• 한국응용과학기술학회지
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• 제37권6호
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• pp.1698-1705
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• 2020

나이가 20-25세인 남녀 성인들 20명(남성 5명, 여성 15명)의 엄지손가락 표면에 상재하는 세균을 채취하고 Luria-Bertani agar에서 배양하였다. 배양된 세균들의 16S rDNA를 polymerase chain reaction을 통하여 증폭하고, 그 염기서열을 분석하였다. 이렇게 얻어진 염기서열을 genbank의 자료들과 비교하여 세균들을 동정한 결과, 총 14종의 세균들이 확인되었다. 개인별로는 평균 2.5종의 배양 가능한 세균들을 손의 피부에 보유하는 것으로 확인되었다. 확인된 세균 중에서는 Staphylococcus 종들이 가장 널리 존재하고 있었으며, 다음으로는 Micrococcus luteus이었다. Staphylococcus 종들의 경우에는 그 분포에 있어서 성별에 따른 차이가 적었으나, Micrococcus luteus의 경우에는 남자보다 여자에게서 훨씬 더 많이 분리되는 경향을 보였다. 이러한 결과는 피부 질환에 대한 연구, 피부질환에 대한 치료제 개발, 피부에 사용하는 화장품개발 등의 분야에 도움이 될 것으로 사료된다.

• 농업과학연구
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• 제48권4호
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• pp.1003-1013
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• 2021

Thioredoxin (TRX) protein is an antioxidant responsible for reducing other proteins by exchanging cysteine thiol-disulfide and is also known for its anti-allergic and anti-aging properties. On the other hand, epidermal growth factor (EGF) is an important material used in the cosmetics industry and an essential protein necessary for dermal wound healing facilitated by the proliferation and migration of keratinocytes. EGF also assists in the formation of granulation tissues and stimulates the motility of fibroblasts. Hence, genetically modified soybeans were developed to overexpress these industrially important proteins for mass production. A single-dose oral-toxicity-based study was conducted to evaluate the potential toxic effects of TRX and EGF proteins, as safety assessments are necessary for the commercial use of seed-specific protein-expressing transgenic soybeans. To achieve this rationale, TRX and EGF proteins were mass purified from recombinant E. coli. The single-dose oral-toxicity tests of the TRX and EGF proteins were carried out in six-week old male and female Institute of Cancer Research (ICR) mice. The initial evaluation of the single-dose TRF and EGF treatments was based on monitoring the toxicity signatures and mortality rates among the mice, and the resultant mortality rates did not show any specific clinical symptoms related to the proteins. Furthermore, no significant differences were observed in the weights between the treatment and control groups of male and female ICR mice. After 14 days of treatment, no differences were observed in the autopsy reports between the various treatment and control groups. These results suggest that the minimum lethal dose of TRX and EGF proteins is higher than the allowed 2,000 mg·kg^-1 limit.

• Toxicological Research
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• 제23권4호
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• pp.405-413
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• 2007

This study was to investigate single and repeated-dose toxicities of Tensolin-$F^{(R)}$, an anti-wrinkle agent, in Sprague-Dawley (SD) rats or ICR mice. In single-dose oral toxicity study, the test materials were administered once by gavage to male and female SD rats at dose levels of 0 and 2,000 mg/kg. No dead animals and abnormal necropsy findings were found in control and Tensolin-$F^{(R)}$ treated group. Therefore, the approximate lethal dose of Tensolin-$F^{(R)}$ was considered to be higher than 2,000 mg/kg in rats. In the 4-week repeated oral toxicity study, the test material was administered once daily by gavage to male and female ICR mice at dose levels of 0, 25, 50 and 100 mg/kg/day for 4-weeks. In the results, no abnormality was observed in mortality, clinical findings, body weight changes, food and water consumptions, opthalmoscopic findings, necropsy findings, histopathological findings. In hematological analysis, there was a trend of increase in reticulocyte at male 25 mg/kg, although such changes were in normal ranges. On the other hand, there was a trend of decrease in hemoglobin at female 50, 100 mg/kg, such changes were in normal ranges. In addition, serum biochemical parameters including sodium, BUN and chloride increased at 25, 50 and 100 mg/kg. Relative organ weights of right testis, brain, lung and left epididymis were increased in 100 mg/kg groups of male rats in contrast to not change in female groups. However, these changes of relative organ weights, hematological and serum biochemical parameters were not accompanied with related signs such as histopathological changes or clinical findings. In conclusion, 4-week repeated oral dose of Tensolin-$F^{(R)}$ to ICR mice did not cause apparent toxicological change at the dose of 25, 50, 100 mg/kg body weight. Consequently the no-observed-adverse-effect level (NOAEL) for Tensolin-$F^{(R)}$ in ICR mice following gavage for at least 4-week is higher than 100 mg/kg/day.

• 대한화장품학회지
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• 제24권3호
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• pp.38-44
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• 1998

The skin permeation and the skin primary irritation of two UV filters from caprylic capryl triglyceride (oil), oil in water (O/W) and water in oil (W/O) emulsions, were evaluated. We selected octyl moth-oxycinnamate (OMC) broadly used in cosmetics and polymeric sunscreen agent (PSA, average MW: 2,000) synthesized by the coupling reaction of 2-ethylhexyl 4-hydroxycinnamate with poly vinylbenzyl chloride, as model UV filters. For in vitro skin permeation experiments, Franz diffusion cells (effective diffusion area:1.766cm) and the excised skin of female hairless mouse aged 8 weeks were used. Oil or emulsion containing UV filters was applied in the donor compartment. The skin primary irritation was evaluated with fe-male guinea pigs (8-10 weeks,350-400 g). In oil and emulsions, the skin permeability and the skin primary irritation of PSA were lower than those of OMC. The skin permeability of UV filters was lower when they were in oil-in-water emulsion (OIW) than water-in-oil emulsion (W/O). We suggest that O/W system would be more useful when compared with W/O system, and PSA could be a good candidate for a future sunscreen agent for reducing the skin irritation.

• 패션비즈니스
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• 제23권6호
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• pp.49-63
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• 2019

The purpose of this study was to determine the satisfaction, trust and word-of-mouth intention of online information according to the type of information search by female cosmetics consumers in their 20's to 40's. For this study, online and offline surveys were conducted by 307 people. Factor, correlation, and multiple regression analysis were used to analyze the data. The main results are summarized as follows. First, the cosmetic consumer's information search types were identified as active, playful, and economic information search types. Second, the results of examinations on the effect of consumer information search types on satisfaction, reliability, and word-of-mouth intention of the online information searches showed that the active information search type had a positive effect on satisfaction, reliability, and word-of-mouth intention. The economic information search type had a positive effect on satisfaction. The active information search type was confirmed to have high satisfaction, reliability, and word-of-mouth intention for the provided information and thus, the acceptance of the provided information was high. The playful information search type was divided into continuous, habitual, and independent information search and a tendency to assign a low value to consumer information was confirmed. The economic information search type showed high satisfaction with the information obtained by searching, but also a passive attitude toward trust or word-of-mouth intention and was categorized as a passive search type. Online information search is a communication channel with a great influence that can provide various benefits to cosmetic consumers.

• 유통과학연구
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• 제19권12호
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• pp.103-114
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• 2021

Purpose: This study was conducted with the goal of increasing research interest in H&B stores as a new distribution channel to identify factors influencing the revitalization of the H&B stores in Korea in distribution channels, in detail, the relationships among perceived values, satisfaction, trust, and loyalty. Research design, data and methodology: With 499 respondents, this study used exploratory factor analysis and reliability analysis to verify the reliability and validity of measured variables. Multiple regression was employed as a statistical method for the hypotheses of the study. Results: According to the results of the analysis, H&B stores are targeted by female customers in their 20s and 30s. The findings showed that four perceived values affect store satisfaction and trust. Store satisfaction and trust have positive effects on loyalty. Comparing the two variables, store satisfaction had a slightly stronger effect on loyalty than on trust. Conclusions: This study identified the store’s diverse values for the revitalization of the H&B stores need to provide to customers. The stores need to form facilities that can enhance the value of shops perceived by customers, and to establish distribution strategies that can further increase store satisfaction, trust, and loyalty to expand trading areas as multi-brand shops.

• 영미문화
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• 제18권2호
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• pp.51-78
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• 2018

To put it simply, thing theory is a study of meaningful capacities of materiality. Although T. S. Eliot regarded pathetic fallacy as the bad example of objective correlatives in his modernism poetry theory, it is clear that many objects in literary works reflect diverse human desires. Among many, Victorian sensation novels are the most distinct genre where the various paraphernalia in them indicate the distorted and exaggerated greed of the industrial revolution era. Whereas the male protagonists are usually related with the norms objects of authority such as portrait and locket, the female characters' connection with cosmetics and white dress shows their oppressed and fragile position in the patriarchal and hierarchical society. In the (post)modern society, the ambiguity of things has grown rapidly due to the increasing discrepancy between objects and things. In special, the new journalism and the psychological realism novels often reveal the post-truth phenomenon because consumerized audience depend more upon the attraction and affect than the mere evidence and facts. For the individual, according to object relations theory, these alternative facts are rather internalized into their mind as the internal object when they are motivated by the non/contact with primary caregivers in their childhood. The dominant material imagery in (post)modern fiction becomes the site of resistance because of their reconstructed and extended meaning. The object relations theory and thing theory can be effectively used to uncover the complicated meanings of desired objects by using the human-object's meaningful relations and early mental images that are secretly alive still in the present.

• 대한화장품학회지
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• 제40권4호
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• pp.373-382
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• 2014

피부는 인체의 외부를 덮고 있는 기관일 뿐 아니라, 체온을 조절하고, 감각기능을 수행하며, 약물을 투입하는 경로가 되기도 하고 내부 기관의 이상을 표현하는 기관이 되기도 한다. 이러한 이유로 인해, 사람들은 타인의 얼굴 피부의 상태를 보고 건강의 이상 징후를 감지하거나, "안색이 좋다", "생기가 있다" 등으로 신체의 컨디션을 표현해왔다. 환경과 노화정도에 따라서 피부색, 피부결, 수분, 탄력 등이 달라지는 것도 알려진 사실이다. 특히, 피부색은 아름다움, 매력도와 같은 주관적인 인상을 판단하는데 영향을 미치는 인자로 작용하는데, 화장품이나 피부시술을 통해 피부색을 개선하고자 하는 소비자를 통해서 그 수요를 짐작할 수 있다. 하지만 피부색이 여러 색의 구성임에도 불구하고, 대부분의 화장품이 하얀 피부로 개선해주는 것에 초점을 맞추고 있으며 여성들이 선호하는 피부색에 대한 연구가 아직까지는 미흡한 실정이다. 본 연구에서는 30 ~ 40대의 한국여성을 대상으로 같은 피부 밝기에서 붉은 정도와 푸른 정도가 달리 주어진 선호도 조사를 통해 긍정적으로 인식하는 피부색의 상태를 발견하였다. 한국여성은 실제 평균 피부색에 비해 붉은색과 푸른색이 높은 피부를 선호하는 것으로 나타났으며, 피부에 대한 표현을 달리하였을 때에도 경향은 유사하였다. 본 연구 결과는 새로운 소비자의 요구를 만족시키는 제품 개발에 활용될 수 있을 것이라고 생각한다.

• 한국콘텐츠학회논문지
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• 제21권6호
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• pp.81-93
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• 2021

본 연구는 화장품 선택속성 및 소비자의 구매의도와 추천의도 간의 영향 관계를 살펴보았다. 또한 소비자의 할인추구성향에 따른 조절효과를 검증하였다. 마지막으로 정보원천에 따라 연구 모형 경로에 대한 차이를 검증하기 위해 다중집단분석을 실시하였다. 본 연구를 통해서 화장품을 구매하는 소비자의 선택속성을 명확화하고, 이러한 선택속성이 할인추구성향에 따른 구매의도와 추천의도에 미치는 영향구조를 정보원천별로 규명함을 통해 보다 세부적이고 실효성 높은 전략적 통찰에 목말라 하는 산업업계의 필요와 요구에 부응하고자 한다. 이러한 필요성에 기인한 연구목적 달성을 위해 한국 여성 소비자 258명의 설문지를 수집하고 연구에 활용하였다. 분석결과는 제품 선택속성, 구매의도와, 추천의도 모두 긍정적인 영향관계에 있는 것으로 나타났다. 또한 소비자의 할인추구성향에 따른 조절효과 분석결과 화장품 선택속성과 구매의도 사이, 선택속성과 추천의도 사이, 구매의도와 추천의도 사이에서 조절효과를 나타내는 결과를 보였다. 마지막으로 모형의 개별 경로들이 정보원천에 따라 차이가 있는지를 검증하기 위해 다중집단분석을 실시한 결과 부분적으로 채택되었다.

• 한국식품위생안전성학회지
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• 제35권6호
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• pp.587-601
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• 2020

국내외적으로 유해물질의 통합 노출에 대한 관심은 높아지고 있다. 이러한 흐름에 따라 다양한 경로를 통해 노출될 수 있는 중금속에 대한 통합 노출 연구가 필요하다. 카드뮴과 납은 각각 신장 독성과 인지 장애 등 다양한 독성을 나타낼 수 있으며 또한 발암 물질로 알려져있다. 따라서 본 연구에서는 카드뮴과 납의 노출량 추정 및 통합 위해성 평가를 진행하였다. 2016, 2017년의 7기 국민건강영양조사에 참여한 10,733명의 식품, 물, 흡연과 간접흡연, 호흡, 화장품, 여성용 위생용품을 통한 중금속 노출 추정량을 계산하였다. 결과적으로 카드뮴과 납 모두 식품을 통한 노출이 제일 높게 나타났다. 이외에도 흡연은 카드뮴의 주요한 노출원이었으며, 납은 화장품을 통해 높은 농도로 노출되었다. 통합 위해평가에서도 식품이 가장 큰 영향을 미쳤다. 지역적 특성의 차이는 노출 추정량의 차이를 보이지 못하였으나, 연령 별, 성별 간 노출 추정량은 큰 차이를 보였다. 특히, 월경 중인 성인 여성의 경우 카드뮴, 월경 중이지 않은 여성은 납의 노출 추정량이 더 높으며 신체 대사를 고려하였을 때, 그 위험성이 더 클 수 있음을 암시하였다. 결론적으로 노출량 추정 및 통합 위해평가 모두 식품이 주요 노출원이었다. 다만, 잠재적 위험을 방지하기 위해 다른 경로에 대한 노출량 추정 및 위해평가가 요구된다.