• 한국임상수의학회지
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• 제17권2호
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• pp.403-410
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• 2000

The Ultrasonographic method alas been widely applied to evaluating gastric motility with safety and reproducibility ill human medicine but few reference to its use in veterinary medicine is appeared. Therefore, in this study, the gastric motility was evaluated with ultrasonography by the cri-terion of mean cycle lime, short and lony axis and the area of pyloric antrum in dogs, fed with liquid of semisolid meals. Furthermore, the animals were evaluated for the effect of metoclopramide on the motility of pyloric antrum. Healthy 5 mongrel male dogs were fed with either 400 ml of milk a: a liquid meal or a mixed meal of 200 ml of milk with two pieces of bread as a semisolid meal. Mean cycle time of pyloric antrum of dogs was significantly delayed after feeding either of liquid and , semi- solid meals(P<0.05), alls it was returned to the fasting state at 60 min. after feeding of liquid meal and 160 min. after feeding of semisolid meal. Mean area of pyloric antrum of dogs was gradually decreased and was returned to the lasting state at 80 min. in doss fed liquid meal. but 1600 min. in dog\ulcorner fed semisolid meal. The administration of metoclopramide (1.0 mg/kg of of B.W.) accelerated the mean cycle time of pyloric antrum from 20 mill. to 60 min. after feeding of liquid meal and from 40 min. to 120 min. after feeding of semisolid meal. From this study, the ultrasonography was confirmed as a valuable diagnostic method leer evaluating the gastric motility and gastric area in dogs. It is non-invasive, safe and reproducible, and provides a method for the study of the effect of drugs and diseases states on gastric motility.

• 한국기계가공학회지
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• 제21권4호
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• pp.91-99
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• 2022

By applying METHOD 514.8 of the US military standard MIL-STD-810H, vibration analysis of the winding core automatic feeding device was performed during vehicle transportation. The contact point between the LM guide and main support frame was weak in the vertical axis, transverse axis, and longitudinal axis during the transportation of the automatic winding core feeder vehicle, and the maximum equivalent stress was 236.31 MPa in the longitudinal axis. When random vibration was applied, the safety margin in the longitudinal direction was 0.26, indicating low safety. The safety margin was changed by increasing the damage factor to 0.1. Finally, the safety margin was improved to 3.48 to secure safety. Resonance occurred with a Q factor of 9.34 in the harmonic response to which the RMS value of the ASD data was input, and the vertical axis safety margin was derived as 0.16. When the damping factor was 0.15, the Q factor was 3.37, and resonance was avoided with a safety margin of 6.62.

• 한국기계가공학회지
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• 제18권1호
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• pp.109-115
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• 2019

In arc-welding applying to the present automobile part manufacturing process, a wrist-hollow type arc welding robot can shorten the welding cycle time, because feedability of a welding wire is not affected by a robot posture and thus facilitates high-quality arc welding, based on stable feeding with no entanglement. In this paper, we will propose the optimization of wrist design for a wrist-hollow type 6-Axis articulated robot. Specifically, we will perform the investigation on the optimized design of inner diameter of hollow arms (Axis 4 and Axis 6) and width of the upper arm by using the simulation of robot motion characteristics, using a Genetic Algorithm (i.e., GA). Our simulations are based on $SolidWorks^{(R)}$ for robot modeling, $MATLAB^{(R)}$ for GA optimization, and $RecurDyn^{(R)}$ for analyzing dynamic characteristics of a robot. Especially $RecurDyn^{(R)}$ is incorporated in the GA module of $MATLAB^{(R)}$ for the optimization process. The results of the simulations will be verified by using $RecurDyn^{(R)}$ to show that the driving torque of each axis of the writs-hollow 6-axis robot with the optimized wrist design should be smaller than the rated output torque of each joint servomotor. Our paper will be a guide for improving the wrist-hollow design by optimizing the wrist shape at a detail design stage when the driving torque of each joint for the wrist-hollow 6-axis robot (to being developed) is not matched with the servomotor specifications.

• 한국군사과학기술학회지
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• 제23권5호
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• pp.459-465
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• 2020

In this paper, a compact antenna assembly for an amplitude comparison direction-finding(DF) method for a small flight vehicle is presented. Designed antenna assembly consists of four antennas and it is mounted on a radius of 1.45 λ_c where λ_c corresponds to the wavelength of the center frequency. To achieve compactness and robustness of the assembly, the elements are fed by end-launch feeding method and have modified aperture shapes of E- or H-sectoral horns. The feeding part consists of SMA connector, stepped impedance matching structure, and square waveguide of 0.6 λ_c × 0.6 λ_c. To achieve different main beam directions for every antenna which is required condition for amplitude comparison DF method, all apertures of the antennas are inclined and it makes the main beam direction of each antenna to top, bottom, left, and right with respect to the axis of the platform. To verify the validation of DF performance of the presented antenna assembly, amplitude comparison curves using measurement results are presented. The bandwidth of the antennas are above 3.2 % in Ku-band(VSWR ≤ 2:1).

• 한국CDE학회논문집
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• 제8권2호
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• pp.115-121
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• 2003

A new Layered Manufacturing(LM) system, named PaperMill, is developed applying micro milling technology. A micro endmill(127 11m in diameter) is introduced as the cutter of build material. The selected build material for this system is an adhesive-coated paper roll which provides advantages such as good bonding between layers, machinability, and low material cost. A 3-axis CNC controller and three step-motors are used for the movement of X-Y-Z table of the system. For simplicity of the control of mechanism, the control system for feeding the paper roll is uncoupled from CNC controller. Two code converters are developed for the toolpath generation of the new LM system. The NC converter generates a set of NC codes for PaperMill using commercial CAM software while the SML converter generates an NC code from Quickslice's SML format. The NC codes generated from the converters consist of a series of profile data and trigger code for paper feeding. Two sample gears were fabricated to prove the concept of the system, which shown that the dimensional errors of the fabricated gears is under 3.4 percent.

• 한국산학기술학회논문지
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• 제11권6호
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• pp.1955-1960
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• 2010

CNC 3축 파이프 형상절단기의 성능은 이송계의 위치결정 정밀도와 공작물의 가공 정밀도를 측정하고 검증함으로써 평가되었다. 위치결정 정밀도는 PLC의 모션 컨트롤러에 의하여 구동된 이송 거리와 레이저 간섭계를 이용 한 실제 이송 거리를 측정 비교하여 오차를 확인하였다. 그리고 가공 정밀도는 절단된 공작물을 스캐닝하고 3D 모델링하여 가공형상을 확보하고, 절단궤적에 해당하는 CL 데이터와 비교하여 오차를 확인하였다.

• 제어로봇시스템학회논문지
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• 제15권7호
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• pp.675-682
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• 2009

Instead of direct driving like BLDC, the induction principle is adopted as a driving one for planar stage. The stage composed of four linear induction motors put in square type is activated by two-axial forces; low-frequency attractive force and thrust force of the linear induction motors. Here, the modified vector control whose new inputs are q-axis current and dc current biased to three phase current instead of d-axis current or flux current is applied extensively to overall motion of the stage. For the developed system, the precision step test and the constant velocity test are tried to guarantee its feasibility for TFT-LCD pattern inspection. However, to exclude a discontinuity due to phase shift and minimize a force ripple synchronized with the command frequency, the initial system is revised to the antagonistic structure over the full degree of freedom. Concretely describing, the porous air bearings guide an air-gapping of the stage up and down and a pair of liner induction motors instead of single motor are activated in the opposite direction each other. The performances of the above systems are compared from trapezoid tracking test and sinusoidal test.

• BMB Reports
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• 제57권3호
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• pp.149-154
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• 2024

The stomach has emerged as a crucial endocrine organ in the regulation of feeding since the discovery of ghrelin. Gut-derived hormones, such as ghrelin and cholecystokinin, can act through the vagus nerve. We previously reported the satiety effect of hypothalamic clusterin, but the impact of peripheral clusterin remains unknown. In this study, we administered clusterin intraperitoneally to mice and observed its ability to suppress fasting-driven food intake. Interestingly, we found its synergism with cholecystokinin and antagonism with ghrelin. These effects were accompanied by increased c-fos immunoreactivity in nucleus tractus solitarius, area postrema, and hypothalamic paraventricular nucleus. Notably, truncal vagotomy abolished this response. The stomach expressed clusterin at high levels among the organs, and gastric clusterin was detected in specific enteroendocrine cells and the submucosal plexus. Gastric clusterin expression decreased after fasting but recovered after 2 hours of refeeding. Furthermore, we confirmed that stomachspecific overexpression of clusterin reduced food intake after overnight fasting. These results suggest that gastric clusterin may function as a gut-derived peptide involved in the regulation of feeding through the gut-brain axis.

• Biomolecules & Therapeutics
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• 제31권4호
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• pp.417-424
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• 2023

Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degeneration induced by Proteus mirabilis (P. mirabilis) on the intestine and brain, simultaneously. C57BL/6J mice received P. mirabilis for 5 days. Ginger (300 mg/kg) and 6-shogaol (10 mg/kg) were treated by gavage feeding for 22 days including the period of P. mirabilis treatment. Results showed that 6-shogaol and ginger improved motor dysfunction and dopaminergic neuronal death induced by P. mirabilis treatment. In addition, they suppressed P. mirabilis-induced intestinal barrier disruption, pro-inflammatory signals such as toll-like receptor and TNF-α, and intestinal α-synuclein aggregation. Moreover, ginger and 6-shogaol significantly inhibited neuroinflammation and α-synuclein in the brain. Taken together, 6-shogaol and ginger have the potential to ameliorate PD-like motor behavior and degeneration of dopaminergic neurons induced by P. mirabilis in mice. Here, these findings are meaningful in that they provide the first experimental evidence that 6-shogaol might attenuate PD via regulating gut-brain axis.

• 한국기계가공학회지
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• 제6권2호
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• pp.28-33
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• 2007

This paper describes development of low cost precision machine that has a vacuum chuck. This study mainly aims to find out a cutting condition for maintaining optimum surface condition and to examine cutting characteristics of the precision machine that is equipped by diamond bites. The cutting materials is oxygen free copper. Several experiments were carried out to find out the main factors that affect the surface roughness such as principal axis RPM(rotation per minute), feeding speed, and cutting depth. As a result, we obtain The optimum cutting condition of the developed precision machine.