• Advances in Traditional Medicine
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• 제7권5호
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• pp.518-526
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• 2008

Recently a major goal in asthma therapy is to reduce or prevent the inflammatory response of airway. Eosinophilic accumulation in the tissue is a prominent feature of allergic diseases including asthma. Production of chemokines by bronchial epithelial cells may contribute to the allergic inflammation by recruiting eosinophils. In this study we evaluated the inhibitory effect of Gamichungsangbohatang (GMCSBHT), used traditionally in treating asthma, on secretion of chemokines for eosinophils in human A549 epithelial cells. Chemokines such as eotaxin, RANTES, IL-8 were inhibited in a dose-dependent manner, but IL-16 showed no inhibition by GMCSBHT. These findings indicate that GMCSBHT might be a therapeutic value in treating asthma by suppression of chemokines secretion associated with local accumulation of eosinophils.

• Journal of Welding and Joining
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• 제17권5호
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• pp.61-68
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• 1999

For the last two decades, waveform control techniques have been successively developed and applied for the inverter welding machines resulting in the substantial reduction of spatter generated in CO₂ welding. One of the constituents commonly involved in those techniques is to delay the instant of current increase to some extent after the initiation of short-circuiting. Although this technique has been known to be quite effective in reducing the spatter generation through the suppression of is instantaneous short circuiting, the delay time necessary for minimum spatter has not been clearly understood. In this study, the control system for varying the delay time was constructed so that the spatter generation rates could be measured over a wide range of delay time, 0.29-2.0 msec. As a result of this study, it was demonstrated that spatter generation rate(SGR) sharply decreased at delay time of 0.6 msec and longer accompanied with the change in characteristics of short circuit mode from the instantaneous short-circuiting(ISC) dominant to normal short-circuiting(NSC) dominant. Another feature that have been found in current waveform of over 0.6msec was the creation of current pulse right after the arc reignition stage. Because of this current pulses weld pool oscillated in wave-like fashion and it looks like to play an important role in developing short circuiting between electrode and weld pool.

• Natural Product Sciences
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• 제17권3호
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• pp.216-220
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• 2011

Activation of hepatic stellate cells (HSCs) characterized by increased proliferation and extracellular matrix deposition is identified as the major pathological feature of hepatic cirrhosis. Therefore, suppression of HSC activation has been proposed as an important antifibrotic therapeutic strategy. In the present study, we investigated the antiproliferative activity of root barks of Ulmus davidiana var. japonica (Ulmaceae) by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Further investigation of the n-hexane and $CHCl_3$ fractions of root barks of U. davidiana var japonica led to the isolation of six triterpenoids: friedelin (1), epifridelanol (2), oleanolic acid (3), maslinic acid (4), ${\beta}$-amyrin (5) and ${\alpha}$-amyrin (6), together with ${\beta}$-sitosterol (7) and daucosterol (8). Among these compounds, 2, 3 and 4 significantly inhibited HSC proliferation. In addition, 4 inhibited HSC proliferation in time- and concentration-related manners, via a partially direct toxic effect, as assessed by morphological changes and release of lactate dehydrogenase.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.370-370
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• 2012

Feature size of Cu interconnects keep shrinking into several tens of nanometer level. For this reason, the Cu interconnects face challenging issues such as increase of electro-migration, line-width dependent electrical resistivity increase, and gap-filling difficulty in high aspect ratio structures. As the thickness of the Cu film decreases below 30 nm, the electrical resistivity is not any more constant, but rather exponential. Research on alloying with other elements have been started to inhibit such escalation in the electrical resistivity. A faint trace of Al added in Cu film by sputtering was reported to contribute to suppression of the increase of the electrical resistivity. From an industrial point of view, we introduced cyclic metal organic chemical vapor deposition (MOCVD) in order to control Al concentration in the Cu film more easily by controlling the delivery time ratio of Cu and Al precursors. The amount of alloying element could be lowered at level of below 1 at%. Process of the alloy formation was applied into gap-filling to evaluate the performance of the gap-filling. Voidless gap-filling even into high aspect ratio trenches was achieved. In-depth analysis will be discussed in detail.

• Korean Journal of Geomatics
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• 제1권1호
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• pp.43-49
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• 2001

Although many kinds of stereo matching method have been developed in the field of computer vision and photogrammetry, wrong matches are not easy to avoid. This paper presents a new method to reduce wrong matches after matching, and experimental results are reported. The main idea is to analyze the histogram of the image attribute differences between each pair of image patches matched. Typical image attributes of image patch are the mean and the standard deviation of gray value for each image patch, but there could be other kinds of image attributes. Another idea is to check relative position among potential matches. This paper proposes to use Gaussian blunder filter to detect the suspicious pair of candidate match in relative position among neighboring candidate matches. If the suspicious candidate matches in image attribute difference or relative position are suppressed, then many wrong matches are removed, but minimizing the suppression of good matches. The proposed method is easy to implement, and also has potential to be applied as post processing after image matching for many kinds of matching methods such as area based matching, feature matching, relaxation matching, dynamic programming, and multi-channel image matching. Results show that the proposed method produces fewer wrong matches than before.

• 반도체디스플레이기술학회지
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• 제19권3호
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• pp.30-35
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• 2020

A microlens has been fabricated by various methods such as a thermal reflow, hot embossing, diamond milling, etc. However, these methods require a relatively complex process to control the microlens shape. In this work, we report on a simple and cost-effective method to fabricate a cylindrical microlens (CML), which can diffuse light widely. We have employed a slot-die head with the dual plate (a meniscus guide with a protruded μ-tip and a shim with a slit channel) for coating of a narrow stripe using poly(methyl methacrylate) (PMMA). We have shown that the higher the coating gap, the lower the maximum coating speed, which causes an increase in the stripe width and thickness. The coated PMMA stripe has the concave shape. To make it in the shape of a convex microlens, we have applied the thermal reflow method. When the stripe thickness is small, however, its effect is negligible. To increase the stripe thickness, we have increased the number of repeated coating. With this scheme, we have fabricated the CML with the width of 223 ㎛ and the thickness of 7.3 ㎛. Finally, we have demonstrated experimentally that the CML can diffuse light widely, a feature demanded for light extraction efficiency of organic light-emitting diodes (OLEDs) and suppression of moiré patterns in displays.

• 한국생산제조학회지
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• 제21권1호
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• pp.175-181
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• 2012

This paper presents a novel dynamic vibration absorber (DVA) to suppress the unbalance response of flexible rotor-bearing systems. The DVA unit consists of two DVAs, an adapter to place the DVAs and an adapter frame to locate the adapter. The essential feature of the proposed DVA unit is to place itself on any desirable location of the shaft without disassembling the rotor-bearing system under consideration. A simulation with a 3D element based commercial rotor dynamic software is made to test the possibility of the proposed DVA on the suppression of unbalance response in rotor-bearing systems. Experiments are performed to validate the proposed DVA unit. The simulation and experiments show that the proposed DVA unit is very effective to suppress the unbalance response in rotor-bearing system at designated rotational speeds of interest.

• Journal of Power Electronics
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• 제19권6호
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• pp.1351-1365
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• 2019

This paper proposes two modified Z-source inverter topologies, namely an embedded L-Z-source inverter (EL-ZSI) and a coupled inductor L-Z source inverter (CL-ZSI). The proposed topologies offer a high voltage gain with a reduced passive component count and reduction in source current ripple when compared to conventional ZSI topologies. Additionally, they prevent overshoot in the dc-link voltage by suppressing heavy inrush currents. This feature reduces the transition time to reach the peak value of the dc-link voltage, and reduces the risk of component failure and overrating due to the inrush current. EL-ZSI and CL-ZSI possess all of the inherent advantages of the conventional L-ZSI topology while eliminating its drawbacks. To verify the effectiveness of the proposed topologies, MATLAB/Simulink models and scaled down laboratory prototypes were constructed. Experiments were performed at a low shoot through duty ratio of 0.1 and a modulation index as high as 0.9 to obtain a peak dc-link voltage of 53 V. This paper demonstrates the superiority of the proposed topologies over conventional ZSI topologies through a detailed comparative analysis. Moreover, experimental results verify that the proposed topologies would be advantageous for renewable energy source applications since they provide voltage gain enhancement, inrush current, dc-link voltage overshoot suppression and a reduction of the peak to peak source current ripple.

• Natural Product Sciences
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• 제29권2호
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• pp.91-97
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• 2023

Mangosteen peel extract is a xanthone group, that plays an important role in anti-angiogenesis. This study investigated mangosteen peel extract on cerebral neovascularization in type 2 diabetes mellitus (DM) rats. This study used 36 rats, randomized into six groups: C1 (negative control); C2 (high fat diet (HFD) and mangosteen peel extract at 200 mg/kg BW); C3 (HFD and diabetic); E1, E2, and E3 (HFD, diabetic, and extract at 100, 200, and 400 mg/kg BW respectively). All groups were measured body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR) and β cell function (HOMA-B), and histopathological feature of cerebral vascular (CV). There were significant differences in BMI, HOMA-IR, HOMA-B, and the mean number of CV (all p < 0.05) among treatment groups. E1-3 groups had a significantly lower level of blood glucose and HOMA-IR, and a higher level of HOMA-B and BMI (all p < 0.05) which tends to reduce cerebral neovascularization. HOMA-IR independently had a positive effect to induce neovascularization of CV (p < 0.05, R² = 26.8%). These findings suggested that mangosteen peel extract increased β-cell function sensitivity, and effectively suppressed insulin resistance, BMI, and cerebral neovascularization process in type 2 DM rats.

• Journal of Photoscience
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• 제9권2호
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• pp.110-113
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• 2002

We demonstrate here a dynamic structure of bacteriorhodopsin (bR) as revealed by $^{13}$ C NMR studies on [3_$^{13}$ C]_,[1-$^{13}$ C]Ala- and/or Val-labeled wild type and a variety of site-directed mutants at ambient temperature. For this purpose, well-resolved (up to twelve) I$^{13}$ C NMR peaks were assigned with reference to the displacement of peaks due to the conformation-dependent I$^{13}$ C chemical shifts and reduced peak-intensities due to site-directed mutations. Revealed bR structure was not rigid as anticipated from 2D crystals of hexagonal array but a dynamically heterogeneous, undergoing a variety of local fluctuations depending upon specific site with frequency range of 10$^2$ -10$^{8}$ Hz. In particular, dynamics- dependent suppression of peaks turned out to be very sensitive to the motion of 10$^{-4}$ s and 10$^{-5}$ s interfered with frequency of magic angle spinning and proton decoupling, respectively. It is also noteworthy that such dynamic feature is strongly dependent upon the manner of 2D crystalline packing: $^{13}$ C NMR peaks of monomeric bR yielded either highly broadened or completely suppressed signals, depending upon the type of $^{13}$ C-labeled amino-acid residues.