• Journal of Information Technology Applications and Management
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• v.27 no.2
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• pp.23-36
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• 2020

The promulgation of the overall framework of Chinese students' development of core literacy has made the implementation of core literacy into specific teaching activities an urgent problem to be solved in the field of education. Based on the analysis of the problems existing in the undergraduate education under the mode of emphasizing theory and neglecting practice, this paper constructs the practical teaching system of Database Principle Course Based on the core quality, expounds the implementation strategy of practical teaching, and probes into how to train the students in the practical teaching of database principle Cultivate scientific spirit, learning ability, practical innovation, responsibility and other core literacy. After 5 rounds of practice, students have achieved better development in independent development and collaborative work, and their awareness of practical innovation has been significantly improved.

• Journal of Technology Innovation
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• v.13 no.3
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• pp.225-255
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• 2005

The similar point of the 19 regional industrial clusters of Japan is that all of the clusters are not limited to an administrational district but rather covers a larger area. When a cluster covers a larger area, there is problem of acquiring responsible businesses and interactive planing. In order to overcome such a problem, private coordinating organizations have been installed and operated to connect and manage inter-activities of industries, universities, and research institutes. TAMA, a private coordinating organization, differs from other associations in a way that it does not deal with one specific field or business. TAMA rather dealswith various product-developing small to middle size companies by offering strategic support for the development of new technologies and expansion of new businesses. Product-developing small to middle size companies comparatively have their own abilities for technological development and marketing which is quite different from other subcontract companies and their relations to large corporations. In such aspect, product-developing companies are actually similar to large corporations with competitiveness in the world market.

• Journal of Korea Technology Innovation Society
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• v.22 no.2
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• pp.207-219
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• 2019

The international trends in activities of government R&D performance measurement is evolving into evidence-based approach to support the verification of objective policy implementation. The European Commission has been implementing KETs (Key Enabling Technologies) policy that incubates nanotech based emerging technologies to support the fourth industrial revolution/revitalization of high-tech manufacturing, and resulting innovations are quantified by KETs Observatory project. The European Commission also built Innovation Radar system that monitors potentially innovative projects within FP7 and Horizon2020 by data analysis. The United States is also upgrading its Federal RePORTER system to quantitatively monitor federal R&D investments with outcomes (including nanotechnology). In the field of Korean nanotechnology, basic statistical data by analyzing NTIS (National Science & Technology Information Service) information is applied in policy field. Developing innovation measurement methodology beyond basic statistical analysis is an international policy issue, and a long-term R&D investment area of a government. The objective of this model study is to quantify the innovation potential of nano R&D investments conducted by Korea government, using input-output based efficiency measurement model and NTIS (National Science & Technology Information Service) that is comprehensive data portal for national R&D investments/outcomes including nanotechnology.

• Journal of Life Science
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• v.24 no.9
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• pp.973-980
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• 2014

This study was conducted to explore new nutraceutical resources from the plant kingdom possessing biological activities. To fulfill this purpose, the anti-oxidative and anti-inflammatory activities of Decaisnea insignis ethanol extract (DIEE) were evaluated. First, DIEE possessed potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl (DPPH), similar to ascorbic acid used as a positive control. Moreover, DIEE inhibited lipopolysaccharide (LPS)- and hydrogen peroxide ($H_2O_2$)-induced reactive oxygen species (ROS) in RAW 264.7 cells. Furthermore, DIEE induced the expression of an anti-oxidative enzyme, heme oxygenase 1 (HO-1), and its upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2), in a dose-dependent manner. The modulation of the HO-1 and Nrf2 expressions might be regulated by mitogen-activated protein kinases (MAPKs) and their upstream signaling pathways. On the other hand, DIEE suppressed LPS-induced nitric oxide (NO) formation without cytotoxicity. The inhibition of the NO formation was the result of the downregulation of inducible NO synthase (iNOS) by DIEE. The suppression of NO and iNOS by DIEE might be modulated by their upstream transcription factors, nuclear factor ${\kappa}B$ ($NF-{\kappa}B$), and activator protein 1 (AP-1) pathways. Taken together, these results provide important new insights that D. insignis possesses anti-oxidative and anti-inflammatory activities. Therefore, it might be utilized as a promising material in the field of nutraceuticals.

• Journal of Korea Technology Innovation Society
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• v.10 no.1
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• pp.98-120
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• 2007

This study analyzed the linkage relations of technological innovation between Daedeok Innopolis and other seven innovative clusters in industrial complexes which have played important roles as innovative centers in Korea. To begin with, we selected major technologies of Daedeok Innopolis for which the linkage with other clusters of innovative activities was analyzed quantitatively and graphically with association matrices, network analysis and dendrogram. Based on this network analysis, we analyzed the technological linkage among clusters and found the direction and strength of technological cooperation of the Daedeok Innopolis with other innovative clusters by technology field. This study analyzed the technological network between the Daedeok Innopolis and other clusters on 6 technology fields in which Daedeok has innovative capabilities. In the analysis was measured the centrality of Daedeok compared with that of other clusters in areas where Daedeok is relatively active in innovative activities. As a result, Daedeok showed the highest centrality with the active innovative activities. Except Daedeok, Banwol-Sihwa cluster showed the highest centrality in all of the 6 technology fields. Putting all the centrality of each innovative cluster and the linkage relations of Daedeok Innopolis together, it need to consider the following policy directions to strengthen the innovative linkage with other clusters. In Daedeok's main technology areas, it needs to increase the regional linkage with the clusters with relatively high centrality and relatively low linkage with Daedeok. For Changwon, Wonju and Gunsan with which Daedeok has the relatively low innovative linkage, it need to examine a new policy to improve the linkage with technologies related with the industry other clusters are nurturing. When Daedeok formulates a plan to cooperate with other clusters, it does not only have to consider the linkage relations of technological innovation analyzed in this study and but also has to examine the cooperative strategies from the comprehensive point of view considering every aspect of their strategic industries, supportive policies, industrial base and competitiveness. This study analyzed the linkage relations between regions based on the network analysis of patents only by co-invention. Consequently, it did not examine the factors inducing the co-invention, which is a limitation of the study and is to be investigated in the future. Also, the exploratory analysis on determinants of linkage intensity and the strategies to get synergy effects through solidified linkage will be the issues of further study.

• Journal of Korean Society for Quality Management
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• v.39 no.1
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• pp.131-140
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• 2011

Today, due to the global recession car sales have been decreased rapidly and auto makers are competing continuously to expand their market share. Automakers are struggling in order to secure competitive cost and quality through continuous cost reduction and quality innovation activities to win in the competition. In this situation, auto parts makers are trying to reinforce price competitiveness by reducing COPQ (Cost Of Poor Quality) in the mass production stages by securing the quality of components in advance from the design stage through DFSS (Design For Six Sigma) activities which is 6 sigma approach in the R&D field. However, auto parts makers have been undergone various confusion, feeling difficulties to get interrelationship among various activities. Thus, this study is going to suggest approach method for much more effective R&D activities by securing interrelationship between ISO/TS 16949 system established in the auto parts industry and DFSS activities.

• Asian Journal of Turfgrass Science
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• v.23 no.2
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• pp.209-218
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• 2009

Bacterial isolates collected from rhizosphere of turfgrass showed strong in vitro antagonistic activities against a number of turfgrass soilborne pathogens such as Rhizoctonia cerealis, R. solani AG-1(1B), Sclerotinia homoeocarpa and Typhula incarnata. In vivo study, four bacterial isolates selected have control values over 60% against one or more turfgrass pathogenic fungi. The antagonistic effects of the bacterial isolates varied depending on fungal species, host plant, and disease pressure, indicating that control effects of the antagonists could be variable depending on field conditions. They were classified as belonging to the genus Pseudomonas species, based on morphological and biochemical characteristics as well as 16S rRNA analysis. The four bacterial isolates are under a study for finding proper cultural conditions and determination formulation type.

• Journal of Life Science
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• v.27 no.8
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• pp.888-895
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• 2017

Salsola collina (S. collina) is an annual plant widely distributed in drought and semi-drought areas, which has been used for a long time as a kind of folk remedy in traditional Chinese medicine for the treatment of hypertension. Previously, the anti-oxidative and anti-cancer activities of S. collina were elucidated in our research group. In this study, the anti-obesity activities of S. collina ethanol extract (SCEE) were evaluated using a pancreatic lipase enzyme inhibition assay and cell culture model. The results showed that SCEE effectively suppressed pancreatic lipase enzyme activity in a dose-dependent manner. Furthermore, SCEE significantly suppressed adipocyte differentiation, lipid accumulation, and triglyceride (TG) content, and triggered lipolysis on insulin, dexamethasone, and 3-isobutyl-l-methylxanthine-treated 3T3-L1 preadipocytes in a dose-dependent manner without cytotoxicity. Its anti-obesity effect was modulated by cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$, and the peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) gene, as well as protein expressions. Taken together, these results offer the important new insight that S. collina possesses anti-obesity properties, such as pancreatic lipase inhibition and anti-adipogenic and lipolysis effects through the modulation of their upstream signaling pathway. It could become a promising source in the field of nutraceuticals, and the identification of active compounds that confer the biological activities of SCEE may be needed.

• Journal of Korea Technology Innovation Society
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• v.20 no.1
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• pp.62-80
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• 2017

The purpose of this paper is to explore the relationship between industrial regulations and the R&D activities of firms by analysing the case of manufacturing enterprises in Korea. The sample is gathered from the 2012 Korean Innovation Survey data of Korean Institute of Science & Technology Evaluation and Planning and merged with Korean Regulation Index data of Korean Institute of Public Administration. The Ordinary Least Square (OLS) as well as 2 Stage Least Square (2SLS) regression results show that the impact of the level of the manufacturing field's regulation on firms' R&D activities or inputs may be both positive and negative, depending on the size of the firms. The analysis results suggest that regulatory policy makers need to formulate and implement R&D programs that consider the different effects of industrial regulations on large enterprises or Small and Medium sized Enterprises (SMEs).

• Journal of Life Science
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• v.24 no.7
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• pp.713-720
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• 2014

In this study, the antioxidative and anti-inflammatory activities of Ardisia arborescens ethanol extract (AAEE) were evaluated using in vitro assays and a cell culture model system. AAEE exhibited potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl (DPPH), similar to ascorbic acid, which was used as a positive control. Moreover, AAEE effectively suppressed lipopolysaccharide (LPS)- and hydrogen peroxide ($H_2O_2$)-induced reactive oxygen species (ROS) in RAW 264.7 cells. Furthermore, AAEE induced the expression of antioxidative enzymes, heme oxygenase 1 (HO-1), and thioredoxin reductase 1 (TrxR1), in addition to their upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2), in a dose-dependent manner. The upstream signaling pathways of mitogen-activated protein kinases (MAPKs) might regulate the modulation of HO-1, TrxR1, and Nrf2 expression. On the other hand, AAEE inhibited LPS-induced nitric oxide (NO) formation, without cytotoxicity. Suppression of NO formation was the result of AEEE-induced down-regulation of inducible NO synthase (iNOS). The suppression of NO and iNOS by AAEE might be modulated by their upstream transcription factor, nuclear factor (NF)-${\kappa}B$, and activator protein (AP)-1 pathways. Taken together, these results provide important new insights into the antioxidative and anti-inflammatory activities of A. arborescens. AAAEE might represent a promising material in the field of nutraceuticals.