well as to insure confidence of decision and data analysis works in local government. In this research, error types of sewer data were classified and pointed the limitation of traditional examination methods. Thus this research suggested more improved method for finding and correcting errors in data input using sewer volume analysis and prediction model as immigrating sewer facility management work to Geographic Information System.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.46 no.5
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• pp.8-14
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• 2009

In the research field of speech recognition, pinpointing the endpoints of speech utterance even with the presence of background noise is of great importance. These noise present during recording introduce disturbances which complicates matters since what we just want is to get the stationary parameters corresponding to each speech section. One major cause of error in automatic recognition of isolated words is the inaccurate detection of the beginning and end boundaries of the test and reference templates, thus the necessity to find an effective method in removing the unnecessary regions of a speech signal. The conventional methods for speech endpoint detection are based on two linear time-domain measurements: the short-time energy, and short-time zero-crossing rate. They perform well for clean speech but their precision is not guaranteed if there is noise present, since the high energy and zero-crossing rate of the noise is mistaken as a part of the speech uttered. This paper proposes a novel approach in finding an apparent threshold between noise and speech based on Lyapunov Exponents (LEs). This proposed method adopts the nonlinear features to analyze the chaos characteristics of the speech signal instead of depending on the unreliable factor-energy. The excellent performance of this approach compared with the conventional methods lies in the fact that it detects the endpoints as a nonlinearity of speech signal, which we believe is an important characteristic and has been neglected by the conventional methods. The proposed method extracts the features based only on the time-domain waveform of the speech signal illustrating its low complexity. Simulations done showed the effective performance of the Proposed method in a noisy environment with an average recognition rate of up 92.85% for unspecified person.